CN109071564A - 乙型肝炎病毒表面抗原抑制剂 - Google Patents

乙型肝炎病毒表面抗原抑制剂 Download PDF

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Publication number
CN109071564A
CN109071564A CN201880001647.2A CN201880001647A CN109071564A CN 109071564 A CN109071564 A CN 109071564A CN 201880001647 A CN201880001647 A CN 201880001647A CN 109071564 A CN109071564 A CN 109071564A
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milliliters
pharmaceutically acceptable
compound
acceptable salt
mms
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CN109071564B (zh
Inventor
孙飞
杜金华
胡彦宾
周丽莉
丁照中
陈曙辉
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Fujian Guangsheng Zhonglin Biotechnology Co.,Ltd.
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Medshine Discovery Inc
Fujian Cosunter Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

作为乙肝表面抗原抑制剂的式(I)的10‑氧代‑6,1‑二氢苯并[e]吡啶并[1,2‑c][1,3]恶嗪‑9‑羧酸衍生物,或其药学上可接受的盐,以及式(I)化合物或其药学上可接受的盐和其药用组合物在制备治疗乙型病毒性肝炎的药物中的应用。

Description

PCT国内申请,说明书已公开。

Claims (23)

  1. PCT国内申请,权利要求书已公开。
CN201880001647.2A 2017-03-09 2018-03-09 乙型肝炎病毒表面抗原抑制剂 Active CN109071564B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017101382755 2017-03-09
CN201710138275 2017-03-09
PCT/CN2018/078581 WO2018161960A1 (zh) 2017-03-09 2018-03-09 乙型肝炎病毒表面抗原抑制剂

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CN109071564A true CN109071564A (zh) 2018-12-21
CN109071564B CN109071564B (zh) 2019-08-27

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Country Status (25)

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US (1) US11008331B2 (zh)
EP (1) EP3590942B1 (zh)
JP (1) JP6783424B2 (zh)
KR (1) KR102087397B1 (zh)
CN (1) CN109071564B (zh)
AU (1) AU2018232071B2 (zh)
BR (1) BR112019018650B1 (zh)
CA (1) CA3055442C (zh)
DK (1) DK3590942T3 (zh)
EA (1) EA038122B9 (zh)
ES (1) ES2879930T3 (zh)
HR (1) HRP20211331T1 (zh)
HU (1) HUE055170T2 (zh)
IL (1) IL269142B (zh)
LT (1) LT3590942T (zh)
MX (1) MX2019010736A (zh)
MY (1) MY174224A (zh)
PH (1) PH12019502052A1 (zh)
PL (1) PL3590942T3 (zh)
PT (1) PT3590942T (zh)
RS (1) RS62094B1 (zh)
SG (1) SG11201908101YA (zh)
SI (1) SI3590942T1 (zh)
WO (1) WO2018161960A1 (zh)
ZA (1) ZA201906252B (zh)

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WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
BR112018067964B1 (pt) 2016-03-07 2024-01-16 Enanta Pharmaceuticals, Inc Composto, composição farmacêutica que o compreende e uso do referido composto
CN110066278B (zh) 2017-06-01 2021-06-08 广东东阳光药业有限公司 稠合三环类化合物及其在药物中的应用
IL272941B2 (en) 2017-08-28 2023-03-01 Enanta Pharm Inc Antiviral agents for viral hepatitis b
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2019169539A1 (en) * 2018-03-05 2019-09-12 Pharmaresources (Shanghai) Co., Ltd. Novel oxa-and aza-tricyclic 4-pyridone-3-carboxylic acid for treatment and prophylaxis of hepatitis b virus infection
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
EP3846808A4 (en) * 2018-09-05 2022-08-17 Children's Medical Center Corporation PAPD5 INHIBITORS AND METHODS OF USE THEREOF
BR112021005091A2 (pt) 2018-09-21 2021-06-08 Enanta Pharmaceuticals, Inc. heterociclos funcionalizados como agentes antivirais
JP2022511378A (ja) 2018-09-30 2022-01-31 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 縮合四環系化合物および医薬品におけるそれらの使用
CN113271946A (zh) 2018-11-21 2021-08-17 英安塔制药有限公司 官能化杂环化合物作为抗病毒剂
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
CA3151696A1 (en) * 2019-09-19 2021-03-25 Fujian Akeylink Biotechnology Co., Ltd. Crystal form of hepatitis b surface antigen inhibitor and application thereof
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN115515596A (zh) * 2020-05-15 2022-12-23 福建广生中霖生物科技有限公司 包含三并环类化合物的组合及其在制备治疗hbv药物中的应用
US20230183263A1 (en) * 2020-05-15 2023-06-15 Fujian Akeylink Biotechnology Co., Ltd. Combination for treating hepatitis b
WO2022112207A1 (en) * 2020-11-25 2022-06-02 F. Hoffmann-La Roche Ag Aromatic spiro ring amide derivatives for the treatment and prophylaxis of hepatitis b virus infection
WO2022152019A1 (zh) * 2021-01-15 2022-07-21 福建广生中霖生物科技有限公司 一种手性噁嗪类化合物的制备方法

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CN103450184A (zh) * 2012-05-29 2013-12-18 上海壹志医药科技有限公司 斯氏紫堇碱衍生物的盐
WO2016128335A1 (en) * 2015-02-11 2016-08-18 F. Hoffmann-La Roche Ag Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
CN107759585A (zh) * 2016-07-29 2018-03-06 银杏树药业(苏州)有限公司 一种异喹啉类化合物及其药用组合物和作为抗病毒药物的应用

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SG11201605970QA (en) 2014-01-30 2016-08-30 Hoffmann La Roche Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
WO2017013046A1 (en) 2015-07-21 2017-01-26 F. Hoffmann-La Roche Ag Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
WO2017017043A1 (en) * 2015-07-28 2017-02-02 F. Hoffmann-La Roche Ag Novel 6,7-dihydropyrido[2,1-a]phthalazin-2-ones for the treatment and prophylaxis of hepatitis b virus infection

Patent Citations (4)

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US20130251647A1 (en) * 2011-09-20 2013-09-26 Basf Se Low molecular weight modulators of the cold menthol receptor trpm8 and use thereof
CN103450184A (zh) * 2012-05-29 2013-12-18 上海壹志医药科技有限公司 斯氏紫堇碱衍生物的盐
WO2016128335A1 (en) * 2015-02-11 2016-08-18 F. Hoffmann-La Roche Ag Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
CN107759585A (zh) * 2016-07-29 2018-03-06 银杏树药业(苏州)有限公司 一种异喹啉类化合物及其药用组合物和作为抗病毒药物的应用

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US20200039995A1 (en) 2020-02-06
JP2020509075A (ja) 2020-03-26
HUE055170T2 (hu) 2021-11-29
PL3590942T3 (pl) 2021-12-13
BR112019018650B1 (pt) 2021-12-14
EP3590942B1 (en) 2021-06-09
LT3590942T (lt) 2021-07-12
CA3055442C (en) 2021-03-23
WO2018161960A1 (zh) 2018-09-13
PH12019502052A1 (en) 2020-07-06
EA038122B1 (ru) 2021-07-09
EP3590942A1 (en) 2020-01-08
AU2018232071A1 (en) 2019-10-17
KR102087397B1 (ko) 2020-03-11
EP3590942A4 (en) 2020-01-08
SG11201908101YA (en) 2019-10-30
IL269142B (en) 2020-07-30
CN109071564B (zh) 2019-08-27
SI3590942T1 (sl) 2021-11-30
US11008331B2 (en) 2021-05-18
MY174224A (en) 2020-03-23
BR112019018650A2 (pt) 2020-04-07
CA3055442A1 (en) 2018-09-13
EA038122B9 (ru) 2021-09-14
PT3590942T (pt) 2021-07-28
KR20190117799A (ko) 2019-10-16
MX2019010736A (es) 2019-11-05
RS62094B1 (sr) 2021-08-31
JP6783424B2 (ja) 2020-11-11
ZA201906252B (en) 2021-04-28
DK3590942T3 (da) 2021-09-06
HRP20211331T1 (hr) 2021-11-26
AU2018232071B2 (en) 2021-07-08
EA201992082A1 (ru) 2020-02-12
ES2879930T3 (es) 2021-11-23

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