CN110198943A - 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物 - Google Patents

作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物 Download PDF

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CN110198943A
CN110198943A CN201880008008.9A CN201880008008A CN110198943A CN 110198943 A CN110198943 A CN 110198943A CN 201880008008 A CN201880008008 A CN 201880008008A CN 110198943 A CN110198943 A CN 110198943A
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added
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CN110198943B (zh
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钱文远
杨纯道
李正伟
李婕
黎健
陈曙辉
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Wuxi Zhikang Hongyi Biotechnology Co ltd
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Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

本发明公开了一类具有Wee1的抑制作用的1,2‑二氢‑3H‑吡唑[3,4‑d]嘧啶‑3‑酮类化合物，并包含这些化合物在治疗各类肿瘤方面的应用。

Description

PCT国内申请，说明书已公开。

Claims (22)

  1. PCT国内申请，权利要求书已公开。
CN201880008008.9A 2017-01-23 2018-01-19 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物 Active CN110198943B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201710058856 2017-01-23
CN2017100588568 2017-01-23
CN201711376769 2017-12-19
CN2017113767693 2017-12-19
PCT/CN2018/073360 WO2018133829A1 (zh) 2017-01-23 2018-01-19 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物

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CN110198943A true CN110198943A (zh) 2019-09-03
CN110198943B CN110198943B (zh) 2021-04-16

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US (1) US10954253B2 (zh)
EP (1) EP3572413B1 (zh)
JP (1) JP6717457B2 (zh)
CN (1) CN110198943B (zh)
ES (1) ES2902050T3 (zh)
WO (1) WO2018133829A1 (zh)

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CN114591334A (zh) * 2020-12-04 2022-06-07 山东轩竹医药科技有限公司 二氢吡唑并嘧啶酮衍生物
WO2024011883A1 (zh) * 2022-07-13 2024-01-18 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途

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WO2019074979A1 (en) 2017-10-09 2019-04-18 Girafpharma, Llc HETEROCYCLIC COMPOUNDS AND USES THEREOF
US10807994B2 (en) 2017-10-09 2020-10-20 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
AU2019227823A1 (en) * 2018-02-28 2020-08-06 The Regents Of The University Of Colorado, A Body Corporate WEE1 kinase inhibitors and methods of treating cancer using the same
EP3762385A4 (en) 2018-03-09 2021-11-24 Recurium IP Holdings, LLC SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO [3,4-D] PYRIMIDINE-3-ONE
KR20210141659A (ko) 2019-03-22 2021-11-23 쇼우야오 홀딩스 (베이징) 코., 엘티디. Wee1 억제제 및 이의 제조 및 용도
JP2022526831A (ja) 2019-04-09 2022-05-26 ニューベイション・バイオ・インコーポレイテッド ヘテロ環式化合物およびその使用
WO2020259703A1 (zh) 2019-06-28 2020-12-30 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用
CN112142748B (zh) 2019-06-28 2023-07-04 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用
EP4169919A1 (en) * 2020-06-17 2023-04-26 Wigen Biomedicine Technology (Shanghai) Co., Ltd. Pyrazolo[3,4-d]pyrimidine-3-ketone derivative as wee-1 inhibitor
CN118176195A (zh) * 2021-11-01 2024-06-11 正大天晴药业集团股份有限公司 吡唑[3,4-d]嘧啶-3-酮类化合物及其医药用途
CN116462687A (zh) 2022-01-18 2023-07-21 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
CN115521309A (zh) * 2022-09-16 2022-12-27 思科(深圳)药物研发有限公司 一种依鲁奥克杂质及其制备方法

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CN101432284A (zh) * 2006-04-27 2009-05-13 万有制药株式会社 二氢吡唑并嘧啶酮衍生物
EP2213673A4 (en) * 2007-10-23 2011-09-07 Msd Kk PYRIDONE-SUBSTITUTED DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE
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CN105829315A (zh) * 2013-12-19 2016-08-03 阿尔麦克探索有限公司 可用作Wee-1激酶抑制剂的嘧啶并嘧啶酮类

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PT2477628E (pt) 2009-09-15 2014-11-25 Merck Sharp & Dohme Preparação de formas de hemihidrato cristalino de dihidropirazolopirimidinona
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WO2013012681A1 (en) 2011-07-15 2013-01-24 Abbott Laboratories Tricyclic inhibitors of kinases useful for the treatment of proliferative diseases
WO2013013031A1 (en) 2011-07-19 2013-01-24 Abbvie Inc. Pyridazino [4, 5 -d] pyrimidin- (6h) -one inhibitors of wee - 1 kinase
EP2755482B1 (en) * 2011-09-15 2016-06-01 Merck Sharp & Dohme Corp. Combination of mk-1775 and mk-8776 for treating cancer
JP2014530867A (ja) 2011-10-20 2014-11-20 アッヴィ・インコーポレイテッド キナーゼのピリドピリミジノン阻害剤
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ES2714576T3 (es) * 2014-07-04 2019-05-29 Qilu Pharmaceutical Co Ltd Oxido de arilfósforo y sulfuro de arilfósforo espirocíclicos
EP3368538B1 (en) 2015-11-01 2021-09-01 The Regents of The University of Colorado, A Body Corporate Wee 1 kinase inhibitors and methods of making and using the same

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CN101432284A (zh) * 2006-04-27 2009-05-13 万有制药株式会社 二氢吡唑并嘧啶酮衍生物
EP2213673A4 (en) * 2007-10-23 2011-09-07 Msd Kk PYRIDONE-SUBSTITUTED DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE
CN105209463A (zh) * 2013-04-11 2015-12-30 阿尔麦克探索有限公司 2-氨基吡啶并[4,3-d]嘧啶-5-酮衍生物及其作为Wee-1抑制剂的用途
CN105829315A (zh) * 2013-12-19 2016-08-03 阿尔麦克探索有限公司 可用作Wee-1激酶抑制剂的嘧啶并嘧啶酮类

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114591334A (zh) * 2020-12-04 2022-06-07 山东轩竹医药科技有限公司 二氢吡唑并嘧啶酮衍生物
CN114591334B (zh) * 2020-12-04 2023-10-20 山东轩竹医药科技有限公司 二氢吡唑并嘧啶酮衍生物
WO2024011883A1 (zh) * 2022-07-13 2024-01-18 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途

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JP6717457B2 (ja) 2020-07-01
US20200017528A1 (en) 2020-01-16
JP2020510630A (ja) 2020-04-09
WO2018133829A1 (zh) 2018-07-26
EP3572413A1 (en) 2019-11-27
EP3572413B1 (en) 2021-11-03
ES2902050T3 (es) 2022-03-24
CN110198943B (zh) 2021-04-16
US10954253B2 (en) 2021-03-23
EP3572413A4 (en) 2020-08-19

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Patentee before: Shijiazhuang Zhikang Hongren New Drug Development Co.,Ltd.