DK2534149T3 - 6-amino-2-{ [ (1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-on-maleat - Google Patents

6-amino-2-{ [ (1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-on-maleat Download PDF

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Publication number
DK2534149T3
DK2534149T3 DK11709025.8T DK11709025T DK2534149T3 DK 2534149 T3 DK2534149 T3 DK 2534149T3 DK 11709025 T DK11709025 T DK 11709025T DK 2534149 T3 DK2534149 T3 DK 2534149T3
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Prior art keywords
purin
methylbutyl
piperidinyl
maleate
dihydro
Prior art date
Application number
DK11709025.8T
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English (en)
Inventor
Robert Hermann Gibbon
Amanda Lucas
Stephen Andrew Hermitage
Original Assignee
Glaxosmithkline Llc
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Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
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Publication of DK2534149T3 publication Critical patent/DK2534149T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
DK11709025.8T 2010-02-10 2011-02-08 6-amino-2-{ [ (1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-on-maleat DK2534149T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30301010P 2010-02-10 2010-02-10
PCT/EP2011/051830 WO2011098452A1 (en) 2010-02-10 2011-02-08 6-amino-2-{ [ (1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate

Publications (1)

Publication Number Publication Date
DK2534149T3 true DK2534149T3 (da) 2015-01-05

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Family Applications (1)

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DK11709025.8T DK2534149T3 (da) 2010-02-10 2011-02-08 6-amino-2-{ [ (1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-on-maleat

Country Status (23)

Country Link
US (1) US8703754B2 (da)
EP (1) EP2534149B1 (da)
JP (1) JP5922587B2 (da)
KR (1) KR101773541B1 (da)
CN (1) CN102753553B (da)
AU (1) AU2011214468B2 (da)
BR (1) BR112012018904A2 (da)
CA (1) CA2786973C (da)
DK (1) DK2534149T3 (da)
EA (1) EA021048B1 (da)
ES (1) ES2525826T3 (da)
HR (1) HRP20141258T1 (da)
IL (1) IL220845A (da)
ME (1) ME01926B (da)
MX (1) MX2012009316A (da)
PL (1) PL2534149T3 (da)
PT (1) PT2534149E (da)
RS (1) RS53745B1 (da)
SG (1) SG182471A1 (da)
SI (1) SI2534149T1 (da)
SM (1) SMT201400196B (da)
WO (1) WO2011098452A1 (da)
ZA (1) ZA201205995B (da)

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Also Published As

Publication number Publication date
US8703754B2 (en) 2014-04-22
EP2534149B1 (en) 2014-10-15
PT2534149E (pt) 2014-12-23
RS53745B1 (en) 2015-06-30
ES2525826T3 (es) 2014-12-30
WO2011098452A1 (en) 2011-08-18
HRP20141258T1 (hr) 2015-02-27
EA021048B1 (ru) 2015-03-31
KR20120135408A (ko) 2012-12-13
AU2011214468A1 (en) 2012-08-09
BR112012018904A2 (pt) 2020-09-01
SG182471A1 (en) 2012-08-30
KR101773541B1 (ko) 2017-08-31
CA2786973C (en) 2018-04-10
MX2012009316A (es) 2012-09-12
EP2534149A1 (en) 2012-12-19
SMT201400196B (it) 2015-01-15
SI2534149T1 (sl) 2015-02-27
CN102753553B (zh) 2016-03-30
ME01926B (me) 2015-05-20
ZA201205995B (en) 2014-01-29
JP2013519645A (ja) 2013-05-30
EA201290631A1 (ru) 2013-03-29
CN102753553A (zh) 2012-10-24
PL2534149T3 (pl) 2015-03-31
US20120308609A1 (en) 2012-12-06
JP5922587B2 (ja) 2016-05-24
CA2786973A1 (en) 2011-08-18
IL220845A (en) 2016-08-31
AU2011214468B2 (en) 2015-05-28

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