EA201100113A1 - Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний - Google Patents

Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний

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Publication number
EA201100113A1
EA201100113A1 EA201100113A EA201100113A EA201100113A1 EA 201100113 A1 EA201100113 A1 EA 201100113A1 EA 201100113 A EA201100113 A EA 201100113A EA 201100113 A EA201100113 A EA 201100113A EA 201100113 A1 EA201100113 A1 EA 201100113A1
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EA
Eurasian Patent Office
Prior art keywords
treatment
allergic
infectious diseases
inflammatory
purin
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EA201100113A
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English (en)
Other versions
EA020631B1 (ru
Inventor
Кейт Биггадайк
Дайан Мэри Коэ
Сяо Цин Льюэлл
Шарлотт Джейн Митчелл
Стефан Аллан Смит
Наимиша Триведи
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ГЛАКСОСМИТКЛАЙН ЭлЭлСи
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Application filed by ГЛАКСОСМИТКЛАЙН ЭлЭлСи filed Critical ГЛАКСОСМИТКЛАЙН ЭлЭлСи
Publication of EA201100113A1 publication Critical patent/EA201100113A1/ru
Publication of EA020631B1 publication Critical patent/EA020631B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Соединения формулы (I)где Rпредставляет собой Cалкиламино, Cалкокси или Сциклоалкилокси; m равен целому числу, имеющему значение от 3 до 6; n равен целому числу, имеющему значение от 0 до 4; и их соли являются индукторами человеческого интерферона. Соединения, которые индуцируют человеческий интерферон, могут быть полезны в лечении различных расстройств, например лечении аллергических заболеваний и других воспалительных состояний, например аллергического ринита и астмы, лечении инфекционных заболеваний и рака, и также могут быть полезны в качестве вакцинных адъювантов.
EA201100113A 2008-08-11 2009-08-07 Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний EA020631B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8777708P 2008-08-11 2008-08-11
PCT/EP2009/060265 WO2010018133A1 (en) 2008-08-11 2009-08-07 Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases

Publications (2)

Publication Number Publication Date
EA201100113A1 true EA201100113A1 (ru) 2011-10-31
EA020631B1 EA020631B1 (ru) 2014-12-30

Family

ID=41187189

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100113A EA020631B1 (ru) 2008-08-11 2009-08-07 Производные пурина для применения в лечении аллергических, воспалительных и инфекционных заболеваний

Country Status (38)

Country Link
US (7) US8765772B2 (ru)
EP (3) EP2324026B1 (ru)
JP (1) JP5529867B2 (ru)
KR (1) KR101669939B1 (ru)
CN (2) CN102177159B (ru)
AU (1) AU2009281197B2 (ru)
BR (1) BRPI0917138A2 (ru)
CA (1) CA2733749C (ru)
CL (1) CL2011000301A1 (ru)
CO (1) CO6351791A2 (ru)
CR (1) CR20110116A (ru)
CY (1) CY1119992T1 (ru)
DK (2) DK2324026T3 (ru)
DO (1) DOP2011000048A (ru)
EA (1) EA020631B1 (ru)
ES (2) ES2549154T3 (ru)
HK (3) HK1157770A1 (ru)
HR (2) HRP20150938T1 (ru)
HU (2) HUE027637T2 (ru)
IL (1) IL210757A (ru)
LT (1) LT3000813T (ru)
MA (1) MA32624B1 (ru)
ME (1) ME02274B (ru)
MX (2) MX336345B (ru)
MY (1) MY162538A (ru)
NO (1) NO3000813T3 (ru)
NZ (2) NZ590782A (ru)
PE (1) PE20110674A1 (ru)
PL (2) PL2324026T3 (ru)
PT (2) PT2324026E (ru)
RS (2) RS56984B1 (ru)
SG (1) SG192547A1 (ru)
SI (2) SI2324026T1 (ru)
SM (1) SMT201500224B (ru)
TR (1) TR201802648T4 (ru)
UA (1) UA103195C2 (ru)
WO (1) WO2010018133A1 (ru)
ZA (1) ZA201100845B (ru)

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