CL2008001898A1 - Compuestos derivados de pirazinona, inhibidores de p38; proceso de preparacion de estos; composicion farmaceutica que los comprende; combinacion farmaceutica que los comprende; uso para tratar enferemedades pulmonares obstructivas cronicas y asma. - Google Patents

Compuestos derivados de pirazinona, inhibidores de p38; proceso de preparacion de estos; composicion farmaceutica que los comprende; combinacion farmaceutica que los comprende; uso para tratar enferemedades pulmonares obstructivas cronicas y asma.

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Publication number
CL2008001898A1
CL2008001898A1 CL2008001898A CL2008001898A CL2008001898A1 CL 2008001898 A1 CL2008001898 A1 CL 2008001898A1 CL 2008001898 A CL2008001898 A CL 2008001898A CL 2008001898 A CL2008001898 A CL 2008001898A CL 2008001898 A1 CL2008001898 A1 CL 2008001898A1
Authority
CL
Chile
Prior art keywords
chronic obstructive
obstructive pulmonary
pyrazinone
asthma
pharmaceutical composition
Prior art date
Application number
CL2008001898A
Other languages
English (en)
Inventor
Richard Evans
Timothy Jon Luker
Stephen Brough
Piotr Raubo
Original Assignee
Astrazeneca Ab
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Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2008001898A1 publication Critical patent/CL2008001898A1/es

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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Abstract

COMPUESTOS DERIVADOS DE PIRAZINONA DE FORMULA (I):<br /> DONDE R1, R2, R3, R4, R5, R6 Y R7 SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA; USO DE DICHO COMPUESTO QUE SIRVE PARA LA FABRICACIÓN DE UN MEDICAMENTO PARA USO EN EL TRATAMIENTO DE LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA (EPOC); Y COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE DICHO COMPUESTO, O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, Y UN ADYUVANTE, DILUYENTE O PORTADOR FARMACÉUTICAMENTE ACEPTABLE.<br />  
CL2008001898A 2007-06-27 2008-06-26 Compuestos derivados de pirazinona, inhibidores de p38; proceso de preparacion de estos; composicion farmaceutica que los comprende; combinacion farmaceutica que los comprende; uso para tratar enferemedades pulmonares obstructivas cronicas y asma. CL2008001898A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94641507P 2007-06-27 2007-06-27
US97816707P 2007-10-08 2007-10-08
US2944408P 2008-02-18 2008-02-18

Publications (1)

Publication Number Publication Date
CL2008001898A1 true CL2008001898A1 (es) 2009-07-17

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CL2008001898A CL2008001898A1 (es) 2007-06-27 2008-06-26 Compuestos derivados de pirazinona, inhibidores de p38; proceso de preparacion de estos; composicion farmaceutica que los comprende; combinacion farmaceutica que los comprende; uso para tratar enferemedades pulmonares obstructivas cronicas y asma.

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EP (1) EP2170848B1 (es)
JP (2) JP5140154B2 (es)
KR (1) KR101541203B1 (es)
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AR (1) AR067444A1 (es)
AU (1) AU2008269516B2 (es)
BR (1) BRPI0813244B8 (es)
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CL (1) CL2008001898A1 (es)
CO (1) CO6251251A2 (es)
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US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
AR073711A1 (es) 2008-10-01 2010-11-24 Astrazeneca Ab Derivados de isoquinolina
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
US8969350B2 (en) * 2008-12-18 2015-03-03 Astrazeneca Ab Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient
US8993808B2 (en) 2009-01-21 2015-03-31 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
MX338041B (es) 2009-09-25 2016-03-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especificos de lisina y su uso.
US8946296B2 (en) 2009-10-09 2015-02-03 Oryzon Genomics S.A. Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
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