JP2016531895A5 - - Google Patents
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- Publication number
- JP2016531895A5 JP2016531895A5 JP2016520004A JP2016520004A JP2016531895A5 JP 2016531895 A5 JP2016531895 A5 JP 2016531895A5 JP 2016520004 A JP2016520004 A JP 2016520004A JP 2016520004 A JP2016520004 A JP 2016520004A JP 2016531895 A5 JP2016531895 A5 JP 2016531895A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- conjugate according
- patient
- polyethylene glycol
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361887111P | 2013-10-04 | 2013-10-04 | |
| US61/887,111 | 2013-10-04 | ||
| PCT/US2014/059146 WO2015051307A1 (en) | 2013-10-04 | 2014-10-03 | Slow-release conjugates of sn-38 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019010029A Division JP6842479B2 (ja) | 2013-10-04 | 2019-01-24 | Ｓｎ−３８の徐放性コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531895A JP2016531895A (ja) | 2016-10-13 |
| JP2016531895A5 true JP2016531895A5 (enExample) | 2017-11-09 |
| JP6473145B2 JP6473145B2 (ja) | 2019-02-20 |
Family
ID=51871275
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016520004A Active JP6473145B2 (ja) | 2013-10-04 | 2014-10-03 | Ｓｎ−３８の徐放性コンジュゲート |
| JP2019010029A Active JP6842479B2 (ja) | 2013-10-04 | 2019-01-24 | Ｓｎ−３８の徐放性コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019010029A Active JP6842479B2 (ja) | 2013-10-04 | 2019-01-24 | Ｓｎ−３８の徐放性コンジュゲート |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10016411B2 (enExample) |
| EP (1) | EP3052101B1 (enExample) |
| JP (2) | JP6473145B2 (enExample) |
| KR (1) | KR102320753B1 (enExample) |
| CN (1) | CN106061483B (enExample) |
| AU (2) | AU2014331591B2 (enExample) |
| BR (1) | BR112016007410B1 (enExample) |
| CA (1) | CA2925132C (enExample) |
| DK (1) | DK3052101T3 (enExample) |
| ES (1) | ES2759905T3 (enExample) |
| MX (1) | MX371201B (enExample) |
| SG (2) | SG11201602258WA (enExample) |
| TW (1) | TWI716342B (enExample) |
| WO (1) | WO2015051307A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6473145B2 (ja) * | 2013-10-04 | 2019-02-20 | プロリンクス エルエルシー | Ｓｎ−３８の徐放性コンジュゲート |
| CN107375288B (zh) * | 2016-05-16 | 2019-08-23 | 博瑞生物医药（苏州）股份有限公司 | 多臂的聚合靶向抗癌偶联物 |
| ES2859473T3 (es) * | 2017-04-21 | 2021-10-04 | Bright Gene Bio Medical Tech Co Ltd | Conjugado anticanceroso dirigido de múltiples brazos |
| RU2020126774A (ru) * | 2018-01-12 | 2022-02-14 | ПРОЛИНКС ЭлЭлСи | Протокол для сведения к минимуму токсического воздействия комбинированных доз и визуализирующий агент для подтверждения |
| JP7546552B2 (ja) | 2018-09-17 | 2024-09-06 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | ポリマーベースの高分子プロドラッグ |
| KR20210150496A (ko) | 2019-04-05 | 2021-12-10 | 프로린크스 엘엘시 | 개선된 컨쥬게이션 링커 |
| MX2022002340A (es) | 2019-08-28 | 2022-04-06 | Prolynx Llc | Inhibidores conjugados de la respuesta al daño de adn. |
| AU2021347611A1 (en) | 2020-09-28 | 2023-05-18 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Peptidic conjugates of sn38 useful in the treatment of cancer |
| US11976196B2 (en) * | 2021-04-14 | 2024-05-07 | Cambridge Crops, Inc. | Silk packaging applications |
| JP2025512809A (ja) | 2022-03-28 | 2025-04-22 | ホスピタル サン ジョアン デ デウ | 抗がん剤のペプチド性水溶性送達システム |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
| WO2004008101A2 (en) * | 2002-07-12 | 2004-01-22 | Biomarin Pharmaceutical Inc. | The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates |
| CN1309763C (zh) | 2002-10-31 | 2007-04-11 | 日本化药株式会社 | 喜树碱的高分子衍生物 |
| US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| SI1675622T1 (sl) * | 2003-09-17 | 2017-09-29 | Nektar Therapeutics | Večkraka polimerna predzdravila |
| US7462627B2 (en) | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| RU2009114154A (ru) * | 2006-09-15 | 2010-10-20 | Энзон Фармасьютикалз, Инк. (Us) | Полимерные пролекарства с направленной доставкой, содержащие полифункциональные линкеры |
| CA2738807A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| JP2012509469A (ja) | 2008-11-18 | 2012-04-19 | バクスター・インターナショナル・インコーポレイテッド | ポリエチレングリコールサンプルの多分散度および／または分子量分布を決定する方法 |
| JP2012528240A (ja) | 2009-05-28 | 2012-11-12 | メルサナ セラピューティックス， インコーポレイテッド | 可変速度放出リンカーを含むポリアル−薬物コンジュゲート |
| EA024533B1 (ru) * | 2009-11-18 | 2016-09-30 | Нектар Терапьютикс | Формы солей кислот конъюгатов полимер-лекарственное средство |
| EP2571496A4 (en) * | 2010-05-05 | 2016-03-30 | Prolynx Llc | CONTROLLED RELEASE OF MEDICINE FROM DENIMERS |
| US8754190B2 (en) | 2010-05-05 | 2014-06-17 | Prolynx Llc | Controlled release from macromolecular conjugates |
| JP2012000072A (ja) * | 2010-06-18 | 2012-01-05 | Japan Health Science Foundation | 新規な抗フィブリン抗体 |
| TW201215412A (en) * | 2010-08-30 | 2012-04-16 | Sun Pharma Advanced Res Co Ltd | Stable pharmaceutical composition |
| JP5899241B2 (ja) * | 2010-12-21 | 2016-04-06 | ネクター セラピューティクス | ペメトレキセドベースの化合物のマルチアームポリマープロドラッグコンジュゲート |
| WO2013036857A1 (en) * | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
| JP6473145B2 (ja) * | 2013-10-04 | 2019-02-20 | プロリンクス エルエルシー | Ｓｎ−３８の徐放性コンジュゲート |
-
2014
- 2014-10-03 JP JP2016520004A patent/JP6473145B2/ja active Active
- 2014-10-03 WO PCT/US2014/059146 patent/WO2015051307A1/en not_active Ceased
- 2014-10-03 DK DK14796322.7T patent/DK3052101T3/da active
- 2014-10-03 BR BR112016007410-6A patent/BR112016007410B1/pt active IP Right Grant
- 2014-10-03 ES ES14796322T patent/ES2759905T3/es active Active
- 2014-10-03 MX MX2016004299A patent/MX371201B/es active IP Right Grant
- 2014-10-03 KR KR1020167011936A patent/KR102320753B1/ko active Active
- 2014-10-03 CN CN201480062543.4A patent/CN106061483B/zh active Active
- 2014-10-03 SG SG11201602258WA patent/SG11201602258WA/en unknown
- 2014-10-03 CA CA2925132A patent/CA2925132C/en active Active
- 2014-10-03 AU AU2014331591A patent/AU2014331591B2/en active Active
- 2014-10-03 TW TW103134678A patent/TWI716342B/zh active
- 2014-10-03 EP EP14796322.7A patent/EP3052101B1/en active Active
- 2014-10-03 SG SG10201811365RA patent/SG10201811365RA/en unknown
- 2014-10-03 US US15/026,579 patent/US10016411B2/en active Active
-
2018
- 2018-06-14 US US16/009,078 patent/US10342792B2/en active Active
- 2018-11-01 AU AU2018256608A patent/AU2018256608A1/en not_active Abandoned
-
2019
- 2019-01-24 JP JP2019010029A patent/JP6842479B2/ja active Active
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