JP2010270124A5 - - Google Patents
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- Publication number
- JP2010270124A5 JP2010270124A5 JP2010151115A JP2010151115A JP2010270124A5 JP 2010270124 A5 JP2010270124 A5 JP 2010270124A5 JP 2010151115 A JP2010151115 A JP 2010151115A JP 2010151115 A JP2010151115 A JP 2010151115A JP 2010270124 A5 JP2010270124 A5 JP 2010270124A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- dmxaa
- dimethylxanthenone
- acetic acid
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- XGOYIMQSIKSOBS-UHFFFAOYSA-N vadimezan Chemical compound C1=CC=C2C(=O)C3=CC=C(C)C(C)=C3OC2=C1CC(O)=O XGOYIMQSIKSOBS-UHFFFAOYSA-N 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 4
- 229960004316 cisplatin Drugs 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 230000001747 exhibiting effect Effects 0.000 claims 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 3
- 229960004397 cyclophosphamide Drugs 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229950008737 vadimezan Drugs 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0121285.1A GB0121285D0 (en) | 2001-09-03 | 2001-09-03 | Anti-cancer combinations |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524567A Division JP2005509599A (ja) | 2001-09-03 | 2002-09-03 | 抗癌組み合わせ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010270124A JP2010270124A (ja) | 2010-12-02 |
| JP2010270124A5 true JP2010270124A5 (enExample) | 2011-01-20 |
Family
ID=9921418
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524567A Ceased JP2005509599A (ja) | 2001-09-03 | 2002-09-03 | 抗癌組み合わせ |
| JP2009133903A Pending JP2009263371A (ja) | 2001-09-03 | 2009-06-03 | 抗癌組み合わせ |
| JP2010151115A Pending JP2010270124A (ja) | 2001-09-03 | 2010-07-01 | 抗癌組み合わせ |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524567A Ceased JP2005509599A (ja) | 2001-09-03 | 2002-09-03 | 抗癌組み合わせ |
| JP2009133903A Pending JP2009263371A (ja) | 2001-09-03 | 2009-06-03 | 抗癌組み合わせ |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US7863322B2 (enExample) |
| EP (3) | EP1423105B9 (enExample) |
| JP (3) | JP2005509599A (enExample) |
| CN (5) | CN100536840C (enExample) |
| AT (1) | ATE415963T1 (enExample) |
| AU (1) | AU2002324143B2 (enExample) |
| BR (1) | BR0212258A (enExample) |
| CA (1) | CA2458459A1 (enExample) |
| CY (1) | CY1110426T1 (enExample) |
| DE (1) | DE60230159D1 (enExample) |
| DK (1) | DK1423105T3 (enExample) |
| EA (3) | EA200801611A1 (enExample) |
| ES (1) | ES2321283T3 (enExample) |
| GB (1) | GB0121285D0 (enExample) |
| IL (1) | IL160178A0 (enExample) |
| IS (1) | IS7144A (enExample) |
| MX (1) | MXPA04002004A (enExample) |
| NO (1) | NO20040591L (enExample) |
| NZ (5) | NZ567456A (enExample) |
| PT (1) | PT1423105E (enExample) |
| SI (1) | SI1423105T1 (enExample) |
| WO (1) | WO2003020259A2 (enExample) |
| ZA (1) | ZA200401078B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| EP1189611B1 (en) * | 1999-06-14 | 2006-05-03 | Cancer Research Technology Limited | Cancer therapy |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| WO2002009700A1 (en) | 2000-07-28 | 2002-02-07 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB0202544D0 (en) | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
| GB2386836B (en) | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2394658A (en) | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
| GB0321999D0 (en) * | 2003-09-19 | 2003-10-22 | Cancer Rec Tech Ltd | Anti-cancer combinations |
| SI1689404T1 (sl) | 2003-11-13 | 2009-02-28 | Pharma Mar Sau | Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka |
| KR101188691B1 (ko) | 2004-10-29 | 2012-10-09 | 파르마 마르 에스.에이. | 엑티나시딘 및 디사카라이드를 포함하는 제제 |
| GB0517387D0 (en) * | 2005-08-26 | 2005-10-05 | Antisoma Res Ltd | Combinations for the treatment of cancer |
| CA2620436A1 (en) * | 2005-08-26 | 2007-03-01 | Antisoma Plc | Combinations comprising dmxaa for the treatment of cancer |
| GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| GB0625283D0 (en) * | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
| CN101896177A (zh) * | 2007-12-13 | 2010-11-24 | 诺瓦提斯公司 | 用于治疗癌症的治疗剂的组合 |
| CN101279967B (zh) * | 2008-05-29 | 2010-11-10 | 武汉远大制药集团有限公司 | 一种治疗癌症的三甲基呫吨酮-4-乙酸药物组合物及其用途 |
| ES2545609T3 (es) | 2008-08-25 | 2015-09-14 | Amplimmune, Inc. | Composiciones de antagonistas de PD-1 y métodos de uso |
| US20100068302A1 (en) * | 2008-09-17 | 2010-03-18 | Traslational Cancer Drugs Pharma, S.L. | Methods and compositions for the treatment of cancer |
| WO2011019782A1 (en) * | 2009-08-11 | 2011-02-17 | Novartis Ag | Combinations of vascular disrupting agents with inhibitor of apoptosis proteins antagonists |
| DK3012329T3 (da) | 2010-06-18 | 2017-11-20 | Myriad Genetics Inc | Fremgangsmåder og materialer til at vurdere tab af heterozygositet |
| DK2609216T3 (en) | 2010-08-24 | 2016-09-12 | Dana Farber Cancer Inst Inc | Methods to predict anti-cancer response |
| CN102786509B (zh) * | 2011-05-16 | 2016-06-01 | 杭州民生药业有限公司 | 2-(5,6-二甲基呫吨酮-4-基)-乙酸的衍生物及其制备方法和用途 |
| EP3693473B1 (en) | 2011-06-17 | 2025-02-19 | Myriad Genetics, Inc. | Methods and materials for assessing allelic imbalance |
| BR112014015152A2 (pt) | 2011-12-21 | 2017-07-04 | Myriad Genetics Inc | métodos e materiais para a avaliação da perda de heterozigosidade |
| EP2617421A1 (en) * | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer |
| DK3415915T3 (da) | 2012-02-23 | 2024-11-04 | Childrens Medical Center | Fremgangsmåde til at forudsige respons til PARP-inhibitorer |
| AU2013273466B2 (en) | 2012-06-07 | 2018-11-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors |
| WO2014160080A1 (en) | 2013-03-14 | 2014-10-02 | Children's Medical Center Corporation | Cancer diagnosis, treatment selection and treatment |
| DK2981624T3 (da) | 2013-04-05 | 2020-03-02 | Myriad Genetics Inc | Fremgangsmåder til vurdering af homolog rekombinationsdeficiens og forudsigelse af respons på cancerbehandling |
| WO2014169067A1 (en) * | 2013-04-09 | 2014-10-16 | Merrimack Pharmaceuticals, Inc. | Compositions for improving outcomes of liposomal chemotherapy |
| EP3071209A4 (en) * | 2013-11-19 | 2017-08-16 | The University of Chicago | Use of sting agonist as cancer treatment |
| WO2015086473A1 (en) | 2013-12-09 | 2015-06-18 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| ES2946251T3 (es) | 2014-08-15 | 2023-07-14 | Myriad Genetics Inc | Métodos y materiales para evaluar la deficiencia de recombinación homóloga |
| EP4141127B1 (en) | 2021-08-30 | 2024-10-09 | Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln | Method for assessing homologous recombination deficiency in ovarian cancer cells |
| CN115282140B (zh) * | 2022-02-07 | 2024-03-08 | 南京市儿童医院 | Aki治疗剂及dmxaa在制备该治疗剂中的应用 |
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| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2386836B (en) | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| GB2394658A (en) | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
| GB0321999D0 (en) | 2003-09-19 | 2003-10-22 | Cancer Rec Tech Ltd | Anti-cancer combinations |
| GT200500186A (es) * | 2004-07-07 | 2006-03-02 | Regimenes anticonceptivos con antagonistas del receptor de progesterona y kits | |
| GB0517387D0 (en) | 2005-08-26 | 2005-10-05 | Antisoma Res Ltd | Combinations for the treatment of cancer |
| CA2620436A1 (en) | 2005-08-26 | 2007-03-01 | Antisoma Plc | Combinations comprising dmxaa for the treatment of cancer |
| BRPI0817712A2 (pt) | 2007-10-23 | 2015-03-31 | Antisoma Res Ltd | Sal de sódio cristalino de ácido 5,6-dimetil-oxo-xantano-4-acético, forma cristalina do mesmo, processos para preparar sal de sódio cristalino de ácido 5,6-dimetil-oxo-xantano-4-acético, e, para preparar forma cristalina, composição farmacêutica, método para preparar uma composição farmacêutica, uso de um sal de sódio cristalino de dmxaa, método para tratar câncer, kit de partes, e, formulação farmacêutica |
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2001
- 2001-09-03 GB GBGB0121285.1A patent/GB0121285D0/en not_active Ceased
-
2002
- 2002-09-03 BR BR0212258-8A patent/BR0212258A/pt not_active IP Right Cessation
- 2002-09-03 MX MXPA04002004A patent/MXPA04002004A/es active IP Right Grant
- 2002-09-03 ES ES02758562T patent/ES2321283T3/es not_active Expired - Lifetime
- 2002-09-03 NZ NZ567456A patent/NZ567456A/en not_active IP Right Cessation
- 2002-09-03 EA EA200801611A patent/EA200801611A1/ru unknown
- 2002-09-03 AU AU2002324143A patent/AU2002324143B2/en not_active Ceased
- 2002-09-03 NZ NZ546573A patent/NZ546573A/en not_active IP Right Cessation
- 2002-09-03 DK DK02758562T patent/DK1423105T3/da active
- 2002-09-03 EA EA200400370A patent/EA008056B1/ru not_active IP Right Cessation
- 2002-09-03 DE DE60230159T patent/DE60230159D1/de not_active Expired - Lifetime
- 2002-09-03 CA CA002458459A patent/CA2458459A1/en not_active Abandoned
- 2002-09-03 CN CNB028172574A patent/CN100536840C/zh not_active Expired - Fee Related
- 2002-09-03 NZ NZ576925A patent/NZ576925A/en not_active IP Right Cessation
- 2002-09-03 CN CNA2009101604101A patent/CN101596187A/zh active Pending
- 2002-09-03 NZ NZ554093A patent/NZ554093A/en not_active IP Right Cessation
- 2002-09-03 CN CNA2006101513931A patent/CN1994287A/zh active Pending
- 2002-09-03 EA EA200601118A patent/EA010857B1/ru not_active IP Right Cessation
- 2002-09-03 AT AT02758562T patent/ATE415963T1/de active
- 2002-09-03 EP EP02758562A patent/EP1423105B9/en not_active Expired - Lifetime
- 2002-09-03 PT PT02758562T patent/PT1423105E/pt unknown
- 2002-09-03 JP JP2003524567A patent/JP2005509599A/ja not_active Ceased
- 2002-09-03 IL IL16017802A patent/IL160178A0/xx unknown
- 2002-09-03 EP EP06077049A patent/EP1759694A3/en not_active Withdrawn
- 2002-09-03 WO PCT/GB2002/004025 patent/WO2003020259A2/en not_active Ceased
- 2002-09-03 NZ NZ531045A patent/NZ531045A/en not_active IP Right Cessation
- 2002-09-03 CN CNA2009101604099A patent/CN101596186A/zh active Pending
- 2002-09-03 SI SI200230798T patent/SI1423105T1/sl unknown
- 2002-09-03 CN CNA2009101604084A patent/CN101607087A/zh active Pending
- 2002-09-03 EP EP10001750A patent/EP2236134A1/en not_active Withdrawn
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2004
- 2004-02-06 IS IS7144A patent/IS7144A/is unknown
- 2004-02-10 ZA ZA200401078A patent/ZA200401078B/en unknown
- 2004-02-10 NO NO20040591A patent/NO20040591L/no unknown
- 2004-03-02 US US10/790,943 patent/US7863322B2/en not_active Expired - Fee Related
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2006
- 2006-11-03 US US11/592,678 patent/US20070060637A1/en not_active Abandoned
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2007
- 2007-07-30 US US11/830,659 patent/US7868040B2/en not_active Expired - Fee Related
- 2007-07-30 US US11/830,677 patent/US7863321B2/en not_active Expired - Fee Related
- 2007-07-30 US US11/830,668 patent/US7863320B2/en not_active Expired - Fee Related
- 2007-07-30 US US11/830,650 patent/US7868039B2/en not_active Expired - Fee Related
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2008
- 2008-12-31 CY CY20081101516T patent/CY1110426T1/el unknown
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2009
- 2009-06-03 JP JP2009133903A patent/JP2009263371A/ja active Pending
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2010
- 2010-07-01 JP JP2010151115A patent/JP2010270124A/ja active Pending