CY1110426T1 - Συνδυασμοι dmxaa και αλλων αντικαρκινικων ουσιων - Google Patents
Συνδυασμοι dmxaa και αλλων αντικαρκινικων ουσιωνInfo
- Publication number
- CY1110426T1 CY1110426T1 CY20081101516T CY081101516T CY1110426T1 CY 1110426 T1 CY1110426 T1 CY 1110426T1 CY 20081101516 T CY20081101516 T CY 20081101516T CY 081101516 T CY081101516 T CY 081101516T CY 1110426 T1 CY1110426 T1 CY 1110426T1
- Authority
- CY
- Cyprus
- Prior art keywords
- combinations
- dmxaa
- cancer substances
- topoisomerase
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά συνεργιστικούς συνδυασμούς της ουσίας 5,6-διμεθυλξανθενονη-4-οξικό οξύ (DMXAA) και μιας ουσίας που επιλέγεται μεταξύ των ουσιών του λευκόχρυσου, των αλκαλοειδών της βίνκα, παραγόντων αλκυλίωσης, ανθρακυκλίνων, αναστολέων τοποϊσομεράσης I, αντιμεταβολιτών και αναστολέων τοποϊσομεράσης II, που έχουν αντικαρκινική δράση. Ειδικότερα, η εφεύρεση αναφέρεται στη χρήση τέτοιων συνδυασμών για την θεραπεία του καρκίνου και στις φαρμακευτικές ουσίες που περιέχουν τους εν λόγω συνδυασμούς.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0121285.1A GB0121285D0 (en) | 2001-09-03 | 2001-09-03 | Anti-cancer combinations |
EP02758562A EP1423105B9 (en) | 2001-09-03 | 2002-09-03 | Combinations of dmxaa and other anti-cancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110426T1 true CY1110426T1 (el) | 2015-04-29 |
Family
ID=9921418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101516T CY1110426T1 (el) | 2001-09-03 | 2008-12-31 | Συνδυασμοι dmxaa και αλλων αντικαρκινικων ουσιων |
Country Status (23)
Country | Link |
---|---|
US (6) | US7863322B2 (el) |
EP (3) | EP1759694A3 (el) |
JP (3) | JP2005509599A (el) |
CN (5) | CN1994287A (el) |
AT (1) | ATE415963T1 (el) |
AU (1) | AU2002324143B2 (el) |
BR (1) | BR0212258A (el) |
CA (1) | CA2458459A1 (el) |
CY (1) | CY1110426T1 (el) |
DE (1) | DE60230159D1 (el) |
DK (1) | DK1423105T3 (el) |
EA (3) | EA200801611A1 (el) |
ES (1) | ES2321283T3 (el) |
GB (1) | GB0121285D0 (el) |
IL (1) | IL160178A0 (el) |
IS (1) | IS7144A (el) |
MX (1) | MXPA04002004A (el) |
NO (1) | NO20040591L (el) |
NZ (5) | NZ531045A (el) |
PT (1) | PT1423105E (el) |
SI (1) | SI1423105T1 (el) |
WO (1) | WO2003020259A2 (el) |
ZA (1) | ZA200401078B (el) |
Families Citing this family (36)
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MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
ES2265948T3 (es) * | 1999-06-14 | 2007-03-01 | Cancer Research Technology Limited | Terapia para el cancer. |
MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
JP2004505047A (ja) | 2000-07-28 | 2004-02-19 | キャンサー・リサーチ・テクノロジー・リミテッド | 複合治療による癌治療 |
GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
GB0202544D0 (en) | 2002-02-04 | 2002-03-20 | Pharma Mar Sa | The synthesis of naturally occuring ecteinascidins and related compounds |
GB2386836B (en) * | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
GB2394658A (en) | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
GB0321999D0 (en) * | 2003-09-19 | 2003-10-22 | Cancer Rec Tech Ltd | Anti-cancer combinations |
DE602004016376D1 (de) | 2003-11-13 | 2008-10-16 | Pharma Mar Sau | Kombination von et-743 mit 5-fluorouracil pro-drugs zur behandlung von krebs |
EP1658848B1 (en) | 2004-10-29 | 2007-08-01 | Pharma Mar S.A., Sociedad Unipersonal | Formulations comprising ecteinascidin and a disaccharide |
GB0517387D0 (en) * | 2005-08-26 | 2005-10-05 | Antisoma Res Ltd | Combinations for the treatment of cancer |
CA2620436A1 (en) * | 2005-08-26 | 2007-03-01 | Antisoma Plc | Combinations comprising dmxaa for the treatment of cancer |
GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
GB0625283D0 (en) * | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
WO2009076170A2 (en) * | 2007-12-13 | 2009-06-18 | Novartis Ag | Combinations of therapeutic agents for treating cancer |
CN101279967B (zh) * | 2008-05-29 | 2010-11-10 | 武汉远大制药集团有限公司 | 一种治疗癌症的三甲基呫吨酮-4-乙酸药物组合物及其用途 |
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US20120129895A1 (en) * | 2009-08-11 | 2012-05-24 | Colleen Conway | Methods of treatment |
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AU2011293635B2 (en) | 2010-08-24 | 2015-11-26 | Children's Medical Center Corporation | Methods for predicting anti-cancer response |
CN105906602B (zh) * | 2011-05-16 | 2018-07-10 | 杭州民生药物研究院有限公司 | 2-(5,6-二甲基呫吨酮-4-基)-乙酸衍生物的制备方法 |
JP6117194B2 (ja) | 2011-06-17 | 2017-04-19 | ミリアド・ジェネティックス・インコーポレイテッド | アレル不均衡を評価するための方法および材料 |
WO2013096843A1 (en) | 2011-12-21 | 2013-06-27 | Myriad Genetics, Inc. | Methods and materials for assessing loss of heterozygosity |
EP2617421A1 (en) * | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer |
WO2013130347A1 (en) | 2012-02-23 | 2013-09-06 | The Children's Hospital Corporation | Methods for predicting anti-cancer response |
EP2859118B1 (en) | 2012-06-07 | 2017-11-22 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
US10308986B2 (en) | 2013-03-14 | 2019-06-04 | Children's Medical Center Corporation | Cancer diagnosis, treatment selection and treatment |
US20140363521A1 (en) | 2013-04-05 | 2014-12-11 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
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US20160287623A1 (en) * | 2013-11-19 | 2016-10-06 | The University Of Chicago | Use of sting agonist as cancer treatment |
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2001
- 2001-09-03 GB GBGB0121285.1A patent/GB0121285D0/en not_active Ceased
-
2002
- 2002-09-03 NZ NZ531045A patent/NZ531045A/en not_active IP Right Cessation
- 2002-09-03 IL IL16017802A patent/IL160178A0/xx unknown
- 2002-09-03 PT PT02758562T patent/PT1423105E/pt unknown
- 2002-09-03 DE DE60230159T patent/DE60230159D1/de not_active Expired - Lifetime
- 2002-09-03 CN CNA2006101513931A patent/CN1994287A/zh active Pending
- 2002-09-03 WO PCT/GB2002/004025 patent/WO2003020259A2/en active Application Filing
- 2002-09-03 NZ NZ567456A patent/NZ567456A/en not_active IP Right Cessation
- 2002-09-03 CN CNA2009101604084A patent/CN101607087A/zh active Pending
- 2002-09-03 ES ES02758562T patent/ES2321283T3/es not_active Expired - Lifetime
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- 2002-09-03 EP EP06077049A patent/EP1759694A3/en not_active Withdrawn
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- 2002-09-03 EA EA200801611A patent/EA200801611A1/ru unknown
- 2002-09-03 EA EA200601118A patent/EA010857B1/ru not_active IP Right Cessation
- 2002-09-03 DK DK02758562T patent/DK1423105T3/da active
- 2002-09-03 CN CNB028172574A patent/CN100536840C/zh not_active Expired - Fee Related
- 2002-09-03 CN CNA2009101604101A patent/CN101596187A/zh active Pending
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- 2002-09-03 AU AU2002324143A patent/AU2002324143B2/en not_active Ceased
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- 2002-09-03 BR BR0212258-8A patent/BR0212258A/pt not_active IP Right Cessation
- 2002-09-03 AT AT02758562T patent/ATE415963T1/de active
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- 2002-09-03 MX MXPA04002004A patent/MXPA04002004A/es active IP Right Grant
- 2002-09-03 CN CNA2009101604099A patent/CN101596186A/zh active Pending
- 2002-09-03 JP JP2003524567A patent/JP2005509599A/ja not_active Ceased
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- 2002-09-03 CA CA002458459A patent/CA2458459A1/en not_active Abandoned
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2004
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- 2004-02-10 NO NO20040591A patent/NO20040591L/no unknown
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2006
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2007
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2008
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2009
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2010
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