JP2005509599A - 抗癌組み合わせ - Google Patents

抗癌組み合わせ Download PDF

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Publication number
JP2005509599A
JP2005509599A JP2003524567A JP2003524567A JP2005509599A JP 2005509599 A JP2005509599 A JP 2005509599A JP 2003524567 A JP2003524567 A JP 2003524567A JP 2003524567 A JP2003524567 A JP 2003524567A JP 2005509599 A JP2005509599 A JP 2005509599A
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JP
Japan
Prior art keywords
topoisomerase
inhibitors
compound selected
dmxaa
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2003524567A
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English (en)
Japanese (ja)
Other versions
JP2005509599A5 (enExample
Inventor
ウィルソン，ウィリアム・ロバート
シーム，ブロンウィン・ゲイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Technology Ltd
Original Assignee
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Technology Ltd filed Critical Cancer Research Technology Ltd
Publication of JP2005509599A publication Critical patent/JP2005509599A/ja
Publication of JP2005509599A5 publication Critical patent/JP2005509599A5/ja
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pyrane Compounds (AREA)
JP2003524567A 2001-09-03 2002-09-03 抗癌組み合わせ Ceased JP2005509599A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0121285.1A GB0121285D0 (en) 2001-09-03 2001-09-03 Anti-cancer combinations
PCT/GB2002/004025 WO2003020259A2 (en) 2001-09-03 2002-09-03 Combinations of dmxaa and other anti-cancer agents

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009133903A Division JP2009263371A (ja) 2001-09-03 2009-06-03 抗癌組み合わせ
JP2010151115A Division JP2010270124A (ja) 2001-09-03 2010-07-01 抗癌組み合わせ

Publications (2)

Publication Number Publication Date
JP2005509599A true JP2005509599A (ja) 2005-04-14
JP2005509599A5 JP2005509599A5 (enExample) 2006-01-05

Family

ID=9921418

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003524567A Ceased JP2005509599A (ja) 2001-09-03 2002-09-03 抗癌組み合わせ
JP2009133903A Pending JP2009263371A (ja) 2001-09-03 2009-06-03 抗癌組み合わせ
JP2010151115A Pending JP2010270124A (ja) 2001-09-03 2010-07-01 抗癌組み合わせ

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009133903A Pending JP2009263371A (ja) 2001-09-03 2009-06-03 抗癌組み合わせ
JP2010151115A Pending JP2010270124A (ja) 2001-09-03 2010-07-01 抗癌組み合わせ

Country Status (23)

Country Link
US (6) US7863322B2 (enExample)
EP (3) EP1423105B9 (enExample)
JP (3) JP2005509599A (enExample)
CN (5) CN100536840C (enExample)
AT (1) ATE415963T1 (enExample)
AU (1) AU2002324143B2 (enExample)
BR (1) BR0212258A (enExample)
CA (1) CA2458459A1 (enExample)
CY (1) CY1110426T1 (enExample)
DE (1) DE60230159D1 (enExample)
DK (1) DK1423105T3 (enExample)
EA (3) EA200801611A1 (enExample)
ES (1) ES2321283T3 (enExample)
GB (1) GB0121285D0 (enExample)
IL (1) IL160178A0 (enExample)
IS (1) IS7144A (enExample)
MX (1) MXPA04002004A (enExample)
NO (1) NO20040591L (enExample)
NZ (5) NZ531045A (enExample)
PT (1) PT1423105E (enExample)
SI (1) SI1423105T1 (enExample)
WO (1) WO2003020259A2 (enExample)
ZA (1) ZA200401078B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009506020A (ja) * 2005-08-26 2009-02-12 アンティソーマ・ピーエルシー 癌治療のための組み合わせ
JP2010527908A (ja) * 2006-12-19 2010-08-19 サイクラセル リミテッド Ｃｎｄａｃ（２’−シアノ−２’−デオキシ−ｎ４−パルミトイル−１−ベータ−ｄ−アラビノフラノシル−シトシン）及び細胞毒性薬を含む組合せ
JP2016538344A (ja) * 2013-11-19 2016-12-08 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ 癌処置としてのｓｔｉｎｇアゴニストの使用

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GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB2386836B (en) * 2002-03-22 2006-07-26 Cancer Res Ventures Ltd Anti-cancer combinations
GB2394658A (en) 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
GB0321999D0 (en) * 2003-09-19 2003-10-22 Cancer Rec Tech Ltd Anti-cancer combinations
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WO2007023302A1 (en) * 2005-08-26 2007-03-01 Antisoma Plc Combinations comprising dmxaa for the treatment of cancer
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CN101279967B (zh) * 2008-05-29 2010-11-10 武汉远大制药集团有限公司 一种治疗癌症的三甲基呫吨酮-4-乙酸药物组合物及其用途
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JPN6009009824, ＨＩＬＬ，Ｓ．Ａ． ｅｔ ａｌ, "Ａｎｔｉ−ｖａｓｃｕｌａｒ ａｐｐｒｏａｃｈｅｓ ｔｏ ｓｏｌｉｄ ｔｕｍｏｕｒ ｔｈｅｒａｐｙ： ｅｖａｌｕａｔｉｏｎ ｏｆ ｖｉｎｂｌａｓｔｉｎｅ ａｎｄ ｆｌａｖｏｎｅ ａｃｅｔｉｃ ａｃｉｄ", Ｉｎｔ Ｊ Ｃａｎｃｅｒ, 1995, Ｖｏｌ．６３， Ｎｏ．１, ｐ．１１９−２３ *
JPN6009037653, 佐々木 常雄, "Ｂｉｏｃｈｅｍｉｃａｌ Ｍｏｄｕｌａｔｉｏｎの研究の現状", 医学のあゆみ, 1993, Ｖｏｌ．１６４， Ｎｏ．５, ｐｐ２５１−２５４ *
JPN7009001126, ＧＨＡＥＭＭＡＧＨＡＭＩ，Ｍ． ｅｔ ａｌ, "Ｎｅｗ ａｇｅｎｔｓ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｓｍａｌｌ ｃｅｌｌ ｌｕｎｇ ｃａｎｃｅｒ", Ｃｈｅｓｔ, 1998, Ｖｏｌ．１１３， Ｎｏ．１ Ｓｕｐｐｌ, ｐ．８６Ｓ−９１Ｓ *
JPN7009003528, ＫＥＬＬＹ，Ｋ．, "Ｎｅｗ ｃｈｅｍｏｔｈｅｒａｐｙ ａｇｅｎｔｓ ｆｏｒ ｓｍａｌｌ ｃｅｌｌ ｌｕｎｇ ｃａｎｃｅｒ", Ｃｈｅｓｔ, 2000, Ｖｏｌ．１１７， Ｎｏ．４ Ｓｕｐｐｌ １, ｐ．１５６Ｓ−１６２Ｓ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009506020A (ja) * 2005-08-26 2009-02-12 アンティソーマ・ピーエルシー 癌治療のための組み合わせ
JP2010527908A (ja) * 2006-12-19 2010-08-19 サイクラセル リミテッド Ｃｎｄａｃ（２’−シアノ−２’−デオキシ−ｎ４−パルミトイル−１−ベータ−ｄ−アラビノフラノシル−シトシン）及び細胞毒性薬を含む組合せ
JP2016538344A (ja) * 2013-11-19 2016-12-08 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ 癌処置としてのｓｔｉｎｇアゴニストの使用

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