ES2061518T3 - Compuestos que tienen propiedades antitumorales y antibacterianas. - Google Patents
Compuestos que tienen propiedades antitumorales y antibacterianas.Info
- Publication number
- ES2061518T3 ES2061518T3 ES87311274T ES87311274T ES2061518T3 ES 2061518 T3 ES2061518 T3 ES 2061518T3 ES 87311274 T ES87311274 T ES 87311274T ES 87311274 T ES87311274 T ES 87311274T ES 2061518 T3 ES2061518 T3 ES 2061518T3
- Authority
- ES
- Spain
- Prior art keywords
- antibacterial properties
- represent
- lower alkyl
- groups
- antitumoral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D311/86—Oxygen atoms, e.g. xanthones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UNA NUEVA CLASE DE ACIDOS XANTENON-4ACETICOS REPRESENTADOS POR LA FORMULA GENERAL (I), DONDE R1 REPRESENTA HASTA DOS GRUPOS: ALQUILO DE CADENA CORTA, HALOGENO, CF3, CN, NO2, NH2, CH3COOH, OR2, OH, NHCOR, NHSO2R2, SR2, SO2R2, CH2CONHR2 O NHR2 (SIENDO R2 UN ALQUILO DE CADENA CORTA QUE PUEDE ESTAR SUSTITUIDO CON FUNCIONES HIDROXI, AMINO O METOXI), EN CUALQUIERA DE LAS POSICIONES 1 A 8 DISPONIBLES, R1 PUEDE TAMBIEN REPRESENTAR LA SUSTITUICION DE UN GRUPO AZA (-N=) POR UNO O DOS GRUPOS METINO EN LOS ANILLOS CARBOCICLICOS Y LOS DOS R1 O DOS CUALESQUIERA DE LAS POSICIONES ADYACENTES PUEDEN TAMBIEN REPRESNETAR EL GRUPO -CH=CH-CH=CH-, PARA FORMAR UN BENCENO CONDENSADO ADICIONAL. TAMBIEN SE REFIERE LA ENVINCION A LAS SALES DE ADICION BASICAS DE ESTOS COMPUESTOS, LOS CUALES POSEEN PROPIEDADES ANTITUMORALES Y ANTIBACTERIANAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ21878186 | 1986-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2061518T3 true ES2061518T3 (es) | 1994-12-16 |
Family
ID=19921928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87311274T Expired - Lifetime ES2061518T3 (es) | 1986-12-23 | 1987-12-22 | Compuestos que tienen propiedades antitumorales y antibacterianas. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0278176B1 (es) |
JP (1) | JP2672101B2 (es) |
AT (1) | ATE102616T1 (es) |
DE (1) | DE3789299T2 (es) |
ES (1) | ES2061518T3 (es) |
HK (1) | HK1000801A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5116954A (en) * | 1988-04-06 | 1992-05-26 | Lipha, Lyonnaise Industrielle Pharmaceutique | Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety |
USH1427H (en) * | 1988-04-06 | 1995-04-04 | Briet; Phillipe | Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2 |
US5238954A (en) * | 1989-01-19 | 1993-08-24 | The Upjohn Company | Fluorinated flavone acetic acid |
US4996230A (en) * | 1990-02-16 | 1991-02-26 | Eli Lilly And Company | Leukotriene antagonists |
JP2554447B2 (ja) * | 1993-09-14 | 1996-11-13 | ナショナル・サイエンス・カウンシル | 新規キサントン化合物 |
AU5717400A (en) * | 1999-06-14 | 2001-01-02 | Cancer Research Ventures Limited | Cancer therapy |
JP2001247459A (ja) * | 2000-03-03 | 2001-09-11 | Oakland Uniservices Ltd | 癌の組み合わせ療法 |
AU2001282717A1 (en) | 2000-07-28 | 2002-02-13 | Cancer Research Technology Limited | Cancer treatment by combination therapy |
KR20030018214A (ko) * | 2001-08-27 | 2003-03-06 | 한국생명공학연구원 | 혈관 신생 저해제용 잔테논계 유도체 및 그를 포함하는혈관 신생 저해 조성물 |
GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
GB2386836B (en) | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
GB2394658A (en) * | 2002-11-01 | 2004-05-05 | Cancer Rec Tech Ltd | Oral anti-cancer composition |
WO2008048117A2 (en) * | 2006-10-17 | 2008-04-24 | Auckland Uniservices Limited | Synthesis of 5,6-dimethyl-9-oxo-9h-xanthen-4-yl- acetic acid (dmxaa) |
CN101195609B (zh) * | 2007-09-28 | 2011-04-20 | 武汉远大制药集团有限公司 | 5,6-二甲基呫吨酮-4-乙酸的制备方法及由此方法制备的衍生物和药物制剂 |
CN101914084B (zh) * | 2010-07-30 | 2012-10-17 | 中国人民解放军第二军医大学 | 双苯吡喃酮氮杂环衍生物及其制备方法与应用 |
CN102786509B (zh) * | 2011-05-16 | 2016-06-01 | 杭州民生药业有限公司 | 2-(5,6-二甲基呫吨酮-4-基)-乙酸的衍生物及其制备方法和用途 |
EP3535243B1 (en) | 2016-11-04 | 2021-12-15 | Auckland Uniservices Limited | Substituted 9h-xanthen-9-one, 9h-thioxanthen-9-one and acridin-9(10h)-one derivatives and related compounds csf-1r inhibitors for the treatment of cancer |
CN106977489B (zh) * | 2017-04-20 | 2019-05-31 | 清华大学 | 一种制备多取代占吨酮类衍生物的方法 |
-
1987
- 1987-12-22 ES ES87311274T patent/ES2061518T3/es not_active Expired - Lifetime
- 1987-12-22 JP JP62325109A patent/JP2672101B2/ja not_active Expired - Lifetime
- 1987-12-22 DE DE3789299T patent/DE3789299T2/de not_active Expired - Lifetime
- 1987-12-22 EP EP87311274A patent/EP0278176B1/en not_active Expired - Lifetime
- 1987-12-22 AT AT87311274T patent/ATE102616T1/de not_active IP Right Cessation
-
1997
- 1997-12-10 HK HK97102378A patent/HK1000801A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2672101B2 (ja) | 1997-11-05 |
EP0278176A3 (en) | 1990-03-28 |
EP0278176B1 (en) | 1994-03-09 |
JPS63295570A (ja) | 1988-12-01 |
DE3789299T2 (de) | 1994-08-04 |
DE3789299D1 (de) | 1994-04-14 |
EP0278176A2 (en) | 1988-08-17 |
ATE102616T1 (de) | 1994-03-15 |
HK1000801A1 (en) | 1998-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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