DE68901958D1 - Kontrastmittel mit stabilen, freien radikalen. - Google Patents

Kontrastmittel mit stabilen, freien radikalen.

Info

Publication number
DE68901958D1
DE68901958D1 DE8989201880T DE68901958T DE68901958D1 DE 68901958 D1 DE68901958 D1 DE 68901958D1 DE 8989201880 T DE8989201880 T DE 8989201880T DE 68901958 T DE68901958 T DE 68901958T DE 68901958 D1 DE68901958 D1 DE 68901958D1
Authority
DE
Germany
Prior art keywords
free radicals
contrast agents
stable
esr
magnetic resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989201880T
Other languages
English (en)
Other versions
DE68901958T2 (de
Inventor
Ib Leunbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health R&D AB
Original Assignee
Hafslund Nycomed Innovation AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hafslund Nycomed Innovation AB filed Critical Hafslund Nycomed Innovation AB
Application granted granted Critical
Publication of DE68901958D1 publication Critical patent/DE68901958D1/de
Publication of DE68901958T2 publication Critical patent/DE68901958T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE8989201880T 1988-07-19 1989-07-17 Kontrastmittel mit stabilen, freien radikalen. Expired - Lifetime DE68901958T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888817137A GB8817137D0 (en) 1988-07-19 1988-07-19 Compositions

Publications (2)

Publication Number Publication Date
DE68901958D1 true DE68901958D1 (de) 1992-08-06
DE68901958T2 DE68901958T2 (de) 1992-12-10

Family

ID=10640699

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989201880T Expired - Lifetime DE68901958T2 (de) 1988-07-19 1989-07-17 Kontrastmittel mit stabilen, freien radikalen.

Country Status (13)

Country Link
US (1) US5322065A (de)
EP (1) EP0351919B1 (de)
JP (1) JPH03506028A (de)
AT (1) ATE77755T1 (de)
AU (1) AU622692B2 (de)
DE (1) DE68901958T2 (de)
DK (1) DK8091D0 (de)
ES (1) ES2033077T3 (de)
GB (1) GB8817137D0 (de)
GR (1) GR3005234T3 (de)
PH (1) PH27247A (de)
WO (1) WO1990000904A1 (de)
ZA (1) ZA895468B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819753D0 (en) * 1988-08-19 1988-09-21 Nycomed As Apparatus
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
GB8929300D0 (en) * 1989-12-29 1990-02-28 Instrumentarium Corp Apparatus
GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
US5264204A (en) * 1992-04-30 1993-11-23 Mallinckrodt Medical, Inc. Hydrophilic free radicals for magnetic resonance imaging
DE4328639C2 (de) * 1993-08-23 2002-10-24 Lancaster Group Gmbh Verfahren zur Messung des antioxidativen Potentials der Haut
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
AU1208697A (en) * 1995-12-28 1997-07-28 Daiichi Radioisotope Laboratories, Ltd. Diagnostic drugs
US5978694A (en) * 1997-02-27 1999-11-02 Uri Rapoport Method and apparatus for detecting a magnetically responsive substance
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6185444B1 (en) * 1998-03-13 2001-02-06 Skelscan, Inc. Solid-state magnetic resonance imaging
US6503478B2 (en) 1999-01-13 2003-01-07 Lightouch Medical, Inc. Chemically specific imaging of tissue
US6574496B1 (en) * 1999-05-19 2003-06-03 Amersham Health As Magnetic resonance imaging
US7574248B2 (en) * 2002-05-17 2009-08-11 General Hospital Corporation Method and apparatus for quantitative bone matrix imaging by magnetic resonance imaging
MX2007001035A (es) 2004-07-30 2007-07-11 Ge Healthcare As Metodo para producir una composicion, la composicion y su uso.
US20070025918A1 (en) * 2005-07-28 2007-02-01 General Electric Company Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization
US8377419B2 (en) 2005-09-28 2013-02-19 The President And Fellows Of Harvard College Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging
CA2628539C (en) 2005-12-01 2014-04-29 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
US20090004114A1 (en) 2005-12-08 2009-01-01 Koninklijke Philips Electronics N. V. System and Method for Monitoring in Vivo Drug Release Using Overhauser-Enhanced Nmr
AU2006326596A1 (en) * 2005-12-10 2007-06-21 The President And Fellows Of Harvard College In situ hyperpolarization of imaging agents
EP1984757A4 (de) * 2006-01-11 2009-11-04 Harvard College Ex-vivo-hyperpolarisation von abbildungsmitteln
WO2008026937A1 (en) 2006-08-30 2008-03-06 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) and compounds and compositions for use in the method
EP2902041A1 (de) 2007-12-19 2015-08-05 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
DE102008064400A1 (de) 2008-06-02 2009-12-03 Rohde & Schwarz Gmbh & Co. Kg Mikrowellenuntersuchung mit einem Kontrastmittel
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
EP2555803B1 (de) 2010-04-08 2018-09-12 Bracco Imaging S.p.A Verfahren zur herstellung von hyperpolarisierten substraten und mri-verfahren
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
WO2013083535A1 (en) 2011-12-05 2013-06-13 Bracco Imaging Spa Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
WO2013149935A1 (en) 2012-04-02 2013-10-10 Bracco Imaging Spa Hyperpolarized amino acids

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2154857A5 (en) * 1971-09-28 1973-05-18 Commissariat Energie Atomique Deuterated nitroxide radical - tetra methyl 2,2,5,5-aza -1-cyclopentane oxa-3-oxyl-1
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4516075A (en) * 1983-01-04 1985-05-07 Wisconsin Alumni Research Foundation NMR scanner with motion zeugmatography
DE3328365A1 (de) * 1983-08-03 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Neue diagnostische mittel
US4615879A (en) * 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
GB8522535D0 (en) * 1985-09-11 1985-10-16 Amersham Int Plc Contrast agent
US4834964A (en) * 1986-03-07 1989-05-30 M.R.I., Inc. Use of charged nitroxides as NMR image enhancing agents for CSF
US4719425A (en) * 1986-04-15 1988-01-12 Scientific Innovations, Inc. NMR imaging method and apparatus
IE61448B1 (en) * 1987-06-23 1994-11-02 Hafslund Nycomed Innovation Improvements in and relating to magnetic resonance imaging
WO1989001342A2 (en) * 1987-08-07 1989-02-23 Mallinckrodt, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
US5042488A (en) * 1987-09-29 1991-08-27 The Washington University Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
US4893627A (en) * 1988-05-26 1990-01-16 The United States Of America As Represented By The United States Department Of Energy Method for nuclear magnetic resonance imaging using deuterum as a contrast agent

Also Published As

Publication number Publication date
GB8817137D0 (en) 1988-08-24
US5322065A (en) 1994-06-21
PH27247A (en) 1993-05-03
GR3005234T3 (de) 1993-05-24
ZA895468B (en) 1990-04-25
DK8091A (da) 1991-01-17
EP0351919B1 (de) 1992-07-01
AU3867889A (en) 1990-02-19
ATE77755T1 (de) 1992-07-15
DE68901958T2 (de) 1992-12-10
WO1990000904A1 (en) 1990-02-08
AU622692B2 (en) 1992-04-16
DK8091D0 (da) 1991-01-17
ES2033077T3 (es) 1993-03-01
JPH03506028A (ja) 1991-12-26
EP0351919A1 (de) 1990-01-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee