SE9004060L - Bensazepin- och bensotiazepin-derivat - Google Patents

Bensazepin- och bensotiazepin-derivat

Info

Publication number
SE9004060L
SE9004060L SE9004060A SE9004060A SE9004060L SE 9004060 L SE9004060 L SE 9004060L SE 9004060 A SE9004060 A SE 9004060A SE 9004060 A SE9004060 A SE 9004060A SE 9004060 L SE9004060 L SE 9004060L
Authority
SE
Sweden
Prior art keywords
benzzepine
bensotiazepine
derivate
image
exhibited
Prior art date
Application number
SE9004060A
Other languages
English (en)
Other versions
SE9004060D0 (sv
Inventor
D M Floyd
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of SE9004060D0 publication Critical patent/SE9004060D0/sv
Publication of SE9004060L publication Critical patent/SE9004060L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
SE9004060A 1988-06-20 1990-12-19 Bensazepin- och bensotiazepin-derivat SE9004060L (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20852188A 1988-06-20 1988-06-20
US07/353,806 US4902684A (en) 1988-06-20 1989-05-22 Benzazepine and benzothiazepine derivatives
PCT/US1989/002270 WO1989012633A1 (en) 1988-06-20 1989-05-23 Benzazepine and benzothiazepine derivatives

Publications (2)

Publication Number Publication Date
SE9004060D0 SE9004060D0 (sv) 1990-12-19
SE9004060L true SE9004060L (sv) 1992-06-20

Family

ID=26903265

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9004060A SE9004060L (sv) 1988-06-20 1990-12-19 Bensazepin- och bensotiazepin-derivat

Country Status (29)

Country Link
US (1) US4902684A (sv)
JP (1) JP2793674B2 (sv)
KR (1) KR970002633B1 (sv)
CN (1) CN1027262C (sv)
AT (1) AT398567B (sv)
AU (1) AU614399B2 (sv)
BE (1) BE1003305A4 (sv)
CA (1) CA1336975C (sv)
CH (1) CH681723A5 (sv)
EG (1) EG19071A (sv)
ES (1) ES2016467A6 (sv)
FI (1) FI94246C (sv)
FR (1) FR2632953B1 (sv)
GB (1) GB2231329B (sv)
GR (1) GR1002099B (sv)
HU (1) HU210929B (sv)
IE (1) IE64242B1 (sv)
IL (1) IL90515A (sv)
IT (1) IT1230884B (sv)
LU (1) LU87865A1 (sv)
NL (1) NL8920642A (sv)
NO (1) NO179449C (sv)
NZ (1) NZ229612A (sv)
PL (1) PL162313B1 (sv)
PT (1) PT90914B (sv)
RU (1) RU2090562C1 (sv)
SE (1) SE9004060L (sv)
WO (1) WO1989012633A1 (sv)
YU (1) YU121389A (sv)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008284A (en) * 1989-02-15 1991-04-16 E. R. Squibb & Sons, Inc. Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US4963671A (en) * 1989-11-20 1990-10-16 E. R. Squibb & Sons, Inc. Process for resolving chiral intermediates used in making calcium channel blockers
US5112969A (en) * 1990-04-02 1992-05-12 Merrell Dow Pharmaceuticals Inc. Cyano esters and azepinones
IT1240686B (it) * 1990-04-27 1993-12-17 Luso Farmaco Inst Derivati 1,5-benzotiazepinonici, loro preparazione e uso farmaceutico
IT1244878B (it) * 1990-12-11 1994-09-12 Lusochimica Spa Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato
ES2190428T3 (es) * 1991-06-28 2003-08-01 Smithkline Beecham Corp Antagonistas biciclicos de fibrinogeno.
IT1255545B (it) * 1992-10-23 1995-11-09 Procedimento per la preparazione di diltiazem
CA2098446A1 (en) * 1992-09-30 1994-03-31 Eckard Weber 2,5-dihydro-2,5-dioxo-1h-azepines and 2,5-dihydro-2-oxo-1h-azepines and the use thereof as excitatory amino acid and glycine receptor antagonists
EP0714299B1 (en) * 1993-07-16 2002-04-24 Merck & Co. Inc. Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
US5854233A (en) * 1993-09-08 1998-12-29 Pharmacy And Therapeutic Advisory Consultancy Ltd. Method of treating liver disease and like indications with vasodilating agents
US6174917B1 (en) 1993-09-08 2001-01-16 Pharmacy And Therapeutic Advisory Consultancy Ltd. Method of treating liver disease and like indications with vasodilating agents
HUP9774624A2 (en) * 1994-03-24 1997-01-28 Merrell Pharma Inc Hypocholesterolemic, antiatheroclerotic and hypotriglyceridemic condensed benzazepine mercaptoacetylamide disulfide derivatives
US5580867A (en) * 1994-09-09 1996-12-03 Universite De Montreal Myocardial protection during ischemia and reperfusion
JP4272261B2 (ja) * 1996-12-10 2009-06-03 アボツト・ラボラトリーズ ３−ピリジルエナンチオマーおよび鎮痛薬としてのその使用
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
US6472533B1 (en) 1999-04-08 2002-10-29 The Texas A & M University System Ligands for chiral catalysis
GB9907895D0 (en) * 1999-04-08 1999-06-02 Texas A & M Univ Sys Novel ligands for chiral catalysis
WO2003088909A2 (en) * 2002-04-19 2003-10-30 University Of Arizona Methods for modulating phototoxicity

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3312691A (en) * 1963-08-23 1967-04-04 Ciba Geigy Corp 2, 3, 4, 5-tetrahydro-1-benzazepin-2-ones
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS59191036A (ja) * 1983-04-14 1984-10-30 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8316032D0 (en) * 1983-06-11 1983-07-13 Tanabe Seiyaku Co Benzothiazepine derivatives
GB2154577A (en) * 1984-02-18 1985-09-11 Tanabe Seiyaku Co 1,5-benzothiazepines
GB2154578A (en) * 1984-02-18 1985-09-11 Tanabe Seiyaku Co Novel 1,5-benzothiazepine derivatives and processes for preparing the same
US4590188A (en) * 1984-02-18 1986-05-20 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and their pharmaceutical use
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
CA1271747A (en) * 1985-06-12 1990-07-17 David M. Floyd Benzazepines derivatives
US4748239A (en) * 1985-06-12 1988-05-31 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1271748A (en) * 1985-12-12 1990-07-17 Jagabandhu Das Benzazepine derivatives
FR2597097B1 (fr) * 1986-04-15 1988-12-02 Synthelabo Derives de benzothiazepine-1, 5, leur preparation et leur application en therapeutique
US4729994A (en) * 1986-08-20 1988-03-08 Mcneilab, Inc. Benzothiazepine vasodilators having aralkyl substitution
ATE64925T1 (de) * 1986-08-20 1991-07-15 Mcneilab Inc Benzothiazepin-vasodilatoren mit aralkylsubstitution.
US4694002A (en) * 1986-08-21 1987-09-15 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
US4752645A (en) * 1986-10-09 1988-06-21 E. R. Squibb & Sons, Inc. Benzazepine derivatives
ZA893392B (en) * 1988-05-24 1990-01-31 Hoffmann La Roche Process for the manufacture of optically active naphthothiazepinones

Also Published As

Publication number Publication date
NZ229612A (en) 1992-07-28
IT8920933A0 (it) 1989-06-20
IE891957L (en) 1989-12-20
LU87865A1 (de) 1991-12-16
GR890100410A (el) 1990-05-11
GB2231329B (en) 1992-10-21
GR1002099B (en) 1995-12-28
JP2793674B2 (ja) 1998-09-03
FI94246B (sv) 1995-04-28
NO905485L (no) 1991-02-19
EG19071A (en) 1994-07-30
FI94246C (sv) 1995-08-10
SE9004060D0 (sv) 1990-12-19
GB9002587D0 (en) 1990-08-29
YU121389A (en) 1991-04-30
JPH04502002A (ja) 1992-04-09
NO179449B (no) 1996-07-01
PT90914B (pt) 1994-12-30
CN1039585A (zh) 1990-02-14
WO1989012633A1 (en) 1989-12-28
FI900813A0 (sv) 1990-02-19
IE64242B1 (en) 1995-07-26
HUT59908A (en) 1992-07-28
NO905485D0 (no) 1990-12-19
KR970002633B1 (en) 1997-03-06
FR2632953A1 (fr) 1989-12-22
HU210929B (en) 1995-09-28
AT398567B (de) 1994-12-27
BE1003305A4 (fr) 1992-02-25
IL90515A0 (en) 1990-01-18
CN1027262C (zh) 1995-01-04
IT1230884B (it) 1991-11-08
IL90515A (en) 1994-07-31
PL162313B1 (pl) 1993-09-30
NO179449C (no) 1996-10-09
AU3859389A (en) 1990-01-12
GB2231329A (en) 1990-11-14
PT90914A (pt) 1989-12-29
HU894298D0 (en) 1991-01-28
RU2090562C1 (ru) 1997-09-20
CA1336975C (en) 1995-09-12
CH681723A5 (sv) 1993-05-14
ATA901089A (de) 1994-05-15
US4902684A (en) 1990-02-20
FR2632953B1 (fr) 1992-05-29
NL8920642A (nl) 1990-06-01
ES2016467A6 (es) 1990-11-01
KR920700207A (ko) 1992-02-19
AU614399B2 (en) 1991-08-29

Similar Documents

Publication Publication Date Title
SE9004060L (sv) Bensazepin- och bensotiazepin-derivat
MX9102407A (es) 4 arilpiperazinas y 4-arilpiperidinas novedosas.
FI914928A0 (fi) Hydroximetyl (metylencyklopentyl) puriner och -pyrimidiner.
ITMI910477A0 (it) Disposizione di guarnizioni
NO179353C (no) Anvendelse av mikrobicide forbindelser av dimetylamin-epiklorhydrinaminer
KR950700875A (ko) 치환된 구아니딘의 제조방법(preparation of substituted guanidines)
FI863836A (fi) Kinolinderivat.
SE9100920D0 (sv) New active compounds
MX9101767A (es) Derivados de heteroaroilo y procedimiento para su obtencion
MX9306588A (es) Compuesto de acilo antirretrovirales.
NO306195B1 (no) Anvendelse av <alfa>-ketoglutarat
DK0532629T3 (da) 1-Piperidinyl-alkanoylarylsulfonamid-derivater
FI930092A (fi) Indanopyrrolidinkarbamater
ITMI912654A1 (it) Combinazione di estrusore-calandra
SE8601963L (sv) O-sulfaterade beta-laktamhydroxamsyror
ITMI920605A0 (it) Associazioni di composti ad attivita' antivirale
ES2093051T3 (es) Purinil- y pirimidil-tetrahidrofuranos.
BR9202577A (pt) Emprego de solucoes
SE9000857D0 (sv) Novel use of theraeutically active compound
ES2032573T3 (es) Procedimiento de preparacion de derivados de 4,4-dimetil-tetrahidropir-2-ona.
KR930026760U (ko) Tvcr의 개선된 구성
RO97339A2 (ro) Sursa trifazata de foarte joasa frecventa
ZA868089B (en) Bisthiolphosphate,their manufacture,their use for combatting pests,and agents therefor
IT9020622A0 (it) sintesi di ossidi
LT2616B (lt) Prostatos liauku susirgimu diferencialines diagnostikos budas

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 9004060-1