ATE77755T1 - Kontrastmittel mit stabilen, freien radikalen. - Google Patents

Kontrastmittel mit stabilen, freien radikalen.

Info

Publication number
ATE77755T1
ATE77755T1 AT89201880T AT89201880T ATE77755T1 AT E77755 T1 ATE77755 T1 AT E77755T1 AT 89201880 T AT89201880 T AT 89201880T AT 89201880 T AT89201880 T AT 89201880T AT E77755 T1 ATE77755 T1 AT E77755T1
Authority
AT
Austria
Prior art keywords
free radicals
stable
contrast agent
esr
magnetic resonance
Prior art date
Application number
AT89201880T
Other languages
English (en)
Inventor
Ib Leunbach
Original Assignee
Hafslund Nycomed Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hafslund Nycomed Innovation filed Critical Hafslund Nycomed Innovation
Application granted granted Critical
Publication of ATE77755T1 publication Critical patent/ATE77755T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT89201880T 1988-07-19 1989-07-17 Kontrastmittel mit stabilen, freien radikalen. ATE77755T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888817137A GB8817137D0 (en) 1988-07-19 1988-07-19 Compositions
EP89201880A EP0351919B1 (de) 1988-07-19 1989-07-17 Kontrastmittel mit stabilen, freien Radikalen

Publications (1)

Publication Number Publication Date
ATE77755T1 true ATE77755T1 (de) 1992-07-15

Family

ID=10640699

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89201880T ATE77755T1 (de) 1988-07-19 1989-07-17 Kontrastmittel mit stabilen, freien radikalen.

Country Status (13)

Country Link
US (1) US5322065A (de)
EP (1) EP0351919B1 (de)
JP (1) JPH03506028A (de)
AT (1) ATE77755T1 (de)
AU (1) AU622692B2 (de)
DE (1) DE68901958T2 (de)
DK (1) DK8091D0 (de)
ES (1) ES2033077T3 (de)
GB (1) GB8817137D0 (de)
GR (1) GR3005234T3 (de)
PH (1) PH27247A (de)
WO (1) WO1990000904A1 (de)
ZA (1) ZA895468B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819753D0 (en) * 1988-08-19 1988-09-21 Nycomed As Apparatus
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
GB8929300D0 (en) * 1989-12-29 1990-02-28 Instrumentarium Corp Apparatus
GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
US5264204A (en) * 1992-04-30 1993-11-23 Mallinckrodt Medical, Inc. Hydrophilic free radicals for magnetic resonance imaging
DE4328639C2 (de) * 1993-08-23 2002-10-24 Lancaster Group Gmbh Verfahren zur Messung des antioxidativen Potentials der Haut
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
AU1208697A (en) * 1995-12-28 1997-07-28 Daiichi Radioisotope Laboratories, Ltd. Diagnostic drugs
US5978694A (en) * 1997-02-27 1999-11-02 Uri Rapoport Method and apparatus for detecting a magnetically responsive substance
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6185444B1 (en) * 1998-03-13 2001-02-06 Skelscan, Inc. Solid-state magnetic resonance imaging
US6503478B2 (en) * 1999-01-13 2003-01-07 Lightouch Medical, Inc. Chemically specific imaging of tissue
US6574496B1 (en) * 1999-05-19 2003-06-03 Amersham Health As Magnetic resonance imaging
AU2003229328A1 (en) * 2002-05-17 2003-12-02 Jerome L. Ackerman Method and apparatus for quantitative bone matrix imaging by magnetic resonance imaging
WO2006011809A1 (en) 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
US20070025918A1 (en) * 2005-07-28 2007-02-01 General Electric Company Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization
US8377419B2 (en) * 2005-09-28 2013-02-19 The President And Fellows Of Harvard College Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging
JP5475995B2 (ja) 2005-12-01 2014-04-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）法
WO2007066247A2 (en) 2005-12-08 2007-06-14 Koninklijke Philips Electronics, N.V. System and method for monitoring in vivo drug release using overhauser-enhanced nmr
EP1968442A4 (de) * 2005-12-10 2009-11-04 Harvard College In-situ-hyperpolarisation von bildgebungsmitteln
JP2009523172A (ja) * 2006-01-11 2009-06-18 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 造影剤のエクスビボ過分極
CN101506179B (zh) 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物
EP2902041A1 (de) 2007-12-19 2015-08-05 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
DE102008064400A1 (de) * 2008-06-02 2009-12-03 Rohde & Schwarz Gmbh & Co. Kg Mikrowellenuntersuchung mit einem Kontrastmittel
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
SG10201405591YA (en) 2009-09-10 2014-10-30 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
CN102892434B (zh) 2010-04-08 2014-11-19 伯拉考成像股份公司 制备超极化底物的方法和mri方法
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
EP2788035B1 (de) 2011-12-05 2016-03-09 Bracco Imaging S.p.A Zusammensetzung mit essigsäureanhydrid und einem gadoliniumkomplex und verfahren zur verwendung in der hyperpolarisations-mri-analyse
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2154857A5 (en) * 1971-09-28 1973-05-18 Commissariat Energie Atomique Deuterated nitroxide radical - tetra methyl 2,2,5,5-aza -1-cyclopentane oxa-3-oxyl-1
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4516075A (en) * 1983-01-04 1985-05-07 Wisconsin Alumni Research Foundation NMR scanner with motion zeugmatography
DE3328365A1 (de) * 1983-08-03 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Neue diagnostische mittel
US4615879A (en) * 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
GB8522535D0 (en) * 1985-09-11 1985-10-16 Amersham Int Plc Contrast agent
US4834964A (en) * 1986-03-07 1989-05-30 M.R.I., Inc. Use of charged nitroxides as NMR image enhancing agents for CSF
US4719425A (en) * 1986-04-15 1988-01-12 Scientific Innovations, Inc. NMR imaging method and apparatus
FI896234A0 (fi) * 1987-06-23 1989-12-22 Hafslund Nycomed Innovation Foerbaettringar i och angaoende magnetisk resonansavbildning.
AU1966188A (en) * 1987-08-07 1989-03-09 Mallinckrodt, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
US5042488A (en) * 1987-09-29 1991-08-27 The Washington University Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
US4893627A (en) * 1988-05-26 1990-01-16 The United States Of America As Represented By The United States Department Of Energy Method for nuclear magnetic resonance imaging using deuterum as a contrast agent

Also Published As

Publication number Publication date
AU3867889A (en) 1990-02-19
EP0351919A1 (de) 1990-01-24
DE68901958T2 (de) 1992-12-10
JPH03506028A (ja) 1991-12-26
AU622692B2 (en) 1992-04-16
ES2033077T3 (es) 1993-03-01
WO1990000904A1 (en) 1990-02-08
PH27247A (en) 1993-05-03
GB8817137D0 (en) 1988-08-24
DK8091A (da) 1991-01-17
US5322065A (en) 1994-06-21
GR3005234T3 (de) 1993-05-24
EP0351919B1 (de) 1992-07-01
DE68901958D1 (de) 1992-08-06
DK8091D0 (da) 1991-01-17
ZA895468B (en) 1990-04-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee