JP2018528184A5 - - Google Patents
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- JP2018528184A5 JP2018528184A5 JP2018506592A JP2018506592A JP2018528184A5 JP 2018528184 A5 JP2018528184 A5 JP 2018528184A5 JP 2018506592 A JP2018506592 A JP 2018506592A JP 2018506592 A JP2018506592 A JP 2018506592A JP 2018528184 A5 JP2018528184 A5 JP 2018528184A5
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- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 88
- 229960004768 irinotecan Drugs 0.000 claims description 88
- 239000012661 PARP inhibitor Substances 0.000 claims description 65
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims description 65
- 239000002246 antineoplastic agent Substances 0.000 claims description 44
- 229940041181 antineoplastic drug Drugs 0.000 claims description 44
- 238000002651 drug therapy Methods 0.000 claims description 43
- 206010028980 Neoplasm Diseases 0.000 claims description 34
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 claims description 28
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims description 28
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims description 28
- 201000011510 cancer Diseases 0.000 claims description 14
- 239000003112 inhibitor Substances 0.000 claims description 14
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 9
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 9
- 201000010881 cervical cancer Diseases 0.000 claims description 9
- FAQDUNYVKQKNLD-UHFFFAOYSA-N olaparib Chemical compound FC1=CC=C(CC2=C3[CH]C=CC=C3C(=O)N=N2)C=C1C(=O)N(CC1)CCN1C(=O)C1CC1 FAQDUNYVKQKNLD-UHFFFAOYSA-N 0.000 claims description 6
- 229960000572 olaparib Drugs 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000002872 contrast media Substances 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 3
- HWGQMRYQVZSGDQ-HZPDHXFCSA-N chembl3137320 Chemical compound CN1N=CN=C1[C@H]([C@H](N1)C=2C=CC(F)=CC=2)C2=NNC(=O)C3=C2C1=CC(F)=C3 HWGQMRYQVZSGDQ-HZPDHXFCSA-N 0.000 claims description 3
- 230000008030 elimination Effects 0.000 claims description 3
- 238000003379 elimination reaction Methods 0.000 claims description 3
- 239000012458 free base Substances 0.000 claims description 3
- 206010017758 gastric cancer Diseases 0.000 claims description 3
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims description 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 230000036470 plasma concentration Effects 0.000 claims description 3
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 3
- 201000011549 stomach cancer Diseases 0.000 claims description 3
- 229950004550 talazoparib Drugs 0.000 claims description 3
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 3
- 230000000118 anti-neoplastic effect Effects 0.000 claims 5
- 238000001990 intravenous administration Methods 0.000 claims 5
- 239000002502 liposome Substances 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 206010061818 Disease progression Diseases 0.000 claims 3
- 230000005750 disease progression Effects 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 231100000402 unacceptable toxicity Toxicity 0.000 claims 3
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- YYLPVHZCJZPFFG-UHFFFAOYSA-N 1,3-dioxa-2$l^{6}-thiacycloundecane 2,2-dioxide Chemical compound O=S1(=O)OCCCCCCCCO1 YYLPVHZCJZPFFG-UHFFFAOYSA-N 0.000 claims 2
- 102000036365 BRCA1 Human genes 0.000 claims 2
- 108700020463 BRCA1 Proteins 0.000 claims 2
- 101150072950 BRCA1 gene Proteins 0.000 claims 2
- 102000052609 BRCA2 Human genes 0.000 claims 2
- 108700020462 BRCA2 Proteins 0.000 claims 2
- 101150008921 Brca2 gene Proteins 0.000 claims 2
- 239000000232 Lipid Bilayer Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000002356 single layer Substances 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562207760P | 2015-08-20 | 2015-08-20 | |
| US201562207709P | 2015-08-20 | 2015-08-20 | |
| US62/207,760 | 2015-08-20 | ||
| US62/207,709 | 2015-08-20 | ||
| US201562269756P | 2015-12-18 | 2015-12-18 | |
| US201562269511P | 2015-12-18 | 2015-12-18 | |
| US62/269,756 | 2015-12-18 | ||
| US62/269,511 | 2015-12-18 | ||
| US201662308924P | 2016-03-16 | 2016-03-16 | |
| US62/308,924 | 2016-03-16 | ||
| US201662323422P | 2016-04-15 | 2016-04-15 | |
| US62/323,422 | 2016-04-15 | ||
| PCT/US2016/047814 WO2017031442A1 (en) | 2015-08-20 | 2016-08-19 | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528184A JP2018528184A (ja) | 2018-09-27 |
| JP2018528184A5 true JP2018528184A5 (enExample) | 2019-09-26 |
| JP7042739B2 JP7042739B2 (ja) | 2022-03-28 |
Family
ID=56801880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506592A Active JP7042739B2 (ja) | 2015-08-20 | 2016-08-19 | 癌処置のためのリポソーム型イリノテカン及びｐａｒｐ阻害薬を使用する併用療法 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9895365B2 (enExample) |
| EP (1) | EP3337467B1 (enExample) |
| JP (1) | JP7042739B2 (enExample) |
| KR (1) | KR20180037210A (enExample) |
| CN (1) | CN108348480A (enExample) |
| AU (1) | AU2016309002B2 (enExample) |
| CA (1) | CA2992789A1 (enExample) |
| ES (1) | ES2848118T3 (enExample) |
| HK (1) | HK1257216A1 (enExample) |
| IL (1) | IL257147B (enExample) |
| MX (1) | MX381475B (enExample) |
| PL (1) | PL3337467T3 (enExample) |
| PT (1) | PT3337467T (enExample) |
| RU (1) | RU2760185C2 (enExample) |
| SG (1) | SG10201913073YA (enExample) |
| SI (1) | SI3337467T1 (enExample) |
| TW (1) | TWI724018B (enExample) |
| WO (2) | WO2017031445A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101462825B1 (ko) | 2004-05-03 | 2014-11-21 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| AU2015360761B2 (en) * | 2014-12-09 | 2021-05-20 | Ipsen Biopharm Ltd. | Treatment of breast cancer with liposomal irinotecan |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| SG10201913073YA (en) | 2015-08-20 | 2020-03-30 | Ipsen Biopharm Ltd | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
| EP3791876A1 (en) | 2015-08-21 | 2021-03-17 | Ipsen Biopharm Ltd. | Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin |
| ES3036518T3 (en) | 2015-10-16 | 2025-09-19 | Ipsen Biopharm Ltd | Stabilizing camptothecin pharmaceutical compositions |
| RU2761953C2 (ru) * | 2016-11-02 | 2021-12-14 | Ипсен Биофарм Лтд. | Лечение рака желудка с применением комбинационных видов терапии, содержащих липосомальный иринотекан, оксалиплатин, 5-фторурацил (и лейковорин) |
| TW202444417A (zh) * | 2017-05-09 | 2024-11-16 | 美商提薩羅有限公司 | 治療癌症的組合療法 |
| CN110913911A (zh) | 2017-05-18 | 2020-03-24 | 特沙诺有限公司 | 用于治疗癌症的组合疗法 |
| GB201709076D0 (en) * | 2017-06-07 | 2017-07-19 | Inst Of Cancer Research: Royal Cancer Hospital | Parp inhibitors for use in methods of treating cancer |
| WO2019067978A1 (en) | 2017-09-30 | 2019-04-04 | Tesaro, Inc. | POLYTHERAPIES FOR THE TREATMENT OF CANCER |
| US11801240B2 (en) | 2017-10-06 | 2023-10-31 | Tesaro, Inc. | Combination therapies and uses thereof |
| EP3703731A4 (en) * | 2017-11-04 | 2021-07-21 | Aravive Biologics, Inc. | METHOD OF TREATMENT OF METASTATIC CANCER USING AXL DECOY RECEPTORS |
| JP2021510702A (ja) * | 2018-01-12 | 2021-04-30 | プロリンクス エルエルシー | 相乗的がん治療 |
| US20210030680A1 (en) * | 2018-04-13 | 2021-02-04 | The Board Of Regents Of University Of Texas System | Nanoparticle compositions and methods of use of parp inhibitor for treatment of cancer |
| WO2019228499A1 (en) * | 2018-06-01 | 2019-12-05 | Beigene, Ltd. | Maintenance therapy of a parp inhibitor in treating gastric cancer |
| CN113631166A (zh) * | 2018-12-14 | 2021-11-09 | 慧源香港创新有限公司 | 用于治疗癌症的口服给药的伊立替康和P-gp抑制剂的治疗组合 |
| CN114053415B (zh) * | 2020-07-30 | 2024-06-18 | 江苏天士力帝益药业有限公司 | Tsl-1502复方药物组合 |
| CN114053271B (zh) * | 2020-07-30 | 2024-05-07 | 江苏天士力帝益药业有限公司 | 一种含有tsl-1502m的药物组合物及其应用 |
| JP2024516825A (ja) * | 2021-04-29 | 2024-04-17 | サイブレクサ ２，インコーポレイテッド | トポイソメラーゼｉ阻害剤のペプチドコンジュゲートの投与レジメン |
| CA3216716A1 (en) * | 2021-05-03 | 2022-11-10 | Tim BERGBREDE | Composition comprising an inhibitor of mitochondrial transcription |
| RU2769543C2 (ru) * | 2021-07-21 | 2022-04-01 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ оценки первичного ответа на проводимую комбинированную химиотерапию спорадического рака яичников III и IV стадий |
| CN114259569B (zh) * | 2021-12-30 | 2024-02-27 | 中山大学附属第八医院（深圳福田） | 基于伊立替康和尼拉帕利的超分子纳米药物的制备方法和应用 |
| EP4209217A1 (en) * | 2022-01-11 | 2023-07-12 | Fundación Profesor Novoa Santos | Method for the treatment of brca1/2 mutated cancer |
| WO2024111564A1 (ja) | 2022-11-21 | 2024-05-30 | 富士フイルム株式会社 | トポテカン又はその塩を内包するリポソーム組成物およびｄｎａ損傷修復阻害剤を含む組合せ医薬 |
| JP2025075711A (ja) * | 2023-10-31 | 2025-05-15 | 国立大学法人 大分大学 | Ｂｒｃａ遺伝子を含む相同組換え欠損が原因となって発症する癌の治療のための治療剤、医薬組成物、化合物、使用、治療方法、及びスクリーニング方法 |
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2016
- 2016-08-19 SG SG10201913073YA patent/SG10201913073YA/en unknown
- 2016-08-19 TW TW105126680A patent/TWI724018B/zh active
- 2016-08-19 WO PCT/US2016/047827 patent/WO2017031445A1/en not_active Ceased
- 2016-08-19 CN CN201680046591.3A patent/CN108348480A/zh active Pending
- 2016-08-19 HK HK18116219.1A patent/HK1257216A1/zh unknown
- 2016-08-19 MX MX2018001659A patent/MX381475B/es unknown
- 2016-08-19 CA CA2992789A patent/CA2992789A1/en active Pending
- 2016-08-19 JP JP2018506592A patent/JP7042739B2/ja active Active
- 2016-08-19 KR KR1020187004965A patent/KR20180037210A/ko not_active Ceased
- 2016-08-19 SI SI201631023T patent/SI3337467T1/sl unknown
- 2016-08-19 AU AU2016309002A patent/AU2016309002B2/en not_active Ceased
- 2016-08-19 ES ES16757498T patent/ES2848118T3/es active Active
- 2016-08-19 EP EP16757498.7A patent/EP3337467B1/en not_active Revoked
- 2016-08-19 PT PT167574987T patent/PT3337467T/pt unknown
- 2016-08-19 WO PCT/US2016/047814 patent/WO2017031442A1/en not_active Ceased
- 2016-08-19 RU RU2018105655A patent/RU2760185C2/ru active
- 2016-08-19 PL PL16757498T patent/PL3337467T3/pl unknown
- 2016-10-28 US US15/337,274 patent/US9895365B2/en active Active
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2017
- 2017-12-22 US US15/852,551 patent/US10478428B2/en active Active
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2019
- 2019-09-27 US US16/586,609 patent/US20200268742A1/en not_active Abandoned
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2022
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