JP2018528184A5 - - Google Patents
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- JP2018528184A5 JP2018528184A5 JP2018506592A JP2018506592A JP2018528184A5 JP 2018528184 A5 JP2018528184 A5 JP 2018528184A5 JP 2018506592 A JP2018506592 A JP 2018506592A JP 2018506592 A JP2018506592 A JP 2018506592A JP 2018528184 A5 JP2018528184 A5 JP 2018528184A5
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- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 88
- 229960004768 irinotecan Drugs 0.000 claims description 88
- 239000012661 PARP inhibitor Substances 0.000 claims description 65
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims description 65
- 239000002246 antineoplastic agent Substances 0.000 claims description 44
- 229940041181 antineoplastic drug Drugs 0.000 claims description 44
- 238000002651 drug therapy Methods 0.000 claims description 43
- 206010028980 Neoplasm Diseases 0.000 claims description 34
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 claims description 28
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims description 28
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims description 28
- 201000011510 cancer Diseases 0.000 claims description 14
- 239000003112 inhibitor Substances 0.000 claims description 14
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 9
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 9
- 201000010881 cervical cancer Diseases 0.000 claims description 9
- FAQDUNYVKQKNLD-UHFFFAOYSA-N olaparib Chemical compound FC1=CC=C(CC2=C3[CH]C=CC=C3C(=O)N=N2)C=C1C(=O)N(CC1)CCN1C(=O)C1CC1 FAQDUNYVKQKNLD-UHFFFAOYSA-N 0.000 claims description 6
- 229960000572 olaparib Drugs 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000002872 contrast media Substances 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 3
- HWGQMRYQVZSGDQ-HZPDHXFCSA-N chembl3137320 Chemical compound CN1N=CN=C1[C@H]([C@H](N1)C=2C=CC(F)=CC=2)C2=NNC(=O)C3=C2C1=CC(F)=C3 HWGQMRYQVZSGDQ-HZPDHXFCSA-N 0.000 claims description 3
- 230000008030 elimination Effects 0.000 claims description 3
- 238000003379 elimination reaction Methods 0.000 claims description 3
- 239000012458 free base Substances 0.000 claims description 3
- 206010017758 gastric cancer Diseases 0.000 claims description 3
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims description 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 230000036470 plasma concentration Effects 0.000 claims description 3
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 3
- 201000011549 stomach cancer Diseases 0.000 claims description 3
- 229950004550 talazoparib Drugs 0.000 claims description 3
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 3
- 230000000118 anti-neoplastic effect Effects 0.000 claims 5
- 238000001990 intravenous administration Methods 0.000 claims 5
- 239000002502 liposome Substances 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 206010061818 Disease progression Diseases 0.000 claims 3
- 230000005750 disease progression Effects 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 231100000402 unacceptable toxicity Toxicity 0.000 claims 3
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- YYLPVHZCJZPFFG-UHFFFAOYSA-N 1,3-dioxa-2$l^{6}-thiacycloundecane 2,2-dioxide Chemical compound O=S1(=O)OCCCCCCCCO1 YYLPVHZCJZPFFG-UHFFFAOYSA-N 0.000 claims 2
- 102000036365 BRCA1 Human genes 0.000 claims 2
- 108700020463 BRCA1 Proteins 0.000 claims 2
- 101150072950 BRCA1 gene Proteins 0.000 claims 2
- 102000052609 BRCA2 Human genes 0.000 claims 2
- 108700020462 BRCA2 Proteins 0.000 claims 2
- 101150008921 Brca2 gene Proteins 0.000 claims 2
- 239000000232 Lipid Bilayer Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000002356 single layer Substances 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562207709P | 2015-08-20 | 2015-08-20 | |
| US201562207760P | 2015-08-20 | 2015-08-20 | |
| US62/207,760 | 2015-08-20 | ||
| US62/207,709 | 2015-08-20 | ||
| US201562269756P | 2015-12-18 | 2015-12-18 | |
| US201562269511P | 2015-12-18 | 2015-12-18 | |
| US62/269,756 | 2015-12-18 | ||
| US62/269,511 | 2015-12-18 | ||
| US201662308924P | 2016-03-16 | 2016-03-16 | |
| US62/308,924 | 2016-03-16 | ||
| US201662323422P | 2016-04-15 | 2016-04-15 | |
| US62/323,422 | 2016-04-15 | ||
| PCT/US2016/047814 WO2017031442A1 (en) | 2015-08-20 | 2016-08-19 | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528184A JP2018528184A (ja) | 2018-09-27 |
| JP2018528184A5 true JP2018528184A5 (enExample) | 2019-09-26 |
| JP7042739B2 JP7042739B2 (ja) | 2022-03-28 |
Family
ID=56801880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506592A Active JP7042739B2 (ja) | 2015-08-20 | 2016-08-19 | 癌処置のためのリポソーム型イリノテカン及びｐａｒｐ阻害薬を使用する併用療法 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9895365B2 (enExample) |
| EP (1) | EP3337467B1 (enExample) |
| JP (1) | JP7042739B2 (enExample) |
| KR (1) | KR20180037210A (enExample) |
| CN (1) | CN108348480A (enExample) |
| AU (1) | AU2016309002B2 (enExample) |
| CA (1) | CA2992789A1 (enExample) |
| ES (1) | ES2848118T3 (enExample) |
| HK (1) | HK1257216A1 (enExample) |
| IL (1) | IL257147B (enExample) |
| MX (1) | MX381475B (enExample) |
| PL (1) | PL3337467T3 (enExample) |
| PT (1) | PT3337467T (enExample) |
| RU (1) | RU2760185C2 (enExample) |
| SG (1) | SG10201913073YA (enExample) |
| SI (1) | SI3337467T1 (enExample) |
| TW (1) | TWI724018B (enExample) |
| WO (2) | WO2017031442A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2424792C2 (ru) | 2004-05-03 | 2011-07-27 | Хермес Байесайенсиз, Инк. | Липосомы, используемые для доставки лекарственных средств |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| JP7113619B2 (ja) * | 2014-12-09 | 2022-08-05 | イプセン バイオファーム リミティド | リポソーマルイリノテカンによる乳がんの治療 |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| HK1257216A1 (zh) | 2015-08-20 | 2019-10-18 | 益普生生物制药有限公司 | 使用脂质体伊立替康和parp抑制剂用於癌症治疗的组合疗法 |
| BR112018002941B1 (pt) | 2015-08-21 | 2023-12-05 | Ipsen Biopharm Ltd | Uso de irinotecano lipossomal, oxaliplatina, leucovorina e 5- fluorouracil no tratamento de primeira linha de adenocarcinoma metastático do pâncreas |
| BR112018006922B1 (pt) | 2015-10-16 | 2023-11-21 | Ipsen Biopharm Ltd | Composições de irinotecano lipossômico estabilizado para armazenamento |
| CN110402163A (zh) | 2016-11-02 | 2019-11-01 | 易普森生物制药有限公司 | 使用包括脂质体伊立替康、奥沙利铂、5-氟尿嘧啶(和甲酰四氢叶酸)的组合疗法治疗胃癌 |
| TWI879716B (zh) * | 2017-05-09 | 2025-04-11 | 美商提薩羅有限公司 | 治療癌症的組合療法 |
| MA49144A (fr) | 2017-05-18 | 2020-03-25 | Tesaro Inc | Polythérapies pour le traitement du cancer |
| GB201709076D0 (en) * | 2017-06-07 | 2017-07-19 | Inst Of Cancer Research: Royal Cancer Hospital | Parp inhibitors for use in methods of treating cancer |
| CA3076515A1 (en) | 2017-09-30 | 2019-04-04 | Tesaro, Inc. | Combination therapies for treating cancer |
| MA50618A (fr) | 2017-10-06 | 2020-08-12 | Tesaro Inc | Polyrhérapies et leurs utilisations |
| KR20200085307A (ko) * | 2017-11-04 | 2020-07-14 | 아라바이브 바이올로직스, 인크. | Axl 유인 수용체를 이용한 전이성 암의 치료 방법 |
| CA3087628A1 (en) * | 2018-01-12 | 2019-07-18 | Prolynx Llc | Synergistic cancer treatment |
| US20210030680A1 (en) * | 2018-04-13 | 2021-02-04 | The Board Of Regents Of University Of Texas System | Nanoparticle compositions and methods of use of parp inhibitor for treatment of cancer |
| CN112292133A (zh) * | 2018-06-01 | 2021-01-29 | 百济神州有限公司 | 在胃癌治疗中的parp抑制剂维持疗法 |
| WO2020124070A1 (en) * | 2018-12-14 | 2020-06-18 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered irinotecan and a p-gp inhibitor for the treatment of cancer |
| CN114053415B (zh) * | 2020-07-30 | 2024-06-18 | 江苏天士力帝益药业有限公司 | Tsl-1502复方药物组合 |
| CN114053271B (zh) * | 2020-07-30 | 2024-05-07 | 江苏天士力帝益药业有限公司 | 一种含有tsl-1502m的药物组合物及其应用 |
| US20240252454A1 (en) * | 2021-05-03 | 2024-08-01 | Lead Discovery Center Gmbh | Composition comprising an inhibitor of mitochondrial transcription |
| RU2769543C2 (ru) * | 2021-07-21 | 2022-04-01 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ оценки первичного ответа на проводимую комбинированную химиотерапию спорадического рака яичников III и IV стадий |
| CN114259569B (zh) * | 2021-12-30 | 2024-02-27 | 中山大学附属第八医院（深圳福田） | 基于伊立替康和尼拉帕利的超分子纳米药物的制备方法和应用 |
| EP4209217A1 (en) * | 2022-01-11 | 2023-07-12 | Fundación Profesor Novoa Santos | Method for the treatment of brca1/2 mutated cancer |
| JPWO2024111564A1 (enExample) | 2022-11-21 | 2024-05-30 |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| JPH0720857B2 (ja) | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5538954A (en) | 1994-06-24 | 1996-07-23 | A/S Dumex (Dumex Ltd.) | Salts of tetracyclines |
| US5783568A (en) | 1994-06-10 | 1998-07-21 | Sugen, Inc. | Methods for treating cancer and other cell proliferative diseases |
| US5543152A (en) | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| US5800833A (en) | 1995-02-27 | 1998-09-01 | University Of British Columbia | Method for loading lipid vesicles |
| DE19605024A1 (de) | 1996-01-31 | 1997-08-07 | Schering Ag | Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| US5997899A (en) | 1996-10-01 | 1999-12-07 | Skyepharma Inc. | Method for producing liposomes with increased percent of compound encapsulated |
| EP0949906A4 (en) | 1996-10-22 | 2004-11-24 | Hermes Biosciences Inc | LIPOSOMES LOADED WITH ACTIVE SUBSTANCE AND THEIR PRODUCTION METHOD |
| US6210707B1 (en) | 1996-11-12 | 2001-04-03 | The Regents Of The University Of California | Methods of forming protein-linked lipidic microparticles, and compositions thereof |
| US6787132B1 (en) | 1997-12-04 | 2004-09-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Combined chemo-immunotherapy with liposomal drugs and cytokines |
| US7244826B1 (en) | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| US6726925B1 (en) | 1998-06-18 | 2004-04-27 | Duke University | Temperature-sensitive liposomal formulation |
| CA2346879A1 (en) | 1998-09-16 | 2000-04-27 | Alza Corporation | Liposome-entrapped topoisomerase inhibitors |
| US7311924B2 (en) | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
| WO2000066125A1 (en) | 1999-04-29 | 2000-11-09 | Aventis Pharma S.A. | Method for treating cancer using camptothecin derivatives and 5-fluorouracil |
| US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| US6511676B1 (en) | 1999-11-05 | 2003-01-28 | Teni Boulikas | Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes |
| ATE341310T1 (de) | 2000-02-04 | 2006-10-15 | Lipoxen Technologies Ltd | Dehydratisierungs-/rehydratisierungsverfahren zur herstellung von liposome |
| US6545010B2 (en) | 2000-03-17 | 2003-04-08 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer |
| JP4679028B2 (ja) | 2000-05-15 | 2011-04-27 | セルジーン コーポレイション | 結腸直腸癌を治療するための組成物および方法 |
| AU7038501A (en) | 2000-06-30 | 2002-01-14 | Inex Pharmaceuticals Corp | Liposomal antineoplastic drugs and uses thereof |
| TWI283575B (en) | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
| JP2004525138A (ja) | 2001-03-26 | 2004-08-19 | アルザ・コーポレーシヨン | 治療剤の改良された細胞内送達のためのリポソーム組成物 |
| US7219016B2 (en) | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
| WO2003030864A1 (en) | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Liposomal formulation of irinotecan |
| JP2005504759A (ja) | 2001-07-23 | 2005-02-17 | エピダウロス・バイオテクノロジー・アクチェンゲゼルシャフト | Ｃｙｐ３ａ５に基づいたがんの改善治療の手段及び方法 |
| US7850990B2 (en) | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| AU2003237864B2 (en) | 2002-05-15 | 2008-12-18 | California Pacific Medical Center | Delivery of nucleic acid-like compounds |
| WO2003101475A1 (en) | 2002-05-31 | 2003-12-11 | Transmolecular Inc. | Treatment of cell proliferative disorders with chlorotoxin |
| WO2004035032A2 (en) | 2002-08-20 | 2004-04-29 | Neopharm, Inc. | Pharmaceutical formulations of camptothecine derivatives |
| RS20150135A1 (sr) | 2003-05-30 | 2015-08-31 | Genentech Inc. | Tretman sa anti-vegf antitelima |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| RU2424792C2 (ru) | 2004-05-03 | 2011-07-27 | Хермес Байесайенсиз, Инк. | Липосомы, используемые для доставки лекарственных средств |
| AP2255A (en) | 2004-06-01 | 2011-07-21 | Yakult Honsha Kk | Irinotecan preparation. |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| TWI375673B (en) | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
| EP1951239A2 (en) | 2005-10-25 | 2008-08-06 | Celator Pharmaceuticals, Inc. | Fixed ratio drug combination treatments for solid tumors |
| WO2007076117A2 (en) | 2005-12-22 | 2007-07-05 | Celator Pharmaceuticals, Inc. | Liposomal formulations comprising secondary and tertiary amines and methods for preparing thereof |
| PL2338487T3 (pl) | 2006-01-17 | 2014-03-31 | Abbvie Bahamas Ltd | Terapia skojarzona z inhibitorami PARP |
| US20080146638A1 (en) | 2006-01-17 | 2008-06-19 | Abbott Laboratories | Combination therapy with parp inhibitors |
| WO2007109184A2 (en) | 2006-03-16 | 2007-09-27 | Bionumerik Pharmaceuticals, Inc. | Anti-cancer activity augmentation compounds and formulations and methods of use thereof |
| HRP20131113T1 (hr) | 2007-02-16 | 2014-01-17 | Merrimack Pharmaceuticals, Inc. | Protutijela protiv erbb3 i njihova uporaba |
| WO2008114274A1 (en) | 2007-03-19 | 2008-09-25 | Fresenius Kabi Onclology Ltd. | Proliposomal and liposomal compositions |
| US20120003160A1 (en) | 2007-06-29 | 2012-01-05 | Amag Pharmaceuticals, Inc. | Macrophage-Enhanced MRI (MEMRI) in a Single Imaging Session |
| ES2550759T3 (es) | 2007-08-17 | 2015-11-12 | Celator Pharmaceuticals, Inc. | Formulaciones farmacológicas de platino mejoradas |
| EP2197917A1 (en) | 2007-09-28 | 2010-06-23 | Universitätsspital Basel | Immunoliposomes for treatment of cancer |
| NZ586123A (en) | 2007-11-12 | 2012-12-21 | Bipar Sciences Inc | Treatment of ovarian cancer with 4-iodo-3-nitrobenzamide in combination with topoisomerase inhibitors |
| CA2708157A1 (en) | 2007-12-07 | 2009-06-11 | Bipar Sciences, Inc. | Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors |
| US20110104256A1 (en) | 2008-03-25 | 2011-05-05 | Yaolin Wang | Methods for treating or preventing colorectal cancer |
| US8067432B2 (en) | 2008-03-31 | 2011-11-29 | University Of Kentucky Research Foundation | Liposomal, ring-opened camptothecins with prolonged, site-specific delivery of active drug to solid tumors |
| MX2010011145A (es) | 2008-04-11 | 2011-04-11 | Merrimack Pharmaceuticals Inc | Enlazadores de la albumina de suero humana y conjugados de la misma. |
| US8852630B2 (en) | 2008-05-13 | 2014-10-07 | Yale University | Chimeric small molecules for the recruitment of antibodies to cancer cells |
| CN102282168A (zh) | 2008-11-18 | 2011-12-14 | 梅里麦克制药股份有限公司 | 人血清白蛋白接头以及其结合物 |
| EP2413901A4 (en) | 2009-03-30 | 2015-05-06 | Cerulean Pharma Inc | POLYMER CONCRETE CONJUGATES, PARTICLES, COMPOSITIONS AND CORRESPONDING USES |
| JP2012525371A (ja) | 2009-05-01 | 2012-10-22 | オンコザイム・ファーマ・インコーポレイテッド | 癌を治療するためのペンタミジンの組み合わせ |
| JP5855568B2 (ja) | 2009-09-15 | 2016-02-09 | セルリアン・ファーマ・インコーポレイテッド | 癌の治療法 |
| ES2547698T3 (es) | 2009-12-03 | 2015-10-08 | Jiangsu Hengrui Medicine Co., Ltd. | Liposoma de irinotecán o su clorhidrato y método de preparación del mismo |
| EP2575804A4 (en) | 2010-06-04 | 2013-10-23 | Abraxis Bioscience Llc | METHOD FOR THE TREATMENT OF PANCREASCRE |
| CN107261110A (zh) | 2010-06-19 | 2017-10-20 | 健康科学西部大学 | Peg化脂质体包封的糖肽抗生素的新制剂 |
| EP2595618A1 (en) | 2010-07-19 | 2013-05-29 | BiPar Sciences, Inc. | Methods of treating breast cancer using 4-iodo-3-nitrobenzamide in combination with anti-tumor agents |
| CA2806076A1 (en) | 2010-07-22 | 2012-01-26 | The Regents Of The University Of California | Anti-tumor antigen antibodies and methods of use |
| RU2541100C2 (ru) | 2010-09-03 | 2015-02-10 | Боард Оф Регентс Оф Зе Юниверсити Оф Небраска | Способ и композиция для лечения рака |
| JP6208582B2 (ja) | 2010-12-06 | 2017-10-04 | メリマック ファーマシューティカルズ インコーポレーティッド | アントラサイクリン系化学療法剤を含有しているｅｒｂｂ２標的免疫リポソームによる治療における心臓毒性を抑制するための用量及び投与 |
| US9226984B2 (en) | 2010-12-14 | 2016-01-05 | Technical University of Denmark and Rigshospitalet | Entrapment of radionuclides in nanoparticle compositions |
| WO2012112730A2 (en) | 2011-02-15 | 2012-08-23 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for delivering nucleic acid to a cell |
| HRP20170713T1 (hr) | 2011-04-19 | 2017-07-14 | Merrimack Pharmaceuticals, Inc. | Bispecifično anti-igf-1r i anti-erbb3 antitijelo |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| AU2013201584A1 (en) | 2012-03-12 | 2013-09-26 | Merrimack Pharmaceuticals, Inc. | Methods for treating pancreatic cancer using combination therapies comprising an anti-ErbB3 antibody |
| WO2013158803A1 (en) | 2012-04-17 | 2013-10-24 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for non-invasive imaging |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| WO2014036470A1 (en) | 2012-08-31 | 2014-03-06 | Sloan-Kettering Institute For Cancer Research | Particles, methods and uses thereof |
| WO2014113167A1 (en) | 2012-12-14 | 2014-07-24 | Merrimack Pharmaceuticals, Inc. | Non-invasive imaging methods for patient selection for treatment with nanoparticulate therapeutic agents |
| UA117581C2 (uk) * | 2013-03-27 | 2018-08-27 | Тайхо Фармасьютікал Ко., Лтд. | Протипухлинний лікарський засіб, який включає низькодозований гідрохлориду іринотекану гідрат |
| WO2015031536A1 (en) | 2013-08-27 | 2015-03-05 | Northeastern University | Nanoparticle drug delivery system and method of treating cancer and neurotrauma |
| US20160303264A1 (en) | 2013-10-23 | 2016-10-20 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for non-invasive imaging and drug delivery |
| JP7113619B2 (ja) | 2014-12-09 | 2022-08-05 | イプセン バイオファーム リミティド | リポソーマルイリノテカンによる乳がんの治療 |
| WO2016168451A1 (en) | 2015-04-14 | 2016-10-20 | Merrimack Pharmaceuticals, Inc. | Compositions for improving the pharmacokinetics and therapeutic index of cancer treatment |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| HK1257216A1 (zh) | 2015-08-20 | 2019-10-18 | 益普生生物制药有限公司 | 使用脂质体伊立替康和parp抑制剂用於癌症治疗的组合疗法 |
| BR112018002941B1 (pt) | 2015-08-21 | 2023-12-05 | Ipsen Biopharm Ltd | Uso de irinotecano lipossomal, oxaliplatina, leucovorina e 5- fluorouracil no tratamento de primeira linha de adenocarcinoma metastático do pâncreas |
| BR112018006922B1 (pt) | 2015-10-16 | 2023-11-21 | Ipsen Biopharm Ltd | Composições de irinotecano lipossômico estabilizado para armazenamento |
| US20170202840A1 (en) | 2016-01-14 | 2017-07-20 | Merrimack Pharmaceuticals, Inc. | Treatment of pancreatic cancer with liposomal irinotecan |
| WO2017172678A1 (en) | 2016-03-30 | 2017-10-05 | Merrimack Pharmaceuticals, Inc. | Methods for treating cancer using combination therapies comprising an oligoclonal anti-egfr antibody preparation and lipsomal irinotecan |
| US20170333421A1 (en) | 2016-05-18 | 2017-11-23 | Ipsen Biopharm Ltd. | Population Pharmacokinetics of Liposomal Irinotecan |
| MA45046A (fr) | 2016-05-18 | 2019-03-27 | Ipsen Biopharm Ltd | Irinotécan nanoliposomal utilisé dans le traitement du cancer bronchique à petites cellules |
| CN110402163A (zh) | 2016-11-02 | 2019-11-01 | 易普森生物制药有限公司 | 使用包括脂质体伊立替康、奥沙利铂、5-氟尿嘧啶(和甲酰四氢叶酸)的组合疗法治疗胃癌 |
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2016
- 2016-08-19 HK HK18116219.1A patent/HK1257216A1/zh unknown
- 2016-08-19 TW TW105126680A patent/TWI724018B/zh active
- 2016-08-19 PL PL16757498T patent/PL3337467T3/pl unknown
- 2016-08-19 MX MX2018001659A patent/MX381475B/es unknown
- 2016-08-19 SG SG10201913073YA patent/SG10201913073YA/en unknown
- 2016-08-19 EP EP16757498.7A patent/EP3337467B1/en not_active Revoked
- 2016-08-19 WO PCT/US2016/047814 patent/WO2017031442A1/en not_active Ceased
- 2016-08-19 JP JP2018506592A patent/JP7042739B2/ja active Active
- 2016-08-19 WO PCT/US2016/047827 patent/WO2017031445A1/en not_active Ceased
- 2016-08-19 KR KR1020187004965A patent/KR20180037210A/ko not_active Ceased
- 2016-08-19 ES ES16757498T patent/ES2848118T3/es active Active
- 2016-08-19 CA CA2992789A patent/CA2992789A1/en active Pending
- 2016-08-19 SI SI201631023T patent/SI3337467T1/sl unknown
- 2016-08-19 PT PT167574987T patent/PT3337467T/pt unknown
- 2016-08-19 RU RU2018105655A patent/RU2760185C2/ru active
- 2016-08-19 CN CN201680046591.3A patent/CN108348480A/zh active Pending
- 2016-08-19 AU AU2016309002A patent/AU2016309002B2/en not_active Ceased
- 2016-10-28 US US15/337,274 patent/US9895365B2/en active Active
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2017
- 2017-12-22 US US15/852,551 patent/US10478428B2/en active Active
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- 2018-01-25 IL IL257147A patent/IL257147B/en unknown
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2019
- 2019-09-27 US US16/586,609 patent/US20200268742A1/en not_active Abandoned
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2022
- 2022-03-24 US US17/703,312 patent/US11844795B2/en active Active
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