JP2019533684A5 - - Google Patents
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- Publication number
- JP2019533684A5 JP2019533684A5 JP2019522381A JP2019522381A JP2019533684A5 JP 2019533684 A5 JP2019533684 A5 JP 2019533684A5 JP 2019522381 A JP2019522381 A JP 2019522381A JP 2019522381 A JP2019522381 A JP 2019522381A JP 2019533684 A5 JP2019533684 A5 JP 2019533684A5
- Authority
- JP
- Japan
- Prior art keywords
- administered
- combination
- leucovorin
- irinotecan
- oxaliplatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229960004768 irinotecan Drugs 0.000 claims description 62
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 62
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims description 46
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 46
- 235000008191 folinic acid Nutrition 0.000 claims description 46
- 239000011672 folinic acid Substances 0.000 claims description 46
- 229960001691 leucovorin Drugs 0.000 claims description 46
- 239000002502 liposome Substances 0.000 claims description 44
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 38
- 229960002949 fluorouracil Drugs 0.000 claims description 38
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 38
- 229960001756 oxaliplatin Drugs 0.000 claims description 38
- 238000002560 therapeutic procedure Methods 0.000 claims description 35
- 230000000259 anti-tumor effect Effects 0.000 claims description 34
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 22
- 206010017758 gastric cancer Diseases 0.000 claims description 22
- 201000011549 stomach cancer Diseases 0.000 claims description 22
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 14
- 235000012000 cholesterol Nutrition 0.000 claims description 7
- WEPNHBQBLCNOBB-FZJVNAOYSA-N sucrose octasulfate Chemical compound OS(=O)(=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@H](COS(=O)(=O)O)O[C@]1(COS(O)(=O)=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](COS(O)(=O)=O)O1 WEPNHBQBLCNOBB-FZJVNAOYSA-N 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 6
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims description 5
- 239000002246 antineoplastic agent Substances 0.000 claims description 3
- 230000003457 anti-vomiting effect Effects 0.000 claims description 2
- 239000003246 corticosteroid Substances 0.000 claims description 2
- 239000002895 emetic Substances 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- 229920002505 N-(Carbonyl-Methoxypolyethylene Glycol 2000)-1,2-Distearoyl-Sn-Glycero-3-Phosphoethanolamine Polymers 0.000 claims 1
- RZBMBMLIIRIAMH-LDLOPFEMSA-N [(2R)-2,3-dihydroxypropyl] 2-[di(octadecanoyl)amino]ethyl hydrogen phosphate Chemical compound C(CCCCCCCCCCCCCCCCC)(=O)N(CCOP(OC[C@@H](CO)O)(=O)O)C(CCCCCCCCCCCCCCCCC)=O RZBMBMLIIRIAMH-LDLOPFEMSA-N 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 125000001095 phosphatidyl group Chemical group 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- SRLOHQKOADWDBV-NRONOFSHSA-M sodium;[(2r)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCOC)OC(=O)CCCCCCCCCCCCCCCCC SRLOHQKOADWDBV-NRONOFSHSA-M 0.000 claims 1
- 238000000034 method Methods 0.000 description 33
- 229960005277 gemcitabine Drugs 0.000 description 5
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 5
- 206010061818 Disease progression Diseases 0.000 description 1
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- KLEAIHJJLUAXIQ-JDRGBKBRSA-N irinotecan hydrochloride hydrate Chemical compound O.O.O.Cl.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 KLEAIHJJLUAXIQ-JDRGBKBRSA-N 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 229940048191 onivyde Drugs 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022146925A JP2022171808A (ja) | 2016-11-02 | 2022-09-15 | リポソームイリノテカン、オキサリプラチン、５－フルオロウラシル（およびロイコボリン）を含む併用療法を用いる胃がんの処置 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416317P | 2016-11-02 | 2016-11-02 | |
| US62/416,317 | 2016-11-02 | ||
| PCT/GB2017/053293 WO2018083470A1 (en) | 2016-11-02 | 2017-11-01 | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022146925A Division JP2022171808A (ja) | 2016-11-02 | 2022-09-15 | リポソームイリノテカン、オキサリプラチン、５－フルオロウラシル（およびロイコボリン）を含む併用療法を用いる胃がんの処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019533684A JP2019533684A (ja) | 2019-11-21 |
| JP2019533684A5 true JP2019533684A5 (enExample) | 2020-12-10 |
Family
ID=60569939
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522381A Ceased JP2019533684A (ja) | 2016-11-02 | 2017-11-01 | リポソームイリノテカン、オキサリプラチン、５−フルオロウラシル（およびロイコボリン）を含む併用療法を用いる胃がんの処置 |
| JP2022146925A Pending JP2022171808A (ja) | 2016-11-02 | 2022-09-15 | リポソームイリノテカン、オキサリプラチン、５－フルオロウラシル（およびロイコボリン）を含む併用療法を用いる胃がんの処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022146925A Pending JP2022171808A (ja) | 2016-11-02 | 2022-09-15 | リポソームイリノテカン、オキサリプラチン、５－フルオロウラシル（およびロイコボリン）を含む併用療法を用いる胃がんの処置 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11071726B2 (enExample) |
| EP (1) | EP3535026A1 (enExample) |
| JP (2) | JP2019533684A (enExample) |
| KR (1) | KR20190077441A (enExample) |
| CN (1) | CN110402163A (enExample) |
| AU (1) | AU2017354903B2 (enExample) |
| BR (1) | BR112019007844A2 (enExample) |
| CA (1) | CA3040395A1 (enExample) |
| EA (1) | EA201990979A1 (enExample) |
| IL (2) | IL266187A (enExample) |
| MA (1) | MA46709A (enExample) |
| MX (1) | MX392408B (enExample) |
| MY (1) | MY202377A (enExample) |
| PH (1) | PH12019500892A1 (enExample) |
| RU (1) | RU2761953C2 (enExample) |
| SG (2) | SG11201903615WA (enExample) |
| TW (1) | TWI791467B (enExample) |
| WO (1) | WO2018083470A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2424792C2 (ru) * | 2004-05-03 | 2011-07-27 | Хермес Байесайенсиз, Инк. | Липосомы, используемые для доставки лекарственных средств |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| HK1257216A1 (zh) | 2015-08-20 | 2019-10-18 | 益普生生物制药有限公司 | 使用脂质体伊立替康和parp抑制剂用於癌症治疗的组合疗法 |
| BR112018002941B1 (pt) | 2015-08-21 | 2023-12-05 | Ipsen Biopharm Ltd | Uso de irinotecano lipossomal, oxaliplatina, leucovorina e 5- fluorouracil no tratamento de primeira linha de adenocarcinoma metastático do pâncreas |
| BR112018006922B1 (pt) | 2015-10-16 | 2023-11-21 | Ipsen Biopharm Ltd | Composições de irinotecano lipossômico estabilizado para armazenamento |
| CN110402163A (zh) | 2016-11-02 | 2019-11-01 | 易普森生物制药有限公司 | 使用包括脂质体伊立替康、奥沙利铂、5-氟尿嘧啶(和甲酰四氢叶酸)的组合疗法治疗胃癌 |
| CN116763734A (zh) | 2017-03-31 | 2023-09-19 | 富士胶片株式会社 | 脂质体组合物的制造方法 |
| CN112312895B (zh) | 2018-06-20 | 2023-05-09 | 富士胶片株式会社 | 包含内含药物的脂质体组合物及免疫检查点抑制剂的组合医药 |
| CN112789032A (zh) * | 2018-10-01 | 2021-05-11 | 富士胶片株式会社 | 包含内含药物的脂质体组合物及铂制剂的组合医药 |
| US12291570B2 (en) * | 2018-10-17 | 2025-05-06 | Biolinerx Ltd. | Treatment of metastatic pancreatic adenocarcinoma |
| WO2020148744A1 (en) * | 2019-01-17 | 2020-07-23 | Biolinerx Ltd. | Combination therapy for treatment of pancreatic cancer |
| US20220072087A1 (en) * | 2019-01-17 | 2022-03-10 | Biolinerx Ltd. | Specific combination therapy for treatment of pancreatic cancer |
| SG11202106435QA (en) * | 2019-02-22 | 2021-07-29 | Novocure Gmbh | Treating gastric cancer using ttfields combined with xelox or folfox |
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2017
- 2017-11-01 CN CN201780080584.XA patent/CN110402163A/zh active Pending
- 2017-11-01 WO PCT/GB2017/053293 patent/WO2018083470A1/en not_active Ceased
- 2017-11-01 BR BR112019007844A patent/BR112019007844A2/pt not_active IP Right Cessation
- 2017-11-01 KR KR1020197014970A patent/KR20190077441A/ko not_active Ceased
- 2017-11-01 US US16/346,436 patent/US11071726B2/en not_active Expired - Fee Related
- 2017-11-01 MX MX2019004783A patent/MX392408B/es unknown
- 2017-11-01 TW TW106137766A patent/TWI791467B/zh active
- 2017-11-01 RU RU2019114952A patent/RU2761953C2/ru active
- 2017-11-01 SG SG11201903615WA patent/SG11201903615WA/en unknown
- 2017-11-01 EA EA201990979A patent/EA201990979A1/ru unknown
- 2017-11-01 MY MYPI2019002087A patent/MY202377A/en unknown
- 2017-11-01 MA MA046709A patent/MA46709A/fr unknown
- 2017-11-01 EP EP17808557.7A patent/EP3535026A1/en not_active Ceased
- 2017-11-01 SG SG10201912338RA patent/SG10201912338RA/en unknown
- 2017-11-01 AU AU2017354903A patent/AU2017354903B2/en active Active
- 2017-11-01 JP JP2019522381A patent/JP2019533684A/ja not_active Ceased
- 2017-11-01 CA CA3040395A patent/CA3040395A1/en active Pending
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2019
- 2019-04-23 IL IL266187A patent/IL266187A/en unknown
- 2019-04-24 PH PH12019500892A patent/PH12019500892A1/en unknown
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2022
- 2022-03-24 IL IL291679A patent/IL291679A/en unknown
- 2022-09-15 JP JP2022146925A patent/JP2022171808A/ja active Pending
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