JP2020507589A5 - - Google Patents
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- Publication number
- JP2020507589A5 JP2020507589A5 JP2019543810A JP2019543810A JP2020507589A5 JP 2020507589 A5 JP2020507589 A5 JP 2020507589A5 JP 2019543810 A JP2019543810 A JP 2019543810A JP 2019543810 A JP2019543810 A JP 2019543810A JP 2020507589 A5 JP2020507589 A5 JP 2020507589A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical composition
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000011167 hydrochloric acid Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022025774A JP7247389B2 (ja) | 2017-02-14 | 2022-02-22 | Ｓｓａｏ阻害剤として有用なアミノピリミジン化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/000157 WO2018148856A1 (en) | 2017-02-14 | 2017-02-14 | Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors |
| CNPCT/CN2017/000157 | 2017-02-14 | ||
| CNPCT/CN2017/117791 | 2017-12-21 | ||
| PCT/CN2017/117791 WO2018149226A1 (en) | 2017-02-14 | 2017-12-21 | Amino pyrimidine compounds useful as ssao inhibitors |
| PCT/US2018/017152 WO2018151985A1 (en) | 2017-02-14 | 2018-02-07 | Amino pyrimidine compounds useful as ssao inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022025774A Division JP7247389B2 (ja) | 2017-02-14 | 2022-02-22 | Ｓｓａｏ阻害剤として有用なアミノピリミジン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020507589A JP2020507589A (ja) | 2020-03-12 |
| JP2020507589A5 true JP2020507589A5 (enExample) | 2021-03-11 |
| JP7030827B2 JP7030827B2 (ja) | 2022-03-07 |
Family
ID=63169081
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019543810A Active JP7030827B2 (ja) | 2017-02-14 | 2018-02-07 | Ｓｓａｏ阻害剤として有用なアミノピリミジン化合物 |
| JP2022025774A Active JP7247389B2 (ja) | 2017-02-14 | 2022-02-22 | Ｓｓａｏ阻害剤として有用なアミノピリミジン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022025774A Active JP7247389B2 (ja) | 2017-02-14 | 2022-02-22 | Ｓｓａｏ阻害剤として有用なアミノピリミジン化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10278970B2 (enExample) |
| EP (1) | EP3582780B1 (enExample) |
| JP (2) | JP7030827B2 (enExample) |
| KR (1) | KR20190117007A (enExample) |
| CN (2) | CN108778278B (enExample) |
| AU (1) | AU2018221322B2 (enExample) |
| CA (1) | CA3052044A1 (enExample) |
| DK (1) | DK3582780T3 (enExample) |
| ES (1) | ES2897666T3 (enExample) |
| IL (1) | IL268625A (enExample) |
| MX (1) | MX2019009501A (enExample) |
| SG (2) | SG10201913492YA (enExample) |
| WO (3) | WO2018148856A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018027892A1 (en) | 2016-08-12 | 2018-02-15 | Eli Lilly And Company | Amino pyrimidine ssao inhibitors |
| WO2018148856A1 (en) | 2017-02-14 | 2018-08-23 | Eli Lilly And Company | Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors |
| CN109251166B (zh) * | 2017-07-13 | 2021-11-05 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| CN109810041B (zh) | 2017-11-21 | 2023-08-15 | 药捷安康(南京)科技股份有限公司 | 卤代烯丙基胺类ssao/vap-1抑制剂及其应用 |
| CN109988106B (zh) * | 2017-12-29 | 2023-03-31 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| WO2020006177A1 (en) * | 2018-06-29 | 2020-01-02 | Blade Therapeutics, Inc. | Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof |
| CN110938059A (zh) * | 2018-09-25 | 2020-03-31 | 上海轶诺药业有限公司 | 胺基脲敏感性胺氧化酶抑制剂制备及其应用 |
| WO2020063854A1 (zh) * | 2018-09-27 | 2020-04-02 | 南京明德新药研发有限公司 | 作为vap-1抑制剂的喹啉类衍生物 |
| US12213970B2 (en) | 2018-10-29 | 2025-02-04 | Boehringer Ingelheim International Gmbh | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
| PH12021550901A1 (en) | 2018-10-29 | 2022-03-21 | Boehringer Ingelheim Int | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
| EP3892621B1 (en) * | 2019-01-11 | 2024-09-18 | TransThera Sciences (Nanjing), Inc. | Haloallylamine compounds and application thereof |
| CN111471037B (zh) * | 2019-01-23 | 2023-02-10 | 药捷安康(南京)科技股份有限公司 | 烯丙基胺类化合物及其应用 |
| EP4051669A4 (en) | 2019-10-29 | 2023-12-13 | Eccogene (Shanghai) Co., Ltd. | SSAO INHIBITORS AND THEIR USE |
| CN113149957A (zh) * | 2020-01-23 | 2021-07-23 | 轶诺(浙江)药业有限公司 | 胺基脲敏感性胺氧化酶抑制剂制备及其应用 |
| IL300853A (en) | 2020-08-25 | 2023-04-01 | Lilly Co Eli | Polymorphs of an ssao inhibitor |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008123469A1 (ja) | 2007-03-30 | 2008-10-16 | Japan Tobacco Inc. | ６員環アミド化合物およびその用途 |
| AU2008280784A1 (en) | 2007-07-20 | 2009-01-29 | Merck Frosst Canada Ltd | Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2009066152A2 (en) * | 2007-11-21 | 2009-05-28 | Pharmaxis Ltd. | Haloallylamine inhibitors of ssao/vap-1 and uses therefor |
| EP2479165B1 (en) * | 2009-09-16 | 2017-10-25 | Astellas Pharma Inc. | Glycine compound |
| JP2011136942A (ja) | 2009-12-28 | 2011-07-14 | Kowa Co | 新規な置換ピリミジン誘導体およびこれを含有する医薬 |
| PL2695881T3 (pl) | 2011-03-15 | 2016-11-30 | Związek guanidynowy | |
| DK2844637T5 (en) | 2012-05-02 | 2018-08-13 | Boehringer Ingelheim Int | SUBSTITUTED 3-HALOALLYLAMINE INHIBITORS BY SSAO AND USES THEREOF |
| AU2013344603B2 (en) | 2012-11-16 | 2017-07-06 | Bristol-Myers Squibb Company | Pyrrolidine GPR40 modulators |
| US8962641B2 (en) * | 2013-04-17 | 2015-02-24 | Boehringer Ingelheim International Gmbh | Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof |
| JP6378752B2 (ja) | 2013-05-17 | 2018-08-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピロリジン誘導体、その医薬組成物及び使用 |
| GB201416444D0 (en) * | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New compounds |
| WO2018027892A1 (en) | 2016-08-12 | 2018-02-15 | Eli Lilly And Company | Amino pyrimidine ssao inhibitors |
| WO2018148856A1 (en) | 2017-02-14 | 2018-08-23 | Eli Lilly And Company | Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors |
-
2017
- 2017-02-14 WO PCT/CN2017/000157 patent/WO2018148856A1/en not_active Ceased
- 2017-12-21 WO PCT/CN2017/117791 patent/WO2018149226A1/en not_active Ceased
-
2018
- 2018-02-07 CA CA3052044A patent/CA3052044A1/en active Pending
- 2018-02-07 SG SG10201913492YA patent/SG10201913492YA/en unknown
- 2018-02-07 JP JP2019543810A patent/JP7030827B2/ja active Active
- 2018-02-07 DK DK18706109.8T patent/DK3582780T3/da active
- 2018-02-07 CN CN201880000825.XA patent/CN108778278B/zh active Active
- 2018-02-07 KR KR1020197026490A patent/KR20190117007A/ko not_active Ceased
- 2018-02-07 MX MX2019009501A patent/MX2019009501A/es unknown
- 2018-02-07 EP EP18706109.8A patent/EP3582780B1/en active Active
- 2018-02-07 WO PCT/US2018/017152 patent/WO2018151985A1/en not_active Ceased
- 2018-02-07 CN CN202210027271.0A patent/CN114369095B/zh active Active
- 2018-02-07 SG SG11201907032RA patent/SG11201907032RA/en unknown
- 2018-02-07 AU AU2018221322A patent/AU2018221322B2/en active Active
- 2018-02-07 ES ES18706109T patent/ES2897666T3/es active Active
- 2018-06-19 US US16/012,140 patent/US10278970B2/en active Active
-
2019
- 2019-03-18 US US16/356,895 patent/US10471060B2/en active Active
- 2019-08-11 IL IL26862519A patent/IL268625A/en unknown
-
2022
- 2022-02-22 JP JP2022025774A patent/JP7247389B2/ja active Active