|
US4838925A
(en)
|
1986-04-25 |
1989-06-13 |
E. I. Du Pont De Nemours And Company |
Heterocyclic acyl sulfonamides
|
|
JP3763997B2
(ja)
|
1999-05-13 |
2006-04-05 |
富士写真フイルム株式会社 |
感熱記録材料
|
|
JP4331823B2
(ja)
|
1999-05-21 |
2009-09-16 |
富士フイルム株式会社 |
ピロロ［１，２−ａ］−１，３，５−トリアジン−４−オン系化合物
|
|
NZ519984A
(en)
|
2000-01-07 |
2004-03-26 |
Transform Pharmaceuticals Inc |
High-throughput formation, identification, and analysis of diverse solid-forms
|
|
TWI243164B
(en)
|
2001-02-13 |
2005-11-11 |
Aventis Pharma Gmbh |
Acylated indanyl amines and their use as pharmaceuticals
|
|
JP4070966B2
(ja)
|
2001-06-28 |
2008-04-02 |
株式会社カネボウ化粧品 |
新規ガラクトシルセラミド類縁体及び用途
|
|
JP2005526003A
(ja)
|
2001-10-22 |
2005-09-02 |
ファイザー株式会社 |
５−ｈｔ４受容体調節剤としてのイミダゾピリジン化合物
|
|
EP1481977A4
(en)
|
2002-03-01 |
2006-02-01 |
Astellas Pharma Inc |
NITROGENIC HETEROCYCLIC COMPOUND
|
|
BR0314584A
(pt)
|
2002-09-20 |
2005-08-09 |
Pfizer |
Compostos piperidinil-imidazopiridina n-substituìda como moduladores e receptores 5-ht4
|
|
DOP2003000703A
(es)
|
2002-09-20 |
2004-03-31 |
Pfizer |
Compuestos de imidazopiradina como agonistas del receptor 5-ht4
|
|
WO2004052315A2
(en)
|
2002-12-11 |
2004-06-24 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
JP2004277337A
(ja)
|
2003-03-14 |
2004-10-07 |
Sumitomo Pharmaceut Co Ltd |
ピラゾロ［１，５−ａ］ピリミジン誘導体
|
|
WO2004094418A1
(en)
|
2003-04-21 |
2004-11-04 |
Pfizer Inc. |
Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity
|
|
BRPI0416216A
(pt)
|
2003-11-12 |
2006-12-26 |
Amicus Therapeutics Inc |
composto de glicoimidazol e polihidroxiciclohexenila e método para sintetizar composto de glicoimidazol e polihidroxiciclohexenila, métodos para inibir glicocerebrosidase, para aumentar a atividade de glicocerebrosidase e para estabilizar glicocerebrosidade, composição farmacêutica, métodos para inibir uma -glicosidade, e para tratar doença de gaucher, derivado de glicoimidazol e derivados de polihidroxiciclohexilamina
|
|
GB0329214D0
(en)
*
|
2003-12-17 |
2004-01-21 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0400812D0
(en)
|
2004-01-14 |
2004-02-18 |
Celltech R&D Ltd |
Novel compounds
|
|
CA2556404A1
(en)
|
2004-02-18 |
2005-08-25 |
Banyu Pharmaceutical Co., Ltd. |
Nitrogenous fused heteroaromatic ring derivative
|
|
WO2005113004A2
(en)
|
2004-05-14 |
2005-12-01 |
The Cleveland Clinic Founfation |
Small molecule inhibitors for mrp1 and other multidrug transporters
|
|
PL1761541T3
(pl)
|
2004-06-21 |
2008-06-30 |
Hoffmann La Roche |
Pochodne pirazolopirymidyny
|
|
AU2005270468A1
(en)
|
2004-08-02 |
2006-02-16 |
Schwarz Pharma Ag |
Indolizine carboxamides and the aza and diaza derivatives thereof
|
|
DE102004049363A1
(de)
|
2004-10-08 |
2006-04-13 |
Henkel Kgaa |
Mittel zum Färben von keratinhaltigen Fasern
|
|
EP1841770B1
(en)
|
2005-01-19 |
2009-11-11 |
Merck & Co., Inc. |
Bicyclic pyrimidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
|
CA2597608C
(en)
|
2005-02-11 |
2013-12-24 |
F. Hoffmann-La Roche Ag |
Pyrazolo-pyrimidine derivatives as mglur2 antagonists
|
|
DE102005007534A1
(de)
|
2005-02-17 |
2006-08-31 |
Bayer Cropscience Ag |
Pyrazolopyrimidine
|
|
EP1884510A4
(en)
|
2005-04-21 |
2010-07-14 |
Dainippon Sumitomo Pharma Co |
N-SUBSTITUTED PHENYLACETAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
|
|
EP1878727A4
(en)
|
2005-04-28 |
2013-11-13 |
Kyowa Hakko Kirin Co Ltd |
2-AMINOQUINAZOLINE DERIVATIVES
|
|
US7632837B2
(en)
|
2005-06-17 |
2009-12-15 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid-1 receptor modulators
|
|
US7723336B2
(en)
|
2005-09-22 |
2010-05-25 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful as kinase modulators
|
|
AR057979A1
(es)
|
2005-10-06 |
2008-01-09 |
Schering Corp |
PIRAZOLPIRIMIDINAS COMO INHIBIDORAS DE PROTEíNA QUINASA. COMPOSICIONES FARMACEUTICAS.
|
|
JP5119157B2
(ja)
*
|
2005-10-21 |
2013-01-16 |
エクセリクシス， インク． |
カゼインキナーゼｉｉ（ｃｋ２）モジュレーターとしてのピラゾロ−ピリミジン類
|
|
AU2006322187A1
(en)
|
2005-12-08 |
2007-06-14 |
Novartis Ag |
Pyrazolo[1,5-a]pyridine-3-carboxylic acids as EphB and VEGFR2 kinase inhibitors
|
|
TW200800997A
(en)
*
|
2006-03-22 |
2008-01-01 |
Astrazeneca Ab |
Chemical compounds
|
|
JP5303458B2
(ja)
|
2006-06-23 |
2013-10-02 |
アミークス セラピューティックス インコーポレイテッド |
β−グルコセレブロシダーゼの活性増強による神経学的疾患の治療方法
|
|
AR061793A1
(es)
|
2006-07-05 |
2008-09-24 |
Mitsubishi Tanabe Pharma Corp |
Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica
|
|
WO2008019363A2
(en)
|
2006-08-07 |
2008-02-14 |
Albany Molecular Research, Inc. |
2-alkylbenzoxazole carboxamides as 5ht3 modulators
|
|
WO2008063669A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic matrix metalloprotease inhibitors
|
|
CA2670083A1
(en)
|
2006-11-20 |
2008-05-29 |
Alantos Pharmaceuticals Holding, Inc. |
Heterobicyclic metalloprotease inhibitors
|
|
CN101801972A
(zh)
|
2007-03-28 |
2010-08-11 |
英诺瓦西亚公司 |
作为硬脂酰-辅酶a去饱和酶抑制剂的吡唑并[1,5-a]嘧啶
|
|
AR067326A1
(es)
|
2007-05-11 |
2009-10-07 |
Novartis Ag |
Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido
|
|
EA201000003A1
(ru)
|
2007-06-21 |
2010-06-30 |
Айрм Ллк |
Ингибиторы протеинкиназ и способы их применения
|
|
JP5479105B2
(ja)
|
2007-11-05 |
2014-04-23 |
国立大学法人佐賀大学 |
新規ユビキリン結合性小分子
|
|
WO2009060197A1
(en)
|
2007-11-08 |
2009-05-14 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
Imidazopyridazines for use as protein kinase inhibitors
|
|
WO2009070567A1
(en)
|
2007-11-28 |
2009-06-04 |
Schering Corporation |
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
|
|
WO2009100375A1
(en)
|
2008-02-06 |
2009-08-13 |
Bristol-Myers Squibb Company |
Substituted imidazopyridazines useful as kinase inhibitors
|
|
JPWO2009119088A1
(ja)
|
2008-03-25 |
2011-07-21 |
武田薬品工業株式会社 |
複素環化合物
|
|
JP5425891B2
(ja)
|
2008-05-01 |
2014-02-26 |
サートリス ファーマシューティカルズ， インコーポレイテッド |
サーチュイン調節薬としてのキノリンおよび関連する類似体
|
|
WO2010043893A1
(en)
|
2008-10-14 |
2010-04-22 |
Astrazeneca Ab |
Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections
|
|
RU2539568C2
(ru)
*
|
2008-10-31 |
2015-01-20 |
Дженентек, Инк. |
Пиразолопиримидиновые соединения-ингибиторы jak и способы
|
|
WO2010086040A1
(en)
|
2009-01-29 |
2010-08-05 |
Biomarin Iga, Ltd. |
Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
GEP201706639B
(en)
|
2009-08-17 |
2017-03-27 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
KR101995013B1
(ko)
*
|
2010-07-13 |
2019-07-02 |
에프. 호프만-라 로슈 아게 |
Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
TW201217312A
(en)
*
|
2010-09-22 |
2012-05-01 |
Gruenenthal Gmbh |
Substituted benzamide compounds
|
|
WO2012075393A2
(en)
|
2010-12-02 |
2012-06-07 |
President And Fellows Of Harvard College |
Activators of proteasomal degradation and uses thereof
|
|
EP2649075B1
(en)
*
|
2010-12-08 |
2018-04-25 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Substituted pyrazolopyrimidines as glucocerebrosidase activators
|
|
JP5808826B2
(ja)
|
2011-02-23 |
2015-11-10 |
インテリカイン， エルエルシー |
複素環化合物およびその使用
|
|
EP2688872A4
(en)
*
|
2011-03-22 |
2014-08-27 |
Merck Sharp & Dohme |
AMIDOPYRAZOLHEMMER OF INTERLEUKIN RECEPTOR-MEDIATED KINASES
|
|
CN103764166B
(zh)
|
2011-06-22 |
2017-10-24 |
通用医疗公司 |
蛋白质病的治疗
|
|
MY166866A
(en)
|
2011-08-18 |
2018-07-24 |
Nippon Shinyaku Co Ltd |
Heterocyclic derivative and pharmaceutical drug
|
|
MX348470B
(es)
|
2011-09-02 |
2017-06-13 |
Bayer Ip Gmbh |
Pirimidinas anilladas sustituidas y uso de las mismas.
|
|
US8961959B2
(en)
|
2011-10-17 |
2015-02-24 |
The Regents Of The University Of Michigan |
Glucosylceramide synthase inhibitors and therapeutic methods using the same
|
|
EP2768509B1
(en)
|
2011-10-20 |
2017-03-22 |
Glaxosmithkline LLC |
Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
|
|
MX2014007731A
(es)
|
2011-12-23 |
2015-01-12 |
Novartis Ag |
Compuestos para inhibir la interaccion de bcl2 con los componentes de enlace.
|
|
WO2013134079A1
(en)
*
|
2012-03-05 |
2013-09-12 |
Amgen Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
US8969565B2
(en)
|
2012-03-09 |
2015-03-03 |
Lexicon Pharmaceuticals, Inc. |
Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use
|
|
HUE036040T2
(hu)
|
2012-03-09 |
2018-06-28 |
Lexicon Pharmaceuticals Inc |
Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére
|
|
WO2013148333A1
(en)
|
2012-03-28 |
2013-10-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Salicylic acid derivatives useful as glucocerebrosidase activators
|
|
KR20150020228A
(ko)
|
2012-05-31 |
2015-02-25 |
에프. 호프만-라 로슈 아게 |
아미노퀴나졸린 및 피리도피리미딘 유도체
|
|
CN104395298A
(zh)
|
2012-06-22 |
2015-03-04 |
住友化学株式会社 |
稠合杂环化合物
|
|
WO2014025651A1
(en)
*
|
2012-08-06 |
2014-02-13 |
Amgen Inc. |
Chroman derivatives as trpm8 inhibitors
|
|
AU2013311826A1
(en)
|
2012-09-05 |
2015-03-26 |
Bayer Cropscience Ag |
Use of substituted 2-amidobenzimidazoles, 2-amidobenzoxazoles and 2-amidobenzothiazoles or salts thereof as active substances against abiotic plant stress
|
|
EP2920181B1
(en)
|
2012-11-16 |
2019-01-09 |
University Health Network |
Pyrazolopyrimidine compounds
|
|
US9938258B2
(en)
|
2012-11-29 |
2018-04-10 |
Karyopharm Therapeutics Inc. |
Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
|
|
WO2014089379A1
(en)
|
2012-12-07 |
2014-06-12 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
KR20140086002A
(ko)
|
2012-12-28 |
2014-07-08 |
한미약품 주식회사 |
Fms 키나아제 저해 활성을 갖는 피리다진 접합고리 유도체
|
|
WO2014141129A2
(en)
|
2013-03-14 |
2014-09-18 |
Grueneberg Dorre A |
Novel methods, compounds, and compositions for inhibition of ros
|
|
US9718816B2
(en)
|
2013-03-15 |
2017-08-01 |
Epizyme, Inc. |
1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof
|
|
US20160159808A1
(en)
|
2013-07-24 |
2016-06-09 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
WO2015026574A1
(en)
|
2013-08-20 |
2015-02-26 |
Bristol-Myers Squibb Company |
Imidazopyridazine kinase inhibitors useful to treating a disease or disorder mediated by aak1, such as alzheimer's disease, bipolar disorder, pain, schizophrenia
|
|
CN105658653A
(zh)
|
2013-08-23 |
2016-06-08 |
因赛特公司 |
可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物
|
|
TW201542550A
(zh)
|
2013-09-06 |
2015-11-16 |
Lexicon Pharmaceuticals Inc |
吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
|
|
AR097543A1
(es)
|
2013-09-06 |
2016-03-23 |
Lexicon Pharmaceuticals Inc |
COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
|
|
WO2015073267A1
(en)
|
2013-11-15 |
2015-05-21 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
|
ES2895490T3
(es)
|
2014-03-27 |
2022-02-21 |
Acad Medisch Ct |
Iminoazúcares N-(5-(bifen-4-ilmetiloxi)pentil)-sustituidos como inhibidores de glucosilceramida sintasa
|
|
US9695180B2
(en)
|
2014-07-10 |
2017-07-04 |
Incyte Corporation |
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
|
|
US20170333435A1
(en)
|
2014-11-06 |
2017-11-23 |
Lysosomal Therapeutics Inc. |
Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
|
|
CA2966581A1
(en)
|
2014-11-06 |
2016-05-12 |
Lysosomal Therapeutics Inc. |
Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
|
|
HRP20240644T1
(hr)
|
2014-11-06 |
2024-08-02 |
Bial-R&D Investments, S.A. |
Supstituirani pirazolo(1,5-a)pirimidini i njihova uporaba u liječenju medicinskih poremećaja
|
|
EP3317282B1
(en)
|
2015-07-01 |
2020-12-09 |
Northwestern University |
Substituted 4-methyl-pyrrolo[1.2-a]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
|
|
US10167270B2
(en)
|
2015-07-01 |
2019-01-01 |
Northwestern University |
Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
|
|
US20190092789A1
(en)
|
2015-09-04 |
2019-03-28 |
Lysosomal Therapeutics Inc. |
Heterobicyclic pyrimidinone compounds and their use in the treatment of medical disorders
|
|
EP4086259A1
(en)
|
2015-11-06 |
2022-11-09 |
Incyte Corporation |
Heterocyclic compounds as pi3k-gamma inhibitors
|
|
US10479793B2
(en)
|
2015-11-18 |
2019-11-19 |
Bristol-Myers Squibb Company |
Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
|
|
EP3416967B1
(en)
|
2016-02-18 |
2022-02-09 |
F. Hoffmann-La Roche AG |
Therapeutic compounds, compositions and methods of use thereof
|
|
US11124516B2
(en)
|
2016-04-06 |
2021-09-21 |
BIAL-BioTech Investments, Inc. |
Pyrrolo[1,2-A]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
JP7046827B2
(ja)
|
2016-04-06 |
2022-04-04 |
リソソーマル・セラピューティクス・インコーポレイテッド |
イミダゾ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
|
|
SG11201808830YA
(en)
|
2016-04-06 |
2018-11-29 |
Lysosomal Therapeutics Inc |
Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
|
|
EP3452045A1
(en)
|
2016-05-04 |
2019-03-13 |
Lysosomal Therapeutics Inc. |
Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds
|
|
JP7164774B2
(ja)
|
2016-05-05 |
2022-11-02 |
ビアル－アール・アンド・ディ・インベストメンツ・ソシエダーデ・アノニマ |
置換イミダゾ［１，２－ｂ］ピリダジン、置換イミダゾ［１，５－ｂ］ピリダジン、関連化合物、および医学的障害の治療におけるその使用
|
|
WO2017192929A1
(en)
|
2016-05-05 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED PYRROLO[1,2-α]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
WO2017192931A1
(en)
|
2016-05-05 |
2017-11-09 |
Lysosomal Therapeutics Inc. |
SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
|
|
EP3728265A1
(en)
|
2017-12-21 |
2020-10-28 |
BIAL - BioTech Investments, Inc. |
Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof
|