JP2004517087A5 - - Google Patents
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- Publication number
- JP2004517087A5 JP2004517087A5 JP2002547912A JP2002547912A JP2004517087A5 JP 2004517087 A5 JP2004517087 A5 JP 2004517087A5 JP 2002547912 A JP2002547912 A JP 2002547912A JP 2002547912 A JP2002547912 A JP 2002547912A JP 2004517087 A5 JP2004517087 A5 JP 2004517087A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclopentyl
- propionamide
- phenyl
- methanesulfonyl
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000004432 carbon atom Chemical group C* 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- -1 (4-methanesulfonyl-3-trifluoromethyl-phenyl) -N-quinolin-2-yl-propionamide Chemical compound 0.000 claims 5
- 150000001721 carbon Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 150000003457 sulfones Chemical class 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- QQZSSOYUTMZBTM-MRXNPFEDSA-N (2r)-n-(1,3-benzothiazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 QQZSSOYUTMZBTM-MRXNPFEDSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- VXZQZJYMVXNSMK-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 VXZQZJYMVXNSMK-UHFFFAOYSA-N 0.000 claims 2
- 238000005897 peptide coupling reaction Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940080818 propionamide Drugs 0.000 claims 2
- SOYSPEAIZRNEAT-LJQANCHMSA-N (2r)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-n-quinolin-2-ylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 SOYSPEAIZRNEAT-LJQANCHMSA-N 0.000 claims 1
- OBWANNDHEQDAJQ-OAHLLOKOSA-N (2r)-n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 OBWANNDHEQDAJQ-OAHLLOKOSA-N 0.000 claims 1
- KYRDLJWNZRNWSG-GOSISDBHSA-N (2r)-n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 KYRDLJWNZRNWSG-GOSISDBHSA-N 0.000 claims 1
- AAQDRZIJUPVUDR-MRXNPFEDSA-N (2r)-n-(1,3-benzoxazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 AAQDRZIJUPVUDR-MRXNPFEDSA-N 0.000 claims 1
- ACXDSKDJMZEDQU-OAHLLOKOSA-N (2r)-n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 ACXDSKDJMZEDQU-OAHLLOKOSA-N 0.000 claims 1
- VXZQZJYMVXNSMK-MRXNPFEDSA-N (2r)-n-(1h-benzimidazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 VXZQZJYMVXNSMK-MRXNPFEDSA-N 0.000 claims 1
- CLTWWLUHQCWZQM-OAHLLOKOSA-N (2r)-n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1[C@H](C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 CLTWWLUHQCWZQM-OAHLLOKOSA-N 0.000 claims 1
- IEDAZVJYMUBPHE-GOSISDBHSA-N (2r)-n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1[C@H](C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 IEDAZVJYMUBPHE-GOSISDBHSA-N 0.000 claims 1
- QZZFVLPXDBVTEZ-UHFFFAOYSA-N 2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentyl-n-quinolin-2-ylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 QZZFVLPXDBVTEZ-UHFFFAOYSA-N 0.000 claims 1
- SOYSPEAIZRNEAT-UHFFFAOYSA-N 2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentyl-n-quinolin-2-ylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 SOYSPEAIZRNEAT-UHFFFAOYSA-N 0.000 claims 1
- AWINNBCBCPJDHB-UHFFFAOYSA-N 2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentyl-n-quinolin-2-ylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 AWINNBCBCPJDHB-UHFFFAOYSA-N 0.000 claims 1
- DAFGCELMAUAKCZ-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-n-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1SC=2CCCCC=2N=1)CC1CCCC1 DAFGCELMAUAKCZ-UHFFFAOYSA-N 0.000 claims 1
- HMOSAIJSNNENRZ-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-n-(6-fluoro-1,3-benzothiazol-2-yl)propanamide Chemical compound S1C2=CC(F)=CC=C2N=C1NC(=O)C(C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 HMOSAIJSNNENRZ-UHFFFAOYSA-N 0.000 claims 1
- CCEZAKRHOWJHQJ-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-n-(6-methylsulfonyl-1,3-benzothiazol-2-yl)propanamide Chemical compound S1C2=CC(S(=O)(=O)C)=CC=C2N=C1NC(=O)C(C=1C=C(Cl)C(Cl)=CC=1)CC1CCCC1 CCEZAKRHOWJHQJ-UHFFFAOYSA-N 0.000 claims 1
- NPIXKNXGHOZWPG-UHFFFAOYSA-N 3-cyclopentyl-2-(3,4-dichlorophenyl)-n-quinolin-2-ylpropanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 NPIXKNXGHOZWPG-UHFFFAOYSA-N 0.000 claims 1
- VDCMBEAIYGSKSX-UHFFFAOYSA-N 3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)-n-quinolin-2-ylpropanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 VDCMBEAIYGSKSX-UHFFFAOYSA-N 0.000 claims 1
- RBFUJKPDVLOKBZ-UHFFFAOYSA-N 3-cyclopentyl-2-(4-methylsulfonylphenyl)-n-quinolin-2-ylpropanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1N=C2C=CC=CC2=CC=1)CC1CCCC1 RBFUJKPDVLOKBZ-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- CDJWHCDZRBGAPD-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 CDJWHCDZRBGAPD-UHFFFAOYSA-N 0.000 claims 1
- QQZSSOYUTMZBTM-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 QQZSSOYUTMZBTM-UHFFFAOYSA-N 0.000 claims 1
- CBSDSSJLVTWRIQ-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 CBSDSSJLVTWRIQ-UHFFFAOYSA-N 0.000 claims 1
- OBWANNDHEQDAJQ-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 OBWANNDHEQDAJQ-UHFFFAOYSA-N 0.000 claims 1
- SKOFSWUZPQBFAM-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)propanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 SKOFSWUZPQBFAM-UHFFFAOYSA-N 0.000 claims 1
- KYRDLJWNZRNWSG-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 KYRDLJWNZRNWSG-UHFFFAOYSA-N 0.000 claims 1
- RNCVQIUDLLDVEL-UHFFFAOYSA-N n-(1,3-benzothiazol-2-yl)-3-cyclopentyl-2-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]propanamide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1SC2=CC=CC=C2N=1)CC1CCCC1 RNCVQIUDLLDVEL-UHFFFAOYSA-N 0.000 claims 1
- XGRBXFPWATYYSK-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 XGRBXFPWATYYSK-UHFFFAOYSA-N 0.000 claims 1
- AAQDRZIJUPVUDR-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-2-(3-chloro-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Cl)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 AAQDRZIJUPVUDR-UHFFFAOYSA-N 0.000 claims 1
- CXKICAVMPHVLQN-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 CXKICAVMPHVLQN-UHFFFAOYSA-N 0.000 claims 1
- ACXDSKDJMZEDQU-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 ACXDSKDJMZEDQU-UHFFFAOYSA-N 0.000 claims 1
- NDVQEFQAKFEDNT-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)propanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 NDVQEFQAKFEDNT-UHFFFAOYSA-N 0.000 claims 1
- DZCJSSWRHOHJCP-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 DZCJSSWRHOHJCP-UHFFFAOYSA-N 0.000 claims 1
- MXRIOGBIGBFHTL-UHFFFAOYSA-N n-(1,3-benzoxazol-2-yl)-3-cyclopentyl-2-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]propanamide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1OC2=CC=CC=C2N=1)CC1CCCC1 MXRIOGBIGBFHTL-UHFFFAOYSA-N 0.000 claims 1
- WVGDMEFWIHUPTL-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-2-(3-bromo-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(Br)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 WVGDMEFWIHUPTL-UHFFFAOYSA-N 0.000 claims 1
- MXHYIYKLWIIIDN-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-2-(3-cyano-4-methylsulfonylphenyl)-3-cyclopentylpropanamide Chemical compound C1=C(C#N)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 MXHYIYKLWIIIDN-UHFFFAOYSA-N 0.000 claims 1
- CLTWWLUHQCWZQM-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(3,4-dichlorophenyl)propanamide Chemical compound C1=C(Cl)C(Cl)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 CLTWWLUHQCWZQM-UHFFFAOYSA-N 0.000 claims 1
- QMQHSWHJSHWERL-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonyl-3-nitrophenyl)propanamide Chemical compound C1=C([N+]([O-])=O)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 QMQHSWHJSHWERL-UHFFFAOYSA-N 0.000 claims 1
- IEDAZVJYMUBPHE-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-(4-methylsulfonylphenyl)propanamide Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 IEDAZVJYMUBPHE-UHFFFAOYSA-N 0.000 claims 1
- AYXGRWBIQWQTFT-UHFFFAOYSA-N n-(1h-benzimidazol-2-yl)-3-cyclopentyl-2-[4-methylsulfonyl-3-(trifluoromethyl)phenyl]propanamide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)C)=CC=C1C(C(=O)NC=1NC2=CC=CC=C2N=1)CC1CCCC1 AYXGRWBIQWQTFT-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25163700P | 2000-12-06 | 2000-12-06 | |
| PCT/EP2001/013870 WO2002046173A1 (en) | 2000-12-06 | 2001-11-28 | Fused heteroaromatic glucokinase activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004517087A JP2004517087A (ja) | 2004-06-10 |
| JP2004517087A5 true JP2004517087A5 (enExample) | 2005-05-26 |
| JP4109111B2 JP4109111B2 (ja) | 2008-07-02 |
Family
ID=22952803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002547912A Expired - Fee Related JP4109111B2 (ja) | 2000-12-06 | 2001-11-28 | 縮合複素環式芳香族グルコキナーゼアクチベーター |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6441184B1 (enExample) |
| EP (1) | EP1341774B1 (enExample) |
| JP (1) | JP4109111B2 (enExample) |
| KR (1) | KR100545431B1 (enExample) |
| CN (1) | CN1226294C (enExample) |
| AR (1) | AR031627A1 (enExample) |
| AT (1) | ATE316965T1 (enExample) |
| AU (2) | AU2190202A (enExample) |
| BR (1) | BR0115999A (enExample) |
| CA (1) | CA2429642C (enExample) |
| DE (1) | DE60117059T2 (enExample) |
| DK (1) | DK1341774T3 (enExample) |
| ES (1) | ES2256340T3 (enExample) |
| GT (1) | GT200100243A (enExample) |
| MX (1) | MXPA03005119A (enExample) |
| PA (1) | PA8534301A1 (enExample) |
| PE (1) | PE20020753A1 (enExample) |
| PT (1) | PT1341774E (enExample) |
| UY (1) | UY27055A1 (enExample) |
| WO (1) | WO2002046173A1 (enExample) |
| ZA (1) | ZA200303748B (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| AU2003243921B2 (en) | 2002-06-27 | 2009-05-07 | Novo Nordisk A/S | Aryl carbonyl derivatives as therapeutic agents |
| KR101124245B1 (ko) | 2002-06-27 | 2012-07-02 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
| US6775812B2 (en) * | 2002-07-17 | 2004-08-10 | Hewlett-Packard Development Company, L.P. | Layout design process and system for providing bypass capacitance and compliant density in an integrated circuit |
| JP2006509774A (ja) * | 2002-10-03 | 2006-03-23 | ノバルティス アクチエンゲゼルシャフト | ２型糖尿病の処置において有用なグルコキナーゼアクチベーターとしての置換（チアゾール−２−イル）−アミドまたはスルホンアミド |
| CA2499329C (en) | 2002-10-03 | 2009-04-21 | F. Hoffmann-La Roche Ag | Indole-3-carboxamides as glucokinase (gk) activators |
| GB0226931D0 (en) * | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| US7132425B2 (en) | 2002-12-12 | 2006-11-07 | Hoffmann-La Roche Inc. | 5-substituted-six-membered heteroaromatic glucokinase activators |
| JP4621198B2 (ja) * | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ（シクロ）置換アミドグルコキナーゼ活性化化合物 |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| WO2005000301A1 (en) * | 2003-06-20 | 2005-01-06 | F. Hoffmann-La Roche Ag | 2-aminobenzothiazoles as cb1 receptor inverse agonists |
| WO2005066145A1 (en) | 2004-01-06 | 2005-07-21 | Novo Nordisk A/S | Heteroaryl-ureas and their use as glucokinase activators |
| ATE426597T1 (de) * | 2004-02-18 | 2009-04-15 | Astrazeneca Ab | Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel |
| BRPI0507734A (pt) * | 2004-02-18 | 2007-07-10 | Astrazeneca Ab | composto ou um sal, pró-droga ou solvato do mesmo, método de tratar doenças mediadas por glk, e, processo para a preparação de um composto |
| EP1737870A1 (en) * | 2004-04-02 | 2007-01-03 | Novartis AG | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
| CN1960995B (zh) * | 2004-04-02 | 2010-12-08 | 诺瓦提斯公司 | 作为葡糖激酶活化剂、可用于治疗ⅱ型糖尿病的磺酰胺-噻唑并吡啶衍生物 |
| AU2005235798A1 (en) * | 2004-04-21 | 2005-11-03 | Prosidion Limited | Tri(cyclo) substituted amide compounds |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| MX2007001650A (es) | 2004-08-12 | 2007-07-13 | Prosidion Ltd | Fenilacetamidas substituidas y su uso como activadores de glucocinasa. |
| GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
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