ATE390922T1 - 2-aminobenzothiazole als cb1 rezeptor inverse agonisten - Google Patents

2-aminobenzothiazole als cb1 rezeptor inverse agonisten

Info

Publication number
ATE390922T1
ATE390922T1 AT04739840T AT04739840T ATE390922T1 AT E390922 T1 ATE390922 T1 AT E390922T1 AT 04739840 T AT04739840 T AT 04739840T AT 04739840 T AT04739840 T AT 04739840T AT E390922 T1 ATE390922 T1 AT E390922T1
Authority
AT
Austria
Prior art keywords
sup
aminobenzothiazole
inverse agonist
receptor inverse
receptor
Prior art date
Application number
AT04739840T
Other languages
English (en)
Inventor
Matthias Nettekoven
Stephan Roever
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE390922T1 publication Critical patent/ATE390922T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT04739840T 2003-06-20 2004-06-11 2-aminobenzothiazole als cb1 rezeptor inverse agonisten ATE390922T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03013403 2003-06-20

Publications (1)

Publication Number Publication Date
ATE390922T1 true ATE390922T1 (de) 2008-04-15

Family

ID=33522251

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04739840T ATE390922T1 (de) 2003-06-20 2004-06-11 2-aminobenzothiazole als cb1 rezeptor inverse agonisten

Country Status (14)

Country Link
US (2) US7297707B2 (de)
EP (1) EP1638556B1 (de)
JP (1) JP2007506654A (de)
KR (1) KR100809201B1 (de)
CN (1) CN100368407C (de)
AT (1) ATE390922T1 (de)
AU (1) AU2004251002B2 (de)
BR (1) BRPI0411699A (de)
CA (1) CA2528785A1 (de)
DE (1) DE602004012858T2 (de)
ES (1) ES2303077T3 (de)
MX (1) MXPA05013733A (de)
RU (1) RU2344132C2 (de)
WO (1) WO2005000301A1 (de)

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AR046132A1 (es) * 2003-10-24 2005-11-23 Solvay Pharm Gmbh Composicin farmaceutica que contiene al menos un compuesto con actividad de receptor de cb1, o un profarmaco , tautomero o sal del mismo, como componente activo adecuado para el tratamiento y/o profilaxis de enfermedades relacionadas con el receptor cb1 en pacientes juveniles y/o para el tratamiento
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US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
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KR20120060207A (ko) 2009-08-26 2012-06-11 사노피 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
CA2826649C (en) 2011-02-25 2016-07-26 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
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US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683702B1 (de) 2011-03-08 2014-12-24 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
FR2974093B1 (fr) 2011-04-15 2015-05-08 Michelin Soc Tech Procede de preparation d'un melange maitre d'elastomere et d'une charge inorganique renforcante
RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
BR112015019836A2 (pt) 2013-02-22 2017-07-18 Merck Sharp & Dohme composto, composição farmacêutica, e, uso de um composto
EP2970119B1 (de) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Neuartige indolderivate als antidiabetika
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
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Also Published As

Publication number Publication date
WO2005000301A1 (en) 2005-01-06
EP1638556B1 (de) 2008-04-02
CN1805745A (zh) 2006-07-19
US7297707B2 (en) 2007-11-20
AU2004251002A1 (en) 2005-01-06
JP2007506654A (ja) 2007-03-22
EP1638556A1 (de) 2006-03-29
MXPA05013733A (es) 2006-03-08
RU2344132C2 (ru) 2009-01-20
CA2528785A1 (en) 2005-01-06
BRPI0411699A (pt) 2006-08-29
US20070021478A1 (en) 2007-01-25
ES2303077T3 (es) 2008-08-01
US20040266845A1 (en) 2004-12-30
KR100809201B1 (ko) 2008-02-29
RU2006101458A (ru) 2007-07-27
DE602004012858T2 (de) 2009-05-14
AU2004251002B2 (en) 2009-10-29
CN100368407C (zh) 2008-02-13
DE602004012858D1 (de) 2008-05-15
KR20060012031A (ko) 2006-02-06

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