PL1620425T3 - Podstawione 3-cyjanotiofenoacetamidy jako antagoniści receptora glukagonu - Google Patents
Podstawione 3-cyjanotiofenoacetamidy jako antagoniści receptora glukagonuInfo
- Publication number
- PL1620425T3 PL1620425T3 PL04726965T PL04726965T PL1620425T3 PL 1620425 T3 PL1620425 T3 PL 1620425T3 PL 04726965 T PL04726965 T PL 04726965T PL 04726965 T PL04726965 T PL 04726965T PL 1620425 T3 PL1620425 T3 PL 1620425T3
- Authority
- PL
- Poland
- Prior art keywords
- glucagon receptor
- substituted
- receptor antagonists
- cyanothiophene
- acetamides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46320003P | 2003-04-16 | 2003-04-16 | |
PCT/EP2004/003884 WO2004092156A1 (en) | 2003-04-16 | 2004-04-13 | Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists |
EP04726965A EP1620425B1 (en) | 2003-04-16 | 2004-04-13 | Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1620425T3 true PL1620425T3 (pl) | 2009-06-30 |
Family
ID=33300050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL04726965T PL1620425T3 (pl) | 2003-04-16 | 2004-04-13 | Podstawione 3-cyjanotiofenoacetamidy jako antagoniści receptora glukagonu |
Country Status (15)
Country | Link |
---|---|
US (1) | US7138529B2 (pl) |
EP (1) | EP1620425B1 (pl) |
JP (1) | JP4599347B2 (pl) |
KR (1) | KR100779324B1 (pl) |
CN (1) | CN100398533C (pl) |
AT (1) | ATE418548T1 (pl) |
AU (1) | AU2004230220B2 (pl) |
BR (1) | BRPI0409454A (pl) |
CA (1) | CA2521732C (pl) |
DE (1) | DE602004018630D1 (pl) |
ES (1) | ES2316978T3 (pl) |
MX (1) | MXPA05010998A (pl) |
PL (1) | PL1620425T3 (pl) |
RU (1) | RU2336274C2 (pl) |
WO (1) | WO2004092156A1 (pl) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2818547B1 (fr) * | 2000-12-22 | 2006-11-17 | Oreal | Nouveaux derives c-glycosides et utilisation |
WO2004024065A2 (en) * | 2002-09-12 | 2004-03-25 | Merck & Co., Inc. | Substituted bicyclic thiophene derivatives, compostions containing such compounds and methods of use |
US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
RS50613B (sr) * | 2004-05-28 | 2010-06-30 | 4Sc Ag | Tetrahidropiridotiofeni |
DE602005007220D1 (de) * | 2004-06-04 | 2008-07-10 | Nycomed Gmbh | Tetrahydropyridothiophenen zur verwendung in der behandlung von krebs |
JP2008501768A (ja) * | 2004-06-11 | 2008-01-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の化合物及びテトラヒドロピリドチオフェンの使用 |
US20090209534A1 (en) * | 2004-06-11 | 2009-08-20 | Klaus Pekari | Novel compounds and use of tetrahydropyridopyridothiophenes |
DE102004051188A1 (de) * | 2004-10-21 | 2006-04-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Cyanothiophene, deren Herstellung und deren Verwendung als Arzneimittel |
JP2008529989A (ja) * | 2005-02-09 | 2008-08-07 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン |
US7741488B2 (en) * | 2005-02-11 | 2010-06-22 | 4Sc Ag | Tetrahydropyridothiophenes as antiproliferative agents for the treatment of cancer |
US20090252706A1 (en) * | 2005-02-11 | 2009-10-08 | Klaus Pekari | Tetrahydropyridothiophenes As Antripoliferative Agents For The Treatment Of Cancer |
AU2006251167A1 (en) * | 2005-05-25 | 2006-11-30 | 4Sc Ag | Tetrahydropyridothiophenes for use in the treatment of cancer |
CA2609004A1 (en) * | 2005-05-25 | 2006-11-30 | Nycomed Gmbh | Tetrahydropyridothiophenes for use in the treatment of cancer |
KR20190126460A (ko) * | 2007-02-09 | 2019-11-11 | 메타베이시스 테라퓨틱스, 인크. | 글루카곤 수용체의 길항제 |
FR2921367B1 (fr) * | 2007-09-26 | 2009-10-30 | Servier Lab | Nouveau procede de synthese du ranelate de strontium et de ses hydrates |
ES2714207T3 (es) | 2008-08-13 | 2019-05-27 | Metabasis Therapeutics Inc | Antagonistas de glucagón |
WO2012085745A1 (en) | 2010-12-23 | 2012-06-28 | Pfizer Inc. | Glucagon receptor modulators |
EA023517B1 (ru) | 2011-02-08 | 2016-06-30 | Пфайзер Инк. | Модуляторы глюкагонового рецептора |
CN103732578B (zh) | 2011-07-22 | 2015-08-12 | 辉瑞大药厂 | 喹啉基胰高血糖素受体调节剂 |
JP2017519000A (ja) | 2014-06-12 | 2017-07-13 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴンアンタゴニスト |
WO2015197861A1 (en) | 2014-06-27 | 2015-12-30 | Nogra Pharma Limited | Aryl receptor modulators and methods of making and using the same |
SG11202012625PA (en) * | 2018-06-19 | 2021-01-28 | Novartis Ag | N-substituted tetrahydrothienopyridine derivatives and uses thereof |
CN114957278B (zh) * | 2021-02-20 | 2023-08-11 | 兰州大学 | 胰高血糖素受体拮抗剂及其用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206375A (en) * | 1985-03-02 | 1993-04-27 | Basf Aktiengesellschaft | Thiophene derivatives |
DE4236400A1 (de) * | 1992-10-28 | 1994-05-05 | Bayer Ag | N-Phenylacetaminonitrile |
ATE208779T1 (de) * | 1993-07-02 | 2001-11-15 | Bayer Ag | Substituierte spiroheterocyclische 1h-3-aryl- pyrrolidin-2,4-dion-derivate, verfahren zu deren herstellung und deren verwendung als schädlingsbekämpfungsmittel |
WO1998040385A1 (en) | 1997-03-07 | 1998-09-17 | Novo Nordisk A/S | 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE |
WO1999046267A1 (en) | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
AU5154699A (en) | 1998-09-02 | 2000-03-27 | Novo Nordisk A/S | 4,5,6,7-tetrahydro-thieno(2,3-c)pyridine derivatives |
US20020045613A1 (en) * | 2000-04-27 | 2002-04-18 | Heinz Pauls | 1-aroyl-piperidinyl benzamidines |
GB0114185D0 (en) * | 2001-06-12 | 2001-08-01 | Protherics Molecular Design Lt | Compounds |
EP1384715A4 (en) * | 2001-04-11 | 2005-06-01 | Senju Pharma Co | NOVEL IMIDAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS A MEDICINAL PRODUCT |
EP1383771A1 (en) * | 2001-04-20 | 2004-01-28 | Vertex Pharmaceuticals Incorporated | 9-deazaguanine derivatives as inhibitors of gsk-3 |
WO2004024066A2 (en) | 2002-09-12 | 2004-03-25 | Merck & Co., Inc. | Method of treating diabetes and related conditions |
WO2004024065A2 (en) | 2002-09-12 | 2004-03-25 | Merck & Co., Inc. | Substituted bicyclic thiophene derivatives, compostions containing such compounds and methods of use |
US7196106B2 (en) | 2002-11-05 | 2007-03-27 | Merck & Co., Inc | Cyanothiophene derivatives, compositions containing such compounds and methods of use |
-
2004
- 2004-04-08 US US10/820,900 patent/US7138529B2/en not_active Expired - Fee Related
- 2004-04-13 BR BRPI0409454-9A patent/BRPI0409454A/pt not_active IP Right Cessation
- 2004-04-13 MX MXPA05010998A patent/MXPA05010998A/es active IP Right Grant
- 2004-04-13 DE DE602004018630T patent/DE602004018630D1/de not_active Expired - Lifetime
- 2004-04-13 PL PL04726965T patent/PL1620425T3/pl unknown
- 2004-04-13 AU AU2004230220A patent/AU2004230220B2/en not_active Ceased
- 2004-04-13 KR KR1020057019795A patent/KR100779324B1/ko not_active IP Right Cessation
- 2004-04-13 AT AT04726965T patent/ATE418548T1/de active
- 2004-04-13 CN CNB2004800099168A patent/CN100398533C/zh not_active Expired - Fee Related
- 2004-04-13 JP JP2006505107A patent/JP4599347B2/ja not_active Expired - Fee Related
- 2004-04-13 CA CA2521732A patent/CA2521732C/en not_active Expired - Fee Related
- 2004-04-13 RU RU2005135338/04A patent/RU2336274C2/ru not_active IP Right Cessation
- 2004-04-13 WO PCT/EP2004/003884 patent/WO2004092156A1/en active Application Filing
- 2004-04-13 EP EP04726965A patent/EP1620425B1/en not_active Expired - Lifetime
- 2004-04-13 ES ES04726965T patent/ES2316978T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2004092156A1 (en) | 2004-10-28 |
CA2521732A1 (en) | 2004-10-28 |
JP4599347B2 (ja) | 2010-12-15 |
CN1774433A (zh) | 2006-05-17 |
MXPA05010998A (es) | 2005-12-12 |
BRPI0409454A (pt) | 2006-05-02 |
EP1620425B1 (en) | 2008-12-24 |
JP2006523641A (ja) | 2006-10-19 |
ATE418548T1 (de) | 2009-01-15 |
RU2005135338A (ru) | 2007-05-27 |
KR100779324B1 (ko) | 2007-11-28 |
KR20060011959A (ko) | 2006-02-06 |
CA2521732C (en) | 2011-06-07 |
AU2004230220A1 (en) | 2004-10-28 |
AU2004230220B2 (en) | 2009-09-17 |
US20040209943A1 (en) | 2004-10-21 |
DE602004018630D1 (en) | 2009-02-05 |
RU2336274C2 (ru) | 2008-10-20 |
EP1620425A1 (en) | 2006-02-01 |
US7138529B2 (en) | 2006-11-21 |
ES2316978T3 (es) | 2009-04-16 |
CN100398533C (zh) | 2008-07-02 |
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