|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
CA2359244C
(en)
|
1999-01-13 |
2013-10-08 |
Bayer Healthcare Llc |
.omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
|
|
EP1415987B1
(en)
|
2000-10-20 |
2007-02-28 |
Eisai R&D Management Co., Ltd. |
Nitrogenous aromatic ring compounds as anti cancer agents
|
|
AU2002351196A1
(en)
†
|
2001-12-03 |
2003-06-17 |
Bayer Pharmaceuticals Corporation |
Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
|
|
EP2324825A1
(en)
|
2002-02-11 |
2011-05-25 |
Bayer Healthcare LLC |
Aryl ureas with angiogenesis inhibiting activity
|
|
US8299108B2
(en)
|
2002-03-29 |
2012-10-30 |
Novartis Ag |
Substituted benzazoles and methods of their use as inhibitors of raf kinase
|
|
ATE447404T1
(de)
|
2002-03-29 |
2009-11-15 |
Novartis Vaccines & Diagnostic |
Substituierte benzazole und ihre verwendung als raf-kinase-hemmer
|
|
DE60304718T2
(de)
|
2002-08-06 |
2007-04-26 |
Astrazeneca Ab |
Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
|
|
WO2004020434A1
(ja)
*
|
2002-08-30 |
2004-03-11 |
Eisai Co., Ltd. |
含窒素芳香環誘導体
|
|
US7365209B2
(en)
|
2003-02-11 |
2008-04-29 |
Pharmacopeia, Inc. |
Nitrogen heterocycle biaryls for osteoporosis and other diseases
|
|
US7531553B2
(en)
*
|
2003-03-21 |
2009-05-12 |
Amgen Inc. |
Heterocyclic compounds and methods of use
|
|
EP2258365B1
(en)
|
2003-03-28 |
2013-05-29 |
Novartis Vaccines and Diagnostics, Inc. |
Use of organic compounds for immunopotentiation
|
|
WO2004085433A2
(en)
*
|
2003-03-28 |
2004-10-07 |
Pharmacia & Upjohn Company Llc |
Positive allosteric modulators of the nicotinic acetylcholine receptor
|
|
DE602004007382T2
(de)
|
2003-05-20 |
2008-04-17 |
Bayer Pharmaceuticals Corp., West Haven |
Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
|
|
US6887798B2
(en)
|
2003-05-30 |
2005-05-03 |
International Business Machines Corporation |
STI stress modification by nitrogen plasma treatment for improving performance in small width devices
|
|
US7691886B2
(en)
|
2003-07-11 |
2010-04-06 |
Merck Patent Gmbh |
Benzimidazole derivatives as raf kinase inhibitors
|
|
DK1663978T3
(da)
|
2003-07-23 |
2008-04-07 |
Bayer Pharmaceuticals Corp |
Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser
|
|
DE10334663A1
(de)
*
|
2003-07-30 |
2005-03-10 |
Merck Patent Gmbh |
Harnstoffderivate
|
|
DE10337942A1
(de)
*
|
2003-08-18 |
2005-03-17 |
Merck Patent Gmbh |
Aminobenzimidazolderivate
|
|
DE10342503A1
(de)
*
|
2003-09-12 |
2005-04-14 |
Merck Patent Gmbh |
Benzyl-Benzimidazolylderivate
|
|
DE10344223A1
(de)
*
|
2003-09-24 |
2005-04-21 |
Merck Patent Gmbh |
1,3-Benzoxazolylderivate als Kinase-Inhibitoren
|
|
JP4755991B2
(ja)
|
2003-10-16 |
2011-08-24 |
ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド |
Ｒａｆキナーゼインヒビターとしての置換ベンゾアゾールおよびその使用
|
|
DE10349587A1
(de)
|
2003-10-24 |
2005-05-25 |
Merck Patent Gmbh |
Benzimidazolylderivate
|
|
WO2005044788A1
(ja)
|
2003-11-11 |
2005-05-19 |
Eisai Co., Ltd. |
ウレア誘導体およびその製造方法
|
|
DE10352979A1
(de)
*
|
2003-11-13 |
2005-06-09 |
Merck Patent Gmbh |
Pyridopyrimidinone
|
|
US20050267182A1
(en)
*
|
2003-11-13 |
2005-12-01 |
Ambit Biosciences Corporation |
Urea derivatives as FLT-3 modulators
|
|
TW200530236A
(en)
|
2004-02-23 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Heteroaryl phenylurea
|
|
US20070191444A1
(en)
*
|
2004-02-26 |
2007-08-16 |
Hans-Peter Buchstaller |
Benzimidazolyl derivatives
|
|
US7459562B2
(en)
|
2004-04-23 |
2008-12-02 |
Bristol-Myers Squibb Company |
Monocyclic heterocycles as kinase inhibitors
|
|
TW200538453A
(en)
|
2004-04-26 |
2005-12-01 |
Bristol Myers Squibb Co |
Bicyclic heterocycles as kinase inhibitors
|
|
JP2007535565A
(ja)
|
2004-04-30 |
2007-12-06 |
バイエル ファーマシューティカルス コーポレーション |
癌の治療に有用な置換ピラゾリル尿素誘導体
|
|
US7439246B2
(en)
|
2004-06-28 |
2008-10-21 |
Bristol-Myers Squibb Company |
Fused heterocyclic kinase inhibitors
|
|
US20050288290A1
(en)
|
2004-06-28 |
2005-12-29 |
Borzilleri Robert M |
Fused heterocyclic kinase inhibitors
|
|
US7432373B2
(en)
|
2004-06-28 |
2008-10-07 |
Bristol-Meyers Squibb Company |
Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
|
|
US20090181092A1
(en)
*
|
2004-07-16 |
2009-07-16 |
Spinal Restoration, Inc. |
Methods for Treating Joints and Discs with a Carrier Matrix and Cells
|
|
ATE428421T1
(de)
|
2004-09-17 |
2009-05-15 |
Eisai R&D Man Co Ltd |
Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
|
|
JP4789180B2
(ja)
*
|
2004-09-28 |
2011-10-12 |
第一三共株式会社 |
６−置換−１−メチル−１−ｈ−ベンズイミダゾール誘導体の製造方法及びその製造中間体
|
|
CN101068770B
(zh)
*
|
2004-09-28 |
2012-01-04 |
三共株式会社 |
制备6-取代的-1-甲基-1-h-苯并咪唑衍生物的方法及其合成中间体
|
|
EP1799679B1
(de)
*
|
2004-10-13 |
2008-01-23 |
Merck Patent GmbH |
Als kinaseinhibitoren geeignete derivate des n,n'-diphenylharnstoffs
|
|
AU2005293839B2
(en)
|
2004-10-13 |
2012-08-23 |
Merck Patent Gmbh |
Heterocyclic substituted bisarylurea derivatives as kinase inhibitors
|
|
GB0423554D0
(en)
*
|
2004-10-22 |
2004-11-24 |
Cancer Rec Tech Ltd |
Therapeutic compounds
|
|
DE102004054216A1
(de)
|
2004-11-10 |
2006-05-11 |
Merck Patent Gmbh |
Substituierte 4-Amino-pyridopyrimidinone
|
|
US7576090B2
(en)
|
2004-12-27 |
2009-08-18 |
4Sc Ag |
Benzazole analogues and uses thereof
|
|
EP1674466A1
(en)
*
|
2004-12-27 |
2006-06-28 |
4Sc Ag |
2,5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors
|
|
EP1925676A4
(en)
|
2005-08-02 |
2010-11-10 |
Eisai R&D Man Co Ltd |
TEST METHOD FOR THE EFFECT OF A VASCULARIZATION INHIBITOR
|
|
US7202513B1
(en)
|
2005-09-29 |
2007-04-10 |
International Business Machines Corporation |
Stress engineering using dual pad nitride with selective SOI device architecture
|
|
US8986650B2
(en)
|
2005-10-07 |
2015-03-24 |
Guerbet |
Complex folate-NOTA-Ga68
|
|
CA2625196C
(fr)
|
2005-10-07 |
2016-04-05 |
Guerbet |
Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
|
|
DK2010528T3
(en)
|
2006-04-19 |
2018-01-15 |
Novartis Ag |
6-O-Substituted Benzoxazole and Benzothiazole Compounds and Methods for Inhibiting CSF-1R Signaling
|
|
CA2649994A1
(en)
|
2006-04-26 |
2007-11-08 |
Cancer Research Technology Limited |
Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
|
|
MX2008013990A
(es)
|
2006-05-09 |
2009-01-29 |
Pfizer Prod Inc |
Derivados de cicloalquilamino acidos.
|
|
WO2007136103A1
(ja)
|
2006-05-18 |
2007-11-29 |
Eisai R & D Management Co., Ltd. |
甲状腺癌に対する抗腫瘍剤
|
|
KR101472600B1
(ko)
|
2006-08-28 |
2014-12-15 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
미분화형 위암에 대한 항종양제
|
|
EP2066642A1
(en)
*
|
2006-09-25 |
2009-06-10 |
Arete Therapeutics, INC. |
Soluble epoxide hydrolase inhibitors
|
|
EP2069294A1
(en)
*
|
2006-09-28 |
2009-06-17 |
Arete Therapeutics, INC. |
Soluble epoxide hydrolase inhibitors
|
|
EP2119707B1
(en)
|
2007-01-29 |
2015-01-14 |
Eisai R&D Management Co., Ltd. |
Composition for treatment of undifferentiated-type of gastric cancer
|
|
CL2008001626A1
(es)
*
|
2007-06-05 |
2009-06-05 |
Takeda Pharmaceuticals Co |
Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer.
|
|
ES2400604T3
(es)
*
|
2007-08-17 |
2013-04-11 |
Icagen, Inc. |
Heterociclos como moduladores del canal de potasio
|
|
US8431608B2
(en)
|
2007-08-17 |
2013-04-30 |
Icagen Inc. |
Heterocycles as potassium channel modulators
|
|
JP5270553B2
(ja)
*
|
2007-08-23 |
2013-08-21 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
JP5350247B2
(ja)
*
|
2007-08-29 |
2013-11-27 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
CN101848895B
(zh)
|
2007-11-09 |
2013-10-23 |
卫材R&D管理有限公司 |
血管新生抑制物质和抗肿瘤性铂络合物的组合使用
|
|
AU2008337286B2
(en)
|
2007-12-19 |
2014-08-07 |
Cancer Research Technology Limited |
Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
|
|
EP2277881A4
(en)
|
2008-04-18 |
2011-09-07 |
Shionogi & Co |
HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K
|
|
GB0807609D0
(en)
*
|
2008-04-25 |
2008-06-04 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
|
WO2009136663A1
(en)
*
|
2008-05-08 |
2009-11-12 |
Takeda Pharmaceutical Company Limited |
Fused heterocyclic derivatives and use thereof
|
|
AU2009262199B2
(en)
|
2008-06-27 |
2012-08-09 |
Amgen Inc. |
Ang-2 inhibition to treat multiple sclerosis
|
|
US8697874B2
(en)
|
2008-12-01 |
2014-04-15 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound and use thereof
|
|
JO3101B1
(ar)
|
2008-12-02 |
2017-09-20 |
Takeda Pharmaceuticals Co |
مشتقات بنزوثيازول كعوامل مضادة للسرطان
|
|
FR2942227B1
(fr)
|
2009-02-13 |
2011-04-15 |
Guerbet Sa |
Utilisation de tampons pour la complexation de radionucleides
|
|
WO2010126922A1
(en)
*
|
2009-04-30 |
2010-11-04 |
Glaxosmithkline Llc |
Benzimidazolecarboxamides as inhibitors of fak
|
|
BR112012003592B8
(pt)
|
2009-08-19 |
2021-05-25 |
Eisai R&D Man Co Ltd |
composição farmacêutica contendo derivado de quinolina
|
|
JP5760010B2
(ja)
|
2010-02-01 |
2015-08-05 |
キャンサー・リサーチ・テクノロジー・リミテッド |
１−（５−ｔｅｒｔ−ブチル−２−フェニル−２Ｈ−ピラゾール−３−イル）−３−［２−フルオロ−４−（１−メチル−２−オキソ−２，３−ジヒドロ−１Ｈ−イミダゾ［４，５−Ｂ］ピリジン−７−イルオキシ）−フェニル］−尿素および関連化合物ならびに治療におけるそれらの使用
|
|
ES2679918T3
(es)
|
2010-02-18 |
2018-08-31 |
Vtv Therapeutics Llc |
Derivados de imidazol condensados sustituidos, composiciones farmacéuticas y métodos de uso de los mismos
|
|
US8759535B2
(en)
|
2010-02-18 |
2014-06-24 |
High Point Pharmaceuticals, Llc |
Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
|
|
CA2802644C
(en)
|
2010-06-25 |
2017-02-21 |
Eisai R & D Management Co., Ltd. |
Antitumor agent using compounds having kinase inhibitory effect in combination
|
|
JP6038792B2
(ja)
|
2010-09-03 |
2016-12-07 |
フォーマ ティーエム， エルエルシー． |
癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体
|
|
FR2968999B1
(fr)
|
2010-12-20 |
2013-01-04 |
Guerbet Sa |
Nanoemulsion de chelate pour irm
|
|
EP2700403B1
(en)
|
2011-04-18 |
2015-11-25 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
|
WO2012166899A2
(en)
|
2011-06-03 |
2012-12-06 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
|
FR2980364B1
(fr)
|
2011-09-26 |
2018-08-31 |
Guerbet |
Nanoemulsions et leur utilisation comme agents de contraste
|
|
AU2013364953A1
(en)
|
2012-12-21 |
2015-04-30 |
Eisai R&D Management Co., Ltd. |
Amorphous form of quinoline derivative, and method for producing same
|
|
FR3001154B1
(fr)
|
2013-01-23 |
2015-06-26 |
Guerbet Sa |
Magneto-emulsion vectorisee
|
|
US9242969B2
(en)
|
2013-03-14 |
2016-01-26 |
Novartis Ag |
Biaryl amide compounds as kinase inhibitors
|
|
CN105264380B
(zh)
|
2013-05-14 |
2017-09-05 |
卫材R&D管理有限公司 |
用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志
|
|
AU2014275198B2
(en)
*
|
2013-05-30 |
2017-04-13 |
KALA BIO, Inc. |
Novel compounds and uses thereof
|
|
GB201320732D0
(en)
|
2013-11-25 |
2014-01-08 |
Cancer Rec Tech Ltd |
Methods of chemical synthesis
|
|
GB201320729D0
(en)
|
2013-11-25 |
2014-01-08 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
|
CA2957005C
(en)
|
2014-08-28 |
2021-10-12 |
Eisai R&D Management Co., Ltd. |
High-purity quinoline derivative and method for manufacturing same
|
|
UY36294A
(es)
|
2014-09-12 |
2016-04-29 |
Novartis Ag |
Compuestos y composiciones como inhibidores de quinasa
|
|
WO2016089648A1
(en)
|
2014-12-01 |
2016-06-09 |
Vtv Therapeutics Llc |
Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
|
|
SG11201706630UA
(en)
|
2015-02-25 |
2017-09-28 |
Eisai R&D Man Co Ltd |
Method for suppressing bitterness of quinoline derivative
|
|
WO2016140717A1
(en)
|
2015-03-04 |
2016-09-09 |
Merck Sharp & Dohme Corp. |
Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
|
|
BR112017027227B1
(pt)
|
2015-06-16 |
2023-12-12 |
Eisai R&D Management Co., Ltd |
Agente anti-câncer
|
|
JP6553726B2
(ja)
|
2015-08-20 |
2019-07-31 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍治療剤
|
|
EP3383852A4
(en)
*
|
2015-11-30 |
2019-08-28 |
Children's Medical Center Corporation |
COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
|
|
EP3515446B1
(en)
|
2016-09-19 |
2023-12-20 |
Novartis AG |
Therapeutic combinations comprising a raf inhibitor and a erk inhibitor
|
|
US12303505B2
(en)
|
2017-02-08 |
2025-05-20 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
|
US11266653B2
(en)
|
2017-05-02 |
2022-03-08 |
Novartis Ag |
Combination therapy
|
|
BR112019023064A2
(pt)
|
2017-05-16 |
2020-06-09 |
Eisai R&D Man Co Ltd |
tratamento de carcinoma hepatocelular
|
|
CN107954939B
(zh)
*
|
2017-12-07 |
2019-09-17 |
福建医科大学 |
一种微波辐射下n,n-二甲基氨基硫代甲酰氯衍生物催化合成苯并咪唑衍生物的方法
|
|
EP3876939A4
(en)
|
2018-11-07 |
2022-08-10 |
Dana-Farber Cancer Institute, Inc. |
Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
|
|
EP3876930A4
(en)
|
2018-11-07 |
2022-07-20 |
Dana-Farber Cancer Institute, Inc. |
BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
|
|
WO2020097400A1
(en)
|
2018-11-07 |
2020-05-14 |
Dana-Farber Cancer Institute, Inc. |
Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof
|
|
CN113905787A
(zh)
*
|
2019-04-05 |
2022-01-07 |
斯托姆治疗有限公司 |
Mettl3抑制化合物
|
|
ES3025633T3
(en)
|
2019-05-13 |
2025-06-09 |
Novartis Ag |
New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
|
|
BR112022022409A2
(pt)
|
2020-05-06 |
2023-02-07 |
Ajax Therapeutics Inc |
6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2
|
|
US20230391753A1
(en)
*
|
2020-10-19 |
2023-12-07 |
Korea University Research And Business Foundation |
Thiobenzimidazole derivative or pharmaceutically acceptable salt thereof and use thereof
|
|
WO2022140527A1
(en)
|
2020-12-23 |
2022-06-30 |
Ajax Therapeutics, Inc. |
6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
|
|
CA3234638A1
(en)
|
2021-11-09 |
2023-05-19 |
Ajax Therapeutics, Inc. |
6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
|
|
WO2023086320A1
(en)
|
2021-11-09 |
2023-05-19 |
Ajax Therapeutics, Inc. |
Forms and compositions of inhibitors of jak2
|
|
TW202346485A
(zh)
|
2022-03-28 |
2023-12-01 |
瑞士商杭斯曼高級材料公司 |
基於2-羥基萘-3-羧酸的分散偶氮染料
|
|
CN115724837B
(zh)
*
|
2022-10-26 |
2024-07-23 |
中国人民解放军海军军医大学 |
一种抑制程序性细胞坏死的苯并噻唑衍生物及其应用
|
|
CN117820253A
(zh)
*
|
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