JP2004532209A5 - - Google Patents

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Publication number
JP2004532209A5
JP2004532209A5 JP2002576959A JP2002576959A JP2004532209A5 JP 2004532209 A5 JP2004532209 A5 JP 2004532209A5 JP 2002576959 A JP2002576959 A JP 2002576959A JP 2002576959 A JP2002576959 A JP 2002576959A JP 2004532209 A5 JP2004532209 A5 JP 2004532209A5
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compound
fluoro
alkyl
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JP2002576959A
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JP2004532209A (ja
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Priority claimed from PCT/US2002/005115 external-priority patent/WO2002078693A2/en
Publication of JP2004532209A publication Critical patent/JP2004532209A/ja
Publication of JP2004532209A5 publication Critical patent/JP2004532209A5/ja
Pending legal-status Critical Current

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JP2002576959A 2001-03-29 2002-03-15 5−ht6受容体の拮抗薬としてのn−(2−アリールエチル)ベンジルアミン Pending JP2004532209A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27992801P 2001-03-29 2001-03-29
US32944901P 2001-10-15 2001-10-15
PCT/US2002/005115 WO2002078693A2 (en) 2001-03-29 2002-03-15 N-(2-arylethyl)benzylamines as antagonists of the 5-ht6 receptor

Publications (2)

Publication Number Publication Date
JP2004532209A JP2004532209A (ja) 2004-10-21
JP2004532209A5 true JP2004532209A5 (enExample) 2005-12-22

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ID=26959969

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JP2002576959A Pending JP2004532209A (ja) 2001-03-29 2002-03-15 5−ht6受容体の拮抗薬としてのn−(2−アリールエチル)ベンジルアミン

Country Status (28)

Country Link
US (3) US7157488B2 (enExample)
EP (1) EP1379239B1 (enExample)
JP (1) JP2004532209A (enExample)
KR (1) KR100894189B1 (enExample)
CN (1) CN1610547A (enExample)
AT (1) ATE372768T1 (enExample)
AU (1) AU2002303094B2 (enExample)
BR (1) BR0208179A (enExample)
CA (1) CA2442114C (enExample)
CY (1) CY1110362T1 (enExample)
CZ (1) CZ305838B6 (enExample)
DE (1) DE60222396T2 (enExample)
DK (2) DK1379239T3 (enExample)
DZ (1) DZ3493A1 (enExample)
EA (1) EA007493B1 (enExample)
ES (2) ES2292758T3 (enExample)
HR (1) HRP20030771B1 (enExample)
HU (1) HU230322B1 (enExample)
IL (3) IL157651A0 (enExample)
MX (1) MXPA03008726A (enExample)
NO (1) NO326160B1 (enExample)
NZ (1) NZ527815A (enExample)
PL (1) PL220721B1 (enExample)
PT (2) PT1859798E (enExample)
SI (1) SI1859798T1 (enExample)
SK (1) SK287463B6 (enExample)
WO (1) WO2002078693A2 (enExample)
ZA (1) ZA200306795B (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1379239T3 (da) * 2001-03-29 2008-01-07 Lilly Co Eli N(2-aryl-ethyl)-benzyl-aminer som antagonister af 5 HT6 receptoren
EP1411925A1 (en) * 2001-08-03 2004-04-28 PHARMACIA & UPJOHN COMPANY 5-arylsulfonyl indoles having 5-ht6 receptor affinity
BR0312176A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario
AU2003248614B2 (en) * 2002-07-17 2007-08-30 Lek Pharmaceuticals D.D. Novel derivatives of pyridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them
PL212616B1 (pl) 2002-09-19 2012-10-31 Lilly Co Eli Eter diarylowy i kompozycja farmaceutyczna zawierajaca ten eter
EP2666772B1 (en) * 2002-12-20 2017-03-01 Basf Se Synthesis of amines and intermediates for the synthesis thereof
BRPI0407616A (pt) 2003-03-07 2006-02-14 Lilly Co Eli composto, composição farmacêutica, método para bloquear uma combinação de receptor de mu, capa, delta (heterodìmero) deste em mamìferos, método para tratar ou prevenir obesidade e doenças relacionadas, uso de um composto, e método de suprimir o apetite em um paciente em necessidade deste"
WO2004080996A1 (en) 2003-03-07 2004-09-23 Eli Lilly And Company Opioid receptor antagonists
DE10320782A1 (de) * 2003-05-09 2004-11-25 Bayer Cropscience Ag Substituierte Oxyarene
JP4198733B2 (ja) 2003-07-22 2008-12-17 アリーナ ファーマシューティカルズ, インコーポレイテッド 関連性障害の予防および処置に有用な、5−ht2aセロトニンレセプターのモジュレーターとしてのジアリールおよびアリールへテロアリールウレア誘導体
CN1894240A (zh) 2003-12-22 2007-01-10 伊莱利利公司 阿片受体拮抗剂
US7381750B2 (en) 2004-03-12 2008-06-03 Eli Lilly And Company Amino-phenoxymethyl-benzamide opioid receptor antagonists
ES2318472T3 (es) 2004-03-15 2009-05-01 Eli Lilly And Company Derivados de 5-(5-(aminoetil)-indol-1-ilmetil)-benzamida y compuestos relacionados como antagonistas del receptor opioide para el tratamiento de la obesidad.
CA2557794A1 (en) 2004-03-15 2005-10-06 Eli Lilly And Company Opioid receptor antagonists
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
WO2006002421A2 (en) * 2004-06-24 2006-01-05 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
EP1632491A1 (en) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
NZ553646A (en) * 2004-09-22 2010-07-30 Janssen Pharmaceutica Nv Inhibitors of the interaction between MDM2 and p53
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
DE102004062542A1 (de) * 2004-12-24 2006-07-06 Bayer Cropscience Ag Substituierte Oxyarene
JP5170742B2 (ja) 2005-12-28 2013-03-27 積水メディカル株式会社 凝集測定用試薬及び凝集測定方法
AU2006332726B2 (en) 2005-12-28 2012-12-13 Vertex Pharmaceuticals Incorporated. Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
EP1973905A4 (en) * 2006-01-06 2010-12-08 Astrazeneca Ab COMPOUNDS
CA2644643C (en) 2006-03-22 2015-05-19 Janssen Pharmaceutica N.V. Inhibitors of the interaction between mdm2 and p53
ATE470665T1 (de) 2006-03-22 2010-06-15 Janssen Pharmaceutica Nv Cycloalkylaminderivate als inhibitoren der wechselwirkung zwischen mdm2 und p53
EP2357174A1 (en) 2006-05-09 2011-08-17 AstraZeneca AB Salt forms of (2S)-(4E)-N-Methyl-5-[(5-Isopropoxy)pyridin-3-yl]-4-penten-2-amine
TWI389889B (zh) 2006-05-09 2013-03-21 Targacept Inc (2s)-(4e)-n-甲基-5-〔3-(5-異丙氧基吡啶)基〕-4-戊烯-2-胺之新穎多晶型
EP1953153A1 (en) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
TW200922557A (en) 2007-08-06 2009-06-01 Janssen Pharmaceutica Nv Substituted phenylenediamines as inhibitors of the interaction between MDM2 and p53
JO2704B1 (en) * 2007-09-21 2013-03-03 جانسين فارماسوتيكا ان في Interference inhibition factors between MD2 and B53
US20090093513A1 (en) * 2007-10-09 2009-04-09 Hamann Mark T Method to Use Compositions Having Antidepressant Anxiolytic and Other Neurological Activity and Compositions of Matter
WO2009073118A1 (en) * 2007-12-04 2009-06-11 Merck & Co., Inc. Tryptamine sulfonamides as 5-ht6 antagonists
EP2508177A1 (en) 2007-12-12 2012-10-10 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
AU2009214724A1 (en) * 2008-02-11 2009-08-20 Organix Inc. Indole compounds and methods of use thereof
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
CA2749209C (en) * 2009-02-04 2017-01-10 Janssen Pharmaceutica Nv Indole derivatives as anticancer agents
JP5083256B2 (ja) * 2009-03-20 2012-11-28 株式会社デンソー 半導体装置およびその製造方法
AU2010226400B2 (en) 2009-03-20 2016-07-14 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8912220B2 (en) 2009-08-10 2014-12-16 Galenea Pharmaceuticals Compounds and methods of use thereof
EP2311823A1 (en) 2009-10-15 2011-04-20 AC Immune S.A. 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases
TW201139370A (en) * 2009-12-23 2011-11-16 Lundbeck & Co As H Processes for the manufacture of a pharmaceutically active agent
FR2961097B1 (fr) * 2010-06-09 2012-07-13 Oreal Procede cosmetique de traitement des odeurs corporelles humaines utilisant un compose 6-alkoxy tryptamine
FR2961095B1 (fr) * 2010-06-09 2012-06-15 Oreal Composition cosmetique et/ou dermatologique comprenant au moins un compose 6-alcoxy tryptamine
US8293218B2 (en) * 2010-07-29 2012-10-23 Conopco, Inc. Skin care compositions comprising substituted monoamines
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CA2865519C (en) 2012-02-27 2018-01-02 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl0-5-hydroxyphenyl-1]-1,4-dihydro-4-oxoquinolone-3-carboxamide for treating cystic fibrosis
CN104220421A (zh) 2012-03-20 2014-12-17 阿达梅德公司 用于治疗中枢神经系统疾病的苄胺的磺酰胺衍生物
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
US20160038484A1 (en) * 2013-04-03 2016-02-11 The University Of Utah Research Foundation Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome
CN104725249B (zh) * 2013-12-20 2019-02-12 广东东阳光药业有限公司 苄胺类衍生物及其在药物上的应用
JO3639B1 (ar) * 2014-07-04 2020-08-27 H Lundbeck As صورة متعددة الشكل جديدة لـ n-[2-(6-فلورو-1h-إندول-3-يل)إيثيل]-3-(2،2،3،3-تترا فلورو بروبوكسي)بنزيل أمين هيدروكلوريد
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
ES2570452B1 (es) * 2014-10-15 2017-04-19 Fundación Para La Investigación Biomédida Del Hospital Universitario De La Princesa Compuestos derivados de acrilato de 3-Alquilamino-1H-Indolilo y su uso en el tratamiento de enfermedades neurodegenerativas
CN105175307A (zh) * 2014-11-18 2015-12-23 苏州晶云药物科技有限公司 Lu AE58054的盐酸盐晶型A及其制备方法和用途
CN104529865B (zh) * 2014-12-12 2017-02-01 广东东阳光药业有限公司 苄胺类衍生物及其在药物上的应用
TW201630881A (zh) 2014-12-12 2016-09-01 H 朗德貝克公司 用於生產艾達魯吡啶之方法
WO2016201373A1 (en) 2015-06-12 2016-12-15 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
HK1247555A1 (zh) 2015-07-15 2018-09-28 Axovant Sciences Gmbh 用於预防和治疗与神经变性疾病相关的幻觉的作为5-ht2a血清素受体的调节剂的二芳基脲和芳基杂芳基脲衍生物
CN108271369A (zh) 2015-10-23 2018-07-10 法尔玛赞公司 用于制备色胺及其衍生物的新工艺
EP3440055B1 (en) 2016-04-08 2020-03-11 H. Lundbeck A/S A process for the manufacture of idalopirdine via hydrogenation of an imine
SI3448430T1 (sl) * 2016-04-26 2023-08-31 H. Lundbeck A/S Uporaba inhibitorja acetilholinesteraze in idalopirdina za zmanjšanje padcev pri bolnikih s parkinsonovo boleznijo
US10864191B2 (en) 2016-05-11 2020-12-15 H. Lundbeck A/S 5-HT6 receptor antagonists for use in the treatment of Alzheimer's disease with apathy as comorbidity
WO2018013686A1 (en) * 2016-07-12 2018-01-18 Concert Pharmaceuticals, Inc. Deuterated idalopirdine
EP3333154A1 (en) 2016-12-07 2018-06-13 Sandoz Ag Crystalline form of a selective 5-ht6 receptor antagonist
CN106632303A (zh) * 2017-01-09 2017-05-10 湖南华腾制药有限公司 一种6‑噻唑基吲哚衍生物的制备方法
WO2018191146A1 (en) * 2017-04-10 2018-10-18 Navitor Pharmaceuticals, Inc. Heteroaryl rheb inhibitors and uses thereof
PL3630098T3 (pl) 2017-05-24 2021-09-06 H. Lundbeck A/S Połączenie antagonisty receptora 5-ht6 i inhibitora acetylocholinoesterazy do zastosowania w leczeniu choroby alzheimera w subpopulacji pacjentów posiadających allele apoe4
AU2018358663B2 (en) * 2017-11-06 2022-09-29 Acelot, Inc. Small molecule drugs and related methods for treatment of diseases related to AB42 oligomer formation
KR20210135521A (ko) 2019-03-06 2021-11-15 다이이찌 산쿄 가부시키가이샤 피롤로피라졸 유도체
CN109942527A (zh) * 2019-04-26 2019-06-28 新乡市润宇新材料科技有限公司 一种3-溴二苯并呋喃的合成方法
CA3182156A1 (en) 2020-05-08 2021-11-11 Psilera Inc. Novel compositions of matter and pharmaceutical compositions
MX2022014605A (es) 2020-05-19 2022-12-16 Cybin Irl Ltd Derivados de triptamina deuterada y metodos de uso.
JP2023539390A (ja) * 2020-09-02 2023-09-13 エンベリック バイオサイエンシズ カナダ インコーポレイテッド ニトロ化サイロシビン誘導体ならびに5-ht2a受容体を調節するためおよび精神障害を処置するためのその使用
AU2022218921A1 (en) * 2021-02-12 2023-09-21 Enveric Biosciences Canada Inc. Multi-substituent psilocybin derivatives and methods of using
AU2022229695A1 (en) * 2021-03-02 2023-09-28 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto
EP4337220A4 (en) * 2021-05-11 2025-07-02 Saint Josephs Univ SELECTIVE, PARTIAL, AND POLARIZED 5-HT2A AGONISTS WITH UTILITY IN VARIOUS DISORDERS
WO2022251351A1 (en) 2021-05-25 2022-12-01 ATAI Life Sciences AG New n,n-dimethyltryptamine salts and crystalline salt forms
WO2022261240A2 (en) 2021-06-08 2022-12-15 ATAI Life Sciences AG Dimethoxyphenylalkylamine activators of serotonin receptors
MX2023014620A (es) 2021-06-09 2024-01-30 Atai Therapeutics Inc Nuevos profarmacos y conjugados de dimetiltriptamina.
WO2023044577A1 (en) * 2021-09-24 2023-03-30 Psygen Inc. Recovery method for tryptamines
JP2024547131A (ja) 2021-12-27 2024-12-26 エーティーエーアイ セラピューティクス,インコーポレイテッド セロトニン受容体のアミノテトラリン活性化剤
WO2023129956A2 (en) 2021-12-30 2023-07-06 ATAI Life Sciences AG Dimethyltryptamine analogues as nitric oxide delivery drugs
US12065404B2 (en) 2022-03-18 2024-08-20 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using
WO2024229149A1 (en) 2023-05-01 2024-11-07 Atai Therapeutics Inc. Compositions and methods for treatment of diseases and disorders
WO2025160304A1 (en) * 2024-01-24 2025-07-31 Automera PTE. LTD Indole derivatives for targeting autophagy

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3597149A (en) * 1969-04-29 1971-08-03 Showa Denko Kk Inhibition of gas-fume fading of dyed cellulose acetate material
FR2181559A1 (en) 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
JPS5764632A (en) 1980-10-09 1982-04-19 Mitsui Toatsu Chem Inc Novel 2-arylethyl ether derivative and thioether derivative, their production and insecticide and acaricide
DE3632329A1 (de) * 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
US5202336A (en) * 1986-09-24 1993-04-13 Bayer Aktiengesellschaft Antiflammatory quinolin methoxy phenylsulphonamides
SE9103745D0 (sv) 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
DE69411143T2 (de) 1993-09-01 1998-10-22 Allelix Biopharma Tryptamin analoge mit 5-ht1d selektivität
US5504101A (en) 1994-05-06 1996-04-02 Allelix Biopharmaceuticals, Inc. 5-HT-1D receptor ligands
CA2302412C (en) 1997-09-29 2005-12-20 Aventis Pharmaceuticals Inc. Aminoalkylphenol derivatives and related compounds
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
DK1149078T3 (da) * 1998-12-11 2006-07-10 Univ Virginia Commonwealth Selektive 5-HT6-receptorligander
AP2001002228A0 (en) * 1999-01-13 2001-09-30 Millenium Pharmaceuticals Inc Functionalized heterocycles as chemokine receptor modulators.
US6750348B1 (en) * 1999-03-24 2004-06-15 Anormed, Inc. Chemokine receptor binding heterocyclic compounds
US6187895B1 (en) * 1999-08-09 2001-02-13 General Electric Company Method for preparing polymers by solid state polymerization
DK1379239T3 (da) 2001-03-29 2008-01-07 Lilly Co Eli N(2-aryl-ethyl)-benzyl-aminer som antagonister af 5 HT6 receptoren

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