HRP20030771B1 - N-(2-arylethyl)benzylamines as antagonists of the 5-ht<sub>6</sub> receptor - Google Patents

N-(2-arylethyl)benzylamines as antagonists of the 5-ht<sub>6</sub> receptor

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Publication number
HRP20030771B1
HRP20030771B1 HR20030771A HRP20030771A HRP20030771B1 HR P20030771 B1 HRP20030771 B1 HR P20030771B1 HR 20030771 A HR20030771 A HR 20030771A HR P20030771 A HRP20030771 A HR P20030771A HR P20030771 B1 HRP20030771 B1 HR P20030771B1
Authority
HR
Croatia
Prior art keywords
group
alkyl
optionally substituted
hydrogen
trifluoromethyl
Prior art date
Application number
HR20030771A
Other languages
English (en)
Croatian (hr)
Inventor
Chen Zhaogen
Philip Cohen Michael
Joseph Fisher Matthew
Giethlen Bruno
Ronald Gillig James
Ray Mccowan Jefferson
Christopher Miller Shawn
Mehnert Schaus John
Original Assignee
Eli Lilly And Company
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Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HRP20030771A2 publication Critical patent/HRP20030771A2/hr
Publication of HRP20030771B1 publication Critical patent/HRP20030771B1/xx

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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    • C07D209/04—Indoles; Hydrogenated indoles
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US8044090B2 (en) 2011-10-25
HRP20030771A2 (en) 2005-08-31
CA2442114A1 (en) 2002-10-10
EP1379239A2 (en) 2004-01-14
WO2002078693A3 (en) 2002-12-05
AU2002303094B2 (en) 2006-11-23
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US20040132800A1 (en) 2004-07-08
EP1379239B1 (en) 2007-09-12
BR0208179A (pt) 2004-03-02
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HK1061649A1 (en) 2004-09-30
WO2002078693A2 (en) 2002-10-10
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ES2292758T3 (es) 2008-03-16
MXPA03008726A (es) 2003-12-12
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EA200301073A1 (ru) 2004-02-26
SK12052003A3 (sk) 2004-09-08
CY1110362T1 (el) 2015-04-29
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CN1610547A (zh) 2005-04-27
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JP2004532209A (ja) 2004-10-21
NZ527815A (en) 2005-05-27
US20060009511A9 (en) 2006-01-12
DK1859798T3 (en) 2016-03-21
EA007493B1 (ru) 2006-10-27
PT1379239E (pt) 2007-12-06
CZ20032614A3 (en) 2004-03-17
US20090306110A1 (en) 2009-12-10
HU230322B1 (hu) 2016-01-28
DK1379239T3 (da) 2008-01-07
IL185871A0 (en) 2008-01-06
SI1859798T1 (sl) 2016-07-29
US7157488B2 (en) 2007-01-02
PT1859798E (pt) 2016-03-31
CA2442114C (en) 2011-06-21
ES2566056T3 (es) 2016-04-08
US20070099909A1 (en) 2007-05-03
CZ305838B6 (cs) 2016-04-06
KR100894189B1 (ko) 2009-04-22
HUP0303651A3 (en) 2004-08-30
NO326160B1 (no) 2008-10-13
PL220721B1 (pl) 2015-12-31

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