RS49997B - Derivati piridopiranoazepina, njihovo pripremanje i terapeutska primena - Google Patents

Derivati piridopiranoazepina, njihovo pripremanje i terapeutska primena

Info

Publication number
RS49997B
RS49997B YUP-596/01A YUP59601A RS49997B RS 49997 B RS49997 B RS 49997B YU P59601 A YUP59601 A YU P59601A RS 49997 B RS49997 B RS 49997B
Authority
RS
Serbia
Prior art keywords
alkyl group
alkyl
group
hydrogen atom
hydrogen
Prior art date
Application number
YUP-596/01A
Other languages
English (en)
Inventor
Frederic Galli
Alistair Lochead
Axelle Samson
Samir Jegham
Original Assignee
Sanofi-Aventis,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis, filed Critical Sanofi-Aventis,
Publication of YU59601A publication Critical patent/YU59601A/sh
Publication of RS49997B publication Critical patent/RS49997B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Abstract

Jedinjenje, u obliku čistih geometrijskih ili optičkih izomera ili mešavine takvih izomera, naz nač eno tim e , što je opšte formule: U kojoj su: R1 atom vodonika, grupa (C1-C4)alkil, grupa fenil(C1-C4)a1kil, grupa fenilhidroksi (C1-C4)alkil, grupa furanil(C1-C4)alkil, ili grupa furanilhidroksitf (C1-C4)alkil, R2 je bilo atom vodonika ili halogena ili grupa trifluorometil, cijano, hidroksil, nitro, acetil, (C1-C6)alkil ili (C1-C6)alkoksi opšte formule NR4R5, u kojoj je R4 vodonikov atom ili grupa (C1-C4)alkil ili (C1-C4)alkanoil, a R5 je atom vodonika ili grupa (C1-C4)alkil ili R4 i R5 obrazuju, zajedno sa atomom vodonika koji ih nosi, prsten C4-C7, ili grupu fenil ili naftil, po želji supstituisanu atomom halogena ili sa trifluorometil, trifluorometoksi, cijano, hidroksil, nitro, acetil, grupom (C1-C6)alkil, (C1-C6)alkoksi ili metilendioksi, vezanom na 2. i 3. poziciji fenilskog prstena, ili R3 je atom vodonika ili halogena ili (C1-C4)alkil grupa, u obliku baze ili adicione soli neke kiseline. Prijava ima 3 zahteva.
YUP-596/01A 1999-03-05 2000-03-01 Derivati piridopiranoazepina, njihovo pripremanje i terapeutska primena RS49997B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9902784A FR2790474B1 (fr) 1999-03-05 1999-03-05 Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
YU59601A YU59601A (sh) 2004-03-12
RS49997B true RS49997B (sr) 2008-09-29

Family

ID=9542888

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-596/01A RS49997B (sr) 1999-03-05 2000-03-01 Derivati piridopiranoazepina, njihovo pripremanje i terapeutska primena

Country Status (37)

Country Link
US (2) US6538003B1 (sr)
EP (1) EP1161434B1 (sr)
JP (1) JP4806123B2 (sr)
KR (2) KR100768355B1 (sr)
CN (1) CN1137894C (sr)
AR (1) AR022820A1 (sr)
AT (1) ATE231869T1 (sr)
AU (1) AU764625B2 (sr)
BG (1) BG65211B1 (sr)
BR (1) BR0008763A (sr)
CA (1) CA2372063C (sr)
CO (1) CO5160250A1 (sr)
CZ (1) CZ302259B6 (sr)
DE (1) DE60001307T2 (sr)
DK (1) DK1161434T3 (sr)
EE (1) EE04497B1 (sr)
ES (1) ES2191611T3 (sr)
FR (1) FR2790474B1 (sr)
HK (1) HK1040398B (sr)
HR (1) HRP20010655B1 (sr)
HU (1) HU228671B1 (sr)
ID (1) ID30116A (sr)
IL (2) IL145150A0 (sr)
MX (1) MXPA01008972A (sr)
NO (1) NO327119B1 (sr)
NZ (1) NZ513561A (sr)
PE (1) PE20001543A1 (sr)
PL (1) PL201683B1 (sr)
RS (1) RS49997B (sr)
RU (1) RU2238273C2 (sr)
SK (1) SK284339B6 (sr)
TR (1) TR200102403T2 (sr)
TW (1) TWI222975B (sr)
UA (1) UA61164C2 (sr)
UY (1) UY26048A1 (sr)
WO (1) WO2000053608A1 (sr)
ZA (1) ZA200106811B (sr)

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DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
KR20120041739A (ko) 2002-07-18 2012-05-02 사이토스 바이오테크놀로지 아게 합텐-캐리어 컨쥬게이트 및 그의 용도
EP2062595A1 (en) * 2002-12-06 2009-05-27 The Feinstein Institute for Medical Research Inhibition of inflammation using alpha 7 receptor-binding cholinergic agonists
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) * 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
US20080255203A1 (en) * 2007-04-12 2008-10-16 Abbott Laboratories Heterocyclic compounds and their methods of use
US20090076059A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched dianicline
CA2707667C (en) 2007-12-07 2016-02-23 Abbott Gmbh & Co. Kg Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
US8703774B2 (en) * 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
JP5645217B2 (ja) * 2007-12-07 2014-12-24 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー ５，６−二置換オキシンドール誘導体およびバソプレッシン依存性疾患を治療するためのこれらの使用
KR20100097195A (ko) * 2007-12-07 2010-09-02 애보트 게엠베하 운트 콤파니 카게 ５－할로겐－치환된 옥스인돌 유도체 및 바소프레신－의존성 질병을 치료하기 위한 이의 용도
US20090221648A1 (en) * 2007-12-21 2009-09-03 Abbott Laboratories Compositions for treatment of cognitive disorders
US8383657B2 (en) * 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
WO2009146031A1 (en) 2008-03-31 2009-12-03 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
PT2540297E (pt) 2008-11-19 2015-08-26 Forum Pharmaceuticals Inc Tratamento de distúrbios cognitivos com (r)-7-cloro-n- (quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida e sais farmaceuticamente aceitáveis desta
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
AU2010247835A1 (en) * 2009-05-11 2011-12-08 Envivo Pharmaceuticals, Inc. Treatment of cognitive disorders with certain alpha-7 nicotinic acid receptors in combination with acetylcholinesterase inhibitors
US9040568B2 (en) * 2009-05-29 2015-05-26 Abbvie Inc. Pharmaceutical compositions for the treatment of pain
SA111320455B1 (ar) 2010-05-17 2014-10-16 Envivo Pharmaceuticals Inc صورة بلورية من (R)-7- كلورو -N- (كينوكليدين -3- يل) بنزو[b] ثيوفين -2- كربوكساميد هيدروكلوريد أحادي الهيدرات
EP3666272A1 (en) 2012-05-08 2020-06-17 Forum Pharmaceuticals Inc. Use of encenicline in the treatment of cognitive impairment, alzheimer's disease, memory deficit
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Also Published As

Publication number Publication date
NO20014270D0 (no) 2001-09-03
CN1137894C (zh) 2004-02-11
WO2000053608A1 (fr) 2000-09-14
CZ20013102A3 (cs) 2002-01-16
TR200102403T2 (tr) 2001-12-21
NZ513561A (en) 2003-06-30
FR2790474B1 (fr) 2001-04-06
KR20070086359A (ko) 2007-08-27
IL145150A (en) 2007-06-03
CO5160250A1 (es) 2002-05-30
HRP20010655B1 (en) 2003-06-30
US20030187012A1 (en) 2003-10-02
US6538003B1 (en) 2003-03-25
BG105828A (bg) 2002-03-29
CA2372063C (en) 2011-01-11
AU764625B2 (en) 2003-08-28
PL352330A1 (en) 2003-08-11
CA2372063A1 (en) 2000-09-14
DK1161434T3 (da) 2003-05-26
RU2238273C2 (ru) 2004-10-20
KR100768355B1 (ko) 2007-10-17
EP1161434B1 (fr) 2003-01-29
HK1040398B (zh) 2003-07-18
HK1040398A1 (en) 2002-06-07
SK284339B6 (sk) 2005-02-04
JP2002539129A (ja) 2002-11-19
US6908927B2 (en) 2005-06-21
UY26048A1 (es) 2000-09-29
NO20014270L (no) 2001-11-05
HUP0201753A3 (en) 2004-12-28
EE200100470A (et) 2002-12-16
DE60001307T2 (de) 2003-12-11
HUP0201753A2 (en) 2002-09-28
FR2790474A1 (fr) 2000-09-08
IL145150A0 (en) 2002-06-30
HU228671B1 (en) 2013-05-28
PE20001543A1 (es) 2001-03-18
MXPA01008972A (es) 2002-03-27
ES2191611T3 (es) 2003-09-16
TWI222975B (en) 2004-11-01
AR022820A1 (es) 2002-09-04
JP4806123B2 (ja) 2011-11-02
ID30116A (id) 2001-11-08
DE60001307D1 (de) 2003-03-06
KR20010102492A (ko) 2001-11-15
NO327119B1 (no) 2009-04-27
UA61164C2 (uk) 2003-11-17
CZ302259B6 (cs) 2011-01-19
AU2922600A (en) 2000-09-28
BG65211B1 (bg) 2007-07-31
EE04497B1 (et) 2005-06-15
HRP20010655A2 (en) 2002-08-31
BR0008763A (pt) 2002-01-02
YU59601A (sh) 2004-03-12
SK12422001A3 (sk) 2002-04-04
PL201683B1 (pl) 2009-04-30
CN1343208A (zh) 2002-04-03
ATE231869T1 (de) 2003-02-15
ZA200106811B (en) 2002-08-19
EP1161434A1 (fr) 2001-12-12

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