DZ3493A1 - N-(2-arylethyl)benzylamines comme antagonistes du recepteur 5-ht6 - Google Patents

N-(2-arylethyl)benzylamines comme antagonistes du recepteur 5-ht6

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Publication number
DZ3493A1
DZ3493A1 DZ023493A DZ023493A DZ3493A1 DZ 3493 A1 DZ3493 A1 DZ 3493A1 DZ 023493 A DZ023493 A DZ 023493A DZ 023493 A DZ023493 A DZ 023493A DZ 3493 A1 DZ3493 A1 DZ 3493A1
Authority
DZ
Algeria
Prior art keywords
arylethyl
benzylamines
receptor antagonists
antagonists
receptor
Prior art date
Application number
DZ023493A
Other languages
English (en)
Inventor
Zhaogen Chen
Michael Cohen
Matthew Fisher
Bruno Giethlen
James Gillig
Jefferson Mccowan
Shawn Miller
John Schaus
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DZ3493A1 publication Critical patent/DZ3493A1/fr

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

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AU2002303094B2 (en) 2006-11-23
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IL157651A0 (en) 2004-03-28
US20090306110A1 (en) 2009-12-10
ATE372768T1 (de) 2007-09-15
CY1110362T1 (el) 2015-04-29
EA007493B1 (ru) 2006-10-27
PT1379239E (pt) 2007-12-06
SK287463B6 (sk) 2010-10-07
NO20034289L (no) 2003-11-28
ZA200306795B (en) 2005-02-23
JP2004532209A (ja) 2004-10-21
CA2442114A1 (fr) 2002-10-10
HRP20030771A2 (en) 2005-08-31
US20070099909A1 (en) 2007-05-03
HUP0303651A2 (hu) 2004-03-01
NO326160B1 (no) 2008-10-13
BR0208179A (pt) 2004-03-02
SI1859798T1 (sl) 2016-07-29
IL157651A (en) 2010-02-17
SK12052003A3 (sk) 2004-09-08
HUP0303651A3 (en) 2004-08-30
EA200301073A1 (ru) 2004-02-26
IL185871A0 (en) 2008-01-06
CZ20032614A3 (en) 2004-03-17
NZ527815A (en) 2005-05-27
DK1859798T3 (en) 2016-03-21
WO2002078693A3 (fr) 2002-12-05
WO2002078693A2 (fr) 2002-10-10
EP1379239B1 (fr) 2007-09-12
DE60222396D1 (de) 2007-10-25
PT1859798E (pt) 2016-03-31
DK1379239T3 (da) 2008-01-07
ES2566056T3 (es) 2016-04-08
KR20030090694A (ko) 2003-11-28
NO20034289D0 (no) 2003-09-25
US8044090B2 (en) 2011-10-25
PL220721B1 (pl) 2015-12-31
US20060009511A9 (en) 2006-01-12
KR100894189B1 (ko) 2009-04-22
HRP20030771B1 (en) 2008-10-31
DE60222396T2 (de) 2008-05-15
CA2442114C (fr) 2011-06-21
PL364458A1 (en) 2004-12-13
US20040132800A1 (en) 2004-07-08
HK1061649A1 (en) 2004-09-30
EP1379239A2 (fr) 2004-01-14
CZ305838B6 (cs) 2016-04-06
MXPA03008726A (es) 2003-12-12
CN1610547A (zh) 2005-04-27
US7157488B2 (en) 2007-01-02

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