JP2004525951A5 - - Google Patents
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- Publication number
- JP2004525951A5 JP2004525951A5 JP2002579451A JP2002579451A JP2004525951A5 JP 2004525951 A5 JP2004525951 A5 JP 2004525951A5 JP 2002579451 A JP2002579451 A JP 2002579451A JP 2002579451 A JP2002579451 A JP 2002579451A JP 2004525951 A5 JP2004525951 A5 JP 2004525951A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonyl
- amino
- carboxamide
- benzo
- dioxolen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28127401P | 2001-04-03 | 2001-04-03 | |
| PCT/US2002/010026 WO2002081463A1 (en) | 2001-04-03 | 2002-03-28 | Antagonists of mcp-1 function and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525951A JP2004525951A (ja) | 2004-08-26 |
| JP2004525951A5 true JP2004525951A5 (enExample) | 2006-01-19 |
Family
ID=23076618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002579451A Withdrawn JP2004525951A (ja) | 2001-04-03 | 2002-03-28 | Ｍｃｐ−１機能のアンタゴニストおよびその使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6677365B2 (enExample) |
| EP (1) | EP1383757B1 (enExample) |
| JP (1) | JP2004525951A (enExample) |
| KR (1) | KR20040018346A (enExample) |
| CN (1) | CN1260222C (enExample) |
| AR (1) | AR035801A1 (enExample) |
| AT (1) | ATE340789T1 (enExample) |
| AU (1) | AU2002307014B2 (enExample) |
| BR (1) | BR0208667A (enExample) |
| CA (1) | CA2442776A1 (enExample) |
| DE (1) | DE60214996T2 (enExample) |
| ES (1) | ES2272761T3 (enExample) |
| MX (1) | MXPA03008962A (enExample) |
| TW (1) | TWI236474B (enExample) |
| WO (1) | WO2002081463A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223796B2 (en) | 2002-04-11 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use |
| IL164249A0 (en) * | 2002-04-11 | 2005-12-18 | Aventis Pharma Gmbh | Acyl-3-carboxphenylurea derivatives, processes forpreparing them and their use |
| GB0230045D0 (en) | 2002-12-23 | 2003-01-29 | Glaxo Group Ltd | Compounds |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| EP1718637A2 (en) * | 2004-02-26 | 2006-11-08 | MERCK PATENT GmbH | Benzimidazolyl derivatives as kinase inhibitors |
| WO2005090352A1 (en) | 2004-03-16 | 2005-09-29 | Glaxo Group Limited | Pyrazolo[3,4-b]pyridine compound, and its use as a pde4 inhibitor |
| JP2008512463A (ja) * | 2004-09-08 | 2008-04-24 | ボーイズ タウン ナショナル リサーチ ホスピタル | マトリックスメタロプロテイナーゼ−１２に関連する糸球体基底膜疾患の治療 |
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| JP2008536932A (ja) * | 2005-04-18 | 2008-09-11 | サイード・アール・カーン | チューブリン重合阻害剤：ボンゾイルフェニル尿素（ｂｐｕ）硫黄類似体の設計及び合成 |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| EP1934219A1 (en) | 2005-09-16 | 2008-06-25 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
| EA200901140A1 (ru) | 2007-03-01 | 2010-04-30 | Пробиодруг Аг | Новое применение ингибиторов глутаминилциклазы |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| JP5369000B2 (ja) * | 2007-12-25 | 2013-12-18 | キッセイ薬品工業株式会社 | 新規なカテコール誘導体、それを含有する医薬組成物およびそれらの用途 |
| UY31636A1 (es) | 2008-02-06 | 2009-08-03 | Farmacoforos duales-antagonistas muscarinicos de pde4 | |
| AR070564A1 (es) | 2008-02-06 | 2010-04-21 | Glaxo Group Ltd | Derivados de 1h-pirazolo[3,4-b]piridin-5-ilo,inhibidores de fosfodiesterasas pde4 y antagonistas de receptores muscarinicos de acetilcolina(machr), utiles en el tratamiento y/o profilaxis de enfermedades respiratorias y alergicas,y composiciones farmaceuticas que los comprenden |
| TW201000476A (en) | 2008-02-06 | 2010-01-01 | Glaxo Group Ltd | Dual pharmacophores-PDE4-muscarinic antagonistics |
| FR2930552B1 (fr) * | 2008-04-24 | 2012-10-12 | Centre Nat Rech Scient | N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog |
| US8563580B2 (en) | 2008-09-23 | 2013-10-22 | Georgetown University | Flavivirus inhibitors and methods for their use |
| WO2010039534A2 (en) * | 2008-09-23 | 2010-04-08 | Georgetown University | Viral and fungal inhibitors |
| CN102695546B (zh) | 2009-09-11 | 2014-09-10 | 前体生物药物股份公司 | 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物 |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| SG183229A1 (en) | 2010-03-10 | 2012-09-27 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| PT2624696T (pt) | 2010-10-06 | 2017-03-21 | Glaxosmithkline Llc | Derivados de benzimidazole como inibidores da cinase pi3 |
| WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
| RS59007B1 (sr) | 2014-02-03 | 2019-08-30 | Vitae Pharmaceuticals Llc | Dihidropirolopiridinski inhibitori ror-gama |
| EA031967B1 (ru) | 2014-10-14 | 2019-03-29 | Вайтаи Фармасьютиклз, Инк. | ДИГИДРОПИРРОЛОПИРИДИНОВЫЕ ИНГИБИТОРЫ ROR-γ |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| KR20180086221A (ko) | 2015-11-20 | 2018-07-30 | 비타이 파마슈티컬즈, 인코포레이티드 | Ror-감마의 조절물질 |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| MA49685A (fr) | 2017-07-24 | 2021-04-14 | Vitae Pharmaceuticals Llc | INHIBITEURS DE ROR gamma |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE32700B1 (en) | 1968-02-03 | 1973-10-31 | Beecham Group Ltd | Penicillins |
| GB1250611A (enExample) | 1968-02-03 | 1971-10-20 | ||
| DE2131034A1 (de) | 1971-06-23 | 1973-01-11 | Hoechst Ag | Acylharnstoffe und verfahren zu ihrer herstellung |
| DE2652004C3 (de) | 1976-11-15 | 1979-09-13 | Basf Ag, 6700 Ludwigshafen | l-Acyl-2-arylamino-2-imidazoline, Verfahren zu ihrer Herstellung und ihre Verwendung |
| FR2672888B1 (fr) | 1991-02-14 | 1994-02-04 | Fabre Medicament Pierre | Nouvelles urees et thiourees, leur preparation et leur application en therapeutique. |
| JP3964478B2 (ja) | 1995-06-30 | 2007-08-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬 |
| AU1208397A (en) | 1995-12-28 | 1997-07-28 | Takeda Chemical Industries Ltd. | Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists |
| JPH09255572A (ja) | 1996-03-26 | 1997-09-30 | Takeda Chem Ind Ltd | ケモカイン受容体拮抗剤 |
| CA2256492C (en) | 1996-05-20 | 2006-04-04 | Teijin Limited | Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists |
| JP2000516210A (ja) | 1996-07-12 | 2000-12-05 | ロイコサイト，インコーポレーテッド | ケモカインレセプターアンタゴニストとその使用方法 |
| US6140338A (en) | 1996-07-29 | 2000-10-31 | Banyu Pharmaceutical, Co., Ltd. | Chemokine receptor antagonists |
| JP2000516611A (ja) | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Ｍｃｐ―１アンタゴニストとしての２―フェニルベンズイミダゾール誘導体 |
| AU5812498A (en) | 1996-12-20 | 1998-07-17 | Merck & Co., Inc. | Substituted aminoquinolines as modulators of chemokine receptor activity |
| GB9716656D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| CA2319494A1 (en) | 1998-02-03 | 1999-08-12 | Boehringer Ingelheim Pharma Kg | 5-membered heterocyclic condensed benzoderivatives, the preparation thereof and their use as pharmaceuticals |
| US6342516B1 (en) | 1998-07-31 | 2002-01-29 | Nippon Soda Co., Ltd. | Phenylazole compounds, process for producing the same and drugs for hyperlipemia |
| GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| US6316449B1 (en) | 1999-07-08 | 2001-11-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists |
| US20020013314A1 (en) | 2000-02-01 | 2002-01-31 | Bing-Yan Zhu | 3,4-dihydro-2H-benzo[1,4]oxazine inhibitors of factor Xa |
| WO2001057044A1 (en) | 2000-02-01 | 2001-08-09 | Daiichi Pharmaceutical Co., Ltd. | Pyridoxazine derivatives |
| EP1255741A2 (en) | 2000-02-01 | 2002-11-13 | Cor Therapeutics, Inc. | 2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa |
-
2002
- 2002-03-25 TW TW091105707A patent/TWI236474B/zh not_active IP Right Cessation
- 2002-03-25 US US10/106,881 patent/US6677365B2/en not_active Expired - Fee Related
- 2002-03-27 AR ARP020101149A patent/AR035801A1/es not_active Application Discontinuation
- 2002-03-28 AU AU2002307014A patent/AU2002307014B2/en not_active Ceased
- 2002-03-28 CA CA002442776A patent/CA2442776A1/en not_active Abandoned
- 2002-03-28 KR KR10-2003-7013006A patent/KR20040018346A/ko not_active Ceased
- 2002-03-28 MX MXPA03008962A patent/MXPA03008962A/es active IP Right Grant
- 2002-03-28 ES ES02763877T patent/ES2272761T3/es not_active Expired - Lifetime
- 2002-03-28 JP JP2002579451A patent/JP2004525951A/ja not_active Withdrawn
- 2002-03-28 DE DE60214996T patent/DE60214996T2/de not_active Expired - Fee Related
- 2002-03-28 WO PCT/US2002/010026 patent/WO2002081463A1/en not_active Ceased
- 2002-03-28 CN CNB028079035A patent/CN1260222C/zh not_active Expired - Fee Related
- 2002-03-28 AT AT02763877T patent/ATE340789T1/de not_active IP Right Cessation
- 2002-03-28 BR BR0208667-0A patent/BR0208667A/pt not_active IP Right Cessation
- 2002-03-28 EP EP02763877A patent/EP1383757B1/en not_active Expired - Lifetime
-
2003
- 2003-11-18 US US10/716,652 patent/US6998407B2/en not_active Expired - Fee Related
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