JP2005526723A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005526723A5 JP2005526723A5 JP2003567880A JP2003567880A JP2005526723A5 JP 2005526723 A5 JP2005526723 A5 JP 2005526723A5 JP 2003567880 A JP2003567880 A JP 2003567880A JP 2003567880 A JP2003567880 A JP 2003567880A JP 2005526723 A5 JP2005526723 A5 JP 2005526723A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- alkyl
- phenyl
- carboxamide
- pyrazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 18
- -1 aralkoxy Chemical group 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000004076 pyridyl group Chemical group 0.000 claims 11
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 125000003386 piperidinyl group Chemical group 0.000 claims 7
- 125000003373 pyrazinyl group Chemical group 0.000 claims 7
- 125000002541 furyl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000002883 imidazolyl group Chemical group 0.000 claims 6
- 125000000842 isoxazolyl group Chemical group 0.000 claims 6
- 125000002757 morpholinyl group Chemical group 0.000 claims 6
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 6
- 125000002971 oxazolyl group Chemical group 0.000 claims 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims 6
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 6
- 125000000168 pyrrolyl group Chemical group 0.000 claims 6
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- 125000001544 thienyl group Chemical group 0.000 claims 6
- 125000001425 triazolyl group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 125000001786 isothiazolyl group Chemical group 0.000 claims 5
- 125000004193 piperazinyl group Chemical group 0.000 claims 5
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- ZBNXLNQOZROTKK-UHFFFAOYSA-N 1-(3-chlorophenyl)-n-isoquinolin-5-yl-5-methylpyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC=CC(Cl)=C1 ZBNXLNQOZROTKK-UHFFFAOYSA-N 0.000 claims 2
- BJIGPOHHQXLJJG-UHFFFAOYSA-N 1-(3-fluorophenyl)-n-isoquinolin-5-yl-5-methylpyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC=CC(F)=C1 BJIGPOHHQXLJJG-UHFFFAOYSA-N 0.000 claims 2
- JXZCRDUDHXLHSO-UHFFFAOYSA-N 1-[2-chloro-5-(trifluoromethyl)phenyl]-n-isoquinolin-5-yl-5-methylpyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC(C(F)(F)F)=CC=C1Cl JXZCRDUDHXLHSO-UHFFFAOYSA-N 0.000 claims 2
- HESDFBZNGHRRPM-UHFFFAOYSA-N 5-methyl-n-(3-methylisoquinolin-5-yl)-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC(C)=NC=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 HESDFBZNGHRRPM-UHFFFAOYSA-N 0.000 claims 2
- FRCOEAAEFSEYPE-UHFFFAOYSA-N 5-methyl-n-quinolin-3-yl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C=C3C=CC=CC3=NC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 FRCOEAAEFSEYPE-UHFFFAOYSA-N 0.000 claims 2
- QKBBWAFNMUOVAZ-UHFFFAOYSA-N 5-methyl-n-quinolin-5-yl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=CN=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 QKBBWAFNMUOVAZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- RNFRFPSSWGWDKI-UHFFFAOYSA-N benzoquinuclidine Chemical group C12=CC=CC=C2N2CCC1CC2 RNFRFPSSWGWDKI-UHFFFAOYSA-N 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- WEKSTRYBSSDRRD-UHFFFAOYSA-N n-[1-acetyl-3-[(dimethylamino)methyl]-3,4-dihydro-2h-quinolin-7-yl]-4-phenylbenzamide Chemical compound C=1C=C2CC(CN(C)C)CN(C(C)=O)C2=CC=1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 WEKSTRYBSSDRRD-UHFFFAOYSA-N 0.000 claims 2
- RLUXNAPFXSKUES-UHFFFAOYSA-N n-[3-[(dimethylamino)methyl]-1,2,3,4-tetrahydroquinolin-7-yl]-4-phenylbenzamide Chemical compound C=1C=C2CC(CN(C)C)CNC2=CC=1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 RLUXNAPFXSKUES-UHFFFAOYSA-N 0.000 claims 2
- XIROUHIROZWIGD-UHFFFAOYSA-N n-[3-[(dimethylamino)methyl]-1-formyl-3,4-dihydro-2h-quinolin-7-yl]-4-phenylbenzamide Chemical compound C=1C=C2CC(CN(C)C)CN(C=O)C2=CC=1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 XIROUHIROZWIGD-UHFFFAOYSA-N 0.000 claims 2
- OXKVEIRVLVYRGP-UHFFFAOYSA-N n-[3-[(dimethylamino)methyl]-1-methylsulfonyl-3,4-dihydro-2h-quinolin-7-yl]-4-phenylbenzamide Chemical compound C=1C=C2CC(CN(C)C)CN(S(C)(=O)=O)C2=CC=1NC(=O)C(C=C1)=CC=C1C1=CC=CC=C1 OXKVEIRVLVYRGP-UHFFFAOYSA-N 0.000 claims 2
- ULGJQTZESNGVFR-UHFFFAOYSA-N n-isoquinolin-5-yl-1-(3-methoxyphenyl)-5-methylpyrazole-3-carboxamide Chemical compound COC1=CC=CC(N2C(=CC(=N2)C(=O)NC=2C3=CC=NC=C3C=CC=2)C)=C1 ULGJQTZESNGVFR-UHFFFAOYSA-N 0.000 claims 2
- CPNKPIYIMJJWTI-UHFFFAOYSA-N n-isoquinolin-5-yl-5-methyl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 CPNKPIYIMJJWTI-UHFFFAOYSA-N 0.000 claims 2
- DZXOOWSJLLMRJJ-UHFFFAOYSA-N 5-amino-n-isoquinolin-5-yl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound NC1=CC(C(=O)NC=2C3=CC=NC=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 DZXOOWSJLLMRJJ-UHFFFAOYSA-N 0.000 claims 1
- BUZFNXOUWRSUBK-UHFFFAOYSA-N 5-methyl-n-quinolin-8-yl-1-[3-(trifluoromethyl)phenyl]pyrazole-3-carboxamide Chemical compound CC1=CC(C(=O)NC=2C3=NC=CC=C3C=CC=2)=NN1C1=CC=CC(C(F)(F)F)=C1 BUZFNXOUWRSUBK-UHFFFAOYSA-N 0.000 claims 1
- 230000008485 antagonism Effects 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- SJDMUMDEWSBHIX-UHFFFAOYSA-N n-[3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-1h-quinolin-7-yl]-4-phenylpiperazine-1-carboxamide Chemical compound C1=C2NC(=O)C(CCN(CC)CC)=C(C)C2=CC=C1NC(=O)N(CC1)CCN1C1=CC=CC=C1 SJDMUMDEWSBHIX-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0203677A GB0203677D0 (en) | 2002-02-15 | 2002-02-15 | Novel compounds |
| GB0203673A GB0203673D0 (en) | 2002-02-15 | 2002-02-15 | Novel compounds |
| GB0203680A GB0203680D0 (en) | 2002-02-15 | 2002-02-15 | Novel compounds |
| GB0209003A GB0209003D0 (en) | 2002-04-19 | 2002-04-19 | Novel compounds |
| GB0209032A GB0209032D0 (en) | 2002-04-19 | 2002-04-19 | Novel compounds |
| GB0209035A GB0209035D0 (en) | 2002-04-19 | 2002-04-19 | Novel compounds |
| GB0221318A GB0221318D0 (en) | 2002-09-13 | 2002-09-13 | Novel compounds |
| PCT/GB2003/000608 WO2003068749A1 (en) | 2002-02-15 | 2003-02-13 | Vanilloid receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005526723A JP2005526723A (ja) | 2005-09-08 |
| JP2005526723A5 true JP2005526723A5 (enExample) | 2006-03-09 |
Family
ID=27739514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003567880A Pending JP2005526723A (ja) | 2002-02-15 | 2003-02-13 | バニロイド受容体モジュレーター |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7538121B2 (enExample) |
| EP (2) | EP2033953A1 (enExample) |
| JP (1) | JP2005526723A (enExample) |
| AR (1) | AR038420A1 (enExample) |
| AT (1) | ATE416168T1 (enExample) |
| AU (1) | AU2003245773A1 (enExample) |
| DE (1) | DE60325025D1 (enExample) |
| ES (1) | ES2316777T3 (enExample) |
| TW (1) | TW200403223A (enExample) |
| WO (1) | WO2003068749A1 (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2033951A3 (en) | 2002-02-01 | 2009-12-23 | Euro-Celtique S.A. | 2-Piperazine-pyridines useful for treating pain |
| US6974818B2 (en) | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| US6984647B2 (en) | 2002-05-17 | 2006-01-10 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid VR1 receptor |
| IL165862A0 (en) | 2002-06-28 | 2006-01-15 | Euro Celtique Sa | Therapeutic piperazine derivatives useful for tre ating pain |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| GB0221157D0 (en) * | 2002-09-12 | 2002-10-23 | Glaxo Group Ltd | Novel treatment |
| US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| GB0226724D0 (en) * | 2002-11-15 | 2002-12-24 | Merck Sharp & Dohme | Therapeutic agents |
| DK1569896T3 (da) | 2002-12-06 | 2007-12-10 | Xention Ltd | Tetrahydronaphthalenderivater |
| US7544716B2 (en) * | 2002-12-09 | 2009-06-09 | Xention Limited | Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists |
| WO2004056774A2 (en) * | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| ATE556067T1 (de) | 2003-05-20 | 2012-05-15 | Ajinomoto Kk | Modulatoren des vanilloid rezeptors |
| KR20060027338A (ko) | 2003-06-12 | 2006-03-27 | 아스텔라스세이야쿠 가부시키가이샤 | 벤즈 아미드 유도체 또는 그 염 |
| MY142655A (en) | 2003-06-12 | 2010-12-15 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| HRP20110180T1 (hr) * | 2003-07-23 | 2011-04-30 | Synta Pharmaceuticals Corporation | Spojevi za upotrebu kod upala i upotrebe vezane uz imunitet |
| SI1867644T1 (sl) | 2003-07-24 | 2009-10-31 | Euro Celtique Sa | Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine |
| GB0319150D0 (en) | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| GB0319151D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| PL1664016T3 (pl) * | 2003-09-22 | 2009-04-30 | Euro Celtique Sa | Środki terapeutyczne przydatne do leczenia bólu |
| EP2017276B1 (en) | 2003-09-22 | 2011-01-19 | Euro-Celtique S.A. | Phenyl-carboxamide compounds useful for treating pain |
| US7615557B2 (en) | 2003-10-01 | 2009-11-10 | Xention Limited | Tetrahydro-naphthalene and urea derivatives |
| JP2007525482A (ja) * | 2003-10-07 | 2007-09-06 | レノビス， インコーポレイテッド | イオンチャネルリガンドとしてのアミド化合物およびその使用 |
| WO2005046683A1 (en) | 2003-10-07 | 2005-05-26 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| GB2413129A (en) * | 2003-10-07 | 2005-10-19 | Renovis Inc | Aromatic amide compounds as ion channel ligands and uses thereof |
| US7544803B2 (en) | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| US20050165028A1 (en) * | 2004-01-23 | 2005-07-28 | Norman Mark H. | Vanilloid receptor ligands and their use in treatments |
| WO2006004793A2 (en) * | 2004-06-28 | 2006-01-12 | Janssen Pharmaceutica Nv | Hetero isonipecotic modulators of vanilloid vr1 receptor |
| EP1775283A4 (en) * | 2004-07-14 | 2008-12-10 | Japan Tobacco Inc | 3-AMINOBENZAMIDE COMPOUND AND INHIBITORS OF THE ACTIVITY OF VANILLOID RECEPTOR 1 (VR1) |
| EP1777225A4 (en) * | 2004-07-15 | 2009-06-24 | Japan Tobacco Inc | FUSED BENZAMIDE COMPOUND AND INHIBITOR OF VANILLOID RECEPTOR 1 (VR1) ACTIVITY |
| WO2006058338A2 (en) * | 2004-11-29 | 2006-06-01 | Janssen Pharmaceutica N.V. | 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor |
| FR2880625B1 (fr) * | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| KR20060087386A (ko) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| FR2888848B1 (fr) * | 2005-07-22 | 2007-09-28 | Sanofi Aventis Sa | Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2888847B1 (fr) * | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| KR101136183B1 (ko) * | 2005-07-22 | 2012-04-17 | 모찌다 세이야쿠 가부시끼가이샤 | 신규 헤테로시클리덴 아세트아미드 유도체 |
| TW200738680A (en) | 2005-08-04 | 2007-10-16 | Hoffmann La Roche | Phenylpyridine derivatives, their manufacture and use as pharmaceutical agents |
| US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
| DE102005059479A1 (de) * | 2005-12-13 | 2007-06-14 | Merck Patent Gmbh | Hydroxychinolinderivate |
| TW200736227A (en) | 2005-12-23 | 2007-10-01 | Astrazeneca Ab | New compounds III |
| EP1967519B1 (en) | 2005-12-28 | 2012-09-05 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compound and inhibitor of vanilloid receptor type 1 (vr1) activity |
| US7906508B2 (en) * | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| US8546579B2 (en) | 2006-03-16 | 2013-10-01 | Evotec (Us) Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| KR20090008286A (ko) * | 2006-03-27 | 2009-01-21 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 키나제 억제제로서의 피리딜- 및 피리미디닐-치환된 피롤-,티오펜- 및 푸란- 유도체 |
| JP2009542798A (ja) * | 2006-07-11 | 2009-12-03 | ファイザー株式会社 | 置換ｎ−二環式アルキル二環式カルボキシアミド化合物 |
| TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| DE602007008742D1 (de) | 2006-09-15 | 2010-10-07 | Pfizer | Substituierte pyridylmethylbicyclocarboxyamidverbindungen |
| EP2222631B1 (en) * | 2006-10-23 | 2011-08-17 | Pfizer Inc. | Substituted phenylmethyl bicyclocarboxyamide compounds |
| WO2008057300A2 (en) * | 2006-10-27 | 2008-05-15 | Redpoint Bio Corporation | Trpvi antagonists and uses thereof |
| CA2669915C (en) | 2006-11-17 | 2012-02-07 | Pfizer Inc. | Substituted bicyclocarboxyamide compounds |
| FR2910473B1 (fr) | 2006-12-26 | 2009-02-13 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique. |
| US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| FR2911605B1 (fr) | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique |
| FR2911604B1 (fr) * | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| PE20081692A1 (es) * | 2007-01-24 | 2008-12-18 | Mochida Pharm Co Ltd | Nuevo derivado de heterocicliden acetamida |
| US20080186971A1 (en) * | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
| CA2685121A1 (en) | 2007-04-27 | 2008-11-06 | Purdue Pharma L.P. | Therapeutic agents useful for treating pain |
| DK2142529T3 (da) * | 2007-04-27 | 2014-02-10 | Purdue Pharma Lp | Trpv1-antagonister og anvendelser deraf |
| CA2709879A1 (en) * | 2007-12-19 | 2009-06-25 | The Scripps Research Institute | Anilides and analogs as rho kinase inhibitors |
| WO2009079011A1 (en) * | 2007-12-19 | 2009-06-25 | The Scripps Research Institute | Benzimidazoles and analogs as rho kinase inhibitors |
| CA2709918A1 (en) * | 2007-12-21 | 2009-06-25 | The Scripps Research Institute | Benzopyrans and analogs as rho kinase inhibitors |
| FR2926554B1 (fr) | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| FR2926553B1 (fr) * | 2008-01-23 | 2010-02-19 | Sanofi Aventis | Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique |
| US8362012B2 (en) | 2008-04-18 | 2013-01-29 | Daewoong Pharmaceutical Co., Ltd. | Benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| ES2834451T3 (es) | 2009-05-01 | 2021-06-17 | Aerie Pharmaceuticals Inc | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
| US8686009B2 (en) | 2009-06-25 | 2014-04-01 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds |
| AU2010266018B2 (en) | 2009-06-25 | 2014-01-09 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
| JP2013525448A (ja) | 2010-04-27 | 2013-06-20 | カルシメディカ，インク． | 細胞内カルシウムを調節する化合物 |
| CA2802733C (en) | 2010-06-24 | 2017-11-21 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| KR101293384B1 (ko) | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| MX358344B (es) | 2011-03-18 | 2018-08-15 | Alkermes Pharma Ireland Ltd | Composiciones farmaceuticas que comprenden un antipsicotico insoluble en agua y esteres de sorbitan. |
| SG10201605163PA (en) | 2011-06-22 | 2016-08-30 | Purdue Pharma Lp | Trpv1 antagonists including dihydroxy substituent and uses thereof |
| WO2013088255A1 (en) | 2011-12-15 | 2013-06-20 | Alkermes Pharma Ireland Limited | Prodrugs of secondary amine compounds |
| FR2984323B1 (fr) * | 2011-12-16 | 2019-08-30 | L'oreal | Coupleur de structure 7 amino-1,2,3,4-tetrahydroquinoleines, composition tinctoriale en comprenant, procedes et utilisations |
| FR2984318B1 (fr) | 2011-12-16 | 2014-06-27 | Oreal | Coupleur de structure 7 amino-1,2,3,4-tetrahydroquinoleines cationiques, composition tinctoriale en comprenant, procedes et utilisations |
| AU2013235523B9 (en) | 2012-03-19 | 2018-01-04 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising glycerol esters |
| NZ630428A (en) | 2012-03-19 | 2017-02-24 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising benzyl alcohol |
| EP2827868B8 (en) | 2012-03-19 | 2019-12-18 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising fatty acid esters |
| WO2014080285A2 (en) | 2012-09-19 | 2014-05-30 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
| US8987461B2 (en) | 2012-12-06 | 2015-03-24 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| EP2976080B1 (en) | 2013-03-15 | 2019-12-25 | Aerie Pharmaceuticals, Inc. | Conjugates of isoquinoline compounds and prostaglandins |
| CN110368360A (zh) | 2014-03-20 | 2019-10-25 | 奥克梅斯制药爱尔兰有限公司 | 具有增加的注射速度的阿立哌唑制剂 |
| US10112939B2 (en) | 2014-08-21 | 2018-10-30 | Bristol-Myers Squibb Company | Tied-back benzamide derivatives as potent rock inhibitors |
| JP2017214290A (ja) * | 2014-09-12 | 2017-12-07 | 田辺三菱製薬株式会社 | 芳香族カルボン酸アミド化合物 |
| MX2019002396A (es) | 2016-08-31 | 2019-07-08 | Aerie Pharmaceuticals Inc | Composiciones oftalmicas. |
| WO2018085348A1 (en) * | 2016-11-03 | 2018-05-11 | Actavalon, Inc. | Substituted quinolines and methods for treating cancer |
| US9840468B1 (en) | 2016-12-30 | 2017-12-12 | Aerie Pharmaceuticals, Inc. | Methods for the preparation of 6-aminoisoquinoline |
| IT201700028127A1 (it) | 2017-03-14 | 2018-09-14 | Fondazione St Italiano Tecnologia | Composti e composizioni per il trattamento della fibrosi cistica |
| JP2020515583A (ja) | 2017-03-31 | 2020-05-28 | アエリエ ファーマシューティカルズ インコーポレイテッド | アリールシクロプロピル−アミノ−イソキノリニルアミド化合物 |
| FR3072286B1 (fr) | 2017-10-13 | 2022-08-12 | Oreal | 7-amino-1,2,3,4-tetrahydroquinoleines particuliers, procede et composition |
| WO2019173230A1 (en) | 2018-03-05 | 2019-09-12 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN112574106B (zh) * | 2020-11-11 | 2022-04-12 | 苏州康润医药有限公司 | 7-氨基-5-溴喹啉的合成方法 |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3200123A (en) * | 1962-01-26 | 1965-08-10 | Richardson Merreil Inc | Imidazoquinolines |
| US3424761A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| JPS4824396B1 (enExample) * | 1970-09-09 | 1973-07-20 | ||
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4456604A (en) | 1981-05-26 | 1984-06-26 | Merck & Co., Inc. | 1-(3-Halo-2-pyridinyl) piperazine |
| EP0130795B1 (en) | 1983-07-05 | 1988-11-23 | Pfizer Inc. | Carboxylic acid derivatives useful for inhibiting the degradation of cartilage |
| US4803162A (en) * | 1984-05-15 | 1989-02-07 | Fluorodiagnostic Limited Partners | Composition, article and process for detecting a microorganism |
| EP0266949B1 (en) | 1986-10-28 | 1990-11-28 | Smith Kline & French Laboratories Limited | Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists |
| DE3701277A1 (de) * | 1987-01-17 | 1988-07-28 | Boehringer Mannheim Gmbh | Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| ATE113205T1 (de) | 1988-06-17 | 1994-11-15 | Procter & Gamble | Anwendung von vanillin-derivaten zur herstellung eines arzneimittels zur behandlung von herpes simplex-infektion. |
| HU206082B (en) | 1988-12-23 | 1992-08-28 | Sandoz Ag | Process for producing capsaicin derivatives and pharmaceutical compositions comprising such compounds |
| CA2017383A1 (en) | 1989-06-08 | 1990-12-08 | Raymond R. Martodam | Use of vanilloids for the treatment of respiratory diseases or disorders |
| WO1992009285A1 (en) | 1990-11-27 | 1992-06-11 | The Procter & Gamble Company | Combinations of vanilloid compounds and phosphonate antiviral compounds for treatment of herpes infections |
| US5342851A (en) | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
| DE4234295A1 (de) | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| WO1994014801A1 (en) | 1992-12-29 | 1994-07-07 | Smithkline Beecham Plc | Heterocyclic urea derivatives as 5ht2c and 5ht2b antagonists |
| DK0765314T3 (da) | 1994-06-15 | 2003-08-25 | Otsuka Pharma Co Ltd | Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer |
| GB9416972D0 (en) | 1994-08-23 | 1994-10-12 | Smithkline Beecham Plc | Carbon side chain/indole/indolene |
| EP0832069B1 (en) * | 1995-06-07 | 2003-03-05 | Pfizer Inc. | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
| TW280869B (en) | 1995-07-17 | 1996-07-11 | Philips Electronics Nv | IDDQ-testing of bias generator circuit |
| BR9509297A (pt) | 1995-08-10 | 1998-07-07 | Astra Ab | Composto composição farmacêutica utilização de um composto e processos de tratamento ou prolifaxia de uma doença ou condição na qual a síntese ou suprasintese da sintetase de óxido nitrico forma uma parte contribuinte e desordens neurodegenerativas ou de enxaqueca ou de prevenção e reversão da tolerância a opiatos e diazepinas ou de tratamento do vicio em tóxicos e de preparação de um composto |
| US6323227B1 (en) | 1996-01-02 | 2001-11-27 | Aventis Pharmaceuticals Products Inc. | Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| GB9605883D0 (en) | 1996-03-20 | 1996-05-22 | Smithkline Beecham Plc | Novel compounds |
| CA2249650A1 (en) | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| TR199802284T2 (xx) | 1996-05-11 | 2000-05-22 | Smithkline Beecham P.L.C. | Dopamin D3 resept�rlerinin mod�lat�rleri olarak tetrahidroizokuinolin t�revleri. |
| CZ416498A3 (cs) * | 1996-06-17 | 1999-06-16 | Smithkline Beecham Plc | Substituovaný benzamidový derivát a jeho použití jako antikonvulsantu |
| US5854245A (en) | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| JP3690423B2 (ja) | 1997-03-18 | 2005-08-31 | スミスクライン ビーチャム パブリック リミテッド カンパニー | 置換イソキノリン誘導体およびその抗痙攣薬としての使用 |
| AUPO622597A0 (en) * | 1997-04-15 | 1997-05-08 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
| AU732863B2 (en) * | 1997-04-18 | 2001-05-03 | Smithkline Beecham Plc | Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity |
| AU7526798A (en) | 1997-04-18 | 1998-11-27 | Smithkline Beecham Plc | Acetamide and urea derivatives, process for their preparation and their use in the treatment of cns disorders |
| JP2001508402A (ja) * | 1997-06-13 | 2001-06-26 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 置換ベンズアミド誘導体およびそれらの抗痙攣薬としての使用 |
| EP1025087A1 (en) * | 1997-10-24 | 2000-08-09 | Smithkline Beecham Plc | Substituted isoquinoline derivatives and their use as anticonvulsants |
| JP3013989B2 (ja) * | 1998-03-26 | 2000-02-28 | 日本たばこ産業株式会社 | アミド誘導体及びノシセプチンアンタゴニスト |
| EP1102535A4 (en) | 1998-07-28 | 2004-09-29 | Smithkline Beecham Corp | COMPOUNDS AND METHODS |
| GB9817424D0 (en) | 1998-08-11 | 1998-10-07 | Smithkline Beecham Plc | Novel compounds |
| IL142388A0 (en) | 1998-10-08 | 2002-03-10 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| AU778393B2 (en) * | 1999-05-12 | 2004-12-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
| HK1048635A1 (zh) * | 1999-06-02 | 2003-04-11 | Nps药物有限公司 | 代谢移变的谷氨酸盐受体拮抗剂和它们治疗中枢神经系统疾病的用途 |
| WO2001021577A2 (en) * | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
| CA2325358C (en) * | 1999-11-10 | 2005-08-02 | Pfizer Products Inc. | 7-¬(4'-trifluoromethyl-biphenyl-2-carbonyl)amino|-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein b |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| JP2002241274A (ja) * | 2000-04-28 | 2002-08-28 | Takeda Chem Ind Ltd | メラニン凝集ホルモン拮抗剤 |
| CN1324845A (zh) | 2000-05-24 | 2001-12-05 | 上海博德基因开发有限公司 | 一种新的多肽——人蛋白合成起始因子2β亚单位16.5和编码这种多肽的多核苷酸 |
| AU8066701A (en) | 2000-07-20 | 2002-02-05 | Neurogen Corp | Capsaicin receptor ligands |
| US6500840B2 (en) | 2000-08-21 | 2002-12-31 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| KR100564902B1 (ko) | 2000-08-21 | 2006-03-30 | 주식회사 태평양 | 신규 티오우레아 유도체 및 이를 함유하는 약제학적 조성물 |
| JP2004506714A (ja) | 2000-08-21 | 2004-03-04 | パシフィック コーポレーション | 新規チオ尿素化合物及びこれを含有する薬学的組成物 |
| KR100453080B1 (ko) | 2000-08-21 | 2004-10-15 | 주식회사 태평양 | 신규 티오카르밤산 유도체 및 이를 함유하는 약제학적조성물 |
| UY26942A1 (es) | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| HUP0400390A2 (hu) * | 2001-07-02 | 2004-09-28 | Akzo Nobel N.V. | Tetrahidrokinolin-származékok és ezeket tartalmazó gyógyszerkészítmények |
| JP4408618B2 (ja) * | 2001-10-25 | 2010-02-03 | 武田薬品工業株式会社 | キノリン化合物 |
| US7084156B2 (en) * | 2001-11-27 | 2006-08-01 | Merck & Co., Inc. | 2-Aminoquinoline compounds |
| CA2468159A1 (en) * | 2001-11-27 | 2003-06-05 | Merck & Co., Inc. | 4-aminoquinoline compounds |
| CA2476936A1 (en) * | 2002-02-20 | 2003-08-28 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor |
-
2003
- 2003-02-13 WO PCT/GB2003/000608 patent/WO2003068749A1/en not_active Ceased
- 2003-02-13 AT AT03739564T patent/ATE416168T1/de not_active IP Right Cessation
- 2003-02-13 DE DE60325025T patent/DE60325025D1/de not_active Expired - Lifetime
- 2003-02-13 US US10/503,648 patent/US7538121B2/en not_active Expired - Fee Related
- 2003-02-13 TW TW092102941A patent/TW200403223A/zh unknown
- 2003-02-13 JP JP2003567880A patent/JP2005526723A/ja active Pending
- 2003-02-13 ES ES03739564T patent/ES2316777T3/es not_active Expired - Lifetime
- 2003-02-13 AR ARP030100474A patent/AR038420A1/es unknown
- 2003-02-13 EP EP08170191A patent/EP2033953A1/en not_active Withdrawn
- 2003-02-13 AU AU2003245773A patent/AU2003245773A1/en not_active Abandoned
- 2003-02-13 EP EP03739564A patent/EP1480954B1/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005526723A5 (enExample) | ||
| CN101679287B (zh) | 烟碱型乙酰胆碱受体调节剂 | |
| RU2454405C2 (ru) | Производные 3-пиридинкарбоксамида и 2-пиразинкарбоксамида в качестве агентов, повышающих уровень лвп-холестерина | |
| JP2021011495A5 (enExample) | ||
| JP2007519754A5 (enExample) | ||
| JP2018530571A5 (enExample) | ||
| JP2008513516A5 (enExample) | ||
| JP2006524222A5 (enExample) | ||
| HRP20230201T1 (hr) | Oksadiazol aminski spojevi derivati kao inhibitor histonske deacetilaze 6 i farmaceutska kompozicija koja sadrži iste | |
| JP2014511869A5 (enExample) | ||
| JP2010505832A5 (enExample) | ||
| AR038420A1 (es) | Compuesto de amida, procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende | |
| CN1152870A (zh) | 杂环化合物作为多巴胺d3配位体的用途 | |
| JP2012503018A5 (enExample) | ||
| JP2009537542A5 (enExample) | ||
| JP2008538557A (ja) | 神経治療アゾール化合物 | |
| JP2010506918A5 (enExample) | ||
| JP2005527542A5 (enExample) | ||
| JP2011517443A5 (enExample) | ||
| WO2005007651A1 (ja) | ２-アシルアミノチアゾール誘導体又はその塩 | |
| JP2004507527A5 (enExample) | ||
| RU2015116816A (ru) | Производное имидазола | |
| WO2014180165A1 (zh) | 苯并异噻唑类化合物及在制备抗精神分裂症药物中的应用 | |
| CA2529126A1 (en) | Azetidine compounds | |
| JP2005505583A5 (enExample) |