JP2005505583A5 - - Google Patents
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- Publication number
- JP2005505583A5 JP2005505583A5 JP2003532465A JP2003532465A JP2005505583A5 JP 2005505583 A5 JP2005505583 A5 JP 2005505583A5 JP 2003532465 A JP2003532465 A JP 2003532465A JP 2003532465 A JP2003532465 A JP 2003532465A JP 2005505583 A5 JP2005505583 A5 JP 2005505583A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- carbamoylphenyl
- ylidene
- benzamide
- diethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- -1 CF 3 Chemical group 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 208000020431 spinal cord injury Diseases 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- OHVDEDNAKONCCN-UHFFFAOYSA-N 3-[[4-(diethylcarbamoyl)phenyl]-piperidin-4-ylidenemethyl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(C=CC=1)C(N)=O)=C1CCNCC1 OHVDEDNAKONCCN-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000016702 sympathetic nervous system disease Diseases 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0103313A SE0103313D0 (sv) | 2001-10-03 | 2001-10-03 | Novel compounds |
| PCT/SE2002/001804 WO2003029215A1 (en) | 2001-10-03 | 2002-10-02 | 4[piperidin-4-yliden-(3-carbamoylphenyl)methyl] benzamide derivatives and their use for the treatment of pain, spinal injuries or gastrointestinal disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005505583A JP2005505583A (ja) | 2005-02-24 |
| JP2005505583A5 true JP2005505583A5 (enExample) | 2006-01-05 |
Family
ID=20285553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532465A Abandoned JP2005505583A (ja) | 2001-10-03 | 2002-10-02 | ４［ピペリジン−４−イリデン−（３−カルバモイルフェニル）メチル］ベンズアミド誘導体、および疼痛、脊髄損傷または胃腸疾患の治療のためのその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7205317B2 (enExample) |
| EP (1) | EP1440060A1 (enExample) |
| JP (1) | JP2005505583A (enExample) |
| KR (1) | KR20040039469A (enExample) |
| CN (1) | CN1692100A (enExample) |
| AR (1) | AR036649A1 (enExample) |
| BR (1) | BR0212959A (enExample) |
| CA (1) | CA2460168A1 (enExample) |
| CO (1) | CO5580822A2 (enExample) |
| HU (1) | HUP0401915A2 (enExample) |
| IL (1) | IL160889A0 (enExample) |
| IS (1) | IS7203A (enExample) |
| MX (1) | MXPA04003056A (enExample) |
| NO (1) | NO20041964L (enExample) |
| PL (1) | PL368804A1 (enExample) |
| RU (1) | RU2004107854A (enExample) |
| SE (1) | SE0103313D0 (enExample) |
| WO (1) | WO2003029215A1 (enExample) |
| ZA (1) | ZA200402514B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1395567E (pt) | 2001-05-18 | 2009-03-26 | Astrazeneca Ab | Derivados de 4(fenil-piperazinil-metil)benzamida e sua utilização para o tratamento da ansiedade da dor ou de distúrbios gastrointestinais |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| EP1572029B1 (en) | 2002-11-07 | 2010-03-24 | Abbott Laboratories | Method of loading beneficial agent to a prosthesis by fluid-jet application |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
| RU2005136524A (ru) * | 2003-05-16 | 2006-06-27 | Астразенека Аб (Se) | Производные диарилметилиденпиперидина, способы их получения и их применение |
| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| AU2004253898A1 (en) * | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
| NZ546834A (en) | 2003-10-01 | 2010-03-26 | Adolor Corp | Spirocyclic heterocyclic derivatives and methods of their use |
| AU2005222719B2 (en) | 2004-03-19 | 2011-03-24 | Abbott Laboratories | Multiple drug delivery from a balloon and a prosthesis |
| US20100030183A1 (en) | 2004-03-19 | 2010-02-04 | Toner John L | Method of treating vascular disease at a bifurcated vessel using a coated balloon |
| KR101234421B1 (ko) | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| WO2008033299A2 (en) | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of n-containing spirocompounds for the enhancement of cognitive function |
| CA2970256C (en) * | 2014-12-19 | 2022-03-29 | Pharmnovo Ab | Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists |
| WO2016099394A1 (en) * | 2014-12-19 | 2016-06-23 | Pharmnovo Ab | Novel selective delta-opioid receptor agonists useful for the treatment of pain, anxiety and depression. |
| WO2022013153A1 (en) * | 2020-07-17 | 2022-01-20 | Pharmnovo Ab | Polymorphs of a hydrochloride salt of pn6047 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| EP1049676B1 (en) | 1997-12-24 | 2005-10-12 | Ortho-Mcneil Pharmaceutical, Inc. | 4- aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0001208D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-10-03 SE SE0103313A patent/SE0103313D0/xx unknown
-
2002
- 2002-09-27 AR ARP020103670A patent/AR036649A1/es unknown
- 2002-10-02 BR BR0212959-0A patent/BR0212959A/pt not_active Application Discontinuation
- 2002-10-02 CA CA002460168A patent/CA2460168A1/en not_active Abandoned
- 2002-10-02 EP EP02775640A patent/EP1440060A1/en not_active Withdrawn
- 2002-10-02 CN CNA028195825A patent/CN1692100A/zh active Pending
- 2002-10-02 JP JP2003532465A patent/JP2005505583A/ja not_active Abandoned
- 2002-10-02 MX MXPA04003056A patent/MXPA04003056A/es unknown
- 2002-10-02 HU HU0401915A patent/HUP0401915A2/hu unknown
- 2002-10-02 KR KR10-2004-7004780A patent/KR20040039469A/ko not_active Withdrawn
- 2002-10-02 WO PCT/SE2002/001804 patent/WO2003029215A1/en not_active Ceased
- 2002-10-02 RU RU2004107854/04A patent/RU2004107854A/ru not_active Application Discontinuation
- 2002-10-02 US US10/491,263 patent/US7205317B2/en not_active Expired - Fee Related
- 2002-10-02 PL PL02368804A patent/PL368804A1/xx not_active Application Discontinuation
- 2002-10-02 IL IL16088902A patent/IL160889A0/xx unknown
-
2004
- 2004-03-30 ZA ZA200402514A patent/ZA200402514B/xx unknown
- 2004-03-31 CO CO04030712A patent/CO5580822A2/es not_active Application Discontinuation
- 2004-03-31 IS IS7203A patent/IS7203A/is unknown
- 2004-04-27 NO NO20041964A patent/NO20041964L/no not_active Application Discontinuation
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