RU2002114343A - Новые соединения - Google Patents

Новые соединения

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Publication number
RU2002114343A
RU2002114343A RU2002114343/04A RU2002114343A RU2002114343A RU 2002114343 A RU2002114343 A RU 2002114343A RU 2002114343/04 A RU2002114343/04 A RU 2002114343/04A RU 2002114343 A RU2002114343 A RU 2002114343A RU 2002114343 A RU2002114343 A RU 2002114343A
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Prior art keywords
compound
formula
compound according
therapy
methyl
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RU2002114343/04A
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RU2258703C2 (ru
Inventor
Уиль м БРАУН (CA)
Уильям БРАУН
Кристофер УОЛПОЛ (CA)
Кристофер Уолпол
Никлас ПЛОБЕК (CA)
Никлас ПЛОБЕК
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Астразенека Аб (Se)
Астразенека Аб
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P23/00—Anaesthetics
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Liquid Crystal (AREA)
  • Furan Compounds (AREA)

Claims (18)

1. Соединение формулы
Figure 00000001
где R1 выбран из (1) фенила; (2) пиридинила
Figure 00000002
(3) тиофенила
Figure 00000003
(4) фуранила
Figure 00000004
(5) имидазолила
Figure 00000005
(6) триазолилиа
Figure 00000006
где каждое фенильное кольцо R1 и гетероароматическое кольцо R1 может быть возможно и независимо дополнительно замещено 1, 2 или 3 заместителями, выбранными из прямого и разветвленного C1-С6алкила, NO2, CF3, C1-С6алкокси, хлоро, фторо, бромо и йодо, замещения на фенильном кольце и на гетероароматическом кольце могут иметь место в любом положении на указанных кольцевых системах,
а также его фармацевтически приемлемые соли и его изомеры.
2. Соединение по п.1, где возможный(ые) заместитель(ли) на ароматическом или гетероароматическом кольце(ах) выбран(ы) любой из NO2, изобутила, CF3, метокси, метила или хлоро.
3. Соединение по п.1 или 2, выбранное из любого из
4-[(4-бензил-1-пиперазинил)(2,2-диметил-2,3-дигидро-1-бензофуран-7-ил)метил]-N,N-диэтилбензамида дигидрохлорида (соединение 6);
4-{(2,2-диметил-2,3-дигидро-1-бензофуран-7-ил)[4-(4-йодбензил)-1-пиперазинил]метил}-N,N-диэтилбензамида дигидрохлорида (соединение 7);
4-{(2,2-диметил-2,3-дигидро-1-бензофуран-7-ил)[4-(3-пиридинилметил)-1-пиперазинил]метил}-N,N-диэтилбензамида дигидрохлорида (соединение 8) и
4-{(2,2-диметил-2,3-дигидро-1-бензофуран-7-ил)[4-(2-пиридинилметил)-1-пиперазинил]метил}-N,N-диэтилбензамида дитрифторацетата (соединение 9).
4. Соединение по любому из пп.1-3, которое находится в виде (+)-энантиомера.
5. Соединение по любому из пп.1-3, которое находится в виде (-)-энантиомера.
6. Соединение по любому из пп.1-5 в форме его солей гидрохлорида, сульфата, тартрата или цитрата.
7. Соединение по любому из пп.1-6 для применения в терапии.
8. Соединение по п.7, где терапия представляет собой устранение боли.
9. Соединение по п.7, где терапия направлена на желудочно-кишечные расстройства.
10. Соединение по п.7, где терапия направлена на повреждения спинного мозга.
11. Соединение по п.7, где терапия направлена на расстройства симпатической нервной системы.
12. Применение соединения формулы I по п.1 для производства лекарства для применения при лечении боли.
13. Применение соединения формулы I по п.1 для производства лекарства для применения при лечении желудочно-кишечных расстройств.
14. Применение соединения формулы I по п.1 для производства лекарства для применения при лечении повреждений спинного мозга.
15. Фармацевтическая композиция, содержащая соединение формулы I по п.1 в качестве активного ингредиента вместе с фармакологически и фармацевтически приемлемым носителем.
16. Способ лечения боли, при котором субъекту, нуждающемуся в устранении боли, вводят эффективное количество соединения формулы I по п.1.
17. Способ лечения желудочно-кишечных расстройств, при котором субъекту, страдающему указанным желудочно-кишечным расстройством, вводят эффективное количество соединения формулы I по п.1.
18. Способ лечения повреждений спинного мозга, при котором субъекту, страдающему указанным повреждением спинного мозга, вводят эффективное количество соединения формулы I по п.1.
RU2002114343/04A 1999-12-20 2000-12-15 Новые соединения RU2258703C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9904674A SE9904674D0 (sv) 1999-12-20 1999-12-20 Novel compounds
SE9904674-0 1999-12-20

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RU2002114343A true RU2002114343A (ru) 2004-01-10
RU2258703C2 RU2258703C2 (ru) 2005-08-20

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US (2) US6680318B2 (ru)
EP (1) EP1242410B1 (ru)
JP (1) JP2003522741A (ru)
KR (2) KR100769814B1 (ru)
CN (1) CN1608064A (ru)
AT (1) ATE275143T1 (ru)
AU (1) AU780799B2 (ru)
BG (1) BG65457B1 (ru)
BR (1) BR0016591A (ru)
CA (1) CA2395300A1 (ru)
CZ (1) CZ20022124A3 (ru)
DE (1) DE60013486T2 (ru)
DK (1) DK1242410T3 (ru)
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HK (1) HK1048308B (ru)
HU (1) HUP0300020A3 (ru)
IL (2) IL150125A0 (ru)
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NO (1) NO322432B1 (ru)
NZ (1) NZ519986A (ru)
PL (1) PL356780A1 (ru)
PT (1) PT1242410E (ru)
RU (1) RU2258703C2 (ru)
SE (1) SE9904674D0 (ru)
SI (1) SI1242410T1 (ru)
SK (1) SK8832002A3 (ru)
UA (1) UA71650C2 (ru)
WO (1) WO2001046174A1 (ru)
ZA (1) ZA200204255B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067950A1 (en) * 1998-07-27 2004-04-08 Schering-Plough Corporation High affinity ligands for nociceptin receptor ORL-1
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
KR100885100B1 (ko) * 2001-05-18 2009-02-20 아스트라제네카 아베 4(페닐-피페라지닐-메틸)벤즈아미드 유도체 및 통증,불안증 또는 위장관 장애 치료를 위한 이들의 용도
CN1596113B (zh) * 2001-10-29 2010-05-26 蒙特库克生物科学公司 δ受体激动剂化合物在制备治疗抑郁症的药物中的应用
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0301441D0 (sv) * 2003-05-16 2003-05-16 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
ES2456705T3 (es) 2003-12-12 2014-04-23 Eli Lilly & Company Antagonistas de receptores opioides
SE0400027D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
DK1781631T3 (da) * 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
EP1856076A1 (en) * 2005-02-28 2007-11-21 AstraZeneca AB Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
GB0606876D0 (en) * 2006-04-05 2006-05-17 Glaxo Group Ltd Compounds
KR20110018317A (ko) * 2008-05-20 2011-02-23 아스트라제네카 아베 불안성 주요 우울 장애의 치료 방법

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH583713A5 (ru) 1973-06-29 1977-01-14 Cermol Sa
DE2900810A1 (de) 1979-01-11 1980-07-24 Cassella Ag Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
IT1140978B (it) 1980-05-23 1986-10-10 Selvi & C Spa 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche
GB8320701D0 (en) 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
IT1196150B (it) 1984-06-19 1988-11-10 Poli Ind Chimica Spa Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono
SE8500573D0 (sv) 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
US5028610A (en) 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
US4829065A (en) 1987-04-24 1989-05-09 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US4826844A (en) 1987-09-30 1989-05-02 American Home Products Corporation Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols
EP0455789B1 (en) 1989-11-22 1994-03-16 Janssen Pharmaceutica N.V. Method of preventing or limiting reperfusion damage
US5681830A (en) 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US5807858A (en) 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5574159A (en) 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
GB9202238D0 (en) 1992-02-03 1992-03-18 Wellcome Found Compounds
FR2696744B1 (fr) 1992-10-12 1994-12-30 Logeais Labor Jacques Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique.
IL110512A (en) 1993-07-30 1998-10-30 Delta Pharmaceuticals Inc History of diarylmethyl piperazine, their preparation and pharmaceutical preparations containing them
JP3352184B2 (ja) 1993-11-12 2002-12-03 株式会社アズウェル ピペラジン不飽和脂肪酸誘導体
US5693843A (en) * 1995-12-22 1997-12-02 E. I. Du Pont De Nemours And Company Process for hydrocyanation of diolefins and isomerization of nonconjugated 2 alkyl-3-monoalkenenitriles
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
EP1049676B1 (en) 1997-12-24 2005-10-12 Ortho-Mcneil Pharmaceutical, Inc. 4- aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds

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HUP0300020A3 (en) 2005-02-28
DE60013486T2 (de) 2005-11-17
PL356780A1 (en) 2004-07-12
BG65457B1 (bg) 2008-08-29
NO322432B1 (no) 2006-10-02
ES2225289T3 (es) 2005-03-16
IL150125A (en) 2006-08-20
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