IT1196150B - Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono - Google Patents

Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono

Info

Publication number
IT1196150B
IT1196150B IT21471/84A IT2147184A IT1196150B IT 1196150 B IT1196150 B IT 1196150B IT 21471/84 A IT21471/84 A IT 21471/84A IT 2147184 A IT2147184 A IT 2147184A IT 1196150 B IT1196150 B IT 1196150B
Authority
IT
Italy
Prior art keywords
heshydro
fluorofenil
fenyl
diazepin
propenyl
Prior art date
Application number
IT21471/84A
Other languages
English (en)
Other versions
IT8421471A1 (it
IT8421471A0 (it
Inventor
Gian Giacomo Massaroli
Original Assignee
Poli Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa
Publication of IT8421471A0 publication Critical patent/IT8421471A0/it
Priority to IT21471/84A priority Critical patent/IT1196150B/it
Priority to IL75386A priority patent/IL75386A0/xx
Priority to EP85107220A priority patent/EP0166302A3/en
Priority to DE198585107220T priority patent/DE166302T1/de
Priority to KR1019850004283A priority patent/KR860000269A/ko
Priority to JP60132886A priority patent/JPS6117574A/ja
Priority to FI852423A priority patent/FI852423L/fi
Priority to ES544299A priority patent/ES8609277A1/es
Publication of IT8421471A1 publication Critical patent/IT8421471A1/it
Application granted granted Critical
Publication of IT1196150B publication Critical patent/IT1196150B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT21471/84A 1984-06-19 1984-06-19 Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono IT1196150B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT21471/84A IT1196150B (it) 1984-06-19 1984-06-19 Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono
IL75386A IL75386A0 (en) 1984-06-19 1985-06-03 1-(bis-(4-fluorophenyl)-methyl)-4-(3-phenyl-2-propenyl)-hexahydro-1h-1,4-diazepine with calcium antagonistic activity,its preparation and compositions containing it
EP85107220A EP0166302A3 (en) 1984-06-19 1985-06-12 "1-[Bis-(4-fluorophyl)methyl]-4-(3-phenyl-2-propenyl)-hexahydro-1H-1,4-diazepine, preparation thereof and compositions containing it
DE198585107220T DE166302T1 (de) 1984-06-19 1985-06-12 1-(reaktion)bis-(4-fluorphenyl)methyli-4-(3-phenyl-2-propenyl)-hexahydro-1h-1,4-diazepin und dieses enthaltende mittel.
KR1019850004283A KR860000269A (ko) 1984-06-19 1985-06-17 칼슘길항성의 1-[비스-(4-플루오로페닐)-메틸-4-(3-페닐-2-프로페닐)-헥사하이드로-1h-1, 4-디아제핀의 제조방법및 이것을 함유한 약학적조성물
JP60132886A JPS6117574A (ja) 1984-06-19 1985-06-18 カルシウム拮抗活性のある１‐〔ビス‐（４‐ルオロフエニル）‐メチル〕‐４‐（３‐フエニル‐２‐プロペニル）‐ヘキサヒドロ‐１ｈ‐１，４‐ジアゼピンとその製法及びそれを含有する医薬組成物
FI852423A FI852423L (fi) 1984-06-19 1985-06-18 1-(bis-(4-fluorofenyl)-metyl)- 4-(3-fenyl-2-propenyl)-hexahydro-1h-1,4-diazepin med kalciumantagonistverkan, dess framstaellning och kompositioner innehaollande densamma.
ES544299A ES8609277A1 (es) 1984-06-19 1985-06-18 Procedimiento para la obtencion de 1-(bis-(4-fluorofenil)- metil)-4-(3-fenil-2-propenil)-hexahidro-1h-1, 4-diacepina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21471/84A IT1196150B (it) 1984-06-19 1984-06-19 Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono

Publications (3)

Publication Number Publication Date
IT8421471A0 IT8421471A0 (it) 1984-06-19
IT8421471A1 IT8421471A1 (it) 1985-12-19
IT1196150B true IT1196150B (it) 1988-11-10

Family

ID=11182299

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21471/84A IT1196150B (it) 1984-06-19 1984-06-19 Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono

Country Status (8)

Country Link
EP (1) EP0166302A3 (it)
JP (1) JPS6117574A (it)
KR (1) KR860000269A (it)
DE (1) DE166302T1 (it)
ES (1) ES8609277A1 (it)
FI (1) FI852423L (it)
IL (1) IL75386A0 (it)
IT (1) IT1196150B (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9504662D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
WO1997044329A1 (en) * 1996-05-20 1997-11-27 Teijin Limited Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
WO2002094794A1 (en) 2001-05-18 2002-11-28 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
KR101234421B1 (ko) 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790971A (fr) * 1971-11-09 1973-05-07 Janssen Pharmaceutica Nv Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen

Also Published As

Publication number Publication date
IT8421471A1 (it) 1985-12-19
DE166302T1 (de) 1986-05-22
EP0166302A2 (en) 1986-01-02
JPS6117574A (ja) 1986-01-25
FI852423A7 (fi) 1985-12-20
FI852423L (fi) 1985-12-20
ES8609277A1 (es) 1986-09-01
EP0166302A3 (en) 1986-03-26
IT8421471A0 (it) 1984-06-19
FI852423A0 (fi) 1985-06-18
ES544299A0 (es) 1986-09-01
KR860000269A (ko) 1986-01-27
IL75386A0 (en) 1985-10-31

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