IT1140978B - 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche - Google Patents

1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche

Info

Publication number
IT1140978B
IT1140978B IT22283/80A IT2228380A IT1140978B IT 1140978 B IT1140978 B IT 1140978B IT 22283/80 A IT22283/80 A IT 22283/80A IT 2228380 A IT2228380 A IT 2228380A IT 1140978 B IT1140978 B IT 1140978B
Authority
IT
Italy
Prior art keywords
sipropil
diidros
chlorobenzidril
piperazine
preparation
Prior art date
Application number
IT22283/80A
Other languages
English (en)
Other versions
IT8022283A0 (it
Inventor
Carlo Milani
Giovanni Maria Carminati
Attilio Sovera
Original Assignee
Selvi & C Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selvi & C Spa filed Critical Selvi & C Spa
Priority to IT22283/80A priority Critical patent/IT1140978B/it
Publication of IT8022283A0 publication Critical patent/IT8022283A0/it
Priority to DE3118162A priority patent/DE3118162C2/de
Priority to FR8109273A priority patent/FR2482965A1/fr
Priority to NL8102361A priority patent/NL8102361A/nl
Priority to BE2/59160A priority patent/BE888811A/nl
Priority to GB8115827A priority patent/GB2076403B/en
Priority to ES502429A priority patent/ES502429A0/es
Priority to JP7856281A priority patent/JPS5731678A/ja
Application granted granted Critical
Publication of IT1140978B publication Critical patent/IT1140978B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT22283/80A 1980-05-23 1980-05-23 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche IT1140978B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT22283/80A IT1140978B (it) 1980-05-23 1980-05-23 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche
DE3118162A DE3118162C2 (de) 1980-05-23 1981-05-07 1-(4-Chlorbenzhydryl)-4-(2,3-bis-hydroxypropyl)-piperazin, dessen Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltendes Arzneimittel
FR8109273A FR2482965A1 (fr) 1980-05-23 1981-05-08 1-(4-chlorobenzhydryl)-4-(2,3-dihydroxypropyl)-piperazine, son procede de preparation et son application en therapeutique
NL8102361A NL8102361A (nl) 1980-05-23 1981-05-13 1-(4-chloorbenzhydryl)-4-(2,3-bis-hydroxypropyl)-piperazine, zijn gebruik als anti-hoestmiddel, antihistaminicum, sedativum, analgeticum en ontstekingsremmend middel, alsmede farmaceutische preparaten met deze stof.
BE2/59160A BE888811A (nl) 1980-05-23 1981-05-15 1-(4-chloorbenzhydryl)-4-(2,3-bis-hydroxypropyl)-piperazine, zijn gebruik als anti-hoesmiddel, antihistaminicum sedativum, analgeticum en ontstekingsremmend middel, alsmede farmaceutische preparaten met deze stof
GB8115827A GB2076403B (en) 1980-05-23 1981-05-22 1-(4-chlorobenzhydryl)-4-(2,3-bishydrocypropyl) piperazine
ES502429A ES502429A0 (es) 1980-05-23 1981-05-22 Procedimiento para la preparacion de 1-(4-clorobencidril)-4-(2,3-dihidroxipropil)-piperacina
JP7856281A JPS5731678A (en) 1980-05-23 1981-05-23 1-(4-chlorobenzhydryl)-4-(2,3-bishydroxypropyl)- piperazine, manufacture and medicinal composition as effective component thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22283/80A IT1140978B (it) 1980-05-23 1980-05-23 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche

Publications (2)

Publication Number Publication Date
IT8022283A0 IT8022283A0 (it) 1980-05-23
IT1140978B true IT1140978B (it) 1986-10-10

Family

ID=11194137

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22283/80A IT1140978B (it) 1980-05-23 1980-05-23 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche

Country Status (8)

Country Link
JP (1) JPS5731678A (it)
BE (1) BE888811A (it)
DE (1) DE3118162C2 (it)
ES (1) ES502429A0 (it)
FR (1) FR2482965A1 (it)
GB (1) GB2076403B (it)
IT (1) IT1140978B (it)
NL (1) NL8102361A (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3611276A1 (de) * 1986-04-04 1987-11-26 Unilever Nv Verpackung mit margarine oder aehnlichem brotaufstrich
JPH01226575A (ja) * 1988-02-25 1989-09-11 Mitsubishi Plastics Ind Ltd もずくの包装体
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
PL367142A1 (en) 2001-05-18 2005-02-21 Astrazeneca Ab 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
MX2007001240A (es) 2004-08-02 2007-03-23 Astrazeneca Ab Derivados de diarilmetil-piperazina, preparaciones y usos de las mismas.
HU227074B1 (en) * 2005-12-08 2010-06-28 Egis Gyogyszergyar Nyrt An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate
EP2062881B1 (en) * 2007-11-21 2011-02-23 Synthon B.V. Process for making N-(diphenylmethyl)piperazines
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines

Also Published As

Publication number Publication date
DE3118162C2 (de) 1984-07-26
JPS5731678A (en) 1982-02-20
DE3118162A1 (de) 1982-02-18
FR2482965B1 (it) 1984-11-23
GB2076403A (en) 1981-12-02
GB2076403B (en) 1983-11-16
NL8102361A (nl) 1981-12-16
ES8203352A1 (es) 1982-04-01
FR2482965A1 (fr) 1981-11-27
BE888811A (nl) 1981-08-28
JPS6135189B2 (it) 1986-08-12
IT8022283A0 (it) 1980-05-23
ES502429A0 (es) 1982-04-01

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