JP2004522781A5 - - Google Patents
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- Publication number
- JP2004522781A5 JP2004522781A5 JP2002567304A JP2002567304A JP2004522781A5 JP 2004522781 A5 JP2004522781 A5 JP 2004522781A5 JP 2002567304 A JP2002567304 A JP 2002567304A JP 2002567304 A JP2002567304 A JP 2002567304A JP 2004522781 A5 JP2004522781 A5 JP 2004522781A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- compound
- coor
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 125000001072 heteroaryl group Chemical group 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 0 CC(C)c1c(C)c(*)c(C(C*)CN2C(*)=O)c2c1* Chemical compound CC(C)c1c(C)c(*)c(C(C*)CN2C(*)=O)c2c1* 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- FNMIWLJPAHYRGW-UHFFFAOYSA-N (4-chloro-3,4-dihydro-2h-quinolin-1-yl)-(5-methoxy-1h-indol-2-yl)methanone Chemical compound C1CC(Cl)C2=CC=CC=C2N1C(=O)C1=CC2=CC(OC)=CC=C2N1 FNMIWLJPAHYRGW-UHFFFAOYSA-N 0.000 description 1
- ZBYLHMJMRQSRQG-UHFFFAOYSA-N COC1=CC2=C(C=C1)NC(=C2)C(=O)N3C(CC4=CC=CC=C43)CCl Chemical compound COC1=CC2=C(C=C1)NC(=C2)C(=O)N3C(CC4=CC=CC=C43)CCl ZBYLHMJMRQSRQG-UHFFFAOYSA-N 0.000 description 1
- HEQLRKRQBGXRAJ-UHFFFAOYSA-N [8-(chloromethyl)-6-(5-methoxy-1h-indole-2-carbonyl)-7,8-dihydropyrrolo[3,2-e]indol-3-yl]-phenylmethanone Chemical compound C=1C2=CC(OC)=CC=C2NC=1C(=O)N1CC(CCl)C(C=2C=C3)=C1C=CC=2N3C(=O)C1=CC=CC=C1 HEQLRKRQBGXRAJ-UHFFFAOYSA-N 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000005549 heteroarylene group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01301609 | 2001-02-22 | ||
| PCT/GB2002/000785 WO2002067937A1 (en) | 2001-02-22 | 2002-02-22 | Indoline and tetrahydro-quinolines as prodrugs for tumour treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004522781A JP2004522781A (ja) | 2004-07-29 |
| JP2004522781A5 true JP2004522781A5 (enExample) | 2006-01-05 |
Family
ID=8181734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002567304A Pending JP2004522781A (ja) | 2001-02-22 | 2002-02-22 | 腫瘍処置のためのプロドラッグとしてのインドリンおよびテトラヒドロ−キノリン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7179921B2 (enExample) |
| EP (1) | EP1408970B1 (enExample) |
| JP (1) | JP2004522781A (enExample) |
| AT (1) | ATE361750T1 (enExample) |
| DE (1) | DE60220057T2 (enExample) |
| ES (1) | ES2287256T3 (enExample) |
| WO (1) | WO2002067937A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4862120B2 (ja) * | 2001-02-22 | 2012-01-25 | ユニヴァーシティ オブ ブラッドフォード | 腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体 |
| FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| FR2844273B1 (fr) | 2002-09-05 | 2008-04-04 | Aventis Pharma Sa | Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens. |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0505644D0 (en) | 2005-03-18 | 2005-04-27 | Univ London Pharmacy | Analogues of the azinomycins as anti-tumour agents and as prodrugs |
| BRPI0707426A2 (pt) * | 2006-02-02 | 2011-05-03 | Syntarga Bv | composto, conjugado, uso de um composto, composição farmacêutica, processo para preparar uma composição farmacêutica, e, métodos de tratamento de um mamìfero estando em necessidade do mesmo, e de tratamento ou prevenção de um tumor em um mamìfero |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| AU2009320481C1 (en) | 2008-11-03 | 2016-12-08 | Syntarga B.V. | Novel CC-1065 analogs and their conjugates |
| PT3056203T (pt) | 2010-04-21 | 2018-02-15 | Syntarga Bv | Conjugados de análogos de cc-1065 e ligantes bifuncionais |
| EP3092010B1 (en) | 2014-01-10 | 2018-07-11 | Synthon Biopharmaceuticals B.V. | Method for purifying cys-linked antibody-drug conjugates |
| AU2015282627B2 (en) | 2014-06-30 | 2020-04-02 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214065A (en) * | 1990-06-11 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Dc-89 derivatives |
| EP0702004A2 (de) | 1994-09-15 | 1996-03-20 | Ciba-Geigy Ag | 2,9-Diamino- und 2-amino-8-carbamoyl-4-hydroxy-alkansäureamid-derivative |
| JPH08143565A (ja) * | 1994-11-16 | 1996-06-04 | Fujisawa Pharmaceut Co Ltd | ベンズアミド化合物 |
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2002
- 2002-02-22 DE DE60220057T patent/DE60220057T2/de not_active Expired - Lifetime
- 2002-02-22 ES ES02712112T patent/ES2287256T3/es not_active Expired - Lifetime
- 2002-02-22 WO PCT/GB2002/000785 patent/WO2002067937A1/en not_active Ceased
- 2002-02-22 JP JP2002567304A patent/JP2004522781A/ja active Pending
- 2002-02-22 AT AT02712112T patent/ATE361750T1/de not_active IP Right Cessation
- 2002-02-22 EP EP02712112A patent/EP1408970B1/en not_active Expired - Lifetime
- 2002-02-22 US US10/468,743 patent/US7179921B2/en not_active Expired - Fee Related