JP2007520440A5 - - Google Patents
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- Publication number
- JP2007520440A5 JP2007520440A5 JP2006518649A JP2006518649A JP2007520440A5 JP 2007520440 A5 JP2007520440 A5 JP 2007520440A5 JP 2006518649 A JP2006518649 A JP 2006518649A JP 2006518649 A JP2006518649 A JP 2006518649A JP 2007520440 A5 JP2007520440 A5 JP 2007520440A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- alkoxy
- halogen
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 claims 1
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004802 cyanophenyl group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48469603P | 2003-07-03 | 2003-07-03 | |
| PCT/US2004/019094 WO2005009941A1 (en) | 2003-07-03 | 2004-06-23 | Indane derivates as muscarinic receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007520440A JP2007520440A (ja) | 2007-07-26 |
| JP2007520440A5 true JP2007520440A5 (enExample) | 2007-09-06 |
Family
ID=34102660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006518649A Pending JP2007520440A (ja) | 2003-07-03 | 2004-06-23 | ムスカリン性受容体アゴニストとしてのインダン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7265246B2 (enExample) |
| EP (1) | EP1644320B1 (enExample) |
| JP (1) | JP2007520440A (enExample) |
| AT (1) | ATE384039T1 (enExample) |
| CA (1) | CA2529036A1 (enExample) |
| DE (1) | DE602004011348T2 (enExample) |
| ES (1) | ES2298819T3 (enExample) |
| WO (1) | WO2005009941A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1754491T3 (pl) * | 2004-05-21 | 2010-08-31 | Senju Pharma Co | Preparat do oczu do wchłaniania przezskórnego zawierający agonistę receptora muskarynowego |
| WO2007075297A2 (en) * | 2005-12-27 | 2007-07-05 | University Of Toledo | Muscarinic agonists and methods of use thereof |
| US20110294835A1 (en) | 2008-05-15 | 2011-12-01 | The Board Of Trustees Of The University Of Illinois | Muscarinic Agonists as Cognitive Enhancers |
| WO2010043721A1 (en) | 2008-10-17 | 2010-04-22 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| WO2010084160A1 (en) | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
| AU2010233917B2 (en) | 2009-04-02 | 2015-07-02 | Merck Serono S.A. | Dihydroorotate dehydrogenase inhibitors |
| WO2010141690A2 (en) * | 2009-06-04 | 2010-12-09 | Dara Biosciences, Inc. | Indane analogs and use as pharmaceutical agents and process of making |
| JP5699152B2 (ja) | 2009-09-25 | 2015-04-08 | オリゾン・ジェノミックス・ソシエダッド・アノニマＯｒｙｚｏｎ Ｇｅｎｏｍｉｃｓ Ｓ．Ａ． | リジン特異的デメチラーゼ−１阻害剤およびその使用 |
| EP2486002B1 (en) | 2009-10-09 | 2019-03-27 | Oryzon Genomics, S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
| US9186337B2 (en) | 2010-02-24 | 2015-11-17 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae |
| WO2011106574A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Inhibitors for antiviral use |
| JP5868948B2 (ja) | 2010-04-19 | 2016-02-24 | オリゾン・ジェノミックス・ソシエダッド・アノニマＯｒｙｚｏｎ Ｇｅｎｏｍｉｃｓ Ｓ．Ａ． | リジン特異的脱メチル化酵素１阻害薬およびその使用 |
| ES2603032T3 (es) | 2010-07-15 | 2017-02-23 | Bayer Intellectual Property Gmbh | Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas |
| WO2012013728A1 (en) | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use |
| US9006449B2 (en) | 2010-07-29 | 2015-04-14 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| WO2012045883A1 (en) | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| EP2712315B1 (en) | 2011-02-08 | 2021-11-24 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| WO2012149524A1 (en) | 2011-04-29 | 2012-11-01 | The University Of Toledo | Muscarinic agonists as enhancers of working memory and cognitive flexibility |
| SG11201401066PA (en) | 2011-10-20 | 2014-10-30 | Oryzon Genomics Sa | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
| AU2012324803B9 (en) | 2011-10-20 | 2017-08-24 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US11046670B2 (en) | 2015-10-19 | 2021-06-29 | Board Of Regents, The University Of Texas System | Piperazinyl norbenzomorphan compounds and methods for using the same |
| WO2017160922A1 (en) | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
| EP3448520A4 (en) * | 2016-04-29 | 2020-07-29 | Board Of Regents, The University Of Texas System | SIGMA RECEIVER BINDERS |
| WO2017190107A1 (en) * | 2016-04-29 | 2017-11-02 | Board Of Regents, The University Of Texas System | Sigma receptor binders |
| CN114736128A (zh) * | 2022-03-10 | 2022-07-12 | 青岛科技大学 | 一种制备邻氨基苯醚的方法 |
| CN118652255B (zh) * | 2024-08-20 | 2024-10-15 | 广州市桐晖药业有限公司 | 一种己酮可可碱的工艺改进方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1834997A (en) | 1996-01-22 | 1997-08-11 | Eli Lilly And Company | Indane derivatives for antipsychotic compositions |
| AU8591898A (en) * | 1997-07-22 | 1999-02-16 | Eli Lilly And Company | Pharmaceutical compounds |
| TWI241190B (en) * | 2001-02-13 | 2005-10-11 | Aventis Pharma Gmbh | 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical |
| CN1556788A (zh) * | 2001-09-21 | 2004-12-22 | 毒蕈碱受体激动剂 |
-
2004
- 2004-06-23 US US10/560,757 patent/US7265246B2/en not_active Expired - Fee Related
- 2004-06-23 CA CA002529036A patent/CA2529036A1/en not_active Abandoned
- 2004-06-23 DE DE602004011348T patent/DE602004011348T2/de not_active Expired - Lifetime
- 2004-06-23 WO PCT/US2004/019094 patent/WO2005009941A1/en not_active Ceased
- 2004-06-23 EP EP04776610A patent/EP1644320B1/en not_active Expired - Lifetime
- 2004-06-23 ES ES04776610T patent/ES2298819T3/es not_active Expired - Lifetime
- 2004-06-23 AT AT04776610T patent/ATE384039T1/de not_active IP Right Cessation
- 2004-06-23 JP JP2006518649A patent/JP2007520440A/ja active Pending
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