JP2005503433A5 - - Google Patents
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- Publication number
- JP2005503433A5 JP2005503433A5 JP2003530652A JP2003530652A JP2005503433A5 JP 2005503433 A5 JP2005503433 A5 JP 2005503433A5 JP 2003530652 A JP2003530652 A JP 2003530652A JP 2003530652 A JP2003530652 A JP 2003530652A JP 2005503433 A5 JP2005503433 A5 JP 2005503433A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkoxy
- alkyl
- halogen
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 9
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 claims description 3
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims 1
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- PTIASGVLWNOMTD-FIRIVFDPSA-N N-[(1R,2R)-6-[[N-[2-(4-fluorophenyl)ethyl]-C-methylcarbonimidoyl]amino]-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-phenylbenzamide Chemical compound FC1=CC=C(CCNC(C)=NC2=CC=C3C[C@H]([C@@H](C3=C2)NC(=O)C2=CC=C(C=C2)C2=CC=CC=C2)O)C=C1 PTIASGVLWNOMTD-FIRIVFDPSA-N 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004802 cyanophenyl group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- -1 nitro Naphthyl Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003233 pyrroles Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 4
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 4
- 239000000556 agonist Substances 0.000 description 4
- 102000017927 CHRM1 Human genes 0.000 description 2
- 101150073075 Chrm1 gene Proteins 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32414101P | 2001-09-21 | 2001-09-21 | |
| PCT/US2002/025969 WO2003027061A2 (en) | 2001-09-21 | 2002-09-09 | Muscarinic agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503433A JP2005503433A (ja) | 2005-02-03 |
| JP2005503433A5 true JP2005503433A5 (enExample) | 2006-01-05 |
| JP4409290B2 JP4409290B2 (ja) | 2010-02-03 |
Family
ID=23262266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530652A Expired - Fee Related JP4409290B2 (ja) | 2001-09-21 | 2002-09-09 | ムスカリン性アゴニスト |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7326731B2 (enExample) |
| EP (1) | EP1436249B1 (enExample) |
| JP (1) | JP4409290B2 (enExample) |
| KR (1) | KR20040053130A (enExample) |
| CN (1) | CN1556788A (enExample) |
| AR (1) | AR036602A1 (enExample) |
| AU (1) | AU2002332541B2 (enExample) |
| BR (1) | BR0212353A (enExample) |
| CA (1) | CA2461218C (enExample) |
| CZ (1) | CZ2004397A3 (enExample) |
| EA (1) | EA006853B1 (enExample) |
| EC (1) | ECSP045027A (enExample) |
| EG (1) | EG25796A (enExample) |
| ES (1) | ES2439093T3 (enExample) |
| HR (1) | HRP20040230B1 (enExample) |
| HU (1) | HUP0401883A2 (enExample) |
| IL (2) | IL160751A0 (enExample) |
| MX (1) | MXPA04002633A (enExample) |
| MY (1) | MY142358A (enExample) |
| NO (1) | NO20041107L (enExample) |
| NZ (1) | NZ531135A (enExample) |
| PE (1) | PE20030707A1 (enExample) |
| PL (1) | PL205708B1 (enExample) |
| SV (1) | SV2004001250A (enExample) |
| TW (1) | TWI327997B (enExample) |
| UA (1) | UA76492C2 (enExample) |
| WO (1) | WO2003027061A2 (enExample) |
| ZA (1) | ZA200402191B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004018411A1 (en) * | 2002-08-22 | 2004-03-04 | Eli Lilly And Company | Muscarinic agonists |
| WO2005009941A1 (en) * | 2003-07-03 | 2005-02-03 | Eli Lilly And Company | Indane derivates as muscarinic receptor agonists |
| US20070104709A1 (en) * | 2003-08-06 | 2007-05-10 | Xiaodong Li | T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds |
| US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| NZ546473A (en) | 2003-10-08 | 2009-09-25 | Bayer Schering Pharma Ag | 1-amino-2-oxy-substituted tetrahydronaphthalene derivatives, methods for the production thereof, and their use as antiphlogistics |
| US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| DE102004029325A1 (de) * | 2004-06-10 | 2006-01-05 | Universität Leipzig | Arzneitmittel zur Behandlung des fetalen Alkoholsyndroms |
| DE102005017316A1 (de) * | 2005-04-14 | 2006-10-19 | Schering Ag | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| WO2007075297A2 (en) * | 2005-12-27 | 2007-07-05 | University Of Toledo | Muscarinic agonists and methods of use thereof |
| EP1834948A1 (de) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| DK3235811T3 (en) | 2006-04-21 | 2018-11-12 | Senomyx Inc | PROCEDURE FOR THE PREPARATION OF OXALAMIDS |
| EP2296471A4 (en) | 2008-05-15 | 2012-03-14 | Univ Toledo | MUSCARIC ACID AGONISTS AS COGNITIVE ENHANCERS |
| NZ590542A (en) * | 2008-06-19 | 2012-12-21 | Xcovery Holding Co Llc | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
| BR112012024815A2 (pt) | 2010-03-29 | 2017-04-11 | Basf Se | imunoderivados fungicidas |
| TWI402072B (zh) | 2010-10-19 | 2013-07-21 | Lilly Co Eli | 組織蛋白酶ｓ抑制劑化合物 |
| US9549928B2 (en) | 2011-04-29 | 2017-01-24 | The University Of Toledo | Muscarinic agonists as enhancers of cognitive flexibility |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1582197A (en) * | 1996-01-22 | 1997-08-11 | Eli Lilly And Company | Combinatorial process for preparing substituted indane libraries |
| US6211364B1 (en) * | 1997-01-22 | 2001-04-03 | Eli Lilly And Company | Process for preparing indane-like compounds |
| CA2297906A1 (en) | 1997-07-22 | 1999-02-04 | Bret Eugene Huff | Pharmaceutical compounds |
-
2002
- 2002-09-09 UA UA2004032068A patent/UA76492C2/uk unknown
- 2002-09-09 WO PCT/US2002/025969 patent/WO2003027061A2/en not_active Ceased
- 2002-09-09 MX MXPA04002633A patent/MXPA04002633A/es active IP Right Grant
- 2002-09-09 EA EA200400454A patent/EA006853B1/ru not_active IP Right Cessation
- 2002-09-09 CA CA2461218A patent/CA2461218C/en not_active Expired - Fee Related
- 2002-09-09 AU AU2002332541A patent/AU2002332541B2/en not_active Ceased
- 2002-09-09 CZ CZ2004397A patent/CZ2004397A3/cs unknown
- 2002-09-09 JP JP2003530652A patent/JP4409290B2/ja not_active Expired - Fee Related
- 2002-09-09 US US10/488,519 patent/US7326731B2/en not_active Expired - Fee Related
- 2002-09-09 ES ES02799555.4T patent/ES2439093T3/es not_active Expired - Lifetime
- 2002-09-09 HU HU0401883A patent/HUP0401883A2/hu unknown
- 2002-09-09 EP EP02799555.4A patent/EP1436249B1/en not_active Expired - Lifetime
- 2002-09-09 PL PL368272A patent/PL205708B1/pl not_active IP Right Cessation
- 2002-09-09 HR HR20040230A patent/HRP20040230B1/xx not_active IP Right Cessation
- 2002-09-09 KR KR10-2004-7004057A patent/KR20040053130A/ko not_active Ceased
- 2002-09-09 CN CNA028185501A patent/CN1556788A/zh active Pending
- 2002-09-09 NZ NZ531135A patent/NZ531135A/en not_active IP Right Cessation
- 2002-09-09 IL IL16075102A patent/IL160751A0/xx unknown
- 2002-09-09 BR BR0212353-3A patent/BR0212353A/pt active Search and Examination
- 2002-09-18 EG EG2002091034A patent/EG25796A/xx active
- 2002-09-19 MY MYPI20023487A patent/MY142358A/en unknown
- 2002-09-19 TW TW091121495A patent/TWI327997B/zh not_active IP Right Cessation
- 2002-09-20 PE PE2002000926A patent/PE20030707A1/es not_active Application Discontinuation
- 2002-09-20 AR ARP020103544A patent/AR036602A1/es unknown
- 2002-09-20 SV SV2002001250A patent/SV2004001250A/es unknown
-
2004
- 2004-03-04 IL IL160751A patent/IL160751A/en not_active IP Right Cessation
- 2004-03-15 NO NO20041107A patent/NO20041107L/no not_active Application Discontinuation
- 2004-03-18 ZA ZA200402191A patent/ZA200402191B/en unknown
- 2004-03-19 EC EC2004005027A patent/ECSP045027A/es unknown
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