JP2007504235A5 - - Google Patents
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- Publication number
- JP2007504235A5 JP2007504235A5 JP2006525396A JP2006525396A JP2007504235A5 JP 2007504235 A5 JP2007504235 A5 JP 2007504235A5 JP 2006525396 A JP2006525396 A JP 2006525396A JP 2006525396 A JP2006525396 A JP 2006525396A JP 2007504235 A5 JP2007504235 A5 JP 2007504235A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- heteroarylalkyl
- alkenyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003710 aryl alkyl group Chemical group 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 17
- 125000004404 heteroalkyl group Chemical group 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000000304 alkynyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 5
- 125000004953 trihalomethyl group Chemical group 0.000 claims 5
- 230000016273 neuron death Effects 0.000 claims 4
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 230000001640 apoptogenic effect Effects 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001338 necrotic effect Effects 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000034994 death Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 *C(*)(C([n]1c2ccc1)=O)NC2=O Chemical compound *C(*)(C([n]1c2ccc1)=O)NC2=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49995603P | 2003-09-03 | 2003-09-03 | |
| US60/499,956 | 2003-09-03 | ||
| PCT/US2004/028308 WO2005023815A2 (en) | 2003-09-03 | 2004-08-31 | Neuroprotective bicyclic compounds and methods for their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007504235A JP2007504235A (ja) | 2007-03-01 |
| JP2007504235A5 true JP2007504235A5 (enExample) | 2007-10-04 |
| JP4842817B2 JP4842817B2 (ja) | 2011-12-21 |
Family
ID=34272894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525396A Expired - Lifetime JP4842817B2 (ja) | 2003-09-03 | 2004-08-31 | 神経保護二環式化合物およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8067425B2 (enExample) |
| EP (1) | EP1664050B1 (enExample) |
| JP (1) | JP4842817B2 (enExample) |
| DK (1) | DK1664050T3 (enExample) |
| ES (1) | ES2564803T3 (enExample) |
| HU (1) | HUE028528T2 (enExample) |
| PL (1) | PL1664050T3 (enExample) |
| SI (1) | SI1664050T1 (enExample) |
| WO (1) | WO2005023815A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1311269E (pt) | 2000-08-04 | 2012-05-10 | Dmi Biosciences Inc | Método de utilização de dicetopiperazinas e composição que contém as mesmas |
| WO2004084809A2 (en) * | 2003-03-20 | 2004-10-07 | Neuren Pharmaceuticals Ltd. | Neuroprotective macrocylic compounds and methods for their use |
| KR20120101164A (ko) | 2003-05-15 | 2012-09-12 | 디엠아이 바이오사이언시스, 인크 | Ｔ-세포 매개성 질환의 치료 방법 |
| US8519127B2 (en) * | 2003-09-03 | 2013-08-27 | Mike John Bickerdike | Cyclic glycyl-2-allyl proline and its use in treatment of peripheral neuropathy |
| US8791117B2 (en) * | 2003-09-03 | 2014-07-29 | Neuren Pharmaceuticals Limited | Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals |
| WO2008063311A2 (en) * | 2006-10-11 | 2008-05-29 | Neuren Pharmaceuticals Limited | Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| US9891219B2 (en) * | 2008-10-10 | 2018-02-13 | Mayo Foundation For Medical Education And Research | Methods for treating neuromyelitis optica (NMO) by administration of eculizumab to an individual that is aquaporin-4 (AQP4)-IgG autoantibody positive |
| US7928233B2 (en) * | 2009-02-10 | 2011-04-19 | Hoffmann-La Roche Inc. | Spiroindolinone pyridine derivatives |
| CA2810844C (en) | 2010-09-07 | 2017-03-21 | Dmi Acquisition Corp. | Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions |
| MX2014003856A (es) | 2011-10-10 | 2015-01-16 | Ampio Pharmaceuticals Inc | Dispositivos medicos implantables con tolerancia inmune incrementada y metodos para hacerlos e implantarlos. |
| EP2766029B1 (en) | 2011-10-10 | 2020-03-25 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
| SG11201400283RA (en) | 2011-10-28 | 2014-03-28 | Ampio Pharmaceuticals Inc | Treatment of rhinitis |
| CN104870452B (zh) * | 2012-10-22 | 2018-04-13 | 希望之城 | Etp衍生物 |
| AU2014232728B2 (en) | 2013-03-15 | 2019-02-21 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| HRP20201002T1 (hr) | 2013-07-25 | 2020-10-16 | Neuren Pharmaceuticals Limited | Neuroprotektivni biciklički spojevi i metode za njihovo korištenje u tretmanu poremećaja autističnog spektra i neurorazvojnih poremećaja |
| EP3183240A4 (en) | 2014-08-18 | 2018-06-27 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| WO2017204321A1 (ja) * | 2016-05-26 | 2017-11-30 | 株式会社アミノアップ化学 | 睡眠改善剤 |
| CA3036852A1 (en) | 2016-09-15 | 2018-03-22 | City Of Hope | Dithio etp derivatives |
| CN119015277A (zh) * | 2018-03-16 | 2024-11-26 | 脑科学香料株式会社 | 缺氧障碍、缺血再灌注障碍或炎症的预防或治疗剂，移植用细胞保护剂，及生物体防腐剂 |
| WO2019222339A1 (en) * | 2018-05-15 | 2019-11-21 | Tran Lloyd Hung Loi | Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders |
| EP4048264A4 (en) | 2019-10-22 | 2023-11-29 | Neuren Pharmaceuticals Limited | BICYCLIC COMPOUNDS AND METHODS FOR USE IN THE TREATMENT OF PITT HOPKINS SYNDROME |
| CA3207384A1 (en) * | 2021-02-12 | 2022-08-18 | Lawrence Irwin Glass | Treatments of prader-willi syndrome |
| BE1032058B1 (nl) * | 2023-10-26 | 2025-10-02 | Rousselot Bv | Cyclische analoog van glycine-proline voor gebruik bij de preventie en/of behandeling van fibrose |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH469006A (de) * | 1965-07-07 | 1969-02-28 | Sandoz Ag | Verfahren zur Herstellung neuer synthetischer Alkaloide |
| FI941826L (fi) * | 1993-04-21 | 1994-10-22 | Takeda Chemical Industries Ltd | Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi |
| US7202279B1 (en) * | 1998-02-11 | 2007-04-10 | Georgetown University | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders |
| AU2002340465A1 (en) * | 2001-11-09 | 2003-05-19 | Neuronz Biosciences, Inc. | Cyclo(prolyl-glycine) and methods of use to treat neural disorders |
| CA2466701C (en) | 2001-11-13 | 2013-11-12 | Loi Tran | Neuroprotective use of cyclic prolyl glycine |
| US7232798B2 (en) * | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| WO2004084809A2 (en) * | 2003-03-20 | 2004-10-07 | Neuren Pharmaceuticals Ltd. | Neuroprotective macrocylic compounds and methods for their use |
-
2004
- 2004-08-31 SI SI200432303T patent/SI1664050T1/sl unknown
- 2004-08-31 ES ES04782733.2T patent/ES2564803T3/es not_active Expired - Lifetime
- 2004-08-31 US US10/570,395 patent/US8067425B2/en not_active Expired - Lifetime
- 2004-08-31 PL PL04782733T patent/PL1664050T3/pl unknown
- 2004-08-31 DK DK04782733.2T patent/DK1664050T3/en active
- 2004-08-31 WO PCT/US2004/028308 patent/WO2005023815A2/en not_active Ceased
- 2004-08-31 JP JP2006525396A patent/JP4842817B2/ja not_active Expired - Lifetime
- 2004-08-31 HU HUE04782733A patent/HUE028528T2/en unknown
- 2004-08-31 EP EP04782733.2A patent/EP1664050B1/en not_active Expired - Lifetime
-
2006
- 2006-04-07 US US11/399,974 patent/US7776876B2/en active Active