JP2008505117A5 - - Google Patents
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- Publication number
- JP2008505117A5 JP2008505117A5 JP2007519511A JP2007519511A JP2008505117A5 JP 2008505117 A5 JP2008505117 A5 JP 2008505117A5 JP 2007519511 A JP2007519511 A JP 2007519511A JP 2007519511 A JP2007519511 A JP 2007519511A JP 2008505117 A5 JP2008505117 A5 JP 2008505117A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- cycloalkyl
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004404 heteroalkyl group Chemical group 0.000 claims 116
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 103
- 125000001072 heteroaryl group Chemical group 0.000 claims 70
- 125000000217 alkyl group Chemical group 0.000 claims 66
- 125000000753 cycloalkyl group Chemical group 0.000 claims 65
- 125000003118 aryl group Chemical group 0.000 claims 58
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 47
- 239000001257 hydrogen Substances 0.000 claims 47
- 125000000547 substituted alkyl group Chemical group 0.000 claims 46
- 125000002947 alkylene group Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 38
- 125000003107 substituted aryl group Chemical group 0.000 claims 38
- 125000004474 heteroalkylene group Chemical group 0.000 claims 37
- 125000001424 substituent group Chemical group 0.000 claims 35
- 239000000203 mixture Substances 0.000 claims 34
- 150000002431 hydrogen Chemical class 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 125000003710 aryl alkyl group Chemical group 0.000 claims 16
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 16
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 5
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- -1 wherein R 5 Chemical compound 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58501804P | 2004-07-02 | 2004-07-02 | |
| US60/585,018 | 2004-07-02 | ||
| PCT/US2005/023675 WO2006014394A1 (en) | 2004-07-02 | 2005-06-29 | Modified pyrimidine glucocorticoid receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008505117A JP2008505117A (ja) | 2008-02-21 |
| JP2008505117A5 true JP2008505117A5 (enExample) | 2008-07-17 |
| JP4958774B2 JP4958774B2 (ja) | 2012-06-20 |
Family
ID=35311764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519511A Expired - Fee Related JP4958774B2 (ja) | 2004-07-02 | 2005-06-29 | 改変されたピリミジン糖質コルチコイドレセプター調節因子 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7576076B2 (enExample) |
| EP (1) | EP1778236B1 (enExample) |
| JP (1) | JP4958774B2 (enExample) |
| KR (1) | KR101210730B1 (enExample) |
| AT (1) | ATE473744T1 (enExample) |
| AU (1) | AU2005270039B2 (enExample) |
| CA (1) | CA2572544C (enExample) |
| CY (1) | CY1110828T1 (enExample) |
| DE (1) | DE602005022319D1 (enExample) |
| DK (1) | DK1778236T3 (enExample) |
| ES (1) | ES2348667T3 (enExample) |
| IL (1) | IL180508A0 (enExample) |
| NZ (1) | NZ552984A (enExample) |
| PT (1) | PT1778236E (enExample) |
| WO (1) | WO2006014394A1 (enExample) |
| ZA (1) | ZA200700616B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102079743B (zh) * | 2004-03-15 | 2020-08-25 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| JP2008524331A (ja) * | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼ阻害剤 |
| NZ566799A (en) | 2005-09-14 | 2011-04-29 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors for treating diabetes |
| WO2008018592A1 (en) * | 2006-08-11 | 2008-02-14 | Taisho Pharmaceutical Co., Ltd. | External preparation comprising prostaglandin derivative |
| TWI410422B (zh) | 2007-01-15 | 2013-10-01 | Mitsubishi Tanabe Pharma Corp | 縮合四氫喹啉衍生物及其醫藥用途 |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| EP2532350A1 (en) | 2007-10-17 | 2012-12-12 | Laboratoire HRA Pharma | Pharmaceutical combination of a glucocorticoid receptor antagonist and a cortisol synthesis inhibitor for treating cushing's syndrome |
| ES2745628T3 (es) | 2008-11-07 | 2020-03-03 | Univ Sheffield | Medicamento y método de diagnóstico |
| CN103596431B (zh) * | 2011-03-18 | 2016-06-22 | 科赛普特治疗公司 | 嘧啶环己基糖皮质激素受体调节剂 |
| EP2712317B1 (en) * | 2011-03-31 | 2018-09-19 | Pop Test Oncology LLC | Prevention of infection |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| KR101686872B1 (ko) * | 2014-08-25 | 2016-12-20 | 부산대학교 산학협력단 | Tlr4에 lps와의 경쟁적 결합을 통한 항산화 및 항염증 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
| WO2016032127A2 (ko) * | 2014-08-25 | 2016-03-03 | 부산대학교 산학협력단 | Tlr4에 lps와의 경쟁적 결합을 통한 항산화 및 항염증 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
| US10183949B2 (en) | 2014-08-29 | 2019-01-22 | The University Of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
| MX383318B (es) | 2015-08-13 | 2025-03-13 | Corcept Therapeutics Inc | Metodo para diagnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina. |
| JP6765443B2 (ja) | 2016-01-19 | 2020-10-07 | コーセプト セラピューティクス， インコーポレイテッド | 異所性クッシング症候群の鑑別診断 |
| AU2018244928B2 (en) | 2017-03-31 | 2023-10-19 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| US11542248B2 (en) * | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| TW201920170A (zh) | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
| CA3102099C (en) * | 2018-06-04 | 2023-09-26 | Corcept Therapeutics Incorporated | Pyrimidine cyclohexenyl glucocorticoid receptor modulators |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN113194931B (zh) | 2018-12-19 | 2023-11-10 | 科塞普特治疗公司 | 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂 |
| JP7569492B2 (ja) * | 2019-12-11 | 2024-10-18 | コーセプト セラピューティクス， インコーポレイテッド | 抗精神病薬誘発性体重増加のミリコリラントによる治療方法 |
| JP7672406B2 (ja) | 2019-12-18 | 2025-05-07 | クリネティックス ファーマシューティカルズ，インク． | Ｇｅｍ－二置換ピペリジンメラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用 |
| JP7651574B2 (ja) | 2019-12-23 | 2025-03-26 | クリネティックス ファーマシューティカルズ，インク． | スピロ環式ピペリジンメラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用 |
| KR102911885B1 (ko) | 2020-05-06 | 2026-01-12 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제의 다형체 |
| AU2021266739B2 (en) | 2020-05-06 | 2024-11-28 | Corcept Therapeutics Incorporated | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| EP4157276A4 (en) | 2020-05-27 | 2024-06-12 | Corcept Therapeutics Incorporated | Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of cyp2c8 and cyp3a4 |
| JP7853982B2 (ja) | 2020-12-21 | 2026-04-30 | コーセプト セラピューティクス， インコーポレイテッド | ピリミジンシクロヘキシルグルココルチコイド受容体調節因子を調製する方法 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12616698B2 (en) | 2021-05-05 | 2026-05-05 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
| WO2024077169A1 (en) | 2022-10-06 | 2024-04-11 | Corcept Therapeutics Incorporated | Formulations of glucocorticoid receptor modulators |
| US12433882B2 (en) | 2022-10-28 | 2025-10-07 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3011809A1 (de) * | 1980-03-27 | 1981-10-01 | Cassella Ag, 6000 Frankfurt | Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung |
| US5008267A (en) | 1988-10-29 | 1991-04-16 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same |
| JPH06128238A (ja) | 1992-10-20 | 1994-05-10 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体 |
| EP0722732A1 (en) | 1995-01-24 | 1996-07-24 | Mitsui Toatsu Chemicals, Inc. | Long-acting drug formulation containing pyrimidinedione derivatives |
| JPH1017555A (ja) * | 1996-07-02 | 1998-01-20 | Mitsui Petrochem Ind Ltd | ６−アミノ−５−メチルウラシル誘導体 |
| ES2246292T3 (es) * | 2000-10-30 | 2006-02-16 | Pfizer Products Inc. | Moduladores de receptor glucocorticoide. |
| GB0029100D0 (en) | 2000-11-29 | 2001-01-10 | Karobio Ab | Compounds active at the glucocorticoid receptor |
| JP2003017555A (ja) | 2001-06-29 | 2003-01-17 | Hitachi Ltd | 半導体集積回路装置およびその製造方法 |
| AU2003216591A1 (en) | 2002-04-10 | 2003-10-20 | Orichid Chemicals And Pharmaceuticals Limited | Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological |
-
2005
- 2005-06-29 US US11/174,096 patent/US7576076B2/en not_active Expired - Lifetime
- 2005-06-29 NZ NZ552984A patent/NZ552984A/en not_active IP Right Cessation
- 2005-06-29 DK DK05771551.8T patent/DK1778236T3/da active
- 2005-06-29 KR KR1020077002664A patent/KR101210730B1/ko not_active Expired - Fee Related
- 2005-06-29 JP JP2007519511A patent/JP4958774B2/ja not_active Expired - Fee Related
- 2005-06-29 AT AT05771551T patent/ATE473744T1/de active
- 2005-06-29 ES ES05771551T patent/ES2348667T3/es not_active Expired - Lifetime
- 2005-06-29 AU AU2005270039A patent/AU2005270039B2/en not_active Ceased
- 2005-06-29 PT PT05771551T patent/PT1778236E/pt unknown
- 2005-06-29 CA CA2572544A patent/CA2572544C/en not_active Expired - Fee Related
- 2005-06-29 WO PCT/US2005/023675 patent/WO2006014394A1/en not_active Ceased
- 2005-06-29 EP EP05771551A patent/EP1778236B1/en not_active Expired - Lifetime
- 2005-06-29 DE DE602005022319T patent/DE602005022319D1/de not_active Expired - Lifetime
-
2007
- 2007-01-02 IL IL180508A patent/IL180508A0/en not_active IP Right Cessation
- 2007-01-22 ZA ZA200700616A patent/ZA200700616B/xx unknown
-
2009
- 2009-07-08 US US12/499,753 patent/US8173664B2/en not_active Expired - Lifetime
-
2010
- 2010-10-11 CY CY20101100904T patent/CY1110828T1/el unknown