JP2008505117A5 - - Google Patents
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- Publication number
- JP2008505117A5 JP2008505117A5 JP2007519511A JP2007519511A JP2008505117A5 JP 2008505117 A5 JP2008505117 A5 JP 2008505117A5 JP 2007519511 A JP2007519511 A JP 2007519511A JP 2007519511 A JP2007519511 A JP 2007519511A JP 2008505117 A5 JP2008505117 A5 JP 2008505117A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- cycloalkyl
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004404 heteroalkyl group Chemical group 0.000 claims 116
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 103
- 125000001072 heteroaryl group Chemical group 0.000 claims 70
- 125000000217 alkyl group Chemical group 0.000 claims 66
- 125000000753 cycloalkyl group Chemical group 0.000 claims 65
- 125000003118 aryl group Chemical group 0.000 claims 58
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 47
- 239000001257 hydrogen Substances 0.000 claims 47
- 125000000547 substituted alkyl group Chemical group 0.000 claims 46
- 125000002947 alkylene group Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 38
- 125000003107 substituted aryl group Chemical group 0.000 claims 38
- 125000004474 heteroalkylene group Chemical group 0.000 claims 37
- 125000001424 substituent group Chemical group 0.000 claims 35
- 239000000203 mixture Substances 0.000 claims 34
- 150000002431 hydrogen Chemical class 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 125000003710 aryl alkyl group Chemical group 0.000 claims 16
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 16
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 5
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- -1 wherein R 5 Chemical compound 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58501804P | 2004-07-02 | 2004-07-02 | |
| US60/585,018 | 2004-07-02 | ||
| PCT/US2005/023675 WO2006014394A1 (en) | 2004-07-02 | 2005-06-29 | Modified pyrimidine glucocorticoid receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008505117A JP2008505117A (ja) | 2008-02-21 |
| JP2008505117A5 true JP2008505117A5 (enExample) | 2008-07-17 |
| JP4958774B2 JP4958774B2 (ja) | 2012-06-20 |
Family
ID=35311764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519511A Expired - Fee Related JP4958774B2 (ja) | 2004-07-02 | 2005-06-29 | 改変されたピリミジン糖質コルチコイドレセプター調節因子 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7576076B2 (enExample) |
| EP (1) | EP1778236B1 (enExample) |
| JP (1) | JP4958774B2 (enExample) |
| KR (1) | KR101210730B1 (enExample) |
| AT (1) | ATE473744T1 (enExample) |
| AU (1) | AU2005270039B2 (enExample) |
| CA (1) | CA2572544C (enExample) |
| CY (1) | CY1110828T1 (enExample) |
| DE (1) | DE602005022319D1 (enExample) |
| DK (1) | DK1778236T3 (enExample) |
| ES (1) | ES2348667T3 (enExample) |
| IL (1) | IL180508A0 (enExample) |
| NZ (1) | NZ552984A (enExample) |
| PT (1) | PT1778236E (enExample) |
| WO (1) | WO2006014394A1 (enExample) |
| ZA (1) | ZA200700616B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA013427B1 (ru) * | 2004-03-15 | 2010-04-30 | Такеда Фармасьютикал Компани Лимитед | Ингибиторы дипептидилпептидазы |
| EP1828192B1 (en) * | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| AU2006290205B2 (en) | 2005-09-14 | 2012-12-13 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
| EP2055305A1 (en) * | 2006-08-11 | 2009-05-06 | Taisho Pharmaceutical Co. Ltd. | External preparation comprising prostaglandin derivative |
| TWI410422B (zh) | 2007-01-15 | 2013-10-01 | Mitsubishi Tanabe Pharma Corp | 縮合四氫喹啉衍生物及其醫藥用途 |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| ES2626131T3 (es) * | 2007-10-17 | 2017-07-24 | Laboratoire Hra Pharma | Antagonistas del receptor de glucocorticoides tales como mifepristona para tratar el síndrome de Cushing |
| GB2477256B (en) * | 2008-11-07 | 2013-12-25 | Univ Sheffield | Determination of predisposition towards subclinical Cushing's syndrome or incidentaloma |
| KR101925955B1 (ko) | 2011-03-18 | 2018-12-06 | 코어셉트 쎄라퓨틱스, 잉크. | 피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제 |
| US8865693B2 (en) * | 2011-03-31 | 2014-10-21 | Pop Test Cortisol Llc | Prevention of infection |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| KR101686872B1 (ko) * | 2014-08-25 | 2016-12-20 | 부산대학교 산학협력단 | Tlr4에 lps와의 경쟁적 결합을 통한 항산화 및 항염증 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
| WO2016032127A2 (ko) * | 2014-08-25 | 2016-03-03 | 부산대학교 산학협력단 | Tlr4에 lps와의 경쟁적 결합을 통한 항산화 및 항염증 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
| US10183949B2 (en) | 2014-08-29 | 2019-01-22 | The University Of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
| KR20180052120A (ko) | 2015-08-13 | 2018-05-17 | 코어셉트 쎄라퓨틱스, 잉크. | Acth-의존성 쿠싱 증후군을 감별 진단하는 방법 |
| KR102197526B1 (ko) | 2016-01-19 | 2020-12-31 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 이소성 쿠싱 증후군의 감별 진단 |
| SG11201908790PA (en) | 2017-03-31 | 2019-10-30 | Corcept Therapeutics Inc | Glucocorticoid receptor modulators to treat cervical cancer |
| US11542248B2 (en) * | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| TW201920170A (zh) | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
| ES2987563T3 (es) * | 2018-06-04 | 2024-11-15 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides ciclohexenilo pirimidina |
| AU2019404026B2 (en) | 2018-12-19 | 2023-06-08 | Corcept Therapeutics Incorporated | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11903945B2 (en) | 2019-12-11 | 2024-02-20 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| PT4077307T (pt) | 2019-12-18 | 2025-06-03 | Crinetics Pharmaceuticals Inc | Antagonistas do recetor de subtipo 2 da melanocortina (mc2r) à base de piperidina gem-dissubstituída e suas utilizações |
| JP7651574B2 (ja) | 2019-12-23 | 2025-03-26 | クリネティックス ファーマシューティカルズ，インク． | スピロ環式ピペリジンメラノコルチンサブタイプ－２受容体（ｍｃ２ｒ）アンタゴニストおよびその使用 |
| MX2022013804A (es) | 2020-05-06 | 2022-11-30 | Corcept Therapeutics Inc | Polimorfos de moduladores de los receptores de pirimidin-ciclohexil-glucocorticoides. |
| WO2021226258A1 (en) | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| KR20230017829A (ko) | 2020-05-27 | 2023-02-06 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 글루코코르티코이드 수용체 조절제 렐라코릴란트 및 cyp2c8과 cyp3a4의 이중 기질인 파클리탁셀의 병용 투여 |
| IL303881A (en) | 2020-12-21 | 2023-08-01 | Corcept Therapeutics Inc | Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12616698B2 (en) | 2021-05-05 | 2026-05-05 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
| WO2024077169A1 (en) | 2022-10-06 | 2024-04-11 | Corcept Therapeutics Incorporated | Formulations of glucocorticoid receptor modulators |
| US12433882B2 (en) | 2022-10-28 | 2025-10-07 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3011809A1 (de) | 1980-03-27 | 1981-10-01 | Cassella Ag, 6000 Frankfurt | Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung |
| US5008267A (en) | 1988-10-29 | 1991-04-16 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same |
| JPH06128238A (ja) | 1992-10-20 | 1994-05-10 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体 |
| EP0722732A1 (en) | 1995-01-24 | 1996-07-24 | Mitsui Toatsu Chemicals, Inc. | Long-acting drug formulation containing pyrimidinedione derivatives |
| JPH1017555A (ja) * | 1996-07-02 | 1998-01-20 | Mitsui Petrochem Ind Ltd | ６−アミノ−５−メチルウラシル誘導体 |
| ES2246292T3 (es) * | 2000-10-30 | 2006-02-16 | Pfizer Products Inc. | Moduladores de receptor glucocorticoide. |
| GB0029100D0 (en) | 2000-11-29 | 2001-01-10 | Karobio Ab | Compounds active at the glucocorticoid receptor |
| JP2003017555A (ja) | 2001-06-29 | 2003-01-17 | Hitachi Ltd | 半導体集積回路装置およびその製造方法 |
| WO2003084936A2 (en) | 2002-04-10 | 2003-10-16 | Orchid Chemicals & Pharmaceuticals Limited | Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological |
-
2005
- 2005-06-29 JP JP2007519511A patent/JP4958774B2/ja not_active Expired - Fee Related
- 2005-06-29 NZ NZ552984A patent/NZ552984A/en not_active IP Right Cessation
- 2005-06-29 PT PT05771551T patent/PT1778236E/pt unknown
- 2005-06-29 DE DE602005022319T patent/DE602005022319D1/de not_active Expired - Lifetime
- 2005-06-29 EP EP05771551A patent/EP1778236B1/en not_active Expired - Lifetime
- 2005-06-29 KR KR1020077002664A patent/KR101210730B1/ko not_active Expired - Fee Related
- 2005-06-29 CA CA2572544A patent/CA2572544C/en not_active Expired - Fee Related
- 2005-06-29 ES ES05771551T patent/ES2348667T3/es not_active Expired - Lifetime
- 2005-06-29 DK DK05771551.8T patent/DK1778236T3/da active
- 2005-06-29 AT AT05771551T patent/ATE473744T1/de active
- 2005-06-29 US US11/174,096 patent/US7576076B2/en active Active
- 2005-06-29 WO PCT/US2005/023675 patent/WO2006014394A1/en not_active Ceased
- 2005-06-29 AU AU2005270039A patent/AU2005270039B2/en not_active Ceased
-
2007
- 2007-01-02 IL IL180508A patent/IL180508A0/en not_active IP Right Cessation
- 2007-01-22 ZA ZA200700616A patent/ZA200700616B/xx unknown
-
2009
- 2009-07-08 US US12/499,753 patent/US8173664B2/en not_active Expired - Lifetime
-
2010
- 2010-10-11 CY CY20101100904T patent/CY1110828T1/el unknown