JP2010511721A5 - - Google Patents
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- Publication number
- JP2010511721A5 JP2010511721A5 JP2009540401A JP2009540401A JP2010511721A5 JP 2010511721 A5 JP2010511721 A5 JP 2010511721A5 JP 2009540401 A JP2009540401 A JP 2009540401A JP 2009540401 A JP2009540401 A JP 2009540401A JP 2010511721 A5 JP2010511721 A5 JP 2010511721A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- compound
- heteroaryl
- alkyl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87304106P | 2006-12-05 | 2006-12-05 | |
| PCT/US2007/086220 WO2008070599A1 (en) | 2006-12-05 | 2007-12-03 | Indazole compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010511721A JP2010511721A (ja) | 2010-04-15 |
| JP2010511721A5 true JP2010511721A5 (enExample) | 2011-01-27 |
Family
ID=39492604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540401A Withdrawn JP2010511721A (ja) | 2006-12-05 | 2007-12-03 | インダゾール化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7825261B2 (enExample) |
| EP (1) | EP2091329A4 (enExample) |
| JP (1) | JP2010511721A (enExample) |
| KR (1) | KR20090127867A (enExample) |
| CN (1) | CN101616587A (enExample) |
| AU (1) | AU2007329480A1 (enExample) |
| CA (1) | CA2671543A1 (enExample) |
| TW (1) | TWI433672B (enExample) |
| WO (1) | WO2008070599A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8697685B2 (en) | 2008-11-20 | 2014-04-15 | Glaxosmithkline Llc | Chemical compounds |
| DE102009049662A1 (de) | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
| ES2574253T3 (es) | 2009-12-18 | 2016-06-16 | Mitsubishi Tanabe Pharma Corporation | Nuevo agente antiplaquetario |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑 |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2970177A1 (en) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Indole compounds that activate ampk |
| CA2913085A1 (en) | 2013-05-23 | 2014-11-27 | Bernhard Lindenthal | Pharmaceutical composition and the use thereof, and application regime of said pharmaceutical composition for on-demand contraception |
| AR096848A1 (es) | 2013-07-09 | 2016-02-03 | Takeda Pharmaceuticals Co | Derivados de indazol con actividad antagonista del receptor de la hormona concentradora de melanina (mch) |
| KR101713303B1 (ko) | 2015-12-24 | 2017-03-07 | 강원대학교산학협력단 | 2ｈ-인다졸 유도체의 제조방법 |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| BR122023024273A2 (pt) | 2018-02-27 | 2024-02-20 | Incyte Corporation | Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| AU2019297361B2 (en) | 2018-07-05 | 2024-06-27 | Incyte Corporation | Fused pyrazine derivatives as A2A / A2B inhibitors |
| PT3860998T (pt) | 2018-10-05 | 2024-04-02 | Annapurna Bio Inc | Compostos e composições para o tratamento de condições associadas à atividade do recetor apj |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| EP3876930A4 (en) | 2018-11-07 | 2022-07-20 | Dana-Farber Cancer Institute, Inc. | BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| JP2022550589A (ja) * | 2019-10-01 | 2022-12-02 | メモリアル スローン ケタリング キャンサー センター | Ｉｄタンパク質の小分子阻害剤 |
| BR112022022409A2 (pt) | 2020-05-06 | 2023-02-07 | Ajax Therapeutics Inc | 6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2 |
| WO2022140527A1 (en) | 2020-12-23 | 2022-06-30 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL332187A1 (en) * | 1996-09-04 | 1999-08-30 | Pfizer | Substitution derivatives of indazole and their application as inhibitors of phosphodiesterase (pde) of iv type and tumor necrosis factor (tnf) |
| WO2000038677A1 (en) * | 1998-12-23 | 2000-07-06 | Allelix Biopharmaceuticals Inc. | Indole and indolizidine derivatives for the treatment of migraine |
| US7141581B2 (en) * | 1999-07-02 | 2006-11-28 | Agouron Pharmaceuticals, Inc. | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use |
| AU2002334355A1 (en) * | 2001-09-06 | 2003-03-18 | Prochon Biotech Ltd. | Protein tyrosine kinase inhibitors |
| WO2004052280A2 (en) * | 2002-12-10 | 2004-06-24 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
| BRPI0409241A (pt) * | 2003-04-10 | 2006-03-28 | Pfizer | compostos bicìclicos como antagonistas do receptor de nr2b, composições farmacêuticas compreendendo os mesmos e seu uso |
| KR20060005375A (ko) * | 2003-04-18 | 2006-01-17 | 메모리 파마슈티칼스 코포레이션 | 포스포디에스테라제 4 억제제로서의 피라졸 유도체 |
| EP1755394A4 (en) | 2004-04-16 | 2009-08-05 | Smithkline Beecham Corp | METHOD OF TREATING CANCER |
| EP1799673A1 (en) * | 2004-10-15 | 2007-06-27 | Memory Pharmaceuticals Corporation | Pyrazole derivatives as phosphodiesterase 4 inhibitors |
| CA2590261C (en) * | 2004-12-27 | 2011-08-16 | Alcon, Inc. | Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions |
| JP5116687B2 (ja) * | 2005-11-02 | 2013-01-09 | バイエル・ファルマ・アクチェンゲゼルシャフト | がんおよび他の過剰増殖性疾患の処置のためのピロロ［２，１−ｆ］［１，２，４］トリアジン−４−イルアミンＩＧＦ−１Ｒキナーゼ阻害剤 |
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2007
- 2007-12-03 EP EP07865081A patent/EP2091329A4/en not_active Withdrawn
- 2007-12-03 JP JP2009540401A patent/JP2010511721A/ja not_active Withdrawn
- 2007-12-03 AU AU2007329480A patent/AU2007329480A1/en not_active Abandoned
- 2007-12-03 WO PCT/US2007/086220 patent/WO2008070599A1/en not_active Ceased
- 2007-12-03 CA CA002671543A patent/CA2671543A1/en not_active Abandoned
- 2007-12-03 US US11/949,070 patent/US7825261B2/en not_active Expired - Fee Related
- 2007-12-03 KR KR1020097014013A patent/KR20090127867A/ko not_active Withdrawn
- 2007-12-03 CN CN200780045197A patent/CN101616587A/zh active Pending
- 2007-12-04 TW TW096146086A patent/TWI433672B/zh not_active IP Right Cessation