JP2012515776A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012515776A5 JP2012515776A5 JP2011547997A JP2011547997A JP2012515776A5 JP 2012515776 A5 JP2012515776 A5 JP 2012515776A5 JP 2011547997 A JP2011547997 A JP 2011547997A JP 2011547997 A JP2011547997 A JP 2011547997A JP 2012515776 A5 JP2012515776 A5 JP 2012515776A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- salt according
- heteroaryl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- -1 -C = NH Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14700209P | 2009-01-23 | 2009-01-23 | |
| US61/147,002 | 2009-01-23 | ||
| US15649609P | 2009-02-28 | 2009-02-28 | |
| US61/156,496 | 2009-02-28 | ||
| US25215609P | 2009-10-15 | 2009-10-15 | |
| US61/252,156 | 2009-10-15 | ||
| US25265209P | 2009-10-17 | 2009-10-17 | |
| US61/252,652 | 2009-10-17 | ||
| PCT/US2010/020373 WO2010085377A2 (en) | 2009-01-23 | 2010-01-07 | Hydroxamic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012515776A JP2012515776A (ja) | 2012-07-12 |
| JP2012515776A5 true JP2012515776A5 (enExample) | 2013-02-21 |
| JP5576402B2 JP5576402B2 (ja) | 2014-08-20 |
Family
ID=42356377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011547997A Active JP5576402B2 (ja) | 2009-01-23 | 2010-01-07 | ヒドロキサム酸誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | USRE46144E1 (enExample) |
| EP (1) | EP2389375B1 (enExample) |
| JP (1) | JP5576402B2 (enExample) |
| CN (1) | CN102186842B (enExample) |
| CA (1) | CA2750413C (enExample) |
| CY (1) | CY1116602T1 (enExample) |
| DK (1) | DK2389375T3 (enExample) |
| ES (1) | ES2544803T3 (enExample) |
| HR (1) | HRP20150778T1 (enExample) |
| HU (1) | HUE025349T2 (enExample) |
| ME (1) | ME02254B (enExample) |
| PL (1) | PL2389375T3 (enExample) |
| PT (1) | PT2389375E (enExample) |
| RS (1) | RS54192B1 (enExample) |
| SI (1) | SI2389375T1 (enExample) |
| SM (1) | SMT201500196B (enExample) |
| WO (1) | WO2010085377A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5749017B2 (ja) | 2008-01-22 | 2015-07-15 | ダウ アグロサイエンシィズ エルエルシー | ５−フルオロピリミジン誘導体 |
| USRE46144E1 (en) * | 2009-01-23 | 2016-09-13 | Purdue Pharmaceutical Products L.P. | Hydroxamic acid derivatives |
| JP5784603B2 (ja) | 2009-08-07 | 2015-09-24 | ダウ アグロサイエンシィズ エルエルシー | Ｎ１−スルホニル−５−フルオロピリミジノン誘導体 |
| UA107671C2 (en) * | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
| UA106889C2 (uk) | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-ацил-5-фторпіримідинону |
| UA112284C2 (uk) | 2009-08-07 | 2016-08-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні 5-фторпіримідинону |
| WO2011085084A1 (en) | 2010-01-07 | 2011-07-14 | Dow Agrosciences Llc | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS |
| CN101928234B (zh) * | 2010-01-15 | 2012-12-12 | 北京欧凯纳斯科技有限公司 | 6/7-（杂）芳基-n-羟基己/庚酰胺化合物及其制备方法 |
| WO2011113175A1 (zh) * | 2010-03-15 | 2011-09-22 | Gao Feng | 阿糖胞苷前药衍生物及其在抗癌抗肿瘤中的用途 |
| WO2012096832A2 (en) * | 2011-01-12 | 2012-07-19 | Crystal Biopharmaceutical Llc | Hdac inhibiting derivatives of camptothecin |
| US8658660B2 (en) | 2011-08-17 | 2014-02-25 | Dow Agrosciences, Llc. | 5-fluoro-4-imino-3,4-dihydropyrimidin-2-(1H)-ones derivatives |
| CN102993102B (zh) * | 2011-09-16 | 2016-08-24 | 杭州民生药业有限公司 | [1-甲基-2-(7’-庚异羟肟酸基)-5-n，n-二(2’-氯乙基)]-1h-苯并咪唑的合成方法 |
| PL2758052T3 (pl) | 2011-09-18 | 2018-10-31 | Euro-Celtique S.A. | Kompozycja farmaceutyczna zawierająca inhibitor HDAC i cyklopolisacharyd |
| CN102432654A (zh) * | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| TWI573792B (zh) * | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
| CN102584737A (zh) * | 2012-02-07 | 2012-07-18 | 盛世泰科生物医药技术(苏州)有限公司 | 抑制组蛋白去乙酰酶的物质的组成和使用 |
| EP2725029A1 (en) * | 2012-10-29 | 2014-04-30 | Laboratoire Biodim | New antibacterial compounds and biological applications thereof |
| RU2015131149A (ru) | 2012-12-28 | 2017-02-03 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | N-(замещенные)-5-фтор-4-имино-3-метил-2-оксо-3,4-дигидропиримидин-1(2н)-карбоксамидные производные |
| EP2938194B1 (en) | 2012-12-28 | 2019-11-27 | Adama Makhteshim Ltd. | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1 (2h)-carboxylate derivatives |
| UA117123C2 (uk) | 2012-12-28 | 2018-06-25 | Адама Махтешім Лтд. | Похідні 1-(заміщений бензоїл)-5-фтор-4-іміно-3-метил-3,4-дигідропіримідин-2(1h)-ону |
| CN112094262A (zh) | 2012-12-31 | 2020-12-18 | 阿达玛马克西姆股份有限公司 | 作为杀真菌剂的化合物 |
| CN103340845B (zh) * | 2013-06-26 | 2015-03-18 | 浙江省食品药品检验研究院 | 药物组合物 |
| WO2015081867A1 (zh) * | 2013-12-04 | 2015-06-11 | 杭州民生药物研究院有限公司 | 吉西他滨衍生物、含该衍生物的组合物及所述衍生物的制药用途 |
| CN106028816A (zh) | 2013-12-31 | 2016-10-12 | 阿达玛马克西姆股份有限公司 | 用防治谷类中真菌的协同杀真菌混合物 |
| NZ722438A (en) | 2013-12-31 | 2018-01-26 | Adama Makhteshim Ltd | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation |
| US10241232B2 (en) | 2014-02-03 | 2019-03-26 | Halliburton Energy Services, Inc. | Geomechanical and geophysical computational model for oil and gas stimulation and production |
| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| KR20170077131A (ko) * | 2014-10-28 | 2017-07-05 | 시오노기세야쿠 가부시키가이샤 | Ampk 활성화 작용을 갖는 복소환 유도체 |
| PT3297992T (pt) | 2015-05-22 | 2020-03-17 | Chong Kun Dang Pharmaceutical Corp | Compostos derivados de alquilo heterocíclicos como inibidores seletivos da histona desacetilase e composições farmacêuticas que compreendem os mesmos |
| ES2969743T3 (es) * | 2015-09-10 | 2024-05-22 | Becton Dickinson Co | Análogos de la ciclofosfamida para uso como inmunógenos y conjugados en un inmunoensayo para la ciclofosfamida y la ifosfamida |
| WO2018068832A1 (en) | 2016-10-11 | 2018-04-19 | Euro-Celtique S.A. | Hodgkin lymphoma therapy |
| CN106905191B (zh) * | 2017-03-05 | 2019-03-29 | 北京化工大学 | 一种含有羟肟酸基团的氮芥类化合物及其制备方法和用途 |
| CN106883217B (zh) * | 2017-04-01 | 2020-05-22 | 清华大学深圳研究生院 | 一种核苷碱基异羟肟酸衍生化合物及其制备方法与应用 |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709405D0 (en) * | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709403D0 (en) * | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| US20210085796A1 (en) * | 2017-07-28 | 2021-03-25 | Yale University | Anticancer drugs and methods of making and using same |
| CN111107939B (zh) | 2017-09-21 | 2022-04-12 | 贝克顿·迪金森公司 | 引导有害污染物样品的收集的系统和模板及使用其的方法 |
| USD859683S1 (en) | 2017-09-21 | 2019-09-10 | Becton, Dickinson And Company | Collection device |
| JP7223749B2 (ja) | 2017-09-21 | 2023-02-16 | ベクトン・ディキンソン・アンド・カンパニー | 危険汚染物質の試験における高ダイナミックレンジの分析器 |
| AU2018337030B2 (en) | 2017-09-21 | 2025-04-10 | Becton, Dickinson And Company | Hazardous contaminant collection kit and rapid testing |
| CN108299313B (zh) * | 2018-01-16 | 2020-10-02 | 长沙霍滋生物科技有限公司 | 一种化合物及其在药学上的应用 |
| CN109516957A (zh) * | 2018-08-03 | 2019-03-26 | 杭州梯诺医药科技有限公司 | Nl-101多晶型及其制备方法 |
| BR112021001652A2 (pt) * | 2018-08-03 | 2021-05-04 | Cellix Bio Private Limited | composto e composição farmacêutica |
| KR102645496B1 (ko) * | 2018-09-01 | 2024-03-07 | 베이징 서우바이 파마슈티컬 컴퍼니 리미티드 | 백금계 화합물 인산염 및 그 제조 방법 |
| EP3897625A1 (en) | 2018-12-18 | 2021-10-27 | Mundipharma International Corporation Limited | Compounds for treating lymphoma or a t-cell malignant disease |
| CN113383222A (zh) | 2019-01-28 | 2021-09-10 | 贝克顿·迪金森公司 | 具有集成的拭子和测试装置的有害污染物收集装置 |
| CN112209884B (zh) * | 2019-07-12 | 2022-11-11 | 杭州梯诺医药科技有限公司 | 1-h苯并咪唑衍生物、制备方法及其应用 |
| CN113307829B (zh) * | 2021-05-08 | 2022-05-24 | 苏州科技大学 | 一种以异羟肟酸衍生物为配体的铂(ii)配合物及其制备方法和应用 |
| WO2024231293A1 (en) | 2023-05-05 | 2024-11-14 | Euro-Celtique S.A. | Combinations for treating cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| ATE310719T1 (de) | 2000-09-29 | 2005-12-15 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine amidgruppe als hdac-inhibitoren |
| CA2561617A1 (en) | 2004-04-05 | 2005-10-20 | Aton Pharma, Inc. | Histone deacetylase inhibitor prodrugs |
| WO2007134169A2 (en) | 2006-05-10 | 2007-11-22 | Nuada, Llc | Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| GB0621160D0 (en) | 2006-10-24 | 2006-12-06 | Imp College Innovations Ltd | Compounds and uses thereof |
| US8987468B2 (en) * | 2008-02-04 | 2015-03-24 | The Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives |
| USRE46144E1 (en) * | 2009-01-23 | 2016-09-13 | Purdue Pharmaceutical Products L.P. | Hydroxamic acid derivatives |
-
2010
- 2010-01-07 US US14/972,750 patent/USRE46144E1/en active Active
- 2010-01-07 ME MEP-2015-541A patent/ME02254B/me unknown
- 2010-01-07 CN CN201080002890.XA patent/CN102186842B/zh active Active
- 2010-01-07 RS RS20150541A patent/RS54192B1/sr unknown
- 2010-01-07 WO PCT/US2010/020373 patent/WO2010085377A2/en not_active Ceased
- 2010-01-07 ES ES10733747.9T patent/ES2544803T3/es active Active
- 2010-01-07 EP EP20100733747 patent/EP2389375B1/en active Active
- 2010-01-07 DK DK10733747.9T patent/DK2389375T3/en active
- 2010-01-07 HR HRP20150778TT patent/HRP20150778T1/hr unknown
- 2010-01-07 CA CA2750413A patent/CA2750413C/en active Active
- 2010-01-07 JP JP2011547997A patent/JP5576402B2/ja active Active
- 2010-01-07 HU HUE10733747A patent/HUE025349T2/en unknown
- 2010-01-07 US US13/143,155 patent/US8609864B2/en not_active Ceased
- 2010-01-07 PT PT107337479T patent/PT2389375E/pt unknown
- 2010-01-07 PL PL10733747T patent/PL2389375T3/pl unknown
- 2010-01-07 SI SI201030986T patent/SI2389375T1/sl unknown
-
2013
- 2013-11-08 US US14/075,145 patent/US9096627B2/en active Active
-
2015
- 2015-08-13 CY CY20151100709T patent/CY1116602T1/el unknown
- 2015-08-13 SM SM201500196T patent/SMT201500196B/xx unknown