JP2012515776A5 - - Google Patents
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- Publication number
- JP2012515776A5 JP2012515776A5 JP2011547997A JP2011547997A JP2012515776A5 JP 2012515776 A5 JP2012515776 A5 JP 2012515776A5 JP 2011547997 A JP2011547997 A JP 2011547997A JP 2011547997 A JP2011547997 A JP 2011547997A JP 2012515776 A5 JP2012515776 A5 JP 2012515776A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- salt according
- heteroaryl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- -1 -C = NH Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14700209P | 2009-01-23 | 2009-01-23 | |
| US61/147,002 | 2009-01-23 | ||
| US15649609P | 2009-02-28 | 2009-02-28 | |
| US61/156,496 | 2009-02-28 | ||
| US25215609P | 2009-10-15 | 2009-10-15 | |
| US61/252,156 | 2009-10-15 | ||
| US25265209P | 2009-10-17 | 2009-10-17 | |
| US61/252,652 | 2009-10-17 | ||
| PCT/US2010/020373 WO2010085377A2 (en) | 2009-01-23 | 2010-01-07 | Hydroxamic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012515776A JP2012515776A (ja) | 2012-07-12 |
| JP2012515776A5 true JP2012515776A5 (enExample) | 2013-02-21 |
| JP5576402B2 JP5576402B2 (ja) | 2014-08-20 |
Family
ID=42356377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011547997A Active JP5576402B2 (ja) | 2009-01-23 | 2010-01-07 | ヒドロキサム酸誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | USRE46144E1 (enExample) |
| EP (1) | EP2389375B1 (enExample) |
| JP (1) | JP5576402B2 (enExample) |
| CN (1) | CN102186842B (enExample) |
| CA (1) | CA2750413C (enExample) |
| CY (1) | CY1116602T1 (enExample) |
| DK (1) | DK2389375T3 (enExample) |
| ES (1) | ES2544803T3 (enExample) |
| HR (1) | HRP20150778T1 (enExample) |
| HU (1) | HUE025349T2 (enExample) |
| ME (1) | ME02254B (enExample) |
| PL (1) | PL2389375T3 (enExample) |
| PT (1) | PT2389375E (enExample) |
| RS (1) | RS54192B1 (enExample) |
| SI (1) | SI2389375T1 (enExample) |
| SM (1) | SMT201500196B (enExample) |
| WO (1) | WO2010085377A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2562166B1 (en) | 2008-01-22 | 2015-08-19 | Dow AgroSciences LLC | 5-fluoro pyrimidine derivatives as fungicides |
| PL2389375T3 (pl) * | 2009-01-23 | 2015-11-30 | Euro Celtique Sa | Pochodne kwasu hydroksamowego |
| JP5784603B2 (ja) | 2009-08-07 | 2015-09-24 | ダウ アグロサイエンシィズ エルエルシー | Ｎ１−スルホニル−５−フルオロピリミジノン誘導体 |
| UA112284C2 (uk) | 2009-08-07 | 2016-08-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні 5-фторпіримідинону |
| UA106889C2 (uk) | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-ацил-5-фторпіримідинону |
| UA107671C2 (en) * | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
| CN102791135B (zh) | 2010-01-07 | 2015-05-20 | 陶氏益农公司 | 噻唑并[5,4-d]嘧啶以及它们作为农用化学品的用途 |
| CN101928234B (zh) * | 2010-01-15 | 2012-12-12 | 北京欧凯纳斯科技有限公司 | 6/7-（杂）芳基-n-羟基己/庚酰胺化合物及其制备方法 |
| WO2011113175A1 (zh) * | 2010-03-15 | 2011-09-22 | Gao Feng | 阿糖胞苷前药衍生物及其在抗癌抗肿瘤中的用途 |
| US8980909B2 (en) * | 2011-01-12 | 2015-03-17 | Crystal Biopharmaceutical Llc | HDAC inhibiting derivatives of camptothecin |
| RS56609B1 (sr) | 2011-08-17 | 2018-02-28 | Adama Makhteshim Ltd | 1-supstituisani derivati 5-fluor-3,6-dihidro-6-imino-2(1h)-pirimidinona kao fungicidna sredstva za upotrebu u proizvodnji bilja |
| CN102993102B (zh) * | 2011-09-16 | 2016-08-24 | 杭州民生药业有限公司 | [1-甲基-2-(7’-庚异羟肟酸基)-5-n，n-二(2’-氯乙基)]-1h-苯并咪唑的合成方法 |
| EP2758052B9 (en) * | 2011-09-18 | 2019-03-27 | Euro-Celtique S.A. | Pharmaceutical composition comprising an HDAC inhibitor and a cyclopolysaccharide |
| CN102432654A (zh) * | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| TWI573792B (zh) * | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
| CN102584737A (zh) * | 2012-02-07 | 2012-07-18 | 盛世泰科生物医药技术(苏州)有限公司 | 抑制组蛋白去乙酰酶的物质的组成和使用 |
| EP2725029A1 (en) * | 2012-10-29 | 2014-04-30 | Laboratoire Biodim | New antibacterial compounds and biological applications thereof |
| WO2014105821A1 (en) | 2012-12-28 | 2014-07-03 | Dow Agrosciences Llc | 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1h)-one derivatives |
| JP6258969B2 (ja) | 2012-12-28 | 2018-01-10 | アダマ・マクテシム・リミテッド | Ｎ−（置換）−５−フルオロ−４−イミノ−３−メチル−２−オキソ−３，４−ジヒドロピリミジン−１（２ｈ）−カルボキサミド誘導体 |
| CN104902757B (zh) | 2012-12-28 | 2019-01-08 | 阿达玛马克西姆股份有限公司 | N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-羧酸酯衍生物 |
| CN112094262A (zh) | 2012-12-31 | 2020-12-18 | 阿达玛马克西姆股份有限公司 | 作为杀真菌剂的化合物 |
| CN103340845B (zh) * | 2013-06-26 | 2015-03-18 | 浙江省食品药品检验研究院 | 药物组合物 |
| JP6212831B2 (ja) * | 2013-12-04 | 2017-10-18 | 杭州源昶医薬科技有限公司 | ゲムシタビン誘導体、該誘導体を含む組成物及び該誘導体の製薬用途 |
| UA129860C2 (uk) | 2013-12-31 | 2025-08-27 | Адама Махтешім Лтд. | 5-фтор-4-іміно-3-(алкіл/заміщений алкіл)-1-(арилсульфоніл)-3,4-дигідропіримідин-2(1h)-он і способи його одержання |
| CR20160344A (es) | 2013-12-31 | 2016-12-19 | Adama Makhteshim Ltd | Mezclas fungicidas sinérgicas para el control fúngico en cereales |
| CA2935250C (en) | 2014-02-03 | 2018-07-24 | Halliburton Energy Services, Inc. | Optimizing a grid for finite element solutions for subterranean region simulations |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409471D0 (en) * | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) * | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| KR20170077131A (ko) * | 2014-10-28 | 2017-07-05 | 시오노기세야쿠 가부시키가이샤 | Ampk 활성화 작용을 갖는 복소환 유도체 |
| JP6507267B2 (ja) | 2015-05-22 | 2019-04-24 | チョン クン ダン ファーマシューティカル コーポレーション | 選択的ヒストンデアセチラーゼ阻害剤としてのヘテロ環状アルキル誘導体化合物及びこれを含有する薬剤学的組成物 |
| WO2017044453A1 (en) * | 2015-09-10 | 2017-03-16 | Becton, Dickinson And Company | Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide |
| US11266631B2 (en) | 2016-10-11 | 2022-03-08 | Purdue Pharmaceutical Products L.P. | Hodgkin lymphoma therapy |
| CN106905191B (zh) * | 2017-03-05 | 2019-03-29 | 北京化工大学 | 一种含有羟肟酸基团的氮芥类化合物及其制备方法和用途 |
| CN106883217B (zh) * | 2017-04-01 | 2020-05-22 | 清华大学深圳研究生院 | 一种核苷碱基异羟肟酸衍生化合物及其制备方法与应用 |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709403D0 (en) * | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709405D0 (en) * | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| CA3071345A1 (en) * | 2017-07-28 | 2019-01-31 | Yale University | Anticancer drugs and methods of making and using same |
| EP3684944B1 (en) | 2017-09-21 | 2025-01-01 | Becton, Dickinson and Company | Hazardous contaminant collection kit and rapid testing |
| USD859683S1 (en) | 2017-09-21 | 2019-09-10 | Becton, Dickinson And Company | Collection device |
| CA3075775A1 (en) | 2017-09-21 | 2019-03-28 | Becton, Dickinson And Company | High dynamic range assays in hazardous contaminant testing |
| CN209400538U (zh) | 2017-09-21 | 2019-09-17 | 贝克顿·迪金森公司 | 引导从表面收集有害污染物样品的模板和包括其的系统 |
| CN108299313B (zh) * | 2018-01-16 | 2020-10-02 | 长沙霍滋生物科技有限公司 | 一种化合物及其在药学上的应用 |
| CN109516957A (zh) * | 2018-08-03 | 2019-03-26 | 杭州梯诺医药科技有限公司 | Nl-101多晶型及其制备方法 |
| CA3108362A1 (en) * | 2018-08-03 | 2020-02-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of cancer |
| WO2020043144A1 (zh) | 2018-09-01 | 2020-03-05 | 北京硕佰医药科技有限责任公司 | 一种铂类化合物磷酸盐及其制备方法 |
| WO2020128913A1 (en) | 2018-12-18 | 2020-06-25 | Mundipharma International Corporation Limited | Compounds for treating multiple myeloma |
| US11280801B2 (en) | 2019-01-28 | 2022-03-22 | Becton, Dickinson And Company | Hazardous contaminant collection device with integrated swab and test device |
| CN112209884B (zh) * | 2019-07-12 | 2022-11-11 | 杭州梯诺医药科技有限公司 | 1-h苯并咪唑衍生物、制备方法及其应用 |
| CN113307829B (zh) * | 2021-05-08 | 2022-05-24 | 苏州科技大学 | 一种以异羟肟酸衍生物为配体的铂(ii)配合物及其制备方法和应用 |
| EP4705341A1 (en) | 2023-05-05 | 2026-03-11 | Euro-Celtique S.A. | Combinations for treating cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| ATE310719T1 (de) | 2000-09-29 | 2005-12-15 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine amidgruppe als hdac-inhibitoren |
| CA2561617A1 (en) * | 2004-04-05 | 2005-10-20 | Aton Pharma, Inc. | Histone deacetylase inhibitor prodrugs |
| WO2007134169A2 (en) | 2006-05-10 | 2007-11-22 | Nuada, Llc | Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| GB0621160D0 (en) | 2006-10-24 | 2006-12-06 | Imp College Innovations Ltd | Compounds and uses thereof |
| US8987468B2 (en) * | 2008-02-04 | 2015-03-24 | The Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives |
| PL2389375T3 (pl) * | 2009-01-23 | 2015-11-30 | Euro Celtique Sa | Pochodne kwasu hydroksamowego |
-
2010
- 2010-01-07 PL PL10733747T patent/PL2389375T3/pl unknown
- 2010-01-07 ME MEP-2015-541A patent/ME02254B/me unknown
- 2010-01-07 WO PCT/US2010/020373 patent/WO2010085377A2/en not_active Ceased
- 2010-01-07 JP JP2011547997A patent/JP5576402B2/ja active Active
- 2010-01-07 CN CN201080002890.XA patent/CN102186842B/zh active Active
- 2010-01-07 HR HRP20150778TT patent/HRP20150778T1/hr unknown
- 2010-01-07 HU HUE10733747A patent/HUE025349T2/en unknown
- 2010-01-07 ES ES10733747.9T patent/ES2544803T3/es active Active
- 2010-01-07 DK DK10733747.9T patent/DK2389375T3/en active
- 2010-01-07 EP EP20100733747 patent/EP2389375B1/en active Active
- 2010-01-07 RS RS20150541A patent/RS54192B1/sr unknown
- 2010-01-07 US US14/972,750 patent/USRE46144E1/en active Active
- 2010-01-07 CA CA2750413A patent/CA2750413C/en active Active
- 2010-01-07 US US13/143,155 patent/US8609864B2/en not_active Ceased
- 2010-01-07 SI SI201030986T patent/SI2389375T1/sl unknown
- 2010-01-07 PT PT107337479T patent/PT2389375E/pt unknown
-
2013
- 2013-11-08 US US14/075,145 patent/US9096627B2/en active Active
-
2015
- 2015-08-13 SM SM201500196T patent/SMT201500196B/xx unknown
- 2015-08-13 CY CY20151100709T patent/CY1116602T1/el unknown