JP2012092103A5 - - Google Patents
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- Publication number
- JP2012092103A5 JP2012092103A5 JP2011237399A JP2011237399A JP2012092103A5 JP 2012092103 A5 JP2012092103 A5 JP 2012092103A5 JP 2011237399 A JP2011237399 A JP 2011237399A JP 2011237399 A JP2011237399 A JP 2011237399A JP 2012092103 A5 JP2012092103 A5 JP 2012092103A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- fluoro
- chloro
- bromo
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000001153 fluoro group Chemical group F* 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 5
- -1 hydroxy, amino Chemical group 0.000 claims 5
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 125000001246 bromo group Chemical group Br* 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000001118 alkylidene group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 0 **C1(*=C)c2c3nn[n](*)c3ccc2C2=C(*)C(*)C3CC12C(*)C3 Chemical compound **C1(*=C)c2c3nn[n](*)c3ccc2C2=C(*)C(*)C3CC12C(*)C3 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63478504P | 2004-12-09 | 2004-12-09 | |
| US60/634,785 | 2004-12-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545542A Division JP2008523065A (ja) | 2004-12-09 | 2005-12-05 | エストロゲン受容体モジュレーター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012092103A JP2012092103A (ja) | 2012-05-17 |
| JP2012092103A5 true JP2012092103A5 (enExample) | 2013-01-17 |
Family
ID=36578441
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545542A Withdrawn JP2008523065A (ja) | 2004-12-09 | 2005-12-05 | エストロゲン受容体モジュレーター |
| JP2011237399A Pending JP2012092103A (ja) | 2004-12-09 | 2011-10-28 | エストロゲン受容体モジュレーター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545542A Withdrawn JP2008523065A (ja) | 2004-12-09 | 2005-12-05 | エストロゲン受容体モジュレーター |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7511152B2 (enExample) |
| EP (1) | EP1827421B1 (enExample) |
| JP (2) | JP2008523065A (enExample) |
| KR (1) | KR20070085874A (enExample) |
| CN (1) | CN101087606B (enExample) |
| AU (1) | AU2005314230B2 (enExample) |
| BR (1) | BRPI0518874A2 (enExample) |
| CA (1) | CA2590860C (enExample) |
| IL (1) | IL183543A (enExample) |
| MX (1) | MX2007006878A (enExample) |
| NO (1) | NO20073511L (enExample) |
| NZ (1) | NZ555316A (enExample) |
| RU (1) | RU2394820C2 (enExample) |
| WO (1) | WO2006062876A2 (enExample) |
| ZA (1) | ZA200704223B (enExample) |
Families Citing this family (26)
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| WO2006065599A1 (en) * | 2004-12-17 | 2006-06-22 | Bionovo, Inc. | Method of using extracts of epimedium species |
| US7482029B2 (en) * | 2005-04-01 | 2009-01-27 | Bionovo, Inc. | Composition for treatment of menopause |
| EP1943224B1 (en) * | 2005-10-05 | 2011-07-27 | Merck Sharp & Dohme Corp. | Estrogen receptor modulators |
| US7700136B2 (en) * | 2005-11-14 | 2010-04-20 | Bionovo, Inc. | Scutellaria barbata extract for the treatment of cancer |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| KR101638035B1 (ko) | 2007-01-22 | 2016-07-11 | 지티엑스, 인코포레이티드 | 핵 수용체에 결합하는 물질 |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US20090042818A1 (en) * | 2007-06-22 | 2009-02-12 | Bionovo, Inc. | Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists |
| US20080319051A1 (en) * | 2007-06-22 | 2008-12-25 | Bionovo, Inc. | Liquiritigenin and derivatives as selective estrogen receptor beta agonists |
| AU2008285325A1 (en) * | 2007-08-08 | 2009-02-12 | Bionovo, Inc. | Extracts of Ligustrum lucidum and uses thereof |
| AU2008296076A1 (en) * | 2007-09-07 | 2009-03-12 | Bionovo, Inc. | Estrogenic extracts of Pueraria lobata Willd, Ohwi of the Leguminosae family and uses thereof |
| US20090068298A1 (en) * | 2007-09-07 | 2009-03-12 | Bionovo, Inc. | ESTROGENIC EXTRACTS OF Astragalus membranaceus Fisch. Bge. Var. mongolicus Bge. of the Leguminosae Family AND USES THEREOF |
| AU2008296136A1 (en) * | 2007-09-07 | 2009-03-12 | Bionovo. Inc. | Estrogenic extracts of Scuttelaria barbata D. Don of the Labiatae Family and uses thereof |
| WO2009033025A1 (en) * | 2007-09-07 | 2009-03-12 | Bionovo, Inc. | Estrogenic extracts of asparagus conchinchinensis (lour.) merr of the liliaceae family and uses thereof |
| US8512961B2 (en) | 2007-11-19 | 2013-08-20 | Bionovo, Inc. | Methods of detecting and treatment of cancers using Scutellaria barbata extract |
| US20090130101A1 (en) * | 2007-11-19 | 2009-05-21 | Bionovo, Inc. | Anti-cancer therapy with an extract of scutellaria barbata |
| AU2008326431A1 (en) * | 2007-11-19 | 2009-05-28 | Bionovo, Inc. | Scutellaria barbata extract and combinations for the treatment of cancer |
| WO2009070478A2 (en) * | 2007-11-19 | 2009-06-04 | Bionovo, Inc. | A process of making purified extract of scutellaria barbata d. don |
| AU2009236339A1 (en) * | 2008-04-14 | 2009-10-22 | Bionovo, Inc. | Calycosin and analogs thereof for the treatment of estrogen receptor beta-mediated diseases |
| JP2011519947A (ja) * | 2008-05-06 | 2011-07-14 | バイオノボ・インコーポレーテッド | 膣および外陰の委縮を治療するために使用するエストロゲン様抽出物 |
| US20090311349A1 (en) * | 2008-06-05 | 2009-12-17 | Bionovo, Inc., A Delaware Corporation | Method of quantification of multiple bioactives from botanical compositions |
| US20090312437A1 (en) * | 2008-06-06 | 2009-12-17 | Bionovo, Inc., A Delaware Corporation | Anthraquinones and Analogs from Rhuem palmatum for Treatment of Estrogen Receptor Beta-Mediated Conditions |
| US20100069480A1 (en) * | 2008-09-03 | 2010-03-18 | Bionovo, Inc. A Delaware Corporation | Methods and compositions for the treatment of cancer |
| WO2010129343A2 (en) * | 2009-04-28 | 2010-11-11 | Bionovo, Inc. | Method of reducing fat accumulation and inducing weight loss |
| CN105960236A (zh) | 2013-12-05 | 2016-09-21 | 卡罗医药股份公司 | 用于治疗间皮瘤的雌激素受体β激动剂 |
| WO2017107754A1 (zh) * | 2015-12-22 | 2017-06-29 | 江苏恒瑞医药股份有限公司 | 苯并哌啶类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (34)
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|---|---|---|---|---|
| US4294926A (en) | 1979-06-15 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4319039A (en) | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| JPS5889191A (ja) | 1981-11-20 | 1983-05-27 | Sankyo Co Ltd | ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法 |
| HU204253B (en) | 1982-11-22 | 1991-12-30 | Sandoz Ag | Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them |
| US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
| US4911165A (en) | 1983-01-12 | 1990-03-27 | Ethicon, Inc. | Pliabilized polypropylene surgical filaments |
| US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US4782084A (en) | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
| US4885314A (en) | 1987-06-29 | 1989-12-05 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| US5180589A (en) | 1988-03-31 | 1993-01-19 | E. R. Squibb & Sons, Inc. | Pravastatin pharmaceuatical compositions having good stability |
| US5030447A (en) | 1988-03-31 | 1991-07-09 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions having good stability |
| US4916239A (en) | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
| US5118853A (en) | 1988-10-13 | 1992-06-02 | Sandoz Ltd. | Processes for the synthesis of 3-disubstituted aminoacroleins |
| US5290946A (en) | 1988-10-13 | 1994-03-01 | Sandoz Ltd. | Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes |
| US4929437A (en) | 1989-02-02 | 1990-05-29 | Merck & Co., Inc. | Coenzyme Q10 with HMG-CoA reductase inhibitors |
| US5189164A (en) | 1989-05-22 | 1993-02-23 | Sandoz Ltd. | Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5177080A (en) | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
| HU9203780D0 (en) | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
| US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| DE19523446A1 (de) * | 1995-06-28 | 1997-01-02 | Bayer Ag | Benzotriazole |
| EA200100972A1 (ru) | 1999-03-15 | 2002-02-28 | Аксис Фармасьютикалз, Инк. | Новые соединения и композиции как ингибиторы протеаз |
| DE60132975T2 (de) | 2000-01-06 | 2009-02-26 | Merck Frosst Canada Inc., Kirkland | Neue substanzen und verbindungen als protease-inhibitoren |
| JP4331913B2 (ja) * | 2000-02-14 | 2009-09-16 | メルク エンド カムパニー インコーポレーテッド | エストロゲンレセプターモデュレーター |
| GB0012209D0 (en) | 2000-05-19 | 2000-07-12 | Novartis Ag | Organic compounds |
| DK1296689T3 (da) * | 2000-06-20 | 2005-11-28 | Novartis Ag | Fremgangsmåde til indgivelse af bisphosphonater |
| JP4119246B2 (ja) * | 2000-11-27 | 2008-07-16 | メルク エンド カムパニー インコーポレーテッド | エストロゲンレセプター修飾物質 |
| JP2005502654A (ja) * | 2001-08-13 | 2005-01-27 | メルク エンド カムパニー インコーポレーテッド | 選択的エストロゲン受容体調節剤 |
| CA2497934A1 (en) | 2002-09-19 | 2004-04-01 | Merck & Co., Inc. | Tryptophan hydroxylase assay |
| AR051597A1 (es) * | 2004-11-01 | 2007-01-24 | Merck & Co Inc | Moduladores de los receptores de estrogeno |
-
2005
- 2005-12-05 WO PCT/US2005/043859 patent/WO2006062876A2/en not_active Ceased
- 2005-12-05 BR BRPI0518874-1A patent/BRPI0518874A2/pt not_active IP Right Cessation
- 2005-12-05 CN CN2005800422962A patent/CN101087606B/zh not_active Expired - Fee Related
- 2005-12-05 KR KR1020077012865A patent/KR20070085874A/ko not_active Ceased
- 2005-12-05 NZ NZ555316A patent/NZ555316A/en not_active IP Right Cessation
- 2005-12-05 MX MX2007006878A patent/MX2007006878A/es active IP Right Grant
- 2005-12-05 CA CA2590860A patent/CA2590860C/en not_active Expired - Fee Related
- 2005-12-05 AU AU2005314230A patent/AU2005314230B2/en not_active Ceased
- 2005-12-05 JP JP2007545542A patent/JP2008523065A/ja not_active Withdrawn
- 2005-12-05 US US11/792,729 patent/US7511152B2/en not_active Expired - Lifetime
- 2005-12-05 EP EP05852923.1A patent/EP1827421B1/en not_active Expired - Lifetime
- 2005-12-05 RU RU2007125655/04A patent/RU2394820C2/ru not_active IP Right Cessation
-
2007
- 2007-05-22 ZA ZA200704223A patent/ZA200704223B/xx unknown
- 2007-05-29 IL IL183543A patent/IL183543A/en not_active IP Right Cessation
- 2007-07-06 NO NO20073511A patent/NO20073511L/no not_active Application Discontinuation
-
2011
- 2011-10-28 JP JP2011237399A patent/JP2012092103A/ja active Pending