JP2012092103A5 - - Google Patents
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- JP2012092103A5 JP2012092103A5 JP2011237399A JP2011237399A JP2012092103A5 JP 2012092103 A5 JP2012092103 A5 JP 2012092103A5 JP 2011237399 A JP2011237399 A JP 2011237399A JP 2011237399 A JP2011237399 A JP 2011237399A JP 2012092103 A5 JP2012092103 A5 JP 2012092103A5
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- Prior art keywords
- alkyl
- fluoro
- chloro
- bromo
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 **C1(*=C)c2c3nn[n](*)c3ccc2C2=C(*)C(*)C3CC12C(*)C3 Chemical compound **C1(*=C)c2c3nn[n](*)c3ccc2C2=C(*)C(*)C3CC12C(*)C3 0.000 description 1
Claims (1)
- 式:
R1は水素、フルオロ、クロロ、ブロモ、ヨード、C1−4アルキル、C2−4アルケニル、C2−4アルキニル、C3−6シクロアルキル、アリール又はヘテロアリールであり、前記アルキル、アルケニル、アルキニル、シクロアルキル、アリール及びヘテロアリール基は場合によりフルオロ、クロロ、ブロモ、ヨード、シアノ及びORaから構成される群から選択される1、2又は3個の基で置換されており;
R2は水素、(C=O)Ra、(C=O)ORa又はSO2Raであり;
R3は水素、フルオロ、クロロ、ブロモ又はヒドロキシであり;
R4は水素、フルオロ、クロロ、ブロモ又はヒドロキシであるか;
あるいはR3とR4は一緒になってそれらが結合している炭素原子と共にカルボニル基を形成し;
R5は水素、フルオロ、クロロ又はC1−5アルキルであり、前記アルキルは場合によりクロロ、ブロモ、ヨード、ORa又は1〜5個のフルオロで置換されており;
Raは水素、C1−4アルキル、及びフェニルから構成される群から選択され、前記アルキル及びフェニル基は場合によりヒドロキシ、アミノ、O(C1−4アルキル)、NH(C1−4アルキル)、N(C1−4アルキル)2、クロロ、ブロモ又は1〜5個のフルオロで置換されており、2個以上のRaが存在する場合には、独立して選択される]の化合物又はその医薬的に許容可能な塩もしくは立体異性体。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63478504P | 2004-12-09 | 2004-12-09 | |
US60/634,785 | 2004-12-09 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007545542A Division JP2008523065A (ja) | 2004-12-09 | 2005-12-05 | エストロゲン受容体モジュレーター |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012092103A JP2012092103A (ja) | 2012-05-17 |
JP2012092103A5 true JP2012092103A5 (ja) | 2013-01-17 |
Family
ID=36578441
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007545542A Withdrawn JP2008523065A (ja) | 2004-12-09 | 2005-12-05 | エストロゲン受容体モジュレーター |
JP2011237399A Pending JP2012092103A (ja) | 2004-12-09 | 2011-10-28 | エストロゲン受容体モジュレーター |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007545542A Withdrawn JP2008523065A (ja) | 2004-12-09 | 2005-12-05 | エストロゲン受容体モジュレーター |
Country Status (15)
Country | Link |
---|---|
US (1) | US7511152B2 (ja) |
EP (1) | EP1827421B1 (ja) |
JP (2) | JP2008523065A (ja) |
KR (1) | KR20070085874A (ja) |
CN (1) | CN101087606B (ja) |
AU (1) | AU2005314230B2 (ja) |
BR (1) | BRPI0518874A2 (ja) |
CA (1) | CA2590860C (ja) |
IL (1) | IL183543A (ja) |
MX (1) | MX2007006878A (ja) |
NO (1) | NO20073511L (ja) |
NZ (1) | NZ555316A (ja) |
RU (1) | RU2394820C2 (ja) |
WO (1) | WO2006062876A2 (ja) |
ZA (1) | ZA200704223B (ja) |
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CN101641013B (zh) | 2007-01-22 | 2014-07-30 | Gtx公司 | 核受体结合剂 |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
US20080319051A1 (en) * | 2007-06-22 | 2008-12-25 | Bionovo, Inc. | Liquiritigenin and derivatives as selective estrogen receptor beta agonists |
US20090042818A1 (en) * | 2007-06-22 | 2009-02-12 | Bionovo, Inc. | Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists |
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AU2008296072A1 (en) * | 2007-09-07 | 2009-03-12 | Bionovo, Inc. | Estrogenic extracts of Astragalus membranaceus Fisch.Bge.Var.mongolicus Bge. of the Leguminosae Family and uses thereof |
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AU2008326429A1 (en) * | 2007-11-19 | 2009-05-28 | Bionovo, Inc. | Anti-cancer therapy with an extract of scutellaria barbata |
JP2011516583A (ja) * | 2008-04-14 | 2011-05-26 | バイオノボ・インコーポレーテッド | エストロゲン受容体β介在疾患の治療のためのカリコシン及びその類似物質 |
US20090304825A1 (en) * | 2008-05-06 | 2009-12-10 | Bionovo, Inc. | Estrogenic extracts for use in treating vaginal and vulvar atrophy |
JP2011523713A (ja) * | 2008-06-05 | 2011-08-18 | バイオノボ・インコーポレーテッド | 植物組成物由来の多種類の生体活性物質の定量方法 |
AU2009255626A1 (en) * | 2008-06-06 | 2009-12-10 | Bionovo, Inc. | Anthraquinones and analogs from Rhuem palmatum for treatment of estrogen receptor beta-mediated conditions |
EP2340027A4 (en) * | 2008-09-03 | 2012-04-04 | Bionovo Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
JP2012525412A (ja) * | 2009-04-28 | 2012-10-22 | バイオノボ・インコーポレーテッド | 脂肪蓄積を減少させ、体重減少を誘導する方法 |
JP2016539954A (ja) | 2013-12-05 | 2016-12-22 | カロ ファーマ エービーKaro Pharma Ab | 中皮腫の処置で使用するためのエストロゲン受容体ベータアゴニスト |
JP2019503346A (ja) * | 2015-12-22 | 2019-02-07 | ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. | ベンゾピペリジン誘導体、その製造方法及びその医薬用途 |
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-
2005
- 2005-12-05 BR BRPI0518874-1A patent/BRPI0518874A2/pt not_active IP Right Cessation
- 2005-12-05 AU AU2005314230A patent/AU2005314230B2/en not_active Ceased
- 2005-12-05 CA CA2590860A patent/CA2590860C/en not_active Expired - Fee Related
- 2005-12-05 RU RU2007125655/04A patent/RU2394820C2/ru not_active IP Right Cessation
- 2005-12-05 CN CN2005800422962A patent/CN101087606B/zh not_active Expired - Fee Related
- 2005-12-05 JP JP2007545542A patent/JP2008523065A/ja not_active Withdrawn
- 2005-12-05 WO PCT/US2005/043859 patent/WO2006062876A2/en active Application Filing
- 2005-12-05 MX MX2007006878A patent/MX2007006878A/es active IP Right Grant
- 2005-12-05 NZ NZ555316A patent/NZ555316A/en not_active IP Right Cessation
- 2005-12-05 US US11/792,729 patent/US7511152B2/en active Active
- 2005-12-05 KR KR1020077012865A patent/KR20070085874A/ko not_active Application Discontinuation
- 2005-12-05 EP EP05852923.1A patent/EP1827421B1/en active Active
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2007
- 2007-05-22 ZA ZA200704223A patent/ZA200704223B/xx unknown
- 2007-05-29 IL IL183543A patent/IL183543A/en not_active IP Right Cessation
- 2007-07-06 NO NO20073511A patent/NO20073511L/no not_active Application Discontinuation
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2011
- 2011-10-28 JP JP2011237399A patent/JP2012092103A/ja active Pending