JP2010095546A5 - - Google Patents

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Publication number
JP2010095546A5
JP2010095546A5 JP2010020146A JP2010020146A JP2010095546A5 JP 2010095546 A5 JP2010095546 A5 JP 2010095546A5 JP 2010020146 A JP2010020146 A JP 2010020146A JP 2010020146 A JP2010020146 A JP 2010020146A JP 2010095546 A5 JP2010095546 A5 JP 2010095546A5
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JP
Japan
Prior art keywords
acylated
structural formula
following structural
compound represented
amine group
Prior art date
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JP2010020146A
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English (en)
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JP5227348B2 (ja
JP2010095546A (ja
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Publication of JP2010095546A publication Critical patent/JP2010095546A/ja
Publication of JP2010095546A5 publication Critical patent/JP2010095546A5/ja
Application granted granted Critical
Publication of JP5227348B2 publication Critical patent/JP5227348B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Claims (3)

  1. 以下の構造式：

    で表される化合物またはその生理学的に許容され得る塩。
  2. 以下の構造式：

    で表されるアミン化合物の第一級アミン基をアシル化し、それによって以下の構造式：

    （式中、R 7 は、CH 3 (CH 2 ) n -またはCH 3 (CH 2 ) n-2 CH=CH-であり、ｎは６または７である）
    で表されるアシル化セラミド化合物を形成する方法。
  3. アミン化合物の第一級アミン基を、R 7 COX
    （式中、Xが、-ClまたはN-ヒドロキシスクシンイミジルであり；かつ
    R 7 が、CH 3 (CH 2 ) n -であり、ｎは６または７である）
    でアシル化し、アシル化セラミド化合物を形成する、請求項２記載の方法。
JP2010020146A 2001-07-16 2010-02-01 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成 Expired - Lifetime JP5227348B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30581401P 2001-07-16 2001-07-16
US60/305,814 2001-07-16

Related Parent Applications (1)

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JP2003513958A Division JP5038582B2 (ja) 2001-07-16 2002-07-16 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成

Related Child Applications (1)

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JP2013041198A Division JP2013136618A (ja) 2001-07-16 2013-02-13 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成

Publications (3)

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JP2010095546A JP2010095546A (ja) 2010-04-30
JP2010095546A5 true JP2010095546A5 (ja) 2010-12-24
JP5227348B2 JP5227348B2 (ja) 2013-07-03

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Family Applications (6)

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JP2003513958A Expired - Lifetime JP5038582B2 (ja) 2001-07-16 2002-07-16 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成
JP2005112378A Expired - Lifetime JP4708073B2 (ja) 2001-07-16 2005-04-08 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成
JP2010020146A Expired - Lifetime JP5227348B2 (ja) 2001-07-16 2010-02-01 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成
JP2013041198A Pending JP2013136618A (ja) 2001-07-16 2013-02-13 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成
JP2015097734A Pending JP2015180656A (ja) 2001-07-16 2015-04-20 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成
JP2016218570A Expired - Lifetime JP6182254B2 (ja) 2001-07-16 2016-11-09 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成

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JP2003513958A Expired - Lifetime JP5038582B2 (ja) 2001-07-16 2002-07-16 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成
JP2005112378A Expired - Lifetime JP4708073B2 (ja) 2001-07-16 2005-04-08 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成

Family Applications After (3)

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JP2013041198A Pending JP2013136618A (ja) 2001-07-16 2013-02-13 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成
JP2015097734A Pending JP2015180656A (ja) 2001-07-16 2015-04-20 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成
JP2016218570A Expired - Lifetime JP6182254B2 (ja) 2001-07-16 2016-11-09 Ｕｄｐ−グルコース：ｎ−アシルスフィンゴシングルコシルトランスフェラーゼインヒビターの合成

Country Status (16)

Country Link
US (11) US6855830B2 (ja)
EP (3) EP2067775B1 (ja)
JP (6) JP5038582B2 (ja)
AT (2) ATE554082T1 (ja)
BE (1) BE2015C029I2 (ja)
BR (3) BRPI0211379B8 (ja)
CA (1) CA2453978C (ja)
CY (1) CY2015028I1 (ja)
DK (3) DK1409467T3 (ja)
ES (3) ES2399323T3 (ja)
FR (1) FR15C0036I2 (ja)
HK (2) HK1132267A1 (ja)
IL (3) IL159905A0 (ja)
LU (1) LU92717I2 (ja)
PT (3) PT2266968E (ja)
WO (1) WO2003008399A1 (ja)

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