BE2015C029I2 - - Google Patents

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Publication number
BE2015C029I2
BE2015C029I2 BE2015C029C BE2015C029C BE2015C029I2 BE 2015C029 I2 BE2015C029 I2 BE 2015C029I2 BE 2015C029 C BE2015C029 C BE 2015C029C BE 2015C029 C BE2015C029 C BE 2015C029C BE 2015C029 I2 BE2015C029 I2 BE 2015C029I2
Authority
BE
Belgium
Prior art keywords
disclosed
synthesis
novel
ceramide
udp
Prior art date
Application number
BE2015C029C
Other languages
English (en)
Original Assignee
Univ Michigan Regents
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23182463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2015C029(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Michigan Regents, Genzyme Corp filed Critical Univ Michigan Regents
Publication of BE2015C029I2 publication Critical patent/BE2015C029I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BE2015C029C 2001-07-16 2015-05-12 BE2015C029I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30581401P 2001-07-16 2001-07-16
PCT/US2002/022659 WO2003008399A1 (fr) 2001-07-16 2002-07-16 Synthese d'inhibiteurs de l'udp-glucose : n-acylsphingosine glycosyltransferase

Publications (1)

Publication Number Publication Date
BE2015C029I2 true BE2015C029I2 (fr) 2021-07-19

Family

ID=23182463

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2015C029C BE2015C029I2 (fr) 2001-07-16 2015-05-12

Country Status (16)

Country Link
US (11) US6855830B2 (fr)
EP (3) EP2067775B1 (fr)
JP (6) JP5038582B2 (fr)
AT (2) ATE555102T1 (fr)
BE (1) BE2015C029I2 (fr)
BR (3) BRPI0211379B8 (fr)
CA (1) CA2453978C (fr)
CY (1) CY2015028I2 (fr)
DK (3) DK1409467T3 (fr)
ES (3) ES2399323T3 (fr)
FR (1) FR15C0036I2 (fr)
HK (2) HK1132267A1 (fr)
IL (3) IL159905A0 (fr)
LU (1) LU92717I2 (fr)
PT (3) PT2067775E (fr)
WO (1) WO2003008399A1 (fr)

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ES2399323T3 (es) 2001-07-16 2013-03-27 Genzyme Corporation Síntesis de inhibidores de la UDP-glucosa:N-acilesfingosina glucosiltransferasa
WO2003045928A1 (fr) * 2001-11-26 2003-06-05 Genzyme Corporation Synthese diastereoselective d'udp-glucose : inhibiteurs de la n-acylsphingosine glucosyltransferase
US20060217560A1 (en) * 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
US6916802B2 (en) * 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
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JP2008519840A (ja) * 2004-11-10 2008-06-12 ジェンザイム・コーポレイション 糖尿病の処置方法
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EP2032134B1 (fr) * 2006-05-09 2015-06-24 Genzyme Corporation Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides
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PE20140617A1 (es) 2011-04-22 2014-05-28 Genzyme Corp Alfa glucosidasa acida modificada con procesamiento acelerado
US8961959B2 (en) 2011-10-17 2015-02-24 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
CA2906396A1 (fr) 2013-03-15 2014-09-25 Concert Pharmaceuticals Inc. Inhibiteurs de l'enzyme udp-glucose : n-acyl-sphingosine glucosyltransferase
CN105745206B (zh) 2013-09-20 2019-08-13 生物马林药物股份有限公司 用于治疗疾病的葡萄糖神经酰胺合成酶抑制剂
WO2015059679A1 (fr) * 2013-10-25 2015-04-30 Dr. Reddy's Laboratories Limited Procédé amélioré pour la préparation d'éliglustat
CA2927798C (fr) 2013-10-29 2022-03-15 Biomarin Pharmaceutical Inc. Derives n-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide utiles en tant qu'inhibiteurs de la glucosylceramide synthase
JP6749923B2 (ja) 2015-02-02 2020-09-02 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン グルコシルセラミドシンターゼ阻害剤及びそれを使用した治療方法
CN104557851B (zh) * 2015-02-10 2017-04-05 苏州明锐医药科技有限公司 依鲁司他的制备方法
WO2016166170A1 (fr) 2015-04-14 2016-10-20 Sandoz Ag Chlorhydrate d'éliglustat cristallin
WO2017068496A1 (fr) * 2015-10-20 2017-04-27 Dr. Reddy' S Laboratories Limited Procédé amélioré pour la préparation d'éliglustat et de ses sels
CN105646442A (zh) * 2015-10-27 2016-06-08 北京凯莱天成医药科技有限公司 一种依利格鲁司他的制备方法
EP3442514B1 (fr) 2016-04-11 2021-06-16 Spedding Research Solutions Inhibiteurs de dégradation des glucosylcéramides dans le traitement des maladies des neurones moteurs
CN106349210A (zh) * 2016-08-24 2017-01-25 北京阳光诺和药物研究有限公司 一种制备酒石酸艾力骨司坦的方法
CN106967042B (zh) * 2017-03-21 2020-08-14 浙江奥翔药业股份有限公司 依利格鲁司他的合成方法及其中间体化合物
CN108822072B (zh) * 2017-04-11 2021-01-12 中国医学科学院药物研究所 一种制备伊力格鲁司他的方法
WO2018193090A2 (fr) 2017-04-21 2018-10-25 Amneal Pharmaceuticals Company Gmbh Procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci
WO2018225085A1 (fr) 2017-06-05 2018-12-13 Cipla Limited Dispersions solides stables d'hémitartrate d'éliglustat
JP2021506789A (ja) 2017-12-15 2021-02-22 ジェンザイム・コーポレーション ゴーシェ病を処置する方法
CN111217791B (zh) * 2018-11-27 2024-02-02 广东东阳光药业股份有限公司 依鲁司他中间体及其制备方法
WO2020194138A1 (fr) * 2019-03-22 2020-10-01 Piramal Enterprises Limited Procédé amélioré pour la préparation d'éliglustat et de son intermédiaire
WO2020193746A1 (fr) 2019-03-28 2020-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction de la survie de patients atteints de mélanome
JP2022553107A (ja) 2019-10-23 2022-12-21 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン グルコシルセラミドシンターゼ阻害剤およびそれを使用する治療方法
WO2021214771A1 (fr) 2020-04-23 2021-10-28 The Israel Institute of Biological Research (IIBR) Inhibiteurs de glucosylcéramide synthase pour la prévention et le traitement de maladies virales
WO2021221953A1 (fr) 2020-04-28 2021-11-04 The Regents Of The University Of Michigan Inhibiteurs pyridine de la glucosylcéramide synthase et procédés thérapeutiques les utilisant
CN116120274A (zh) 2021-11-12 2023-05-16 曙方(上海)医药科技有限公司 依利格鲁司他可药用盐及其晶型
EP4201403A1 (fr) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Composés tirapazamine et quazinone à utiliser dans le traitement des gangliosidoses gm2

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CA2434028C (fr) 2001-01-10 2010-11-09 The Regents Of The University Of Michigan Composes du type amino-ceramide et procedes therapeutiques d'utilisation
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US7148251B2 (en) 2001-01-10 2006-12-12 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
ES2399323T3 (es) 2001-07-16 2013-03-27 Genzyme Corporation Síntesis de inhibidores de la UDP-glucosa:N-acilesfingosina glucosiltransferasa
US6916802B2 (en) 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
US20060217560A1 (en) 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
EP2032134B1 (fr) * 2006-05-09 2015-06-24 Genzyme Corporation Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides

Also Published As

Publication number Publication date
US8779163B2 (en) 2014-07-15
JP2005255686A (ja) 2005-09-22
HK1153733A1 (fr) 2012-04-05
US20050009872A1 (en) 2005-01-13
US7763738B2 (en) 2010-07-27
DK2266968T3 (da) 2013-04-08
JP2005502635A (ja) 2005-01-27
IL159905A0 (en) 2004-06-20
ES2399323T3 (es) 2013-03-27
EP2266968B1 (fr) 2013-01-09
US20150148534A1 (en) 2015-05-28
BR0211379A (pt) 2004-08-17
DK1409467T3 (da) 2012-07-16
US20050222244A1 (en) 2005-10-06
PT2067775E (pt) 2012-07-16
BR122015016313B8 (pt) 2021-05-25
WO2003008399A1 (fr) 2003-01-30
CY2015028I1 (el) 2016-07-27
EP2067775B1 (fr) 2012-04-25
JP2013136618A (ja) 2013-07-11
JP6182254B2 (ja) 2017-08-16
BR122015016314B1 (pt) 2019-04-16
BRPI0211379B1 (pt) 2018-02-14
BRPI0211379B8 (pt) 2021-05-25
DK2067775T3 (da) 2012-07-16
EP2266968A3 (fr) 2011-05-18
PT2266968E (pt) 2013-02-25
US20070203223A1 (en) 2007-08-30
HK1132267A1 (en) 2010-02-19
IL193244A0 (en) 2009-02-11
JP4708073B2 (ja) 2011-06-22
JP2010095546A (ja) 2010-04-30
EP1409467B1 (fr) 2012-04-18
JP5038582B2 (ja) 2012-10-03
ES2395463T4 (es) 2013-02-12
CA2453978A1 (fr) 2003-01-30
US20120296088A1 (en) 2012-11-22
US20110003987A1 (en) 2011-01-06
US8138353B2 (en) 2012-03-20
US20210171507A1 (en) 2021-06-10
BR122015016314B8 (pt) 2021-05-25
CY2015028I2 (el) 2016-07-27
US9546161B2 (en) 2017-01-17
FR15C0036I1 (fr) 2015-06-26
CA2453978C (fr) 2011-10-11
ES2395463T3 (es) 2013-02-15
US7265228B2 (en) 2007-09-04
BR122015016313B1 (pt) 2019-04-16
US20170334888A1 (en) 2017-11-23
JP2015180656A (ja) 2015-10-15
US6855830B2 (en) 2005-02-15
US7196205B2 (en) 2007-03-27
US7615573B2 (en) 2009-11-10
US20080058514A1 (en) 2008-03-06
LU92717I2 (fr) 2015-11-24
EP1409467A1 (fr) 2004-04-21
ATE555102T1 (de) 2012-05-15
IL159905A (en) 2009-05-04
ATE554082T1 (de) 2012-05-15
ES2395122T3 (es) 2013-02-08
FR15C0036I2 (fr) 2016-05-27
EP2266968A2 (fr) 2010-12-29
US20190322649A1 (en) 2019-10-24
PT1409467E (pt) 2012-10-24
EP2067775A1 (fr) 2009-06-10
JP2017075151A (ja) 2017-04-20
US20030050299A1 (en) 2003-03-13
JP5227348B2 (ja) 2013-07-03

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