HK1132267A1 - A n-acylsphingosine glucosyltransferase inhibitor n- - Google Patents

A n-acylsphingosine glucosyltransferase inhibitor n-

Info

Publication number
HK1132267A1
HK1132267A1 HK09111547.6A HK09111547A HK1132267A1 HK 1132267 A1 HK1132267 A1 HK 1132267A1 HK 09111547 A HK09111547 A HK 09111547A HK 1132267 A1 HK1132267 A1 HK 1132267A1
Authority
HK
Hong Kong
Prior art keywords
acylsphingosine glucosyltransferase
glucosyltransferase inhibitor
acylsphingosine
disclosed
synthesis
Prior art date
Application number
HK09111547.6A
Other languages
English (en)
Inventor
Bradford H Hirth
Craig Siegal
James A Shayman
Carol Anne Nelson
David J Harris
Diane Copeland
Original Assignee
Genzyme Corp
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23182463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1132267(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp, Univ Michigan filed Critical Genzyme Corp
Publication of HK1132267A1 publication Critical patent/HK1132267A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK09111547.6A 2001-07-16 2009-12-09 A n-acylsphingosine glucosyltransferase inhibitor n- HK1132267A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30581401P 2001-07-16 2001-07-16

Publications (1)

Publication Number Publication Date
HK1132267A1 true HK1132267A1 (en) 2010-02-19

Family

ID=23182463

Family Applications (2)

Application Number Title Priority Date Filing Date
HK09111547.6A HK1132267A1 (en) 2001-07-16 2009-12-09 A n-acylsphingosine glucosyltransferase inhibitor n-
HK11106527.6A HK1153733A1 (fr) 2001-07-16 2011-06-23

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK11106527.6A HK1153733A1 (fr) 2001-07-16 2011-06-23

Country Status (16)

Country Link
US (11) US6855830B2 (fr)
EP (3) EP2266968B1 (fr)
JP (6) JP5038582B2 (fr)
AT (2) ATE555102T1 (fr)
BE (1) BE2015C029I2 (fr)
BR (3) BR122015016314B8 (fr)
CA (1) CA2453978C (fr)
CY (1) CY2015028I2 (fr)
DK (3) DK2266968T3 (fr)
ES (3) ES2395122T3 (fr)
FR (1) FR15C0036I2 (fr)
HK (2) HK1132267A1 (fr)
IL (3) IL159905A0 (fr)
LU (1) LU92717I2 (fr)
PT (3) PT1409467E (fr)
WO (1) WO2003008399A1 (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890949B1 (en) * 1999-07-09 2005-05-10 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
WO2002062777A2 (fr) 2001-01-10 2002-08-15 The Regents Of The University Of Michigan Composes du type amino-ceramide et procedes therapeutiques d'utilisation
US7723296B2 (en) 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
DK2266968T3 (da) * 2001-07-16 2013-04-08 Genzyme Corp Syntese af UDP-glucose: N-acylsphingosin-glucosyltransferase-hæmmere
WO2003045928A1 (fr) * 2001-11-26 2003-06-05 Genzyme Corporation Synthese diastereoselective d'udp-glucose : inhibiteurs de la n-acylsphingosine glucosyltransferase
US20060217560A1 (en) * 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
US6916802B2 (en) * 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
JP4195411B2 (ja) * 2004-04-12 2008-12-10 セイコーエプソン株式会社 有機エレクトロルミネッセンス装置の製造方法
EP1811991B1 (fr) * 2004-11-10 2018-11-07 Genzyme Corporation Traitement du diabete de type 2 en utilisant d'inhibiteurs de la synthese des glycosphingolipides
US8288556B2 (en) * 2005-01-26 2012-10-16 Allergan, Inc. 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immuno stimulant activity
EP2923699B1 (fr) * 2006-05-09 2018-06-20 Genzyme Corporation Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides
PL2121713T3 (pl) 2007-01-18 2013-11-29 Genzyme Corp Oligosacharydy zawierające grupę aminooksylową oraz ich koniugaty
US20140179925A1 (en) 2009-09-04 2014-06-26 Allergan, Inc. Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds
US8173683B2 (en) 2007-03-06 2012-05-08 Allergan, Inc. Methods for treating cognitive disorders
US9314466B2 (en) 2007-03-06 2016-04-19 Allergan, Inc. Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds
CA2680324A1 (fr) * 2007-03-06 2008-09-12 John E. Donello Procedes de traitement des troubles cognitifs au moyen d'amides d'acides 3-aryl-3-hydroxy-2-amino-propioniques, d'amides d'acides 3-heteroaryl-3-hydroxy-2-amino-propioniques et decomposes apparentes
EP2594562B1 (fr) 2007-05-31 2016-07-20 Genzyme Corporation Inhibiteurs de glucosylcéramide synthase de type 2-acylaminopropanol
KR20160085917A (ko) * 2007-10-05 2016-07-18 젠자임 코포레이션 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법
US8168631B2 (en) 2008-02-05 2012-05-01 Allergan, Inc. 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity
EP2320886B1 (fr) 2008-07-28 2017-06-28 Genzyme Corporation Inhibition de synthase de glucosylcéramide pour le traitement du glomérulopathie avec collapsus, et d'un autre trouble glomérulaire
MX2011003517A (es) 2008-10-03 2011-05-25 Genzyme Corp Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol.
EP4212541A1 (fr) 2008-12-16 2023-07-19 Genzyme Corporation Conjugués oligosaccharide-protéine et ses produits intermédiaires
PT3133070T (pt) * 2009-11-27 2019-11-11 Genzyme Corp Eliglustat (genz 112638) como inibidor de glicosilceramida-sintase para utilização num método de tratamento de doença de fabry ou de gaucher, o método compreendendo ajustar a dose terapêutica individual ao metabolismo do p-450 do doente
US8880109B2 (en) 2010-04-16 2014-11-04 Kyocera Corporation Radio communication system, high-power base station, low-power base station, and communication control method
BR112013026976A2 (pt) 2011-04-22 2019-09-24 Genzyme Corp alfa glucosidade ácida modificada com processamento acelerado
US8961959B2 (en) 2011-10-17 2015-02-24 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
WO2014150043A1 (fr) 2013-03-15 2014-09-25 Concert Pharmaceuticals Inc. Inhibiteurs de l'enzyme udp-glucose : n-acyl-sphingosine glucosyltransférase
EP3046920B1 (fr) 2013-09-20 2021-08-04 BioMarin Pharmaceutical Inc. Inhibiteurs de la glucosylcéramide synthase pour le traitement de maladies
WO2015059679A1 (fr) * 2013-10-25 2015-04-30 Dr. Reddy's Laboratories Limited Procédé amélioré pour la préparation d'éliglustat
EP3063141B1 (fr) 2013-10-29 2018-02-28 BioMarin Pharmaceutical Inc. Dérivés n-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide utiles en tant qu'inhibiteurs de la glucosylcéramide synthase
US10202340B2 (en) 2015-02-02 2019-02-12 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
CN104557851B (zh) * 2015-02-10 2017-04-05 苏州明锐医药科技有限公司 依鲁司他的制备方法
ES2716420T3 (es) 2015-04-14 2019-06-12 Sandoz Ag Clorhidrato de eliglustat cristalino
WO2017068496A1 (fr) * 2015-10-20 2017-04-27 Dr. Reddy' S Laboratories Limited Procédé amélioré pour la préparation d'éliglustat et de ses sels
CN105646442A (zh) * 2015-10-27 2016-06-08 北京凯莱天成医药科技有限公司 一种依利格鲁司他的制备方法
WO2017178499A1 (fr) 2016-04-11 2017-10-19 Spedding Research Solutions Inhibiteurs de dégradation des glucosylcéramides dans le traitement des maladies des neurones moteurs
CN106349210A (zh) * 2016-08-24 2017-01-25 北京阳光诺和药物研究有限公司 一种制备酒石酸艾力骨司坦的方法
CN106967042B (zh) 2017-03-21 2020-08-14 浙江奥翔药业股份有限公司 依利格鲁司他的合成方法及其中间体化合物
CN108822072B (zh) * 2017-04-11 2021-01-12 中国医学科学院药物研究所 一种制备伊力格鲁司他的方法
WO2018193090A2 (fr) 2017-04-21 2018-10-25 Amneal Pharmaceuticals Company Gmbh Procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci
WO2018225085A1 (fr) 2017-06-05 2018-12-13 Cipla Limited Dispersions solides stables d'hémitartrate d'éliglustat
SG11202004954YA (en) 2017-12-15 2020-06-29 Genzyme Corp Methods for treating gaucher disease
CN111217791B (zh) * 2018-11-27 2024-02-02 广东东阳光药业股份有限公司 依鲁司他中间体及其制备方法
EP3941917A4 (fr) * 2019-03-22 2022-12-21 Piramal Pharma Limited Procédé amélioré pour la préparation d'éliglustat et de son intermédiaire
WO2020193746A1 (fr) 2019-03-28 2020-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction de la survie de patients atteints de mélanome
US11220479B2 (en) 2019-10-23 2022-01-11 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
WO2021214771A1 (fr) 2020-04-23 2021-10-28 The Israel Institute of Biological Research (IIBR) Inhibiteurs de glucosylcéramide synthase pour la prévention et le traitement de maladies virales
WO2021221953A1 (fr) 2020-04-28 2021-11-04 The Regents Of The University Of Michigan Inhibiteurs pyridine de la glucosylcéramide synthase et procédés thérapeutiques les utilisant
CN116120274A (zh) 2021-11-12 2023-05-16 曙方(上海)医药科技有限公司 依利格鲁司他可药用盐及其晶型
EP4201403A1 (fr) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Composés tirapazamine et quazinone à utiliser dans le traitement des gangliosidoses gm2

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
DE3522475A1 (de) 1985-06-22 1987-01-02 Kali Chemie Pharma Gmbh Neue aromatische verbindungen, ihre herstellung und verwendung
JPH0416856A (ja) 1990-05-10 1992-01-21 Canon Inc 正帯電性非磁性トナー
ZA929008B (en) 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
HUT73527A (en) * 1993-08-13 1996-08-28 Seikagaku Kogyo Co Ltd Remedy for nervous diseases
DK0742789T3 (da) * 1994-02-02 2000-11-13 Liposome Co Inc Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse
AU698833B2 (en) * 1994-06-10 1998-11-12 Seikagaku Corporation 2-acylaminopropanol compound and medical composition
FR2734819B1 (fr) 1995-05-31 1997-07-04 Adir Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant
WO2001004108A1 (fr) 1999-07-09 2001-01-18 Regents Of The University Of Michigan Composes de type amino-ceramide et procedes therapeutiques d'utilisation
US5916911A (en) * 1995-09-20 1999-06-29 The Regents Of The University Of Michigan Amino ceramide--like compounds and therapeutic methods of use
US6255336B1 (en) * 1995-09-20 2001-07-03 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US6890949B1 (en) * 1999-07-09 2005-05-10 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US20030073680A1 (en) * 1995-09-20 2003-04-17 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
JP3993908B2 (ja) * 1995-12-08 2007-10-17 生化学工業株式会社 アミノアルコール誘導体及び該誘導体の製造方法
NO965193L (no) * 1995-12-08 1997-06-09 Seikagaku Kogyo Kk Seikagaku C Aminalkoholderivat og fremgangsmåte for fremstilling derav
JP4140984B2 (ja) 1995-12-20 2008-08-27 生化学工業株式会社 分化誘導作用を有する薬剤
US5916802A (en) * 1997-02-19 1999-06-29 Fritz Berthold Device for measuring ATP
US5972928A (en) 1997-05-21 1999-10-26 Johns Hopkins University Methods for treatment of conditions associated with lactosylceramide
JP4036500B2 (ja) 1997-05-23 2008-01-23 生化学工業株式会社 アミノアルコール誘導体及びそれを含有する医薬
JP4176170B2 (ja) 1997-06-06 2008-11-05 生化学工業株式会社 アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬
ATE358473T1 (de) * 1998-07-27 2007-04-15 Univ Johns Hopkins Diamino-propanol-verbindungen zur behandlung von ischaemien
US20020198240A1 (en) * 2001-01-10 2002-12-26 Shayman James A. Amino ceramide - like compounds and therapeutic methods of use
WO2002062777A2 (fr) 2001-01-10 2002-08-15 The Regents Of The University Of Michigan Composes du type amino-ceramide et procedes therapeutiques d'utilisation
US20040260099A1 (en) 2001-01-10 2004-12-23 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US7148251B2 (en) * 2001-01-10 2006-12-12 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
DK2266968T3 (da) * 2001-07-16 2013-04-08 Genzyme Corp Syntese af UDP-glucose: N-acylsphingosin-glucosyltransferase-hæmmere
US20060217560A1 (en) 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
US6916802B2 (en) * 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
EP2923699B1 (fr) * 2006-05-09 2018-06-20 Genzyme Corporation Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides

Also Published As

Publication number Publication date
FR15C0036I1 (fr) 2015-06-26
JP2010095546A (ja) 2010-04-30
BR0211379A (pt) 2004-08-17
US20050009872A1 (en) 2005-01-13
FR15C0036I2 (fr) 2016-05-27
BE2015C029I2 (fr) 2021-07-19
US20190322649A1 (en) 2019-10-24
US20080058514A1 (en) 2008-03-06
EP2266968A2 (fr) 2010-12-29
US7196205B2 (en) 2007-03-27
US7615573B2 (en) 2009-11-10
US20210171507A1 (en) 2021-06-10
JP2005502635A (ja) 2005-01-27
US20150148534A1 (en) 2015-05-28
CY2015028I1 (el) 2016-07-27
HK1153733A1 (fr) 2012-04-05
BR122015016314B8 (pt) 2021-05-25
JP4708073B2 (ja) 2011-06-22
US8138353B2 (en) 2012-03-20
ES2395463T3 (es) 2013-02-15
BR122015016313B8 (pt) 2021-05-25
EP2067775A1 (fr) 2009-06-10
BR122015016314B1 (pt) 2019-04-16
JP2005255686A (ja) 2005-09-22
DK2067775T3 (da) 2012-07-16
EP2266968A3 (fr) 2011-05-18
IL159905A0 (en) 2004-06-20
JP2015180656A (ja) 2015-10-15
BR122015016313B1 (pt) 2019-04-16
US8779163B2 (en) 2014-07-15
CY2015028I2 (el) 2016-07-27
JP6182254B2 (ja) 2017-08-16
JP5038582B2 (ja) 2012-10-03
DK2266968T3 (da) 2013-04-08
WO2003008399A1 (fr) 2003-01-30
US20050222244A1 (en) 2005-10-06
US20170334888A1 (en) 2017-11-23
IL193244A0 (en) 2009-02-11
JP2013136618A (ja) 2013-07-11
EP2067775B1 (fr) 2012-04-25
BRPI0211379B1 (pt) 2018-02-14
ES2395463T4 (es) 2013-02-12
EP1409467A1 (fr) 2004-04-21
US20120296088A1 (en) 2012-11-22
CA2453978C (fr) 2011-10-11
ATE554082T1 (de) 2012-05-15
JP2017075151A (ja) 2017-04-20
ES2395122T3 (es) 2013-02-08
PT1409467E (pt) 2012-10-24
US20070203223A1 (en) 2007-08-30
DK1409467T3 (da) 2012-07-16
US9546161B2 (en) 2017-01-17
ES2399323T3 (es) 2013-03-27
US7763738B2 (en) 2010-07-27
CA2453978A1 (fr) 2003-01-30
BRPI0211379B8 (pt) 2021-05-25
US7265228B2 (en) 2007-09-04
US20030050299A1 (en) 2003-03-13
IL159905A (en) 2009-05-04
ATE555102T1 (de) 2012-05-15
LU92717I2 (fr) 2015-11-24
PT2067775E (pt) 2012-07-16
PT2266968E (pt) 2013-02-25
JP5227348B2 (ja) 2013-07-03
EP1409467B1 (fr) 2012-04-18
EP2266968B1 (fr) 2013-01-09
US20110003987A1 (en) 2011-01-06
US6855830B2 (en) 2005-02-15

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