HK1132267A1 - A n-acylsphingosine glucosyltransferase inhibitor n- - Google Patents
A n-acylsphingosine glucosyltransferase inhibitor n-Info
- Publication number
- HK1132267A1 HK1132267A1 HK09111547.6A HK09111547A HK1132267A1 HK 1132267 A1 HK1132267 A1 HK 1132267A1 HK 09111547 A HK09111547 A HK 09111547A HK 1132267 A1 HK1132267 A1 HK 1132267A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- acylsphingosine glucosyltransferase
- glucosyltransferase inhibitor
- acylsphingosine
- disclosed
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cosmetics (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30581401P | 2001-07-16 | 2001-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1132267A1 true HK1132267A1 (en) | 2010-02-19 |
Family
ID=23182463
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09111547.6A HK1132267A1 (en) | 2001-07-16 | 2009-12-09 | A n-acylsphingosine glucosyltransferase inhibitor n- |
HK11106527.6A HK1153733A1 (fr) | 2001-07-16 | 2011-06-23 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11106527.6A HK1153733A1 (fr) | 2001-07-16 | 2011-06-23 |
Country Status (16)
Country | Link |
---|---|
US (11) | US6855830B2 (fr) |
EP (3) | EP2266968B1 (fr) |
JP (6) | JP5038582B2 (fr) |
AT (2) | ATE555102T1 (fr) |
BE (1) | BE2015C029I2 (fr) |
BR (3) | BR122015016314B8 (fr) |
CA (1) | CA2453978C (fr) |
CY (1) | CY2015028I2 (fr) |
DK (3) | DK2266968T3 (fr) |
ES (3) | ES2395122T3 (fr) |
FR (1) | FR15C0036I2 (fr) |
HK (2) | HK1132267A1 (fr) |
IL (3) | IL159905A0 (fr) |
LU (1) | LU92717I2 (fr) |
PT (3) | PT1409467E (fr) |
WO (1) | WO2003008399A1 (fr) |
Families Citing this family (51)
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US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
WO2002062777A2 (fr) | 2001-01-10 | 2002-08-15 | The Regents Of The University Of Michigan | Composes du type amino-ceramide et procedes therapeutiques d'utilisation |
US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
DK2266968T3 (da) * | 2001-07-16 | 2013-04-08 | Genzyme Corp | Syntese af UDP-glucose: N-acylsphingosin-glucosyltransferase-hæmmere |
WO2003045928A1 (fr) * | 2001-11-26 | 2003-06-05 | Genzyme Corporation | Synthese diastereoselective d'udp-glucose : inhibiteurs de la n-acylsphingosine glucosyltransferase |
US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
JP4195411B2 (ja) * | 2004-04-12 | 2008-12-10 | セイコーエプソン株式会社 | 有機エレクトロルミネッセンス装置の製造方法 |
EP1811991B1 (fr) * | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Traitement du diabete de type 2 en utilisant d'inhibiteurs de la synthese des glycosphingolipides |
US8288556B2 (en) * | 2005-01-26 | 2012-10-16 | Allergan, Inc. | 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immuno stimulant activity |
EP2923699B1 (fr) * | 2006-05-09 | 2018-06-20 | Genzyme Corporation | Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides |
PL2121713T3 (pl) | 2007-01-18 | 2013-11-29 | Genzyme Corp | Oligosacharydy zawierające grupę aminooksylową oraz ich koniugaty |
US20140179925A1 (en) | 2009-09-04 | 2014-06-26 | Allergan, Inc. | Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
US8173683B2 (en) | 2007-03-06 | 2012-05-08 | Allergan, Inc. | Methods for treating cognitive disorders |
US9314466B2 (en) | 2007-03-06 | 2016-04-19 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
CA2680324A1 (fr) * | 2007-03-06 | 2008-09-12 | John E. Donello | Procedes de traitement des troubles cognitifs au moyen d'amides d'acides 3-aryl-3-hydroxy-2-amino-propioniques, d'amides d'acides 3-heteroaryl-3-hydroxy-2-amino-propioniques et decomposes apparentes |
EP2594562B1 (fr) | 2007-05-31 | 2016-07-20 | Genzyme Corporation | Inhibiteurs de glucosylcéramide synthase de type 2-acylaminopropanol |
KR20160085917A (ko) * | 2007-10-05 | 2016-07-18 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
US8168631B2 (en) | 2008-02-05 | 2012-05-01 | Allergan, Inc. | 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity |
EP2320886B1 (fr) | 2008-07-28 | 2017-06-28 | Genzyme Corporation | Inhibition de synthase de glucosylcéramide pour le traitement du glomérulopathie avec collapsus, et d'un autre trouble glomérulaire |
MX2011003517A (es) | 2008-10-03 | 2011-05-25 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol. |
EP4212541A1 (fr) | 2008-12-16 | 2023-07-19 | Genzyme Corporation | Conjugués oligosaccharide-protéine et ses produits intermédiaires |
PT3133070T (pt) * | 2009-11-27 | 2019-11-11 | Genzyme Corp | Eliglustat (genz 112638) como inibidor de glicosilceramida-sintase para utilização num método de tratamento de doença de fabry ou de gaucher, o método compreendendo ajustar a dose terapêutica individual ao metabolismo do p-450 do doente |
US8880109B2 (en) | 2010-04-16 | 2014-11-04 | Kyocera Corporation | Radio communication system, high-power base station, low-power base station, and communication control method |
BR112013026976A2 (pt) | 2011-04-22 | 2019-09-24 | Genzyme Corp | alfa glucosidade ácida modificada com processamento acelerado |
US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
WO2014150043A1 (fr) | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals Inc. | Inhibiteurs de l'enzyme udp-glucose : n-acyl-sphingosine glucosyltransférase |
EP3046920B1 (fr) | 2013-09-20 | 2021-08-04 | BioMarin Pharmaceutical Inc. | Inhibiteurs de la glucosylcéramide synthase pour le traitement de maladies |
WO2015059679A1 (fr) * | 2013-10-25 | 2015-04-30 | Dr. Reddy's Laboratories Limited | Procédé amélioré pour la préparation d'éliglustat |
EP3063141B1 (fr) | 2013-10-29 | 2018-02-28 | BioMarin Pharmaceutical Inc. | Dérivés n-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide utiles en tant qu'inhibiteurs de la glucosylcéramide synthase |
US10202340B2 (en) | 2015-02-02 | 2019-02-12 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
CN104557851B (zh) * | 2015-02-10 | 2017-04-05 | 苏州明锐医药科技有限公司 | 依鲁司他的制备方法 |
ES2716420T3 (es) | 2015-04-14 | 2019-06-12 | Sandoz Ag | Clorhidrato de eliglustat cristalino |
WO2017068496A1 (fr) * | 2015-10-20 | 2017-04-27 | Dr. Reddy' S Laboratories Limited | Procédé amélioré pour la préparation d'éliglustat et de ses sels |
CN105646442A (zh) * | 2015-10-27 | 2016-06-08 | 北京凯莱天成医药科技有限公司 | 一种依利格鲁司他的制备方法 |
WO2017178499A1 (fr) | 2016-04-11 | 2017-10-19 | Spedding Research Solutions | Inhibiteurs de dégradation des glucosylcéramides dans le traitement des maladies des neurones moteurs |
CN106349210A (zh) * | 2016-08-24 | 2017-01-25 | 北京阳光诺和药物研究有限公司 | 一种制备酒石酸艾力骨司坦的方法 |
CN106967042B (zh) | 2017-03-21 | 2020-08-14 | 浙江奥翔药业股份有限公司 | 依利格鲁司他的合成方法及其中间体化合物 |
CN108822072B (zh) * | 2017-04-11 | 2021-01-12 | 中国医学科学院药物研究所 | 一种制备伊力格鲁司他的方法 |
WO2018193090A2 (fr) | 2017-04-21 | 2018-10-25 | Amneal Pharmaceuticals Company Gmbh | Procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci |
WO2018225085A1 (fr) | 2017-06-05 | 2018-12-13 | Cipla Limited | Dispersions solides stables d'hémitartrate d'éliglustat |
SG11202004954YA (en) | 2017-12-15 | 2020-06-29 | Genzyme Corp | Methods for treating gaucher disease |
CN111217791B (zh) * | 2018-11-27 | 2024-02-02 | 广东东阳光药业股份有限公司 | 依鲁司他中间体及其制备方法 |
EP3941917A4 (fr) * | 2019-03-22 | 2022-12-21 | Piramal Pharma Limited | Procédé amélioré pour la préparation d'éliglustat et de son intermédiaire |
WO2020193746A1 (fr) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes de prédiction de la survie de patients atteints de mélanome |
US11220479B2 (en) | 2019-10-23 | 2022-01-11 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
WO2021214771A1 (fr) | 2020-04-23 | 2021-10-28 | The Israel Institute of Biological Research (IIBR) | Inhibiteurs de glucosylcéramide synthase pour la prévention et le traitement de maladies virales |
WO2021221953A1 (fr) | 2020-04-28 | 2021-11-04 | The Regents Of The University Of Michigan | Inhibiteurs pyridine de la glucosylcéramide synthase et procédés thérapeutiques les utilisant |
CN116120274A (zh) | 2021-11-12 | 2023-05-16 | 曙方(上海)医药科技有限公司 | 依利格鲁司他可药用盐及其晶型 |
EP4201403A1 (fr) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Composés tirapazamine et quazinone à utiliser dans le traitement des gangliosidoses gm2 |
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GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
DE3522475A1 (de) | 1985-06-22 | 1987-01-02 | Kali Chemie Pharma Gmbh | Neue aromatische verbindungen, ihre herstellung und verwendung |
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HUT73527A (en) * | 1993-08-13 | 1996-08-28 | Seikagaku Kogyo Co Ltd | Remedy for nervous diseases |
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AU698833B2 (en) * | 1994-06-10 | 1998-11-12 | Seikagaku Corporation | 2-acylaminopropanol compound and medical composition |
FR2734819B1 (fr) | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
WO2001004108A1 (fr) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Composes de type amino-ceramide et procedes therapeutiques d'utilisation |
US5916911A (en) * | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
US6255336B1 (en) * | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20030073680A1 (en) * | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
JP3993908B2 (ja) * | 1995-12-08 | 2007-10-17 | 生化学工業株式会社 | アミノアルコール誘導体及び該誘導体の製造方法 |
NO965193L (no) * | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
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JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
JP4176170B2 (ja) | 1997-06-06 | 2008-11-05 | 生化学工業株式会社 | アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬 |
ATE358473T1 (de) * | 1998-07-27 | 2007-04-15 | Univ Johns Hopkins | Diamino-propanol-verbindungen zur behandlung von ischaemien |
US20020198240A1 (en) * | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
WO2002062777A2 (fr) | 2001-01-10 | 2002-08-15 | The Regents Of The University Of Michigan | Composes du type amino-ceramide et procedes therapeutiques d'utilisation |
US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US7148251B2 (en) * | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
DK2266968T3 (da) * | 2001-07-16 | 2013-04-08 | Genzyme Corp | Syntese af UDP-glucose: N-acylsphingosin-glucosyltransferase-hæmmere |
US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
EP2923699B1 (fr) * | 2006-05-09 | 2018-06-20 | Genzyme Corporation | Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides |
-
2002
- 2002-07-16 DK DK10075429.0T patent/DK2266968T3/da active
- 2002-07-16 CA CA2453978A patent/CA2453978C/fr not_active Expired - Lifetime
- 2002-07-16 DK DK02750099.0T patent/DK1409467T3/da active
- 2002-07-16 EP EP10075429A patent/EP2266968B1/fr not_active Expired - Lifetime
- 2002-07-16 EP EP02750099A patent/EP1409467B1/fr not_active Expired - Lifetime
- 2002-07-16 PT PT02750099T patent/PT1409467E/pt unknown
- 2002-07-16 JP JP2003513958A patent/JP5038582B2/ja not_active Expired - Lifetime
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