IL159905A0 - Enantioselective synthesis of ceramide-like compounds, novel intermediates, their preparation and pyrrole derivatives - Google Patents
Enantioselective synthesis of ceramide-like compounds, novel intermediates, their preparation and pyrrole derivativesInfo
- Publication number
- IL159905A0 IL159905A0 IL15990502A IL15990502A IL159905A0 IL 159905 A0 IL159905 A0 IL 159905A0 IL 15990502 A IL15990502 A IL 15990502A IL 15990502 A IL15990502 A IL 15990502A IL 159905 A0 IL159905 A0 IL 159905A0
- Authority
- IL
- Israel
- Prior art keywords
- ceramide
- compounds
- preparation
- novel intermediates
- pyrrole derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30581401P | 2001-07-16 | 2001-07-16 | |
PCT/US2002/022659 WO2003008399A1 (fr) | 2001-07-16 | 2002-07-16 | Synthese d'inhibiteurs de l'udp-glucose : n-acylsphingosine glycosyltransferase |
Publications (1)
Publication Number | Publication Date |
---|---|
IL159905A0 true IL159905A0 (en) | 2004-06-20 |
Family
ID=23182463
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15990502A IL159905A0 (en) | 2001-07-16 | 2002-07-16 | Enantioselective synthesis of ceramide-like compounds, novel intermediates, their preparation and pyrrole derivatives |
IL159905A IL159905A (en) | 2001-07-16 | 2004-01-16 | Antibiotic synthesis of ceramide image compound, intermediate, preparation and pyrolysis history |
IL193244A IL193244A0 (en) | 2001-07-16 | 2008-08-05 | Amine derivatives useul for the synthesis of ceramide-like compounds and methods utilizing the same |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL159905A IL159905A (en) | 2001-07-16 | 2004-01-16 | Antibiotic synthesis of ceramide image compound, intermediate, preparation and pyrolysis history |
IL193244A IL193244A0 (en) | 2001-07-16 | 2008-08-05 | Amine derivatives useul for the synthesis of ceramide-like compounds and methods utilizing the same |
Country Status (16)
Country | Link |
---|---|
US (11) | US6855830B2 (fr) |
EP (3) | EP2266968B1 (fr) |
JP (6) | JP5038582B2 (fr) |
AT (2) | ATE555102T1 (fr) |
BE (1) | BE2015C029I2 (fr) |
BR (3) | BR122015016314B8 (fr) |
CA (1) | CA2453978C (fr) |
CY (1) | CY2015028I2 (fr) |
DK (3) | DK2067775T3 (fr) |
ES (3) | ES2395463T3 (fr) |
FR (1) | FR15C0036I2 (fr) |
HK (2) | HK1132267A1 (fr) |
IL (3) | IL159905A0 (fr) |
LU (1) | LU92717I2 (fr) |
PT (3) | PT2067775E (fr) |
WO (1) | WO2003008399A1 (fr) |
Families Citing this family (52)
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US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
CA2434028C (fr) | 2001-01-10 | 2010-11-09 | The Regents Of The University Of Michigan | Composes du type amino-ceramide et procedes therapeutiques d'utilisation |
US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
ATE555102T1 (de) * | 2001-07-16 | 2012-05-15 | Genzyme Corp | N-acylsphingosinglucosyltransferase-inhibitor |
US6835831B2 (en) * | 2001-11-26 | 2004-12-28 | Genzyme Corporation | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
JP4195411B2 (ja) * | 2004-04-12 | 2008-12-10 | セイコーエプソン株式会社 | 有機エレクトロルミネッセンス装置の製造方法 |
JP2008519840A (ja) * | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
JP5042040B2 (ja) * | 2005-01-26 | 2012-10-03 | アラーガン、インコーポレイテッド | 鎮痛活性および/または免疫賦活活性を有する1−アリール−1−ヒドロキシ−2,3−ジアミノ−プロピルアミン、1−ヘテロアリール−1−ヒドロキシ−2,3−ジアミノ−プロピルアミンおよび関連化合物 |
ES2546181T3 (es) | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
LT2457920T (lt) | 2007-01-18 | 2018-02-12 | Genzyme Corporation | Oligosacharidai, apimantys aminooksigrupę, ir jų konjugatai |
US20140179925A1 (en) | 2009-09-04 | 2014-06-26 | Allergan, Inc. | Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
US9314466B2 (en) | 2007-03-06 | 2016-04-19 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
WO2008109285A1 (fr) | 2007-03-06 | 2008-09-12 | Allergan, Inc. | Procédés de traitement de troubles cognitifs |
CA2680324A1 (fr) | 2007-03-06 | 2008-09-12 | John E. Donello | Procedes de traitement des troubles cognitifs au moyen d'amides d'acides 3-aryl-3-hydroxy-2-amino-propioniques, d'amides d'acides 3-heteroaryl-3-hydroxy-2-amino-propioniques et decomposes apparentes |
EP2167485B1 (fr) | 2007-05-31 | 2015-09-30 | Genzyme Corporation | Inhibiteurs de glucosylcéramide synthase de type 2-acylaminopropanol |
MX2010003603A (es) * | 2007-10-05 | 2010-06-02 | Genzyme Corp | Metodo para el tratamiento de enfermedades de riñon poliquisticas con derivados de ceramida. |
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CA2731685A1 (fr) * | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Inhibition de synthase de glucosylceramide pour le traitement du glomerulopathie avec collapsus, et d'un autre trouble glomerulaire |
MX2011003517A (es) * | 2008-10-03 | 2011-05-25 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol. |
CA2747230C (fr) | 2008-12-16 | 2019-06-11 | Genzyme Corporation | Conjugues oligosaccharide-proteine |
EP3133070B1 (fr) * | 2009-11-27 | 2019-08-14 | Genzyme Corporation | Eliglustat (genz 112638) en tant que inhibiteur de la glucosylcéramide synthase pour l'utilisation dans un procédé pour traiter la maladie de fabry ou de gaucher, le procédé comprenant ajuster la dose individuelle au métabolisme du p-450 du patient |
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US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
WO2014150043A1 (fr) * | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals Inc. | Inhibiteurs de l'enzyme udp-glucose : n-acyl-sphingosine glucosyltransférase |
MX2016003486A (es) | 2013-09-20 | 2016-06-28 | Biomarin Pharm Inc | Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades. |
WO2015059679A1 (fr) * | 2013-10-25 | 2015-04-30 | Dr. Reddy's Laboratories Limited | Procédé amélioré pour la préparation d'éliglustat |
SI3063141T1 (sl) | 2013-10-29 | 2018-11-30 | Biomarin Pharmaceutical Inc. | N-(1-hidroksi-3-(pirolidinil)propan-2-il)pirolidin-3-karboksamidni derivati kot inhibitorji glukozilceramid sintaze |
EP3253734B1 (fr) | 2015-02-02 | 2020-12-23 | The Regents of The University of Michigan | Inhibiteurs de la glucosylcéramide synthase et méthodes thérapeutiques les utilisant |
CN104557851B (zh) * | 2015-02-10 | 2017-04-05 | 苏州明锐医药科技有限公司 | 依鲁司他的制备方法 |
EP3283483B1 (fr) | 2015-04-14 | 2018-12-19 | Sandoz AG | Chlorhydrate d'éliglustat cristallin |
WO2017068496A1 (fr) * | 2015-10-20 | 2017-04-27 | Dr. Reddy' S Laboratories Limited | Procédé amélioré pour la préparation d'éliglustat et de ses sels |
CN105646442A (zh) * | 2015-10-27 | 2016-06-08 | 北京凯莱天成医药科技有限公司 | 一种依利格鲁司他的制备方法 |
EP3442514B1 (fr) | 2016-04-11 | 2021-06-16 | Spedding Research Solutions | Inhibiteurs de dégradation des glucosylcéramides dans le traitement des maladies des neurones moteurs |
CN106349210A (zh) * | 2016-08-24 | 2017-01-25 | 北京阳光诺和药物研究有限公司 | 一种制备酒石酸艾力骨司坦的方法 |
CN106967042B (zh) * | 2017-03-21 | 2020-08-14 | 浙江奥翔药业股份有限公司 | 依利格鲁司他的合成方法及其中间体化合物 |
CN108822072B (zh) * | 2017-04-11 | 2021-01-12 | 中国医学科学院药物研究所 | 一种制备伊力格鲁司他的方法 |
WO2018193090A2 (fr) | 2017-04-21 | 2018-10-25 | Amneal Pharmaceuticals Company Gmbh | Procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci |
ZA201803719B (en) | 2017-06-05 | 2019-04-24 | Cipla Ltd | Stable solid dispersions of eliglustat hemitartrate |
SG11202004954YA (en) | 2017-12-15 | 2020-06-29 | Genzyme Corp | Methods for treating gaucher disease |
US12064414B2 (en) | 2017-12-20 | 2024-08-20 | Aizant Drug Research Solutions Private Limited. | Stable amorphous Eliglustat premix and process for the preparation thereof |
CN111217791B (zh) * | 2018-11-27 | 2024-02-02 | 广东东阳光药业股份有限公司 | 依鲁司他中间体及其制备方法 |
US20220185788A1 (en) * | 2019-03-22 | 2022-06-16 | Piramal Pharma Limited | An improved process for the preparation of eliglustat and its intermediate |
WO2020193746A1 (fr) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes de prédiction de la survie de patients atteints de mélanome |
JP2022553107A (ja) | 2019-10-23 | 2022-12-21 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | グルコシルセラミドシンターゼ阻害剤およびそれを使用する治療方法 |
WO2021214771A1 (fr) | 2020-04-23 | 2021-10-28 | The Israel Institute of Biological Research (IIBR) | Inhibiteurs de glucosylcéramide synthase pour la prévention et le traitement de maladies virales |
WO2021221953A1 (fr) | 2020-04-28 | 2021-11-04 | The Regents Of The University Of Michigan | Inhibiteurs pyridine de la glucosylcéramide synthase et procédés thérapeutiques les utilisant |
CN116120274A (zh) | 2021-11-12 | 2023-05-16 | 曙方(上海)医药科技有限公司 | 依利格鲁司他可药用盐及其晶型 |
EP4201403A1 (fr) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Composés tirapazamine et quazinone à utiliser dans le traitement des gangliosidoses gm2 |
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US7148251B2 (en) * | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
ATE555102T1 (de) * | 2001-07-16 | 2012-05-15 | Genzyme Corp | N-acylsphingosinglucosyltransferase-inhibitor |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
ES2546181T3 (es) * | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
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