BR0211379A - Sìntese de inibidores de udp-glicose: n-acil-esfingosina glicosiltransferase - Google Patents
Sìntese de inibidores de udp-glicose: n-acil-esfingosina glicosiltransferaseInfo
- Publication number
- BR0211379A BR0211379A BR0211379-1A BRPI0211379A BR0211379A BR 0211379 A BR0211379 A BR 0211379A BR PI0211379 A BRPI0211379 A BR PI0211379A BR 0211379 A BR0211379 A BR 0211379A
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis
- glycosyltransferase
- udp
- glucose
- inhibitors
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 102000051366 Glycosyltransferases Human genes 0.000 title abstract 3
- 108700023372 Glycosyltransferases Proteins 0.000 title abstract 3
- YDNKGFDKKRUKPY-TURZORIXSA-N N-hexadecanoylsphingosine Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCCCC YDNKGFDKKRUKPY-TURZORIXSA-N 0.000 title abstract 3
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 abstract 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 abstract 1
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 abstract 1
- 229940106189 ceramide Drugs 0.000 abstract 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cosmetics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR122015016313A BR122015016313B8 (pt) | 2001-07-16 | 2002-07-16 | composto semelhante à ceramida e método de preparar um composto |
BR122015016314A BR122015016314B8 (pt) | 2001-07-16 | 2002-07-16 | método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30581401P | 2001-07-16 | 2001-07-16 | |
US60/305,814 | 2001-07-16 | ||
PCT/US2002/022659 WO2003008399A1 (en) | 2001-07-16 | 2002-07-16 | Synthesis of udp-glucose: n-acylsphingosine glucosyltransferase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0211379A true BR0211379A (pt) | 2004-08-17 |
BRPI0211379B1 BRPI0211379B1 (pt) | 2018-02-14 |
BRPI0211379B8 BRPI0211379B8 (pt) | 2021-05-25 |
Family
ID=23182463
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0211379-1 BRPI0211379B8 (pt) | 2001-07-16 | 2002-07-16 | síntese de inibidores de udp-glicose: n-acil-esfingosina glicosiltransferase |
BR122015016313A BR122015016313B8 (pt) | 2001-07-16 | 2002-07-16 | composto semelhante à ceramida e método de preparar um composto |
BR122015016314A BR122015016314B8 (pt) | 2001-07-16 | 2002-07-16 | método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122015016313A BR122015016313B8 (pt) | 2001-07-16 | 2002-07-16 | composto semelhante à ceramida e método de preparar um composto |
BR122015016314A BR122015016314B8 (pt) | 2001-07-16 | 2002-07-16 | método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida |
Country Status (16)
Country | Link |
---|---|
US (11) | US6855830B2 (pt) |
EP (3) | EP2067775B1 (pt) |
JP (6) | JP5038582B2 (pt) |
AT (2) | ATE555102T1 (pt) |
BE (1) | BE2015C029I2 (pt) |
BR (3) | BRPI0211379B8 (pt) |
CA (1) | CA2453978C (pt) |
CY (1) | CY2015028I2 (pt) |
DK (3) | DK2067775T3 (pt) |
ES (3) | ES2399323T3 (pt) |
FR (1) | FR15C0036I2 (pt) |
HK (2) | HK1132267A1 (pt) |
IL (3) | IL159905A0 (pt) |
LU (1) | LU92717I2 (pt) |
PT (3) | PT1409467E (pt) |
WO (1) | WO2003008399A1 (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
JP2004531478A (ja) | 2001-01-10 | 2004-10-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | アミノセラミド様化合物および治療目的での使用方法 |
US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
ES2399323T3 (es) * | 2001-07-16 | 2013-03-27 | Genzyme Corporation | Síntesis de inhibidores de la UDP-glucosa:N-acilesfingosina glucosiltransferasa |
US6835831B2 (en) * | 2001-11-26 | 2004-12-28 | Genzyme Corporation | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
JP4195411B2 (ja) * | 2004-04-12 | 2008-12-10 | セイコーエプソン株式会社 | 有機エレクトロルミネッセンス装置の製造方法 |
US8003617B2 (en) * | 2004-11-10 | 2011-08-23 | Genzyme Corporation | Methods of treating diabetes mellitus |
ES2436612T3 (es) | 2005-01-26 | 2014-01-03 | Allergan, Inc. | 3-heteroaril-3-hidroxi-2-amino-propilaminas y compuestos relacionados que tienen actividad analgésica y/o inmunoestimulante |
HUE026057T2 (en) | 2006-05-09 | 2016-05-30 | Genzyme Corp | Procedures for the Treatment of Fatty Liver Disease, which comprises inhibition of glycosphingolipid synthesis |
IL243117B2 (en) | 2007-01-18 | 2023-03-01 | Genzyme Corp | Oligosaccharides containing an amino group and their conjugates |
WO2008109610A1 (en) * | 2007-03-06 | 2008-09-12 | Allergan, Inc. | Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
US20140179925A1 (en) | 2009-09-04 | 2014-06-26 | Allergan, Inc. | Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
WO2008109285A1 (en) | 2007-03-06 | 2008-09-12 | Allergan, Inc. | Methods for treating cognitive disorders |
US9314466B2 (en) | 2007-03-06 | 2016-04-19 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
WO2008150486A2 (en) | 2007-05-31 | 2008-12-11 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
EP2550965B1 (en) | 2007-10-05 | 2019-01-16 | Genzyme Corporation | Ceramide derivatives for treating polycystic kidney disease |
US8168631B2 (en) | 2008-02-05 | 2012-05-01 | Allergan, Inc. | 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity |
WO2010014554A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
EP2349255B1 (en) | 2008-10-03 | 2016-03-30 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
CN105879047A (zh) | 2008-12-16 | 2016-08-24 | 建新公司 | 寡糖-蛋白缀合物 |
CA2781676C (en) * | 2009-11-27 | 2020-05-05 | Genzyme Corporation | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
EP3236686A1 (en) | 2010-04-16 | 2017-10-25 | Kyocera Corporation | Radio communication system, high-power base station, low-power base station, and communication control method |
EP2699676A1 (en) | 2011-04-22 | 2014-02-26 | Genzyme Corporation | Modified acid alpha glucosidase with accelerated processing |
US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
AU2014237569B2 (en) * | 2013-03-15 | 2019-03-14 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme UDP-glucose: N-acyl-sphingosine glucosyltransferase |
AU2014321397C1 (en) | 2013-09-20 | 2019-08-01 | Biomarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
WO2015059679A1 (en) * | 2013-10-25 | 2015-04-30 | Dr. Reddy's Laboratories Limited | Improved process for the preparation of eliglustat |
HUE040220T2 (hu) | 2013-10-29 | 2019-02-28 | Biomarin Pharm Inc | N-(1-hidroxi-3-(pirrolidinil)propan-2-il)pirrolidin-3-karboxamid származékok mint glükozilceramid-szintáz inhibitorok |
WO2016126572A2 (en) | 2015-02-02 | 2016-08-11 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
CN104557851B (zh) * | 2015-02-10 | 2017-04-05 | 苏州明锐医药科技有限公司 | 依鲁司他的制备方法 |
ES2716420T3 (es) | 2015-04-14 | 2019-06-12 | Sandoz Ag | Clorhidrato de eliglustat cristalino |
WO2017068496A1 (en) * | 2015-10-20 | 2017-04-27 | Dr. Reddy' S Laboratories Limited | Improved process for the preparation of eliglustat and its salts |
CN105646442A (zh) * | 2015-10-27 | 2016-06-08 | 北京凯莱天成医药科技有限公司 | 一种依利格鲁司他的制备方法 |
WO2017178499A1 (en) | 2016-04-11 | 2017-10-19 | Spedding Research Solutions | Inhibitors of glucosylceramide degradation in the treatment of diseases of the motor units |
CN106349210A (zh) * | 2016-08-24 | 2017-01-25 | 北京阳光诺和药物研究有限公司 | 一种制备酒石酸艾力骨司坦的方法 |
CN106967042B (zh) * | 2017-03-21 | 2020-08-14 | 浙江奥翔药业股份有限公司 | 依利格鲁司他的合成方法及其中间体化合物 |
CN108822072B (zh) * | 2017-04-11 | 2021-01-12 | 中国医学科学院药物研究所 | 一种制备伊力格鲁司他的方法 |
WO2018193090A2 (en) | 2017-04-21 | 2018-10-25 | Amneal Pharmaceuticals Company Gmbh | Process for preparation of eliglustat hemitartrate and intermediates thereof |
WO2018225085A1 (en) | 2017-06-05 | 2018-12-13 | Cipla Limited | Stable solid dispersions of eliglustat hemitartrate |
MX2020006272A (es) | 2017-12-15 | 2020-09-14 | Genzyme Corp | Metodos para tratar la enfermedad de gaucher. |
CN111217791B (zh) * | 2018-11-27 | 2024-02-02 | 广东东阳光药业股份有限公司 | 依鲁司他中间体及其制备方法 |
WO2020194138A1 (en) * | 2019-03-22 | 2020-10-01 | Piramal Enterprises Limited | An improved process for the preparation of eliglustat and its intermediate |
WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
JP2022553107A (ja) | 2019-10-23 | 2022-12-21 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | グルコシルセラミドシンターゼ阻害剤およびそれを使用する治療方法 |
WO2021214771A1 (en) | 2020-04-23 | 2021-10-28 | The Israel Institute of Biological Research (IIBR) | Glucosylceramide synthase inhibitors for prevention and treatment of viral diseases |
US20230212123A1 (en) | 2020-04-28 | 2023-07-06 | The Regents Of The University Of Michigan | Pyridine Inhibitors of Glucosylceramide Synthase and Therapeutic Methods Using the Same |
CN116120274A (zh) | 2021-11-12 | 2023-05-16 | 曙方(上海)医药科技有限公司 | 依利格鲁司他可药用盐及其晶型 |
EP4201403A1 (en) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
DE3522475A1 (de) | 1985-06-22 | 1987-01-02 | Kali Chemie Pharma Gmbh | Neue aromatische verbindungen, ihre herstellung und verwendung |
JPH0416856A (ja) | 1990-05-10 | 1992-01-21 | Canon Inc | 正帯電性非磁性トナー |
ZA929008B (en) | 1991-12-13 | 1993-05-21 | Bristol Myers Squibb Co | Piperazinyl- and piperidinyl-cyclohexanols. |
AU676361B2 (en) * | 1993-08-13 | 1997-03-06 | Seikagaku Corporation | Remedy for nervous diseases |
PT742789E (pt) * | 1994-02-02 | 2000-12-29 | Liposome Co Inc | Lipossomas e compostos farmaceuticamente activos e metodos para a sua utilizacao |
DE69524592T2 (de) * | 1994-06-10 | 2002-07-18 | Seikagaku Kogyo Co Ltd | 2-Acylaminopropanolverbindung und ihre pharmazeutische Zusammensetzung |
FR2734819B1 (fr) | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
US6890949B1 (en) | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
WO2001004108A1 (en) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US6255336B1 (en) * | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20030073680A1 (en) | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
WO1997010817A1 (en) * | 1995-09-20 | 1997-03-27 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
JP3993908B2 (ja) * | 1995-12-08 | 2007-10-17 | 生化学工業株式会社 | アミノアルコール誘導体及び該誘導体の製造方法 |
NO965193L (no) * | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
JP4140984B2 (ja) | 1995-12-20 | 2008-08-27 | 生化学工業株式会社 | 分化誘導作用を有する薬剤 |
US5916802A (en) * | 1997-02-19 | 1999-06-29 | Fritz Berthold | Device for measuring ATP |
US5972928A (en) * | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
JP4176170B2 (ja) | 1997-06-06 | 2008-11-05 | 生化学工業株式会社 | アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬 |
US6511979B1 (en) * | 1998-07-27 | 2003-01-28 | Johns Hopkins University | Methods for treating conditions modulated by lactosylceramide |
US20020198240A1 (en) | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
US7148251B2 (en) * | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
JP2004531478A (ja) * | 2001-01-10 | 2004-10-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | アミノセラミド様化合物および治療目的での使用方法 |
ES2399323T3 (es) | 2001-07-16 | 2013-03-27 | Genzyme Corporation | Síntesis de inhibidores de la UDP-glucosa:N-acilesfingosina glucosiltransferasa |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
HUE026057T2 (en) * | 2006-05-09 | 2016-05-30 | Genzyme Corp | Procedures for the Treatment of Fatty Liver Disease, which comprises inhibition of glycosphingolipid synthesis |
-
2002
- 2002-07-16 ES ES10075429T patent/ES2399323T3/es not_active Expired - Lifetime
- 2002-07-16 DK DK09003291.3T patent/DK2067775T3/da active
- 2002-07-16 JP JP2003513958A patent/JP5038582B2/ja not_active Expired - Lifetime
- 2002-07-16 AT AT09003291T patent/ATE555102T1/de active
- 2002-07-16 EP EP09003291A patent/EP2067775B1/en not_active Expired - Lifetime
- 2002-07-16 AT AT02750099T patent/ATE554082T1/de active
- 2002-07-16 PT PT02750099T patent/PT1409467E/pt unknown
- 2002-07-16 BR BRPI0211379-1 patent/BRPI0211379B8/pt active IP Right Grant
- 2002-07-16 ES ES02750099T patent/ES2395122T3/es not_active Expired - Lifetime
- 2002-07-16 DK DK02750099.0T patent/DK1409467T3/da active
- 2002-07-16 WO PCT/US2002/022659 patent/WO2003008399A1/en active Application Filing
- 2002-07-16 PT PT100754290T patent/PT2266968E/pt unknown
- 2002-07-16 EP EP10075429A patent/EP2266968B1/en not_active Expired - Lifetime
- 2002-07-16 PT PT09003291T patent/PT2067775E/pt unknown
- 2002-07-16 ES ES09003291T patent/ES2395463T3/es not_active Expired - Lifetime
- 2002-07-16 US US10/197,227 patent/US6855830B2/en not_active Expired - Lifetime
- 2002-07-16 BR BR122015016313A patent/BR122015016313B8/pt not_active IP Right Cessation
- 2002-07-16 EP EP02750099A patent/EP1409467B1/en not_active Expired - Lifetime
- 2002-07-16 BR BR122015016314A patent/BR122015016314B8/pt not_active IP Right Cessation
- 2002-07-16 DK DK10075429.0T patent/DK2266968T3/da active
- 2002-07-16 CA CA2453978A patent/CA2453978C/en not_active Expired - Lifetime
- 2002-07-16 IL IL15990502A patent/IL159905A0/xx unknown
-
2004
- 2004-01-16 IL IL159905A patent/IL159905A/en active Protection Beyond IP Right Term
- 2004-08-12 US US10/916,824 patent/US7265228B2/en not_active Expired - Lifetime
-
2005
- 2005-03-28 US US11/091,836 patent/US7196205B2/en active Active
- 2005-04-08 JP JP2005112378A patent/JP4708073B2/ja not_active Expired - Lifetime
-
2007
- 2007-02-05 US US11/702,425 patent/US7615573B2/en not_active Expired - Lifetime
- 2007-08-24 US US11/895,632 patent/US7763738B2/en not_active Expired - Lifetime
-
2008
- 2008-08-05 IL IL193244A patent/IL193244A0/en unknown
-
2009
- 2009-12-09 HK HK09111547.6A patent/HK1132267A1/xx not_active IP Right Cessation
-
2010
- 2010-02-01 JP JP2010020146A patent/JP5227348B2/ja not_active Expired - Lifetime
- 2010-07-06 US US12/830,962 patent/US8138353B2/en not_active Expired - Fee Related
-
2011
- 2011-06-23 HK HK11106527.6A patent/HK1153733A1/xx not_active IP Right Cessation
-
2012
- 2012-03-14 US US13/420,108 patent/US8779163B2/en not_active Expired - Lifetime
-
2013
- 2013-02-13 JP JP2013041198A patent/JP2013136618A/ja active Pending
-
2014
- 2014-06-26 US US14/315,453 patent/US9546161B2/en not_active Expired - Lifetime
-
2015
- 2015-04-20 JP JP2015097734A patent/JP2015180656A/ja active Pending
- 2015-05-12 BE BE2015C029C patent/BE2015C029I2/fr unknown
- 2015-05-13 LU LU92717C patent/LU92717I2/xx unknown
- 2015-05-13 FR FR15C0036C patent/FR15C0036I2/fr active Active
- 2015-07-08 CY CY2015028C patent/CY2015028I2/el unknown
-
2016
- 2016-11-09 JP JP2016218570A patent/JP6182254B2/ja not_active Expired - Lifetime
- 2016-12-30 US US15/395,329 patent/US20170334888A1/en not_active Abandoned
-
2018
- 2018-11-21 US US16/198,258 patent/US20190322649A1/en not_active Abandoned
-
2020
- 2020-07-23 US US16/937,437 patent/US20210171507A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0211379A (pt) | Sìntese de inibidores de udp-glicose: n-acil-esfingosina glicosiltransferase | |
SE0000540D0 (sv) | New compounds | |
EP1613728A4 (en) | MODULATION OF EXPRESSION OF DIACYLGLYCEROL ACYLTRANSFERASE 1 | |
ITMI20021876A1 (it) | Procedimento migliorato per realizzare un rotore di un | |
BG105515A (en) | Substituted 2-phenylbenzimidazoles, the production thereof and their use | |
UY26721A1 (es) | Nuevos derivados de la fenilglicina | |
NO20024808D0 (no) | Fremgangsmåte ved syntesen av perindopril og farmasöytisk akseptable salter derav | |
RS81904A (en) | Phosphate prodrugs of fluorooxindoles | |
FR2833089B1 (fr) | Regulateur de pression du type a volet d'etranglement | |
AU2003248647A8 (en) | Stereoselective synthesis of 1,2-disubstituted cycloalkyls | |
FR2850042B1 (fr) | Generateur d'efforts dynamiques a balourd | |
IS5951A (is) | 5HT1 mótlyf fyrir meðferð gegn þunglyndi | |
BR0208812A (pt) | Derivados fenil heterociclil éter como inibidores de recaptação de serotonina | |
CY1107776T1 (el) | Νεα παραγωγα ολιγο-νουκλεοτιδιων για στοχευμενη αναστολη της εκφρασης γονιδιων | |
HUP9802586A2 (hu) | A (-)-[2-(2-tienil)-etilamino]-(2-halogénfenil)-acetamidok racemizálási eljárása | |
ITMI20010077A0 (it) | Procedimento per la produzione dell'imipenem | |
ITMI20000026A0 (it) | Procedimento per la produzione di gas di sintesi | |
MXPA03006057A (es) | Proceso para preparar (+) trans-4-p-fluorofenil -3 hidroximetil. | |
CY1113586T1 (el) | Ενας αναστολεας ν-ακυλοσφιγγοσινο γλυκοζυλοτρανσφερασης | |
AU2001258344A1 (en) | Synthesis of midodrine hci from a novel intermediate 1-(2',5'-dimethoxyphenyl)-2-azidoethanone | |
HUP0300100A2 (en) | Peptide betha-turn mimetic compounds and processes for making them | |
IT1316990B1 (it) | Metodo per aumentare l'espressione genica per geni trasfettati. | |
DE60224381D1 (de) | Neuer sphingolipid-synthese-hemmer | |
FR2849768B1 (fr) | Distributeur d'instruments dentaires | |
AU2003222958A1 (en) | Asymmetric synthesis of glycidic amides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25G | Requested change of headquarter approved |
Owner name: GENZYME CORPORATION (US) , THE REGENTS OF THE UNIV Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 018080029522/SP DE 14/05/2008. |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 295/12, C07C 231/18, C07C 215/30, C07C 237/20, C07D 498/04, A61P 35/00 Ipc: C07D 295/12 (2011.01), C07C 231/18 (2011.01), C07C |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B25G | Requested change of headquarter approved |
Owner name: GENZYME CORPORATION (US) , THE REGENTS OF THE UNIV |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/07/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: "INPI NO 52402.000121/2022-46 ORIGEM: 4A VARA FEDERAL CIVEL DA SJDF (TRF1) PROCESSO NO: 1088996-39.2021.4.01.3400 ACAO DE PROCEDIMENTO COMUM AUTOR: GENZYME CORPORATION E THE REGENTS OF THE UNIVERSITYOF MICHIGAN REU(S): INPI - INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL" |
|
B19A | Notification of judicial decision: notification of judicial decision |
Free format text: PROCESSO INPI NO 52402.001404/2023-96 TRIBUNAL REGIONAL FEDERAL DA PRIMEIRA REGIAO AUTOR: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA AUTOR: GENZYME CORPORATION REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL DECISAO: ANTE O EXPOSTO, PRESENTES OS REQUISITOS AUTORIZADORES, DEFIRO O PEDIDO DE ANTECIPACAO DA TUTELA RECURSAL, A FIM DE SUSPENDER OS EFEITOS DO DESPACHO 16.3 DO INPI, IMPEDINDO-SE, ASSIM, A DECLARACAO DE EXTINCAO DO PRAZO DA PATENTE PI 0211379-1 PELO INPI. |
|
B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: "INPI NO 52402.001404/2023-96 ORIGEM: TRIBUNAL REGIONAL FEDERAL DA 1A REGIAO PROCESSO NO: 1001008-24.2023.4.01.0000 SUB JUDICE COM PEDIDO DE ANTECIPACAO DE TUTELA AUTOR: GENZYME CORPORATION E THEREGENTS OF THE UNIVERSITY OF MICHIGAN, REU(S): INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI" |