BR122015016314B8 - método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida - Google Patents
método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramidaInfo
- Publication number
- BR122015016314B8 BR122015016314B8 BR122015016314A BR122015016314A BR122015016314B8 BR 122015016314 B8 BR122015016314 B8 BR 122015016314B8 BR 122015016314 A BR122015016314 A BR 122015016314A BR 122015016314 A BR122015016314 A BR 122015016314A BR 122015016314 B8 BR122015016314 B8 BR 122015016314B8
- Authority
- BR
- Brazil
- Prior art keywords
- preparing
- compound
- type compound
- sphingosine
- ceramide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 8
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 150000001260 acyclic compounds Chemical class 0.000 title abstract 2
- -1 amine compound Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 abstract 1
- 102000051366 Glycosyltransferases Human genes 0.000 abstract 1
- 108700023372 Glycosyltransferases Proteins 0.000 abstract 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 abstract 1
- YDNKGFDKKRUKPY-TURZORIXSA-N N-hexadecanoylsphingosine Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCCCC YDNKGFDKKRUKPY-TURZORIXSA-N 0.000 abstract 1
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 abstract 1
- 229940106189 ceramide Drugs 0.000 abstract 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cosmetics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida. divulgam-se novos inibidores como ceramida de síntese enantiomérica de udp-glicose: n-acil-esfingosina glicosiltransferase. divulgam-se também novos intermediários formados durante a síntese.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30581401P | 2001-07-16 | 2001-07-16 | |
US60/305,814 | 2001-07-16 | ||
BR0211379-1 BRPI0211379B8 (pt) | 2001-07-16 | 2002-07-16 | síntese de inibidores de udp-glicose: n-acil-esfingosina glicosiltransferase |
PCT/US2002/022659 WO2003008399A1 (en) | 2001-07-16 | 2002-07-16 | Synthesis of udp-glucose: n-acylsphingosine glucosyltransferase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR122015016314B1 BR122015016314B1 (pt) | 2019-04-16 |
BR122015016314B8 true BR122015016314B8 (pt) | 2021-05-25 |
Family
ID=23182463
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0211379-1 BRPI0211379B8 (pt) | 2001-07-16 | 2002-07-16 | síntese de inibidores de udp-glicose: n-acil-esfingosina glicosiltransferase |
BR122015016313A BR122015016313B8 (pt) | 2001-07-16 | 2002-07-16 | composto semelhante à ceramida e método de preparar um composto |
BR122015016314A BR122015016314B8 (pt) | 2001-07-16 | 2002-07-16 | método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0211379-1 BRPI0211379B8 (pt) | 2001-07-16 | 2002-07-16 | síntese de inibidores de udp-glicose: n-acil-esfingosina glicosiltransferase |
BR122015016313A BR122015016313B8 (pt) | 2001-07-16 | 2002-07-16 | composto semelhante à ceramida e método de preparar um composto |
Country Status (16)
Country | Link |
---|---|
US (11) | US6855830B2 (pt) |
EP (3) | EP2067775B1 (pt) |
JP (6) | JP5038582B2 (pt) |
AT (2) | ATE554082T1 (pt) |
BE (1) | BE2015C029I2 (pt) |
BR (3) | BRPI0211379B8 (pt) |
CA (1) | CA2453978C (pt) |
CY (1) | CY2015028I1 (pt) |
DK (3) | DK2067775T3 (pt) |
ES (3) | ES2395463T3 (pt) |
FR (1) | FR15C0036I2 (pt) |
HK (2) | HK1132267A1 (pt) |
IL (3) | IL159905A0 (pt) |
LU (1) | LU92717I2 (pt) |
PT (3) | PT2266968E (pt) |
WO (1) | WO2003008399A1 (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
WO2002062777A2 (en) | 2001-01-10 | 2002-08-15 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
ATE554082T1 (de) * | 2001-07-16 | 2012-05-15 | Genzyme Corp | N-acetylsphingosin glukosyltransferase inhibitor |
US6835831B2 (en) * | 2001-11-26 | 2004-12-28 | Genzyme Corporation | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
JP4195411B2 (ja) * | 2004-04-12 | 2008-12-10 | セイコーエプソン株式会社 | 有機エレクトロルミネッセンス装置の製造方法 |
US8003617B2 (en) * | 2004-11-10 | 2011-08-23 | Genzyme Corporation | Methods of treating diabetes mellitus |
JP5042040B2 (ja) * | 2005-01-26 | 2012-10-03 | アラーガン、インコーポレイテッド | 鎮痛活性および/または免疫賦活活性を有する1−アリール−1−ヒドロキシ−2,3−ジアミノ−プロピルアミン、1−ヘテロアリール−1−ヒドロキシ−2,3−ジアミノ−プロピルアミンおよび関連化合物 |
PT2032134E (pt) | 2006-05-09 | 2015-10-07 | Genzyme Corp | Métodos de tratamento da doença do fígado gorduroso |
CN101631794B (zh) | 2007-01-18 | 2013-01-02 | 建新公司 | 包含氨基氧基基团的寡糖及其轭合物 |
US20140179925A1 (en) | 2009-09-04 | 2014-06-26 | Allergan, Inc. | Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
US9314466B2 (en) | 2007-03-06 | 2016-04-19 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
PT2481407T (pt) * | 2007-03-06 | 2018-12-28 | Allergan Inc | Compostos para utilização no tratamento de distúrbios cognitivos |
US8173683B2 (en) | 2007-03-06 | 2012-05-08 | Allergan, Inc. | Methods for treating cognitive disorders |
EP2594565B1 (en) | 2007-05-31 | 2018-10-24 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
BRPI0823522A2 (pt) | 2007-10-05 | 2014-01-07 | Genzyme Corp | Uso de um composto derivado de ceramida |
US8168631B2 (en) | 2008-02-05 | 2012-05-01 | Allergan, Inc. | 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity |
WO2010014554A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
WO2010039256A1 (en) | 2008-10-03 | 2010-04-08 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
BR122020010601B8 (pt) | 2008-12-16 | 2021-07-27 | Genzyme Corp | conjugados de proteína-oligossacarídeo, seus usos, e composições farmacêuticas |
SI3133070T1 (sl) * | 2009-11-27 | 2019-11-29 | Genzyme Corp | Eliglustat (GENZ 112638) kot inhibitor sintaze glukozilceramida za uporabo v postopku zdravljenja Fabrjyeve ali Gaucherjeve bolezni, kjer postopek obsega prilagajanje individualnega terapevtskega odmerka metabolizmu P-450 pacienta |
EP3236686A1 (en) | 2010-04-16 | 2017-10-25 | Kyocera Corporation | Radio communication system, high-power base station, low-power base station, and communication control method |
AU2012245280A1 (en) | 2011-04-22 | 2013-11-07 | Genzyme Corporation | Modified acid alpha glucosidase with accelerated processing |
US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
CA2906396A1 (en) | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
EP3912977A1 (en) | 2013-09-20 | 2021-11-24 | BioMarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
WO2015059679A1 (en) * | 2013-10-25 | 2015-04-30 | Dr. Reddy's Laboratories Limited | Improved process for the preparation of eliglustat |
WO2015065937A1 (en) | 2013-10-29 | 2015-05-07 | Biomarin Pharmaceutical Inc. | N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors |
ES2856898T3 (es) | 2015-02-02 | 2021-09-28 | Univ Michigan Regents | Inhibidores de glucosilceramida sintasa y métodos terapéuticos que usan los mismos |
CN104557851B (zh) * | 2015-02-10 | 2017-04-05 | 苏州明锐医药科技有限公司 | 依鲁司他的制备方法 |
EP3283483B1 (en) | 2015-04-14 | 2018-12-19 | Sandoz AG | Crystalline eliglustat hydrochloride |
WO2017068496A1 (en) * | 2015-10-20 | 2017-04-27 | Dr. Reddy' S Laboratories Limited | Improved process for the preparation of eliglustat and its salts |
CN105646442A (zh) * | 2015-10-27 | 2016-06-08 | 北京凯莱天成医药科技有限公司 | 一种依利格鲁司他的制备方法 |
WO2017178499A1 (en) | 2016-04-11 | 2017-10-19 | Spedding Research Solutions | Inhibitors of glucosylceramide degradation in the treatment of diseases of the motor units |
CN106349210A (zh) * | 2016-08-24 | 2017-01-25 | 北京阳光诺和药物研究有限公司 | 一种制备酒石酸艾力骨司坦的方法 |
CN106967042B (zh) | 2017-03-21 | 2020-08-14 | 浙江奥翔药业股份有限公司 | 依利格鲁司他的合成方法及其中间体化合物 |
CN108822072B (zh) * | 2017-04-11 | 2021-01-12 | 中国医学科学院药物研究所 | 一种制备伊力格鲁司他的方法 |
WO2018193090A2 (en) | 2017-04-21 | 2018-10-25 | Amneal Pharmaceuticals Company Gmbh | Process for preparation of eliglustat hemitartrate and intermediates thereof |
ZA201803719B (en) | 2017-06-05 | 2019-04-24 | Cipla Ltd | Stable solid dispersions of eliglustat hemitartrate |
US10888544B2 (en) | 2017-12-15 | 2021-01-12 | Genzyme Corporation | Methods for treating Gaucher disease |
CN111217791B (zh) * | 2018-11-27 | 2024-02-02 | 广东东阳光药业股份有限公司 | 依鲁司他中间体及其制备方法 |
EP3941917A4 (en) * | 2019-03-22 | 2022-12-21 | Piramal Pharma Limited | IMPROVED PROCESS FOR THE PREPARATION OF ELIGLUSTAT AND ITS INTERMEDIATE |
WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
US11220479B2 (en) | 2019-10-23 | 2022-01-11 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
WO2021214771A1 (en) | 2020-04-23 | 2021-10-28 | The Israel Institute of Biological Research (IIBR) | Glucosylceramide synthase inhibitors for prevention and treatment of viral diseases |
US20230212123A1 (en) | 2020-04-28 | 2023-07-06 | The Regents Of The University Of Michigan | Pyridine Inhibitors of Glucosylceramide Synthase and Therapeutic Methods Using the Same |
CN116120274A (zh) | 2021-11-12 | 2023-05-16 | 曙方(上海)医药科技有限公司 | 依利格鲁司他可药用盐及其晶型 |
EP4201403A1 (en) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
DE3522475A1 (de) | 1985-06-22 | 1987-01-02 | Kali Chemie Pharma Gmbh | Neue aromatische verbindungen, ihre herstellung und verwendung |
JPH0416856A (ja) | 1990-05-10 | 1992-01-21 | Canon Inc | 正帯電性非磁性トナー |
ZA929008B (en) | 1991-12-13 | 1993-05-21 | Bristol Myers Squibb Co | Piperazinyl- and piperidinyl-cyclohexanols. |
CN1128951A (zh) | 1993-08-13 | 1996-08-14 | 生化学工业株式会社 | 治疗神经元疾病的药物 |
ATE195944T1 (de) * | 1994-02-02 | 2000-09-15 | Liposome Co Inc | Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung |
AU698833B2 (en) | 1994-06-10 | 1998-11-12 | Seikagaku Corporation | 2-acylaminopropanol compound and medical composition |
FR2734819B1 (fr) | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
WO2001004108A1 (en) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20030073680A1 (en) * | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US6255336B1 (en) | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US6890949B1 (en) | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
WO1997010817A1 (en) * | 1995-09-20 | 1997-03-27 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
NO965193L (no) | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
JP3993908B2 (ja) * | 1995-12-08 | 2007-10-17 | 生化学工業株式会社 | アミノアルコール誘導体及び該誘導体の製造方法 |
JP4140984B2 (ja) | 1995-12-20 | 2008-08-27 | 生化学工業株式会社 | 分化誘導作用を有する薬剤 |
US5916802A (en) * | 1997-02-19 | 1999-06-29 | Fritz Berthold | Device for measuring ATP |
US5972928A (en) * | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
JP4176170B2 (ja) | 1997-06-06 | 2008-11-05 | 生化学工業株式会社 | アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬 |
EP1098642B1 (en) * | 1998-07-27 | 2007-04-04 | Johns Hopkins University | Diamino-propanol-compounds for treating ischemia |
US20020198240A1 (en) * | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
WO2002062777A2 (en) | 2001-01-10 | 2002-08-15 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US7148251B2 (en) | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
ATE554082T1 (de) | 2001-07-16 | 2012-05-15 | Genzyme Corp | N-acetylsphingosin glukosyltransferase inhibitor |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
PT2032134E (pt) * | 2006-05-09 | 2015-10-07 | Genzyme Corp | Métodos de tratamento da doença do fígado gorduroso |
-
2002
- 2002-07-16 AT AT02750099T patent/ATE554082T1/de active
- 2002-07-16 DK DK09003291.3T patent/DK2067775T3/da active
- 2002-07-16 ES ES09003291T patent/ES2395463T3/es not_active Expired - Lifetime
- 2002-07-16 PT PT100754290T patent/PT2266968E/pt unknown
- 2002-07-16 IL IL15990502A patent/IL159905A0/xx unknown
- 2002-07-16 PT PT02750099T patent/PT1409467E/pt unknown
- 2002-07-16 EP EP09003291A patent/EP2067775B1/en not_active Expired - Lifetime
- 2002-07-16 BR BR0211379-1 patent/BRPI0211379B8/pt active IP Right Grant
- 2002-07-16 US US10/197,227 patent/US6855830B2/en not_active Expired - Lifetime
- 2002-07-16 JP JP2003513958A patent/JP5038582B2/ja not_active Expired - Lifetime
- 2002-07-16 EP EP02750099A patent/EP1409467B1/en not_active Expired - Lifetime
- 2002-07-16 ES ES10075429T patent/ES2399323T3/es not_active Expired - Lifetime
- 2002-07-16 BR BR122015016313A patent/BR122015016313B8/pt not_active IP Right Cessation
- 2002-07-16 AT AT09003291T patent/ATE555102T1/de active
- 2002-07-16 EP EP10075429A patent/EP2266968B1/en not_active Expired - Lifetime
- 2002-07-16 WO PCT/US2002/022659 patent/WO2003008399A1/en active Application Filing
- 2002-07-16 BR BR122015016314A patent/BR122015016314B8/pt not_active IP Right Cessation
- 2002-07-16 CA CA2453978A patent/CA2453978C/en not_active Expired - Lifetime
- 2002-07-16 PT PT09003291T patent/PT2067775E/pt unknown
- 2002-07-16 ES ES02750099T patent/ES2395122T3/es not_active Expired - Lifetime
- 2002-07-16 DK DK02750099.0T patent/DK1409467T3/da active
- 2002-07-16 DK DK10075429.0T patent/DK2266968T3/da active
-
2004
- 2004-01-16 IL IL159905A patent/IL159905A/en active Protection Beyond IP Right Term
- 2004-08-12 US US10/916,824 patent/US7265228B2/en not_active Expired - Lifetime
-
2005
- 2005-03-28 US US11/091,836 patent/US7196205B2/en active Active
- 2005-04-08 JP JP2005112378A patent/JP4708073B2/ja not_active Expired - Lifetime
-
2007
- 2007-02-05 US US11/702,425 patent/US7615573B2/en not_active Expired - Lifetime
- 2007-08-24 US US11/895,632 patent/US7763738B2/en not_active Expired - Lifetime
-
2008
- 2008-08-05 IL IL193244A patent/IL193244A0/en unknown
-
2009
- 2009-12-09 HK HK09111547.6A patent/HK1132267A1/xx not_active IP Right Cessation
-
2010
- 2010-02-01 JP JP2010020146A patent/JP5227348B2/ja not_active Expired - Lifetime
- 2010-07-06 US US12/830,962 patent/US8138353B2/en not_active Expired - Fee Related
-
2011
- 2011-06-23 HK HK11106527.6A patent/HK1153733A1/xx not_active IP Right Cessation
-
2012
- 2012-03-14 US US13/420,108 patent/US8779163B2/en not_active Expired - Lifetime
-
2013
- 2013-02-13 JP JP2013041198A patent/JP2013136618A/ja active Pending
-
2014
- 2014-06-26 US US14/315,453 patent/US9546161B2/en not_active Expired - Lifetime
-
2015
- 2015-04-20 JP JP2015097734A patent/JP2015180656A/ja active Pending
- 2015-05-12 BE BE2015C029C patent/BE2015C029I2/fr unknown
- 2015-05-13 FR FR15C0036C patent/FR15C0036I2/fr active Active
- 2015-05-13 LU LU92717C patent/LU92717I2/xx unknown
- 2015-07-08 CY CY2015028C patent/CY2015028I1/el unknown
-
2016
- 2016-11-09 JP JP2016218570A patent/JP6182254B2/ja not_active Expired - Lifetime
- 2016-12-30 US US15/395,329 patent/US20170334888A1/en not_active Abandoned
-
2018
- 2018-11-21 US US16/198,258 patent/US20190322649A1/en not_active Abandoned
-
2020
- 2020-07-23 US US16/937,437 patent/US20210171507A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR122015016314B8 (pt) | método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida | |
BR0305767A (pt) | Métodos e composições para a preparação de derivados de ácido 4-substituìdo 3-hidroxibutìrico | |
LTC1436271I2 (lt) | Fenilpiperazino dariniai, kaip serotonino grįžtamos absorbcijos inhibitoriai | |
HK1088597A1 (en) | Method for the production of substituted 3-aryl-butyl amine compounds | |
TW200635913A (en) | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof | |
GB2432609A (en) | Method of expansion | |
ITMI20021876A1 (it) | Procedimento migliorato per realizzare un rotore di un | |
CY1113362T1 (el) | Διαρυλ-αιθερες, ως ανταγωνιστης οπιοειδους υποδοχεως | |
ATE401066T1 (de) | Methoden zur behandlung der essstörungen | |
BR0206433A (pt) | Composto, composição farmacêutica, processo para a prepapação de um composto, e, uso de um composto | |
EA200401551A1 (ru) | Получение сульфинилацетамида | |
EA200400491A1 (ru) | Полиморфная форма римонабанта, способ её получения и содержащие её фармацевтические композиции | |
AR021716A1 (es) | Inhibidores de transferasa de proteina farnesilo. | |
CY1107635T1 (el) | Μεθοδος για την παρασκευη σιταλοπραμης | |
EA200700766A1 (ru) | Способ получения производных [1,4,5]-оксадиазепина | |
ATE316075T1 (de) | Verfahren zur monomethylierung von stickstoffhaltigen heterocyclen | |
BRPI0411308A8 (pt) | Composto, composição farmacêutica, processo para a preparação de um composto, e, uso de um composto | |
EA200100040A1 (ru) | Химический синтез морфолиновых производных | |
MXPA04005305A (es) | Nuevo polimorfo cristalino de clorhidrato de venlafaxina y metodos para preparacion del mismo. | |
PT1358179E (pt) | Processo de sintese e intermediarios de piridin-2-il-metilamina | |
DK1252327T3 (da) | Fremgangsmåde til enzymatisk racematopdeling af aminomethyl-aryl-cyclohexanol-derivater | |
UA91153C2 (ru) | Способ получения формы и венлафаксина гидрохлорида | |
MXPA03012073A (es) | Amidoderivados heterociclicos. | |
ATE522499T1 (de) | Verfahren zur herstellung von tamsulosin und seinen derivaten | |
TW200719921A (en) | Hair treating agent |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25G | Requested change of headquarter approved |
Owner name: GENZYME CORPORATION (US) , THE REGENTS OF THE UNIV |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/04/2019, OBSERVADAS AS CONDICOES LEGAIS |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/07/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 16/07/2022 |