ATE195944T1 - Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung - Google Patents

Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung

Info

Publication number
ATE195944T1
ATE195944T1 AT95910923T AT95910923T ATE195944T1 AT E195944 T1 ATE195944 T1 AT E195944T1 AT 95910923 T AT95910923 T AT 95910923T AT 95910923 T AT95910923 T AT 95910923T AT E195944 T1 ATE195944 T1 AT E195944T1
Authority
AT
Austria
Prior art keywords
group
chain
liposomes
production
active compounds
Prior art date
Application number
AT95910923T
Other languages
English (en)
Inventor
Yong-Wei Pei
Eric Mayhew
Imran Ahmad
Andrew S Janoff
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ATE195944T1 publication Critical patent/ATE195944T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
AT95910923T 1994-02-02 1995-02-02 Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung ATE195944T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19029594A 1994-02-02 1994-02-02
PCT/US1995/001490 WO1995021175A1 (en) 1994-02-02 1995-02-02 Pharmaceutically active compounds and liposomes, and methods of use therof

Publications (1)

Publication Number Publication Date
ATE195944T1 true ATE195944T1 (de) 2000-09-15

Family

ID=22700754

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95910923T ATE195944T1 (de) 1994-02-02 1995-02-02 Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung

Country Status (14)

Country Link
US (3) US5631394A (de)
EP (2) EP0742789B1 (de)
JP (1) JPH09508900A (de)
AT (1) ATE195944T1 (de)
AU (1) AU691886B2 (de)
CA (1) CA2182485A1 (de)
DE (1) DE69518627T2 (de)
DK (1) DK0742789T3 (de)
ES (1) ES2149350T3 (de)
FI (1) FI116620B (de)
GR (1) GR3034521T3 (de)
NO (1) NO314405B1 (de)
PT (1) PT742789E (de)
WO (1) WO1995021175A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255336B1 (en) 1995-09-20 2001-07-03 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
US5916911A (en) * 1995-09-20 1999-06-29 The Regents Of The University Of Michigan Amino ceramide--like compounds and therapeutic methods of use
CA2262870C (en) * 1996-04-04 2008-01-29 Cilag Ag Liposome-based topical vitamin d formulation
US6274309B1 (en) * 1996-07-26 2001-08-14 Richard Kolesnick Method for the modulation of acid-sphingomyelinase-related apoptosis
CN1055640C (zh) * 1996-11-29 2000-08-23 沃维汉 人降钙素基因相关肽脂质体组合物及其制法
US6982142B2 (en) 1997-12-01 2006-01-03 John Wayne Cancer Institute Methods for screening therapeutically effective agents
US7683044B2 (en) 1999-03-25 2010-03-23 Center For Molecular Medicine And Immunology Sphingomyelin therapy of autoimmune disease
JP2002540172A (ja) 1999-03-25 2002-11-26 センター・フォー・モレキュラー・メディシン・アンド・イムノロジー 腫瘍治療の増強のためのスフィンゴミエリン含有調製物
US7820718B1 (en) * 1999-04-07 2010-10-26 Roger Williams Hospital Combinations of ceramide and chemotherapeutic agents for inducing cell death and uses thereof in treating cancer
TW502133B (en) 1999-06-10 2002-09-11 Wako Pure Chem Ind Ltd Resist composition, agent and method for reducing substrate dependence thereof
US6682545B1 (en) * 1999-10-06 2004-01-27 The Penn State Research Foundation System and device for preventing restenosis in body vessels
AU1548101A (en) * 1999-11-24 2001-06-04 Sagami Chemical Research Center Sphingosine derivatives
US6410597B1 (en) * 2000-02-25 2002-06-25 Virginia Commonwealth University Hydroxyalkyl amide analogs of ceramide
US20030096022A1 (en) * 2000-12-22 2003-05-22 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
EP2266968B1 (de) 2001-07-16 2013-01-09 Genzyme Corporation Synthese von UDP-Glukose: N-Acetylsphingosin Glikosyltransferase Inhibitoren
EP1287815A1 (de) * 2001-08-31 2003-03-05 Cosmoferm B.V. Verwendung einer Sphingoidbase zur Inhibierung von Ceramidase-Aktivität
US20060217560A1 (en) * 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
US6916802B2 (en) * 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
EP1601344A2 (de) * 2003-03-07 2005-12-07 Celator Technologies Inc. Verbesserte verabreichung von sphingolipiden
US20060198882A1 (en) * 2003-03-21 2006-09-07 Yechezkel Barenholz Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
EP1617808A4 (de) * 2003-04-25 2011-11-02 Penn State Res Found Verfahren und system für die systemische abgabe von wachstumshemmenden von lipiden stammenden bioaktiven verbindungen
US7906122B2 (en) 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
US8242089B2 (en) * 2003-06-18 2012-08-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids polyalkylamine conjugates for use in transfection
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
CA2586761A1 (en) * 2004-11-10 2006-05-18 Genzyme Corporation Methods of treating diabetes mellitus
US20080058274A1 (en) * 2004-11-15 2008-03-06 Yechezkel Barenholz Combination Therapy
JP4791082B2 (ja) * 2005-05-30 2011-10-12 株式会社クラレ リポソームおよびそれを含む皮膚外用剤
EP1933813A4 (de) * 2005-10-11 2013-02-27 Univ Pittsburgh Sphingomyelin-liposome zur behandlung von hyperaktiven blasenstörungen
EP2032134B1 (de) * 2006-05-09 2015-06-24 Genzyme Corporation Verfahren zur behandlung von krankhafter fettleber durch hemmung der glucosphingolipid-synthese
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
CN101687031B (zh) 2006-10-27 2014-05-14 勒帕斯公司 用于治疗眼疾和眼病的组合物及方法
KR101581279B1 (ko) 2006-10-27 2015-12-31 엘파스, 인크. 스핑고신-1-포스페이트 결합을 위한 조성물 및 방법
US8304447B2 (en) 2007-05-31 2012-11-06 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
KR20160085917A (ko) 2007-10-05 2016-07-18 젠자임 코포레이션 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법
WO2009132082A2 (en) * 2008-04-22 2009-10-29 Medical College Of Georgia Research Institute, Inc. Immunogenic compositions containing ceramide and methods of use thereof
WO2010014554A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
US8309593B2 (en) 2008-10-03 2012-11-13 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
PL3133070T3 (pl) 2009-11-27 2020-01-31 Genzyme Corporation Eliglustat (Genz 112638) jako inhibitor syntazy glukozyloceramidowej do zastosowania w sposobie leczenia choroby Fabry’ego lub choroby Gauchera, przy czym sposób obejmuje dostosowanie indywidualnej dawki terapeutycznej do metabolizmu P450 u pacjenta
WO2013024843A1 (ja) * 2011-08-15 2013-02-21 国立大学法人 千葉大学 セラミド誘導体およびこれを用いたゴルジ体標識化蛍光プローブ
KR102423002B1 (ko) * 2021-02-17 2022-07-21 주식회사 엘씨에스바이오텍 신규 세라마이드, 그의 제조방법 및 그의 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
US5030453A (en) * 1983-03-24 1991-07-09 The Liposome Company, Inc. Stable plurilamellar vesicles
US4721612A (en) * 1984-04-12 1988-01-26 The Liposome Company, Inc. Steroidal liposomes
US5008050A (en) * 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US4975282A (en) * 1985-06-26 1990-12-04 The Liposome Company, Inc. Multilamellar liposomes having improved trapping efficiencies
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
FR2637598B1 (fr) * 1988-10-06 1991-10-11 Agronomique Inst Nat Rech Nouveaux sphingophospholipides a inositol, leur obtention, et leur application comme inducteurs de resistance a diverses maladies cryptogamiques chez les vegetaux
US5100662A (en) * 1989-08-23 1992-03-31 The Liposome Company, Inc. Steroidal liposomes exhibiting enhanced stability
DE4021082C2 (de) * 1990-07-03 1995-08-17 Hans Dr Lautenschlaeger Hautbehandlungsmittel mit hohen Lipidgehalten unter Verwendung eines Bilayer enthaltenden Systems, Salzen organischer Säuren, Alkohol und Stabilisator
EP0543922A4 (en) * 1990-08-13 1993-07-28 Duke University Methods for inducing cell differentiation using ceramides
GB9022921D0 (en) * 1990-10-22 1990-12-05 Unilever Plc Cosmetic composition
GB9100816D0 (en) * 1991-01-15 1991-02-27 Unilever Plc Cosmetic composition
DE4201461A1 (de) * 1992-01-21 1993-07-22 Mueller Schulte Detlef Dr Mittel fuer die selektive tumortherapie auf der basis ferromagnetischer partikel - verfahren zu ihrer herstellung und verwendung

Also Published As

Publication number Publication date
GR3034521T3 (en) 2000-12-29
NO963224L (no) 1996-09-27
FI116620B (fi) 2006-01-13
FI963045L (fi) 1996-08-01
EP0742789B1 (de) 2000-08-30
US5681589A (en) 1997-10-28
JPH09508900A (ja) 1997-09-09
EP1008342A2 (de) 2000-06-14
US5631394A (en) 1997-05-20
NO314405B1 (no) 2003-03-17
ES2149350T3 (es) 2000-11-01
US5677337A (en) 1997-10-14
EP1008342A3 (de) 2004-12-29
EP0742789A1 (de) 1996-11-20
PT742789E (pt) 2000-12-29
NO963224D0 (no) 1996-08-01
DE69518627T2 (de) 2001-01-11
DK0742789T3 (da) 2000-11-13
AU1871295A (en) 1995-08-21
CA2182485A1 (en) 1995-08-10
WO1995021175A1 (en) 1995-08-10
FI963045A0 (fi) 1996-08-01
DE69518627D1 (de) 2000-10-05
AU691886B2 (en) 1998-05-28

Similar Documents

Publication Publication Date Title
ATE195944T1 (de) Pharmazeutisch wirksame verbindungen und liposome und verfahren zu deren herstellung
AU689391B2 (en) Cyclic peptide antifungal agents and process for preparation thereof
DE69034202D1 (de) Zwischenprodukte zur Herstellung von non-peptiden retroviralproteasehemmenden Verbindungen
GR3032083T3 (en) Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone
ZA9710292B (en) Atherosclerosis treatment
UA27220C2 (uk) Спосіб одержання похідних 1-фенілімідазолін-2,5-діону
PL350775A1 (en) Pharmaceutical compounds
HUT59139A (en) Process for producing tricyclic compounds and antimicrobial pharmaceutical compositions comprising same
DK0958280T3 (da) Arylpiperidinopropanol- og arylpiperazinopropanolderivater og farmaceutiske midler der indeholder disse
HU9200656D0 (en) Method for producing morpholinyl derivatives of doxorubicine and pharmaceutical preparatives containing said compounds
GR3020190T3 (en) Diclofenac choline salt, a method for the preparation thereof and pharmaceutical compositions containing it
HU900654D0 (en) Process for preparation of new pyrrolidine derivatives and pharmaceutical preparations containing the said compounds
HU9501466D0 (en) Glycopyranoside benzothiophenes
WO2000010992A3 (en) Water-dispersible or water-soluble d-tocotrienol compounds and methods for making therefor
HU9202103D0 (en) Method for producing inosite-phosphate analogues and pharmaceutical preparatives containing these compounds
DE3864336D1 (en) Aromatische thioaether.
AU2202892A (en) Ammonium salt of methyl 4,4,4-trifluoro-3-oxo-butanethioate
IL103202A0 (en) Method for treating hypertension
TW275629B (de)
DE69711506D1 (de) Methylsulfomycin 1, Verfahren zu dessen Herstellung und Verwendung
TW227527B (en) An aniline offshoot condenser's divergent agent and synthesizing method
CA2238710A1 (en) New amino alcohol derivatives, processes for their production and pharmaceutical agents containing these compounds
MX9801963A (es) Derivados de benzotiazolona.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee