GR3034521T3 - Pharmaceutically active compounds and liposomes, and methods of use therof - Google Patents

Pharmaceutically active compounds and liposomes, and methods of use therof

Info

Publication number
GR3034521T3
GR3034521T3 GR20000402211T GR20000402211T GR3034521T3 GR 3034521 T3 GR3034521 T3 GR 3034521T3 GR 20000402211 T GR20000402211 T GR 20000402211T GR 20000402211 T GR20000402211 T GR 20000402211T GR 3034521 T3 GR3034521 T3 GR 3034521T3
Authority
GR
Greece
Prior art keywords
group
liposomes
methods
active compounds
pharmaceutically active
Prior art date
Application number
GR20000402211T
Other languages
English (en)
Inventor
Yong-Wei Pei
Eric Mayhew
Imran Ahmad
Andrew S Janoff
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of GR3034521T3 publication Critical patent/GR3034521T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR20000402211T 1994-02-02 2000-09-29 Pharmaceutically active compounds and liposomes, and methods of use therof GR3034521T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19029594A 1994-02-02 1994-02-02
PCT/US1995/001490 WO1995021175A1 (en) 1994-02-02 1995-02-02 Pharmaceutically active compounds and liposomes, and methods of use therof

Publications (1)

Publication Number Publication Date
GR3034521T3 true GR3034521T3 (en) 2000-12-29

Family

ID=22700754

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000402211T GR3034521T3 (en) 1994-02-02 2000-09-29 Pharmaceutically active compounds and liposomes, and methods of use therof

Country Status (14)

Country Link
US (3) US5631394A (el)
EP (2) EP0742789B1 (el)
JP (1) JPH09508900A (el)
AT (1) ATE195944T1 (el)
AU (1) AU691886B2 (el)
CA (1) CA2182485A1 (el)
DE (1) DE69518627T2 (el)
DK (1) DK0742789T3 (el)
ES (1) ES2149350T3 (el)
FI (1) FI116620B (el)
GR (1) GR3034521T3 (el)
NO (1) NO314405B1 (el)
PT (1) PT742789E (el)
WO (1) WO1995021175A1 (el)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916911A (en) * 1995-09-20 1999-06-29 The Regents Of The University Of Michigan Amino ceramide--like compounds and therapeutic methods of use
US6255336B1 (en) 1995-09-20 2001-07-03 The Regents Of The University Of Michigan Amino ceramide-like compounds and therapeutic methods of use
WO1997037637A1 (en) * 1996-04-04 1997-10-16 Ortho Pharmaceutical Corporation Liposome-based topical vitamin d formulation
US6274309B1 (en) * 1996-07-26 2001-08-14 Richard Kolesnick Method for the modulation of acid-sphingomyelinase-related apoptosis
CN1055640C (zh) * 1996-11-29 2000-08-23 沃维汉 人降钙素基因相关肽脂质体组合物及其制法
US6982142B2 (en) 1997-12-01 2006-01-03 John Wayne Cancer Institute Methods for screening therapeutically effective agents
JP2002540172A (ja) * 1999-03-25 2002-11-26 センター・フォー・モレキュラー・メディシン・アンド・イムノロジー 腫瘍治療の増強のためのスフィンゴミエリン含有調製物
US7683044B2 (en) 1999-03-25 2010-03-23 Center For Molecular Medicine And Immunology Sphingomyelin therapy of autoimmune disease
US7820718B1 (en) * 1999-04-07 2010-10-26 Roger Williams Hospital Combinations of ceramide and chemotherapeutic agents for inducing cell death and uses thereof in treating cancer
TW502133B (en) 1999-06-10 2002-09-11 Wako Pure Chem Ind Ltd Resist composition, agent and method for reducing substrate dependence thereof
US6682545B1 (en) * 1999-10-06 2004-01-27 The Penn State Research Foundation System and device for preventing restenosis in body vessels
AU1548101A (en) * 1999-11-24 2001-06-04 Sagami Chemical Research Center Sphingosine derivatives
US6410597B1 (en) * 2000-02-25 2002-06-25 Virginia Commonwealth University Hydroxyalkyl amide analogs of ceramide
CA2432978C (en) * 2000-12-22 2012-08-28 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
PT2266968E (pt) 2001-07-16 2013-02-25 Genzyme Corp Síntese de udp-glucose: inibidores de n-acil esfingosinaglucosiltransferase
EP1287815A1 (en) * 2001-08-31 2003-03-05 Cosmoferm B.V. Use of a sphingoid base for inhibiting ceramidase activity
US20060217560A1 (en) * 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
US6916802B2 (en) * 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
US20070031480A1 (en) * 2003-03-07 2007-02-08 Lawrence Mayer Enhanced delivery of sphingolipids
WO2004087097A2 (en) * 2003-03-31 2004-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
EP1617808A4 (en) * 2003-04-25 2011-11-02 Penn State Res Found METHOD AND SYSTEM FOR THE SYSTEMIC DISTRIBUTION OF GROWTH-INHIBITORS OF LIPID-DERIVED BIOACTIVE COMPOUNDS
BRPI0411505A (pt) * 2003-06-18 2006-07-25 Yissum Res Dev Co uso de um composto, método para modular a resposta imune de um indivìduo, composição farmacêutica, vacina, complexo, e, kit para a captura de uma molécula biologicamente ativa
US7906122B2 (en) 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
JP2008519840A (ja) * 2004-11-10 2008-06-12 ジェンザイム・コーポレイション 糖尿病の処置方法
CN101102752A (zh) * 2004-11-15 2008-01-09 耶路撒冷希伯来大学伊萨姆研发公司 联合优选为神经酰胺与细胞毒性药物的联合疗法
JP4791082B2 (ja) * 2005-05-30 2011-10-12 株式会社クラレ リポソームおよびそれを含む皮膚外用剤
WO2007044748A2 (en) * 2005-10-11 2007-04-19 University Of Pittsburgh Sphingomyelin liposomes for the treatment of hyperactive bladder disorders
PL2032134T3 (pl) 2006-05-09 2015-11-30 Genzyme Corp Sposoby leczenia stłuszczeniowej choroby wątroby obejmujące hamowanie syntezy glikosfingolipidów
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
MX2009004532A (es) 2006-10-27 2009-09-04 Lpath Inc Composiciones y metodos para unir esfingosina-1-fosfato.
US8444970B2 (en) 2006-10-27 2013-05-21 Lpath, Inc. Compositions and methods for treating ocular diseases and conditions
EP2594564B1 (en) 2007-05-31 2016-09-28 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
RU2517345C9 (ru) 2007-10-05 2014-08-20 Гензим Корпорейшн Способ лечения поликистозных заболеваний почек с помощью производных церамида
WO2009132082A2 (en) * 2008-04-22 2009-10-29 Medical College Of Georgia Research Institute, Inc. Immunogenic compositions containing ceramide and methods of use thereof
CA2731685A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
KR101687039B1 (ko) 2008-10-03 2016-12-15 젠자임 코포레이션 2-아실아미노프로판올형 글루코실세라미드 합성효소 억제제
HUE029371T2 (en) 2009-11-27 2017-02-28 Genzyme Corp GENZ 112638 For treatment of Gaucher or Fabry disease in combination therapy
JP6120222B2 (ja) * 2011-08-15 2017-04-26 国立大学法人 千葉大学 セラミド誘導体およびこれを用いたゴルジ体標識化蛍光プローブ
KR102423002B1 (ko) * 2021-02-17 2022-07-21 주식회사 엘씨에스바이오텍 신규 세라마이드, 그의 제조방법 및 그의 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
US5030453A (en) * 1983-03-24 1991-07-09 The Liposome Company, Inc. Stable plurilamellar vesicles
US4721612A (en) * 1984-04-12 1988-01-26 The Liposome Company, Inc. Steroidal liposomes
US5008050A (en) * 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
US4975282A (en) * 1985-06-26 1990-12-04 The Liposome Company, Inc. Multilamellar liposomes having improved trapping efficiencies
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
FR2637598B1 (fr) * 1988-10-06 1991-10-11 Agronomique Inst Nat Rech Nouveaux sphingophospholipides a inositol, leur obtention, et leur application comme inducteurs de resistance a diverses maladies cryptogamiques chez les vegetaux
US5100662A (en) * 1989-08-23 1992-03-31 The Liposome Company, Inc. Steroidal liposomes exhibiting enhanced stability
DE4021082C2 (de) * 1990-07-03 1995-08-17 Hans Dr Lautenschlaeger Hautbehandlungsmittel mit hohen Lipidgehalten unter Verwendung eines Bilayer enthaltenden Systems, Salzen organischer Säuren, Alkohol und Stabilisator
BR9106744A (pt) * 1990-08-13 1993-07-20 Univ Duke Processo para induzir diferenciacao celular,preparacao farmaceutica,composicao e uso de um composto
GB9022921D0 (en) * 1990-10-22 1990-12-05 Unilever Plc Cosmetic composition
GB9100816D0 (en) * 1991-01-15 1991-02-27 Unilever Plc Cosmetic composition
DE4201461A1 (de) * 1992-01-21 1993-07-22 Mueller Schulte Detlef Dr Mittel fuer die selektive tumortherapie auf der basis ferromagnetischer partikel - verfahren zu ihrer herstellung und verwendung

Also Published As

Publication number Publication date
CA2182485A1 (en) 1995-08-10
AU1871295A (en) 1995-08-21
US5681589A (en) 1997-10-28
NO963224L (no) 1996-09-27
NO963224D0 (no) 1996-08-01
EP1008342A2 (en) 2000-06-14
US5677337A (en) 1997-10-14
DE69518627T2 (de) 2001-01-11
NO314405B1 (no) 2003-03-17
AU691886B2 (en) 1998-05-28
DE69518627D1 (de) 2000-10-05
PT742789E (pt) 2000-12-29
FI116620B (fi) 2006-01-13
ATE195944T1 (de) 2000-09-15
FI963045A0 (fi) 1996-08-01
EP0742789B1 (en) 2000-08-30
US5631394A (en) 1997-05-20
ES2149350T3 (es) 2000-11-01
FI963045A (fi) 1996-08-01
DK0742789T3 (da) 2000-11-13
EP1008342A3 (en) 2004-12-29
JPH09508900A (ja) 1997-09-09
EP0742789A1 (en) 1996-11-20
WO1995021175A1 (en) 1995-08-10

Similar Documents

Publication Publication Date Title
GR3034521T3 (en) Pharmaceutically active compounds and liposomes, and methods of use therof
IL139960A0 (en) Macrocylic analogs and methods of their use and preparation
HK1012337A1 (en) Retroviral protease inhibiting compounds
AU689391B2 (en) Cyclic peptide antifungal agents and process for preparation thereof
GR3024255T3 (en) Benzo-fused lactams
NZ334886A (en) Heteroaryl succinamides and their use as metalloproteinase inhibitors
NZ231983A (en) Substituted 1,3-diazoles and 1,2,4-triazoles; fungicidal compositions, methods for preparation and combating fungal disease
GR3032083T3 (en) Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone
HK1019878A1 (en) Total synthesis of antitumor acylfulvenes.
HK1012341A1 (en) Pyrrolocarbazole
CA2149872A1 (en) Diabetes prevention and treatment
EP0192210A3 (en) New cephem compounds and processes for preparation thereof
GB8726763D0 (en) Thiazole compounds
EP1034783A4 (en) AMIDE DERIVATIVES
HU900654D0 (en) Process for preparation of new pyrrolidine derivatives and pharmaceutical preparations containing the said compounds
EP0974347A4 (en) ANTIVIRAL AGENTS
HU9501466D0 (en) Glycopyranoside benzothiophenes
TW275629B (el)
IL103202A0 (en) Method for treating hypertension
EP0372582A3 (en) 6-aminoalkyl carbapenems
DE69405999D1 (de) Pharmazeutisch wirksame enantiomere
GR3006223T3 (el)
ZA9510964B (en) Antiherpes peptidomimetic compounds
DE3660546D1 (en) Phosphoroimidates
CA2011668A1 (en) Germicidal composition

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees