DK0742789T3 - Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse - Google Patents

Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse

Info

Publication number
DK0742789T3
DK0742789T3 DK95910923T DK95910923T DK0742789T3 DK 0742789 T3 DK0742789 T3 DK 0742789T3 DK 95910923 T DK95910923 T DK 95910923T DK 95910923 T DK95910923 T DK 95910923T DK 0742789 T3 DK0742789 T3 DK 0742789T3
Authority
DK
Denmark
Prior art keywords
group
chain
liposomes
methods
active compounds
Prior art date
Application number
DK95910923T
Other languages
English (en)
Inventor
Andrew S Janoff
Imran Ahmad
Yong-Wei Pei
Eric Mayhew
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of DK0742789T3 publication Critical patent/DK0742789T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK95910923T 1994-02-02 1995-02-02 Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse DK0742789T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19029594A 1994-02-02 1994-02-02
PCT/US1995/001490 WO1995021175A1 (en) 1994-02-02 1995-02-02 Pharmaceutically active compounds and liposomes, and methods of use therof

Publications (1)

Publication Number Publication Date
DK0742789T3 true DK0742789T3 (da) 2000-11-13

Family

ID=22700754

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95910923T DK0742789T3 (da) 1994-02-02 1995-02-02 Farmaceutisk aktive forbindelser og liposomer og fremgangsmåder til anvendelse af disse

Country Status (14)

Country Link
US (3) US5631394A (da)
EP (2) EP0742789B1 (da)
JP (1) JPH09508900A (da)
AT (1) ATE195944T1 (da)
AU (1) AU691886B2 (da)
CA (1) CA2182485A1 (da)
DE (1) DE69518627T2 (da)
DK (1) DK0742789T3 (da)
ES (1) ES2149350T3 (da)
FI (1) FI116620B (da)
GR (1) GR3034521T3 (da)
NO (1) NO314405B1 (da)
PT (1) PT742789E (da)
WO (1) WO1995021175A1 (da)

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US6982142B2 (en) * 1997-12-01 2006-01-03 John Wayne Cancer Institute Methods for screening therapeutically effective agents
ES2269121T3 (es) 1999-03-25 2007-04-01 Center For Molecular Medicine And Immunology Preparacion que contiene esfingomielina destinada a mejorar la terapia tumoral.
US7683044B2 (en) * 1999-03-25 2010-03-23 Center For Molecular Medicine And Immunology Sphingomyelin therapy of autoimmune disease
US7820718B1 (en) * 1999-04-07 2010-10-26 Roger Williams Hospital Combinations of ceramide and chemotherapeutic agents for inducing cell death and uses thereof in treating cancer
TW502133B (en) 1999-06-10 2002-09-11 Wako Pure Chem Ind Ltd Resist composition, agent and method for reducing substrate dependence thereof
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AU1548101A (en) * 1999-11-24 2001-06-04 Sagami Chemical Research Center Sphingosine derivatives
US6410597B1 (en) * 2000-02-25 2002-06-25 Virginia Commonwealth University Hydroxyalkyl amide analogs of ceramide
US6881546B2 (en) * 2000-12-22 2005-04-19 Medlyte, Inc., Sdsu Heart Institute Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
DK2067775T3 (da) * 2001-07-16 2012-07-16 Genzyme Corp N-acylsphingosinglucosyltransferase-inhibitor
EP1287815A1 (en) * 2001-08-31 2003-03-05 Cosmoferm B.V. Use of a sphingoid base for inhibiting ceramidase activity
US6916802B2 (en) * 2002-04-29 2005-07-12 Genzyme Corporation Amino ceramide-like compounds and therapeutic methods of use
US20060217560A1 (en) * 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
US20070031480A1 (en) * 2003-03-07 2007-02-08 Lawrence Mayer Enhanced delivery of sphingolipids
EP1610763A2 (en) * 2003-03-31 2006-01-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Stable liposomes or micelles comprising a sphingolipid and a peg-lipopolymer
CN1812766A (zh) * 2003-04-25 2006-08-02 宾州研究基金会 用于全身传递使生长停滞的、衍生于脂质的生物活性化合物的方法和系统
US7906122B2 (en) 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
EP1638610B1 (en) * 2003-06-18 2015-03-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingoid polyalkylamine conjugates for vaccination
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
BRPI0517701A8 (pt) * 2004-11-10 2018-01-23 Genzyme Corp métodos de tratamento de diabetes mellitus
WO2006051549A2 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combination therapy associating preferably a ceramide with a cytotoxic drug
JP4791082B2 (ja) * 2005-05-30 2011-10-12 株式会社クラレ リポソームおよびそれを含む皮膚外用剤
JP5815915B2 (ja) * 2005-10-11 2015-11-17 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 過活動膀胱障害の治療のためのスフィンゴミエリンリポソーム
EP2923699B1 (en) 2006-05-09 2018-06-20 Genzyme Corporation Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
AU2007329759B2 (en) 2006-10-27 2013-05-30 Lpath, Inc. Compositions and methods for binding sphingosine-1-phosphate
US8614103B2 (en) 2006-10-27 2013-12-24 Lpath, Inc. Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions
EP2594563B1 (en) 2007-05-31 2018-07-18 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
CN102940627A (zh) 2007-10-05 2013-02-27 简詹姆公司 使用脑酰胺衍生物治疗多囊性肾疾病的方法
WO2009132082A2 (en) * 2008-04-22 2009-10-29 Medical College Of Georgia Research Institute, Inc. Immunogenic compositions containing ceramide and methods of use thereof
WO2010014554A1 (en) 2008-07-28 2010-02-04 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
EP3078373A1 (en) 2008-10-03 2016-10-12 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitor
EA029990B1 (ru) 2009-11-27 2018-06-29 Джензим Корпорэйшн Способы лечения ингибиторами глюкозилцерамидсинтазы
US9207232B2 (en) * 2011-08-15 2015-12-08 National University Corporation Chiba University Ceramide derivative and Golgi apparatus-labeling fluorescent probe using same
KR102423002B1 (ko) * 2021-02-17 2022-07-21 주식회사 엘씨에스바이오텍 신규 세라마이드, 그의 제조방법 및 그의 용도

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Also Published As

Publication number Publication date
DE69518627D1 (de) 2000-10-05
NO963224D0 (no) 1996-08-01
ATE195944T1 (de) 2000-09-15
FI963045A0 (fi) 1996-08-01
US5631394A (en) 1997-05-20
AU1871295A (en) 1995-08-21
PT742789E (pt) 2000-12-29
CA2182485A1 (en) 1995-08-10
AU691886B2 (en) 1998-05-28
EP1008342A2 (en) 2000-06-14
FI963045A (fi) 1996-08-01
WO1995021175A1 (en) 1995-08-10
DE69518627T2 (de) 2001-01-11
JPH09508900A (ja) 1997-09-09
EP1008342A3 (en) 2004-12-29
US5677337A (en) 1997-10-14
NO314405B1 (no) 2003-03-17
NO963224L (no) 1996-09-27
EP0742789B1 (en) 2000-08-30
ES2149350T3 (es) 2000-11-01
FI116620B (fi) 2006-01-13
EP0742789A1 (en) 1996-11-20
GR3034521T3 (en) 2000-12-29
US5681589A (en) 1997-10-28

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