HK1153733A1 - - Google Patents

Info

Publication number
HK1153733A1
HK1153733A1 HK11106527.6A HK11106527A HK1153733A1 HK 1153733 A1 HK1153733 A1 HK 1153733A1 HK 11106527 A HK11106527 A HK 11106527A HK 1153733 A1 HK1153733 A1 HK 1153733A1
Authority
HK
Hong Kong
Prior art keywords
disclosed
synthesis
novel
ceramide
udp
Prior art date
Application number
HK11106527.6A
Other languages
English (en)
Inventor
Bradford Hirth
Craig Siegel
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23182463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1153733(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of HK1153733A1 publication Critical patent/HK1153733A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK11106527.6A 2001-07-16 2011-06-23 HK1153733A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30581401P 2001-07-16 2001-07-16

Publications (1)

Publication Number Publication Date
HK1153733A1 true HK1153733A1 (fr) 2012-04-05

Family

ID=23182463

Family Applications (2)

Application Number Title Priority Date Filing Date
HK09111547.6A HK1132267A1 (en) 2001-07-16 2009-12-09 A n-acylsphingosine glucosyltransferase inhibitor n-
HK11106527.6A HK1153733A1 (fr) 2001-07-16 2011-06-23

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK09111547.6A HK1132267A1 (en) 2001-07-16 2009-12-09 A n-acylsphingosine glucosyltransferase inhibitor n-

Country Status (16)

Country Link
US (11) US6855830B2 (fr)
EP (3) EP2266968B1 (fr)
JP (6) JP5038582B2 (fr)
AT (2) ATE555102T1 (fr)
BE (1) BE2015C029I2 (fr)
BR (3) BR122015016314B8 (fr)
CA (1) CA2453978C (fr)
CY (1) CY2015028I2 (fr)
DK (3) DK2266968T3 (fr)
ES (3) ES2395122T3 (fr)
FR (1) FR15C0036I2 (fr)
HK (2) HK1132267A1 (fr)
IL (3) IL159905A0 (fr)
LU (1) LU92717I2 (fr)
PT (3) PT1409467E (fr)
WO (1) WO2003008399A1 (fr)

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US20060217560A1 (en) * 2002-04-29 2006-09-28 Shayman James A Amino ceramide-like compounds and therapeutic methods of use
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JP4195411B2 (ja) * 2004-04-12 2008-12-10 セイコーエプソン株式会社 有機エレクトロルミネッセンス装置の製造方法
EP1811991B1 (fr) * 2004-11-10 2018-11-07 Genzyme Corporation Traitement du diabete de type 2 en utilisant d'inhibiteurs de la synthese des glycosphingolipides
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EP2923699B1 (fr) * 2006-05-09 2018-06-20 Genzyme Corporation Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides
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US8961959B2 (en) 2011-10-17 2015-02-24 The Regents Of The University Of Michigan Glucosylceramide synthase inhibitors and therapeutic methods using the same
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EP3046920B1 (fr) 2013-09-20 2021-08-04 BioMarin Pharmaceutical Inc. Inhibiteurs de la glucosylcéramide synthase pour le traitement de maladies
WO2015059679A1 (fr) * 2013-10-25 2015-04-30 Dr. Reddy's Laboratories Limited Procédé amélioré pour la préparation d'éliglustat
EP3063141B1 (fr) 2013-10-29 2018-02-28 BioMarin Pharmaceutical Inc. Dérivés n-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide utiles en tant qu'inhibiteurs de la glucosylcéramide synthase
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CN104557851B (zh) * 2015-02-10 2017-04-05 苏州明锐医药科技有限公司 依鲁司他的制备方法
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WO2017178499A1 (fr) 2016-04-11 2017-10-19 Spedding Research Solutions Inhibiteurs de dégradation des glucosylcéramides dans le traitement des maladies des neurones moteurs
CN106349210A (zh) * 2016-08-24 2017-01-25 北京阳光诺和药物研究有限公司 一种制备酒石酸艾力骨司坦的方法
CN106967042B (zh) 2017-03-21 2020-08-14 浙江奥翔药业股份有限公司 依利格鲁司他的合成方法及其中间体化合物
CN108822072B (zh) * 2017-04-11 2021-01-12 中国医学科学院药物研究所 一种制备伊力格鲁司他的方法
WO2018193090A2 (fr) 2017-04-21 2018-10-25 Amneal Pharmaceuticals Company Gmbh Procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci
WO2018225085A1 (fr) 2017-06-05 2018-12-13 Cipla Limited Dispersions solides stables d'hémitartrate d'éliglustat
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CN111217791B (zh) * 2018-11-27 2024-02-02 广东东阳光药业股份有限公司 依鲁司他中间体及其制备方法
EP3941917A4 (fr) * 2019-03-22 2022-12-21 Piramal Pharma Limited Procédé amélioré pour la préparation d'éliglustat et de son intermédiaire
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WO2021214771A1 (fr) 2020-04-23 2021-10-28 The Israel Institute of Biological Research (IIBR) Inhibiteurs de glucosylcéramide synthase pour la prévention et le traitement de maladies virales
WO2021221953A1 (fr) 2020-04-28 2021-11-04 The Regents Of The University Of Michigan Inhibiteurs pyridine de la glucosylcéramide synthase et procédés thérapeutiques les utilisant
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EP2923699B1 (fr) * 2006-05-09 2018-06-20 Genzyme Corporation Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides

Also Published As

Publication number Publication date
FR15C0036I1 (fr) 2015-06-26
HK1132267A1 (en) 2010-02-19
JP2010095546A (ja) 2010-04-30
BR0211379A (pt) 2004-08-17
US20050009872A1 (en) 2005-01-13
FR15C0036I2 (fr) 2016-05-27
BE2015C029I2 (fr) 2021-07-19
US20190322649A1 (en) 2019-10-24
US20080058514A1 (en) 2008-03-06
EP2266968A2 (fr) 2010-12-29
US7196205B2 (en) 2007-03-27
US7615573B2 (en) 2009-11-10
US20210171507A1 (en) 2021-06-10
JP2005502635A (ja) 2005-01-27
US20150148534A1 (en) 2015-05-28
CY2015028I1 (el) 2016-07-27
BR122015016314B8 (pt) 2021-05-25
JP4708073B2 (ja) 2011-06-22
US8138353B2 (en) 2012-03-20
ES2395463T3 (es) 2013-02-15
BR122015016313B8 (pt) 2021-05-25
EP2067775A1 (fr) 2009-06-10
BR122015016314B1 (pt) 2019-04-16
JP2005255686A (ja) 2005-09-22
DK2067775T3 (da) 2012-07-16
EP2266968A3 (fr) 2011-05-18
IL159905A0 (en) 2004-06-20
JP2015180656A (ja) 2015-10-15
BR122015016313B1 (pt) 2019-04-16
US8779163B2 (en) 2014-07-15
CY2015028I2 (el) 2016-07-27
JP6182254B2 (ja) 2017-08-16
JP5038582B2 (ja) 2012-10-03
DK2266968T3 (da) 2013-04-08
WO2003008399A1 (fr) 2003-01-30
US20050222244A1 (en) 2005-10-06
US20170334888A1 (en) 2017-11-23
IL193244A0 (en) 2009-02-11
JP2013136618A (ja) 2013-07-11
EP2067775B1 (fr) 2012-04-25
BRPI0211379B1 (pt) 2018-02-14
ES2395463T4 (es) 2013-02-12
EP1409467A1 (fr) 2004-04-21
US20120296088A1 (en) 2012-11-22
CA2453978C (fr) 2011-10-11
ATE554082T1 (de) 2012-05-15
JP2017075151A (ja) 2017-04-20
ES2395122T3 (es) 2013-02-08
PT1409467E (pt) 2012-10-24
US20070203223A1 (en) 2007-08-30
DK1409467T3 (da) 2012-07-16
US9546161B2 (en) 2017-01-17
ES2399323T3 (es) 2013-03-27
US7763738B2 (en) 2010-07-27
CA2453978A1 (fr) 2003-01-30
BRPI0211379B8 (pt) 2021-05-25
US7265228B2 (en) 2007-09-04
US20030050299A1 (en) 2003-03-13
IL159905A (en) 2009-05-04
ATE555102T1 (de) 2012-05-15
LU92717I2 (fr) 2015-11-24
PT2067775E (pt) 2012-07-16
PT2266968E (pt) 2013-02-25
JP5227348B2 (ja) 2013-07-03
EP1409467B1 (fr) 2012-04-18
EP2266968B1 (fr) 2013-01-09
US20110003987A1 (en) 2011-01-06
US6855830B2 (en) 2005-02-15

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